{"id":"https://openalex.org/W2139532093","doi":"https://doi.org/10.4049/jimmunol.136.12.4487","title":"The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon- gamma .","display_name":"The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon- gamma .","publication_year":1986,"publication_date":"1986-06-01","ids":{"openalex":"https://openalex.org/W2139532093","doi":"https://doi.org/10.4049/jimmunol.136.12.4487","mag":"2139532093","pmid":"https://pubmed.ncbi.nlm.nih.gov/3086433"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.136.12.4487","doi":"https://doi.org/10.4049/jimmunol.136.12.4487","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.136.12.4487","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H E Broxmeyer","raw_affiliation_strings":["Department of Microbiology and Immunoloy , 541 Clinical Drive, Indianapolis, IN 46223","Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunoloy , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110221989","display_name":"Douglas E. Williams","orcid":"https://orcid.org/0000-0001-5343-4783","observed_orcids":["https://orcid.org/0000-0001-5343-4783"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Williams","raw_affiliation_strings":["Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030296400","display_name":"Li Lu","orcid":"https://orcid.org/0000-0002-7132-5035","observed_orcids":["https://orcid.org/0000-0002-7132-5035"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Lu","raw_affiliation_strings":["Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034118912","display_name":"Scott H. Cooper","orcid":"https://orcid.org/0000-0001-9091-8269","observed_orcids":["https://orcid.org/0000-0001-9091-8269"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Cooper","raw_affiliation_strings":["Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045849420","display_name":"Sylvia L. Anderson","orcid":"https://orcid.org/0000-0001-7980-0040","observed_orcids":["https://orcid.org/0000-0001-7980-0040"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S L Anderson","raw_affiliation_strings":["The Lindsley F. Kimball Research Institute of the New York Blood Center, Department of Lymphokine Biology , 310 East 67th Street, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lindsley F. Kimball Research Institute of the New York Blood Center, Department of Lymphokine Biology , 310 East 67th Street, New York, NY 10021","institution_ids":["https://openalex.org/I1343675862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022446184","display_name":"G S Beyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Beyer","raw_affiliation_strings":["Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Hoffman","raw_affiliation_strings":["Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, the Walther Medical Research Institute, and the Elks Cancer Research Center, Department of Medicine (Hematology/Oncology) , 541 Clinical Drive, Indianapolis, IN 46223","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035145274","display_name":"B Y Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Y Rubin","raw_affiliation_strings":["The Lindsley F. Kimball Research Institute of the New York Blood Center, Department of Lymphokine Biology , 310 East 67th Street, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lindsley F. Kimball Research Institute of the New York Blood Center, Department of Lymphokine Biology , 310 East 67th Street, New York, NY 10021","institution_ids":["https://openalex.org/I1343675862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":25.7396,"has_fulltext":false,"cited_by_count":466,"citation_normalized_percentile":{"value":0.9984284,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"136","issue":"12","first_page":"4487","last_page":"4495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.7549999952316284},{"id":"https://openalex.org/keywords/bfu-e","display_name":"BFU-E","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cfu-gemm","display_name":"CFU-GEMM","score":0.9259999990463257},{"id":"https://openalex.org/keywords/colony-formation-inhibition","display_name":"colony formation inhibition","score":0.722000002861023},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5630000233650208},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.890999972820282},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.7160000205039978},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.5559999942779541},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.453000009059906},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/anti-tnf-antibodies","display_name":"anti-TNF