{"id":"https://openalex.org/W2139508982","doi":"https://doi.org/10.1210/mend.14.7.0478","title":"Regulable Expression of Inhibin A in Wild-Type and Inhibin\u03b1 Null Mice","display_name":"Regulable Expression of Inhibin A in Wild-Type and Inhibin\u03b1 Null Mice","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2139508982","doi":"https://doi.org/10.1210/mend.14.7.0478","mag":"2139508982","pmid":"https://pubmed.ncbi.nlm.nih.gov/10894156"},"language":"en","primary_location":{"id":"doi:10.1210/mend.14.7.0478","doi":"https://doi.org/10.1210/mend.14.7.0478","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.7.0478","pdf_url":"https://academic.oup.com/mend/article-pdf/14/7/1075/8949851/mend1075.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/14/7/1075/8949851/mend1075.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042515119","display_name":"Tyler Mark Pierson","orcid":"https://orcid.org/0000-0003-1985-3671","observed_orcids":["https://orcid.org/0000-0003-1985-3671"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Mark Pierson","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, Texas 77030, USA","Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002237217","display_name":"Yaolin Wang","orcid":"https://orcid.org/0000-0003-1932-9810","observed_orcids":["https://orcid.org/0000-0003-1932-9810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaolin Wang","raw_affiliation_strings":["Schering-Plough Corp. Research Institute (Y.W.) Kenilworth, New Jersey 07033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Corp. Research Institute (Y.W.) Kenilworth, New Jersey 07033","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069048623","display_name":"Francesco John DeMayo","orcid":"https://orcid.org/0000-0002-9480-7336","observed_orcids":["https://orcid.org/0000-0002-9480-7336","https://orcid.org/0000-0001-8825-503X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco J. DeMayo","raw_affiliation_strings":["Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050632280","display_name":"Martin Matthew Matzuk","orcid":"https://orcid.org/0000-0002-1445-8632","observed_orcids":["https://orcid.org/0000-0002-1445-8632"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin M. Matzuk","raw_affiliation_strings":["Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","Department of Molecular and Human Genetics (M.M.M.) Baylor College of Medicine Houston, Texas 77030","Department of Pathology (M.M.M.), Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Human Genetics (M.M.M.) Baylor College of Medicine Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pathology (M.M.M.), Texas 77030","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082214330","display_name":"Sophia Y. Tsai","orcid":"https://orcid.org/0000-0002-5138-7159","observed_orcids":["https://orcid.org/0000-0002-5138-7159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Y. Tsai","raw_affiliation_strings":["Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057978718","display_name":"Bert W. O\u2019Malley","orcid":"https://orcid.org/0000-0003-3332-1399","observed_orcids":["https://orcid.org/0000-0003-3332-1399"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bert W. O\u2019Malley","raw_affiliation_strings":["Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology (T.M.P., F.J.D., M.M.M., S.Y.T., B.W.O.) Texas 77030","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057978718"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.8877,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.98213572,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"7","first_page":"1075","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.12309999763965607,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibin-a","display_name":"inhibin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inducible-gene-expression","display_name":"inducible gene expression","score":0.765999972820282},{"id":"https://openalex.org/keywords/liver-specific-expression","display_name":"liver-specific gene expression","score":0.6050000190734863},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/testicular-volume","display_name":"testicular volume","score":0.7179999947547913},{"id":"https://openalex.org/keywords/fsh-suppression","display_name":"FSH suppression","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8786277770996094},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5710248351097107},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5600172281265259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5356459617614746},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4478866457939148},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.44624441862106323},{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.4440239369869232},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.4294029772281647},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.41311758756637573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41016411781311035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3874852657318115},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3737347722053528},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37241828441619873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26555413007736206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1900099515914917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/mend.14.7.0478","doi":"https://doi.org/10.1210/mend.14.7.0478","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.7.0478","pdf_url":"https://academic.oup.com/mend/article-pdf/14/7/1075/8949851/mend1075.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:10894156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10894156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/mend.14.7.0478","doi":"https://doi.org/10.1210/mend.14.7.0478","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.7.0478","pdf_url":"https://academic.oup.com/mend/article-pdf/14/7/1075/8949851/mend1075.