{"id":"https://openalex.org/W2139507872","doi":"https://doi.org/10.1080/15476910802482854","title":"Mercury modulates interplay between IL-1\u03b2, TNF-\u03b1, and gap junctional intercellular communication in keratinocytes: mitigation by lycopene","display_name":"Mercury modulates interplay between IL-1\u03b2, TNF-\u03b1, and gap junctional intercellular communication in keratinocytes: mitigation by lycopene","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2139507872","doi":"https://doi.org/10.1080/15476910802482854","mag":"2139507872","pmid":"https://pubmed.ncbi.nlm.nih.gov/19404869"},"language":"en","primary_location":{"id":"doi:10.1080/15476910802482854","doi":"https://doi.org/10.1080/15476910802482854","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15476910802482854","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15476910802482854?needAccess=true","source":{"id":"https://openalex.org/S82112532","display_name":"Journal of Immunotoxicology","issn_l":"1547-6901","issn":["1547-6901","1547-691X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15476910802482854?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081097470","display_name":"Roberto Zefferino","orcid":"https://orcid.org/0000-0001-9398-7139","observed_orcids":["https://orcid.org/0000-0001-9398-7139"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberto Zefferino","raw_affiliation_strings":["Department of Medical and Occupational Sciences, University of Foggia, Italy. r.zefferino@unifg.it","Department of Medical and Occupational Sciences, University of Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Occupational Sciences, University of Foggia, Italy. r.zefferino@unifg.it","institution_ids":["https://openalex.org/I106296451"]},{"raw_affiliation_string":"Department of Medical and Occupational Sciences, University of Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070240117","display_name":"Antonella Leone","orcid":"https://orcid.org/0000-0002-5610-4031","observed_orcids":["https://orcid.org/0000-0002-5610-4031"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Leone","raw_affiliation_strings":["CNR, Italian National Research Council-ISPA-LECCE, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR, Italian National Research Council-ISPA-LECCE, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009477924","display_name":"Simona Piccaluga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Piccaluga","raw_affiliation_strings":["Department of Medical and Occupational Sciences, University of Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Occupational Sciences, University of Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025286337","display_name":"Raffaele Ivan Cincione","orcid":"https://orcid.org/0000-0002-5361-9275","observed_orcids":["https://orcid.org/0000-0002-5361-9275"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Cincione","raw_affiliation_strings":["Department of Biomedical Sciences, University of Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001726925","display_name":"L. Ambrosi","orcid":"https://orcid.org/0000-0003-4010-152X","observed_orcids":["https://orcid.org/0000-0003-4010-152X"]},"institutions":[{"id":"https://openalex.org/I4210105320","display_name":"Fondazione Salvatore Maugeri","ror":"https://ror.org/01e8tvg28","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Ambrosi","raw_affiliation_strings":["S. Maugeri Foundation, Cassano Delle Murge (BA), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Maugeri Foundation, Cassano Delle Murge (BA), Italy","institution_ids":["https://openalex.org/I4210105320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081097470"],"corresponding_institution_ids":["https://openalex.org/I106296451"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":null,"fwci":0.5633,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.623744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"353","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.1923999935388565,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mercury-poisoning","display_name":"mercury toxicity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.9309999942779541},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":0.9909999966621399},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6620000004768372},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.6809999942779541},{"id":"https://openalex.org/keywords/dietary-antioxidants","display_name":"dietary antioxidants","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6037774085998535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5983130931854248},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.542432963848114},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5201188325881958},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47718346118927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4422226846218109},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.42052802443504333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3657088577747345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34454575181007385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33140623569488525},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26025909185409546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2531319260597229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0799674391746521}],"mesh":[{"descriptor_ui":"D000077276","descriptor_name":"Lycopene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008627","descriptor_name":"Mercuric Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008628","descriptor_name":"Mercury","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/15476910802482854","doi":"https://doi.org/10.1080/15476910802482854","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15476910802482854","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15476910802482854?needAccess=true","source":{"id":"https://openalex.org/S82112532","display_name":"Journal of Immunotoxicology","issn_l":"1547-6901","issn":["1547-6901","1547-691X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotoxicology","raw_type":"journal-article"},{"id":"pmid:19404869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19404869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunotoxicology","raw_type":"Journal Article"},{"id":"pmh:oai:zenodo.org:97455","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/97455","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1080/15476910802482854","doi":"https://doi.org/10.1080/15476910802482854","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15476910802482854","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15476910802482854?needAccess=true","source":{"id":"https://openalex.org/S82112532","display_name":"Journal of Immunotoxicology","issn_l":"1547-6901","issn":["1547-6901","1547-691X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotoxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139507872.pdf","grobid_xml":"https://content.openalex.org/works/W2139507872.