{"id":"https://openalex.org/W2139507985","doi":"https://doi.org/10.2174/1386207053764549","title":"Improving on Natures Defenses: Optimization & High Throughput Screening of Antimicrobial Peptides","display_name":"Improving on Natures Defenses: Optimization & High Throughput Screening of Antimicrobial Peptides","publication_year":2005,"publication_date":"2005-04-30","ids":{"openalex":"https://openalex.org/W2139507985","doi":"https://doi.org/10.2174/1386207053764549","mag":"2139507985","pmid":"https://pubmed.ncbi.nlm.nih.gov/15892624"},"language":"en","primary_location":{"id":"doi:10.2174/1386207053764549","doi":"https://doi.org/10.2174/1386207053764549","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207053764549","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry &amp; High Throughput Screening","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109228344","display_name":"Dorotea Ravent\u00f3s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106887733","display_name":"Novozymes (Denmark)","ror":"https://ror.org/03ejz0s07","country_code":"DK","type":"company","lineage":["https://openalex.org/I106887733","https://openalex.org/I2801134892","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"D. Raventos","raw_affiliation_strings":["Novozymes A/S, 2880 Bagsvaerd, Denmark","Novozymes A/S, 2880 Bagsv\u00e6rd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novozymes A/S, 2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I106887733"]},{"raw_affiliation_string":"Novozymes A/S, 2880 Bagsv\u00e6rd, Denmark","institution_ids":["https://openalex.org/I106887733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005294445","display_name":"Olivier Taboureau","orcid":"https://orcid.org/0000-0001-7081-2491","observed_orcids":["https://orcid.org/0000-0001-7081-2491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Taboureau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089235883","display_name":"Per Holse Mygind","orcid":"https://orcid.org/0009-0005-1043-8078","observed_orcids":["https://orcid.org/0009-0005-1043-8078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Mygind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Nielsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Nielsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078334243","display_name":"Carsten P. S\u00f6nksen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Sonksen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110441565","display_name":"H. H. Kristensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106887733","display_name":"Novozymes (Denmark)","ror":"https://ror.org/03ejz0s07","country_code":"DK","type":"company","lineage":["https://openalex.org/I106887733","https://openalex.org/I2801134892","https://openalex.org/I4210159963","https://openalex.org/I4405271692"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H.- Kristensen","raw_affiliation_strings":["Novozymes A/S, Building 1U1.25, 2880 Bagsvaerd, Denmark.,Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novozymes A/S, Building 1U1.25, 2880 Bagsvaerd, Denmark.,Denmark","institution_ids":["https://openalex.org/I106887733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.679,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.66390706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"219","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":1.0},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.9110000133514404},{"id":"https://openalex.org/keywords/peptide-optimization","display_name":"peptide optimization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/qsar","display_name":"QSAR","score":0.8389999866485596},{"id":"https://openalex.org/keywords/peptide-membrane-interactions","display_name":"peptide-membrane interactions","score":0.8410000205039978},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.5619999766349792},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8777651786804199},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.708544909954071},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6513767242431641},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.6035884618759155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5984190106391907},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5913925766944885},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4649428427219391},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46469682455062866},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.45554912090301514},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.45126840472221375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3992138206958771},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34275928139686584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3325463831424713},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3053648769855499},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2281407117843628},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20530009269714355},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.17847630381584167},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.136606365442276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12046024203300476},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09897857904434204},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08918008208274841}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1386207053764549","doi":"https://doi.org/10.2174/1386207053764549","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207053764549","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry &amp; High Throughput Screening","raw_type":"journal-article"},{"id":"pmid:15892624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15892624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial chemistry & high throughput screening","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326432","display_name":"Novozymes","ror":"https://ror.org/032vcz886"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400766694","https://openalex.org/W2399821848","https://openalex.org/W4365461630","https://openalex.org/W4403767533","https://openalex.org/W2058037164","https://openalex.org/W3202664340","https://openalex.org/W2964838463","https://openalex.org/W4382989522","https://openalex.org/W3001892650","https://openalex.org/W1922101630"],"abstract_inverted_index":{"Antimicrobial":[0],"peptides":[1],"(AMPs)":[2],"are":[3],"ubiquitous":[4],"in":[5,12,71,76,80,103,109],"nature":[6],"where":[7,118,149],"they":[8],"play":[9],"important":[10],"roles":[11],"host":[13],"defense":[14],"and":[15,24,74,111,161,176,190],"microbial":[16],"control.":[17],"Despite":[18],"their":[19,140],"natural":[20],"origin,":[21],"antimicrobial":[22,123,142],"spectrum":[23],"potency,":[25],"the":[26,119,126,150,158,167,182],"lead":[27,137],"peptide":[28],"candidates":[29,138],"that":[30],"so":[31],"far":[32],"have":[33,37,56],"entered":[34],"pharmaceutical":[35],"development":[36],"all":[38],"been":[39,57],"further":[40],"optimized":[41],"by":[42],"rational":[43],"or":[44,133,143,154],"semi-rational":[45],"approaches.":[46],"In":[47],"recent":[48],"years,":[49],"several":[50,85],"high":[51],"throughput":[52],"screening":[53,82,113,130,172],"(HTS)":[54],"systems":[55,73,83,105,186],"developed":[58],"to":[59],"specifically":[60],"address":[61],"optimization":[62],"of":[63,69,131,136,184,197],"AMPs.":[64],"These":[65],"include":[66],"a":[67],"range":[68],"computational":[70,86],"silico":[72],"cell-based":[75],"vivo":[77],"systems.":[78,114,199],"The":[79,102,115,146],"silico-based":[81],"comprise":[84],"methods":[87,98],"such":[88],"as":[89,94,96,193,195],"Quantitative":[90],"Structure/Activity":[91],"Relationships":[92],"(QSAR)":[93],"well":[95,194],"simulation":[97],"mimicking":[99],"peptide/membrane":[100],"interactions.":[101],"vivo-based":[104],"can":[106],"be":[107],"divided":[108],"cis-acting":[110,116],"trans-acting":[112,147],"pre-screens,":[117],"AMP":[120,151],"exerts":[121],"its":[122],"effect":[124],"on":[125],"producing":[127,159,168],"cell,":[128,169],"allow":[129,170],"millions":[132],"even":[134],"billions":[135],"for":[139,171,188],"basic":[141],"membrane-perturbating":[144],"activity.":[145],"screens,":[148],"is":[152],"secreted":[153],"actively":[155],"liberated":[156],"from":[157,166],"cell":[160],"interacts":[162],"with":[163],"cells":[164],"different":[165],"under":[173],"more":[174],"complex":[175],"application-relevant":[177],"conditions.":[178],"This":[179],"review":[180],"describes":[181],"application":[183],"HTS":[185],"employed":[187],"AMPs":[189],"lists":[191],"advantages":[192],"limitations":[196],"these":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