antibodies","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.8011080622673035},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6579023599624634},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6212047934532166},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.5553688406944275},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5514793395996094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5435649156570435},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5361452102661133},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.48708605766296387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.456644743680954},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.432073712348938},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.41782301664352417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35436609387397766},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3011607229709625},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15141567587852478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08595240116119385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07206815481185913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.136.12.4487","doi":"https://doi.org/10.4049/jimmunol.136.12.4487","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.136.12.4487","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:3086433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3086433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G54219016","display_name":"INTERFERON PROPERTIES, ACTIONS, &PATIENT PRESCREENING","funder_award_id":"R01CA038661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8470211613","display_name":"REGULATION OF MYELOPOIESIS:  SUPPRESSOR FACTOR SYNERGISM","funder_award_id":"R01CA036740","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8804476219","display_name":"REGULATION OF BLOOD CELL PROLIFERATION-DIFFERENTIATION","funder_award_id":"1t32am007519-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116898348","https://openalex.org/W1987855294","https://openalex.org/W288838515","https://openalex.org/W2058185384","https://openalex.org/W2089640569","https://openalex.org/W2463811210","https://openalex.org/W2297665892","https://openalex.org/W2126868381","https://openalex.org/W2471656651","https://openalex.org/W2141690432"],"abstract_inverted_index":{"The":[0,109,130,151,286],"influences":[1],"of":[2,67,112,139,154,177,207,231,254,257,283,290,295,310,315,345,353],"human":[3,10,13,36,128,214,220],"tumor":[4],"necrosis":[5],"factor":[6],"(TNF)":[7],"(LuKII),":[8],"recombinant":[9,16,60,116,329,335],"TNF-alpha,":[11],"natural":[12,19,333],"interferon-gamma":[14],"(HuIFN-gamma),":[15],"HuIFN-gamma,":[17,336],"and":[18,43,59,73,88,99,115,125,141,173,247,276,317,348],"HuIFN-alpha":[20],"were":[21,79,102,118,216,240,264,272,319,365],"evaluated":[22,320],"alone":[23],"or":[24,188,303,328,334],"in":[25,30,52,168,186,212,243,301],"combination":[26],"for":[27,182,199],"their":[28],"effects":[29,111,138,153,362],"vitro":[31],"on":[32],"colony":[33,68,291,343],"formation":[34,69,292,344],"by":[35,95,269,293],"bone":[37,170,232,281,351],"marrow":[38,171,178,221,227,233,282,352],"granulocyte-macrophage":[39],"(CFU-GM),":[40],"erythroid":[41],"(BFU-E),":[42],"multipotential":[44],"(CFU-GEMM)":[45],"progenitor":[46],"cells":[47,179,195,263],"incubated":[48],"at":[49,356],"5%":[50],"CO2":[51],"lowered":[53],"(5%)":[54],"O2":[55],"tension.":[56],"TNF":[57,113,123,149,155,181,198,215,270,289,316,326,330],"(LuKII)":[58,114,124,132,327],"TNF-alpha":[61,117,140,145],"caused":[62],"a":[63,174],"similar":[64],"dose-dependent":[65],"inhibition":[66,94,106,191,268],"from":[70,234,279,350],"CFU-GM,":[71,346],"BFU-E,":[72,347],"CFU-GEMM.":[74],"Day":[75],"7":[76,90],"CFU-GM":[77,86,91,222,228,245,274,294],"colonies":[78,87,98,101,223,275],"more":[80,217,265],"sensitive":[81,104,266],"than":[82,224,271],"both":[83],"day":[84,89],"14":[85],"clusters":[92,277],"to":[93,105,159,267,288,341],"TNF.":[96,108],"BFU-E":[97],"CFU-GEMM":[100,349],"least":[103],"with":[107,121,180,194,197,236,297,308,332,339],"suppressive":[110,137,152,361],"inactivated":[119],"respectively":[120],"hetero-anti-human":[122],"monoclonal":[126,143],"anti-recombinant":[127,144],"TNF-alpha.":[129],"hetero-anti-TNF":[131],"did":[133,146,156],"not":[134,147,157,338],"inactivate":[135,148],"the":[136,142,169,200,244,249,273,280],"(LuKII).":[150],"appear":[158],"be":[160],"mediated":[161],"via":[162],"endogenous":[163],"T":[164],"lymphocytes":[165],"and/or":[166],"monocytes":[167],"preparation,":[172],"pulse":[175],"exposure":[176],"60":[183],"min":[184],"resulted":[185],"maximal":[187,190],"near":[189],"when":[192,363],"compared":[193],"left":[196],"full":[201],"culture":[202],"incubation":[203],"period.":[204],"A":[205],"degree":[206],"species":[208],"specificity":[209],"was":[210,306,323],"noted":[211,324],"that":[213,309,325,358],"active":[218],"against":[219,225],"mouse":[226],"colonies.":[229],"Samples":[230],"patients":[235,296],"non-remission":[237],"myeloid":[238],"leukemia":[239,300],"set":[241],"up":[242],"assay":[246],"formed":[248],"characteristic":[250],"abnormal":[251],"growth":[252],"pattern":[253],"large":[255],"numbers":[256],"small":[258],"sized":[259],"clusters.":[260],"These":[261],"cluster-forming":[262],"grown":[278],"normal":[284,311,354],"donors.":[285,312],"sensitivity":[287],"acute":[298],"myelogenous":[299],"partial":[302],"complete":[304],"remission":[305],"comparable":[307],"When":[313],"combinations":[314],"HuIFN":[318],"together,":[321],"it":[322],"synergized":[331],"but":[337],"HuIFN-alpha,":[340],"suppress":[342],"donors":[355],"concentrations":[357],"had":[359],"no":[360],"molecules":[364],"used":[366],"alone.(ABSTRACT":[367],"TRUNCATED":[368],"AT":[369],"400":[370],"WORDS)":[371]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}