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G168000598","display_name":null,"funder_award_id":"HL59314","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1846358234","display_name":"Mouse Models to Study Gonadal Tumor Development","funder_award_id":"R01CA060651","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5278720985","display_name":null,"funder_award_id":"CA 60651","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139508982.pdf","grobid_xml":"https://content.openalex.org/works/W2139508982.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1930907473","https://openalex.org/W1970586355","https://openalex.org/W1974837569","https://openalex.org/W1985411380","https://openalex.org/W1988607142","https://openalex.org/W1991046191","https://openalex.org/W2007048730","https://openalex.org/W2007095985","https://openalex.org/W2009823022","https://openalex.org/W2011025411","https://openalex.org/W2013596574","https://openalex.org/W2016791091","https://openalex.org/W2020838536","https://openalex.org/W2021043660","https://openalex.org/W2021824698","https://openalex.org/W2027576665","https://openalex.org/W2035066075","https://openalex.org/W2039736672","https://openalex.org/W2041418516","https://openalex.org/W2047119340","https://openalex.org/W2055304898","https://openalex.org/W2056015074","https://openalex.org/W2065475477","https://openalex.org/W2085321659","https://openalex.org/W2092224562","https://openalex.org/W2093392304","https://openalex.org/W2114512872","https://openalex.org/W2124338103","https://openalex.org/W2139366844","https://openalex.org/W2142128509","https://openalex.org/W2147612074","https://openalex.org/W2399438391","https://openalex.org/W2409456257","https://openalex.org/W4230663649","https://openalex.org/W4255946357"],"related_works":["https://openalex.org/W2151543108","https://openalex.org/W4254369171","https://openalex.org/W2051296031","https://openalex.org/W4233491362","https://openalex.org/W2064149288","https://openalex.org/W2031604686","https://openalex.org/W2138468070","https://openalex.org/W1989023875","https://openalex.org/W4390466071","https://openalex.org/W4390472947"],"abstract_inverted_index":{"Exogenous":[0],"regulation":[1],"of":[2,12,28,55,61,71,77,101,122,140,154,163,166,173,239,252,264,280,304],"protein":[3,67],"expression":[4,54,121,165],"creates":[5],"the":[6,10,26,53,59,99,106,113,150,170,196,222,229,237,243,250,276,301],"potential":[7],"to":[8,33,51,79,202,216,231,289,310],"examine":[9],"consequences":[11],"homeostatic":[13],"Dysregulation":[14],"in":[15,22,90,176,193,242,255,277,316],"many":[16],"physiological":[17,82,294],"systems":[18],"and,":[19],"when":[20],"used":[21,44,309],"transgenic":[23,116,132],"mice,":[24],"provides":[25],"capability":[27],"restoring":[29],"a":[30,45,65,123,136,180,191,281,285,312],"gene":[31],"product":[32],"its":[34,72,81,291],"knockout":[35,314],"background":[36,247],"without":[37],"antigenicity":[38],"issues.":[39],"In":[40,296],"this":[41],"study,":[42],"we":[43],"mifeprisone-inducible":[46],"system":[47,307],"(the":[48],"GeneSwitch":[49,114],"system)":[50],"regulate":[52],"inhibin":[56,155,167,174,224,244,253,256],"A":[57,93,168,175,225,254],"from":[58,169,267,284],"liver":[60],"mice.":[62,209],"Inhibin":[63,86],"is":[64,75,87],"heterodimeric":[66,282],"(alpha/beta)":[68],"wherein":[69,182],"one":[70],"subunits":[73],"(beta)":[74],"capable":[76,162],"homodimerizing":[78],"form":[80],"antagonist,":[83],"activin":[84,203],"(beta/beta).":[85],"also":[88],"expressed":[89],"two":[91],"forms,":[92],"and":[94,152,188,293],"B,":[95],"as":[96],"determined":[97],"by":[98],"subtype":[100],"beta-subunit":[102],"that":[103,221],"dimerizes":[104],"with":[105,119,131,261],"alpha-subunit":[107],"(alpha/betaA":[108],"or":[109],"alpha/betaB).":[110],"To":[111],"utilize":[112],"system,":[115],"transactivator":[117],"mice":[118,134,161,178,241,260,266],"liver-specific":[120],"mifepristone-activated":[124],"chimeric":[125],"nuclear":[126],"receptor":[127,206],"(GLVP)":[128],"were":[129,212],"crossed":[130],"target":[133],"containing":[135],"GVLP-responsive":[137],"promoter":[138,288],"upstream":[139],"polio-virus":[141],"IRES":[142],"(internal":[143],"ribosome":[144],"entry":[145],"site)-linked":[146],"sequences":[147],"coding":[148],"for":[149,249],"alpha-":[151],"beta-subunits":[153],"A.":[156],"This":[157,273],"intercross":[158],"produced":[159,179],"\"bigenic\"":[160],"regulable":[164],"liver.":[171],"Overexpression":[172],"wild-type":[177],"phenotype":[181,315],"males":[183],"had":[184,190],"decreased":[185],"testis":[186],"size":[187],"females":[189],"block":[192],"folliculogenesis":[194],"at":[195],"early":[197],"antral":[198],"stage,":[199],"findings":[200],"similar":[201],"type":[204],"IIA":[205],"(ActRIIA)":[207],"null":[208,246,258],"These":[210],"phenotypes":[211],"most":[213],"likely":[214],"due":[215],"suppressed":[217],"serum":[218,230],"FSH,":[219],"confirming":[220],"liver-derived":[223],"was":[226],"secreted":[227],"into":[228],"down-regulate":[232],"pituitary":[233],"FSH":[234],"levels.":[235],"Furthermore,":[236],"generation":[238],"bigenic":[240],"alpha":[245,257],"allowed":[248],"induction":[251],"male":[259],"subsequent":[262],"rescue":[263],"these":[265,298],"their":[268],"gonadal":[269],"tumor-induced":[270],"lethal":[271,313],"phenotype.":[272],"work":[274],"demonstrates":[275],"vivo":[278],"production":[279],"hormone":[283],"single":[286],"inducible":[287,306],"study":[290],"therapeutic":[292],"effects.":[295],"addition,":[297],"studies":[299],"are":[300],"first":[302],"example":[303],"an":[305,317],"being":[308],"prevent":[311],"animal":[318],"model.":[319]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