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W168276155","https://openalex.org/W195835998","https://openalex.org/W1536077708","https://openalex.org/W1540356264","https://openalex.org/W1580762659","https://openalex.org/W1812976842","https://openalex.org/W1824823787","https://openalex.org/W1905572846","https://openalex.org/W1908988494","https://openalex.org/W1921006759","https://openalex.org/W1923071885","https://openalex.org/W1975664866","https://openalex.org/W1981682289","https://openalex.org/W1985682634","https://openalex.org/W1988482255","https://openalex.org/W1988851047","https://openalex.org/W1991865867","https://openalex.org/W1995561582","https://openalex.org/W1999411953","https://openalex.org/W2000021697","https://openalex.org/W2001082072","https://openalex.org/W2011465678","https://openalex.org/W2011558575","https://openalex.org/W2015179981","https://openalex.org/W2016316911","https://openalex.org/W2036373313","https://openalex.org/W2043654463","https://openalex.org/W2049651957","https://openalex.org/W2049960884","https://openalex.org/W2050186600","https://openalex.org/W2061039816","https://openalex.org/W2062323384","https://openalex.org/W2063695629","https://openalex.org/W2067637968","https://openalex.org/W2069367439","https://openalex.org/W2069514079","https://openalex.org/W2078106042","https://openalex.org/W2088263550","https://openalex.org/W2088686339","https://openalex.org/W2096775962","https://openalex.org/W2101591849","https://openalex.org/W2108332722","https://openalex.org/W2113962650","https://openalex.org/W2116092123","https://openalex.org/W2117352925","https://openalex.org/W2118267837","https://openalex.org/W2126120263","https://openalex.org/W2134830414","https://openalex.org/W2139007691","https://openalex.org/W2144469468","https://openalex.org/W2149272914","https://openalex.org/W2150224103","https://openalex.org/W2153017264","https://openalex.org/W2153430949","https://openalex.org/W2154441568","https://openalex.org/W2157210567","https://openalex.org/W2158109610","https://openalex.org/W2164694820","https://openalex.org/W2190128865","https://openalex.org/W2220056071","https://openalex.org/W2395026719","https://openalex.org/W2410046865","https://openalex.org/W2416205313","https://openalex.org/W2442486047","https://openalex.org/W4244240316","https://openalex.org/W4254863145"],"related_works":["https://openalex.org/W2410046865","https://openalex.org/W2395026719","https://openalex.org/W1968825735","https://openalex.org/W2100367240","https://openalex.org/W2168846999","https://openalex.org/W2060403220","https://openalex.org/W2963892560","https://openalex.org/W1977750158","https://openalex.org/W2030761520","https://openalex.org/W1652186470"],"abstract_inverted_index":{"Gap":[0],"junctional":[1],"intercellular":[2],"communication":[3],"(GJIC)":[4],"is":[5,12,30,102],"used":[6],"to":[7,38,87,105,205],"control":[8],"cell":[9,64,97],"proliferation.":[10],"It":[11,101,217],"not":[13],"surprising":[14],"then":[15],"that":[16,107,220,242,248,262,275],"a":[17,40,93,137,176,221],"lack":[18],"of":[19,24,119,136,145,156,210,238,264,271,296],"GJIC":[20,44,128,159,193,233,281],"(i.e.,":[21,179],"during":[22,54],"loss":[23],"contact":[25],"inhibition":[26],"among":[27],"adjacent":[28],"cells)":[29],"associated":[31],"with":[32,224,255],"cancer":[33,63,89,113,138],"promotion/progression.":[34],"There":[35],"also":[36,58],"seems":[37],"be":[39,290],"link":[41],"between":[42],"ineffective":[43],"and":[45,68,75,129,160,163,194,201,240,274,282],"increases":[46],"in":[47,62,80,115,132,150,166,199,212,215,286],"inflammatory":[48,56],"events.":[49],"Interestingly,":[50],"many":[51,146],"cytokines":[52],"released":[53],"an":[55,180,287],"response":[57],"have":[59,153],"critical":[60],"roles":[61],"survival.":[65],"Specifically,":[66],"TNFalpha":[67,162,241],"IL-1beta":[69,164,239],"are":[70],"important":[71],"for":[72,96,189,252],"initiating/augmenting":[73],"CD8(+)-":[74],"NK-cell":[76],"mediated":[77],"killing;":[78],"however,":[79],"what":[81],"appears":[82],"counterintuitive,":[83],"each--at":[84],"times--can":[85],"act":[86,111],"protect":[88],"cells":[90,214],"against":[91],"apoptosis,":[92],"major":[94],"mechanism":[95],"killing":[98],"from":[99],"within.":[100],"thus":[103],"plausible":[104],"assume":[106],"certain":[108],"toxicants":[109,147],"might":[110],"as":[112],"promoters":[114],"manners":[116],"distinct":[117],"from/augmentive":[118],"direct":[120],"effects":[121,144,155,191,209,263,278],"on":[122,158,161,192,268,279],"DNA,":[123],"i.e.,":[124],"by":[125,197,292],"concurrently":[126],"altering":[127],"cytokine":[130,195,283],"formation":[131,196,237],"host":[133],"or":[134],"microenvironment":[135],"cell.":[139],"Our":[140],"research":[141],"has":[142],"evaluated":[143],"upon":[148],"keratinocytes;":[149],"particular,":[151],"we":[152],"examined":[154,188],"mercury":[157,211,265],"levels":[165],"(and":[167],"secretion":[168],"by)":[169],"these":[170],"cells.":[171],"In":[172],"the":[173,183,207,213,225,236],"studies":[174],"here,":[175],"tomato":[177],"preparation":[178],"oleoresin)":[181],"bearing":[182],"antioxidant":[184],"carotenoid":[185],"lycopene":[186],"was":[187,218],"its":[190,202,276],"keratinocytes":[198],"general,":[200],"potential":[203,277],"ability":[204],"mitigate/reverse":[206],"toxic":[208],"particular.":[216],"shown":[219],"4-hr":[222],"treatment":[223],"oleoresin":[226],"(containing":[227],"56,":[228],"6":[229],"nM":[230,257],"lycopene)":[231],"re-established":[232],"among--and":[234],"increased":[235,293],"had":[243,249],"been":[244,250],"significantly":[245],"reduced":[246],"within--keratinocytes":[247],"pre-treated":[251],"24":[253],"hr":[254],"10":[256],"HgCl(2).":[258],"These":[259],"results":[260],"show":[261],"likely":[266],"depend":[267],"some":[269],"level":[270],"oxidative":[272],"stress":[273],"keratinocyte":[280],"concentrations":[284],"could,":[285],"exposed":[288],"host,":[289],"mitigated/reversed":[291],"dietary":[294],"intake":[295],"carotenoids":[297],"like":[298],"lycopene.":[299]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}