{"id":"https://openalex.org/W2139485932","doi":"https://doi.org/10.1182/blood-2001-12-0290","title":"Augmentation of umbilical cord blood (UCB) transplantation with ex vivo\u2013expanded UCB cells: results of a phase 1 trial using the AastromReplicell System","display_name":"Augmentation of umbilical cord blood (UCB) transplantation with ex vivo\u2013expanded UCB cells: results of a phase 1 trial using the AastromReplicell System","publication_year":2003,"publication_date":"2003-02-25","ids":{"openalex":"https://openalex.org/W2139485932","doi":"https://doi.org/10.1182/blood-2001-12-0290","mag":"2139485932","pmid":"https://pubmed.ncbi.nlm.nih.gov/12595310"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2001-12-0290","doi":"https://doi.org/10.1182/blood-2001-12-0290","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2001-12-0290","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083330958","display_name":"Jennifer Jaroscak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Jaroscak","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112006329","display_name":"Kristin L. Goltry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Goltry","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alan Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Smith","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005609746","display_name":"Barbara Waters\u2010Pick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Waters-Pick","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103218774","display_name":"Paul L. Martin","orcid":"https://orcid.org/0000-0001-8141-5678","observed_orcids":["https://orcid.org/0000-0001-8141-5678"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L. Martin","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103991891","display_name":"Timothy Alan Driscoll","orcid":"https://orcid.org/0000-0002-3053-8683","observed_orcids":["https://orcid.org/0000-0002-3053-8683"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Driscoll","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006637795","display_name":"Richard P. Howrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Howrey","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034651124","display_name":"Nelson Jen An Chao","orcid":"https://orcid.org/0000-0001-6725-7220","observed_orcids":["https://orcid.org/0000-0001-6725-7220"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson Chao","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108770359","display_name":"Judy Douville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Douville","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020640291","display_name":"Sue Burhop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Burhop","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059061070","display_name":"Pingfu Fu","orcid":"https://orcid.org/0000-0002-2334-5218","observed_orcids":["https://orcid.org/0000-0002-2334-5218"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingfu Fu","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060384074","display_name":"Joanne Kurtzberg","orcid":"https://orcid.org/0000-0002-3370-0703","observed_orcids":["https://orcid.org/0000-0002-3370-0703"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Kurtzberg","raw_affiliation_strings":["From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Pediatric and Adult Bone Marrow Transplant Programs at Duke University Medical Center, Durham, NC; Aastrom Biosciences, Ann Arbor, MI; and Rainbow Babies and Childrens Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4210151235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":12.4515,"has_fulltext":false,"cited_by_count":302,"citation_normalized_percentile":{"value":0.99299359,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"101","issue":"12","first_page":"5061","last_page":"5067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/graft-augmentation","display_name":"graft augmentation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.859000027179718},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/flt3-ligand","display_name":"Flt3 ligand","score":0.906000018119812},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.7972768545150757},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7565847039222717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7009579539299011},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.675176739692688},{"id":"https://openalex.org/C2908824208","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Umbilical Cord Blood Transplantation","level":4,"score":0.5578184723854065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34969040751457214},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3064078688621521},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.29293298721313477},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.27038460969924927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16521146893501282},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D036101","descriptor_name":"Cord Blood Stem Cell Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2001-12-0290","doi":"https://doi.org/10.1182/blood-2001-12-0290","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2001-12-0290","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:12595310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12595310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W29953550","https://openalex.org/W35113883","https://openalex.org/W80850850","https://openalex.org/W113410267","https://openalex.org/W214080586","https://openalex.org/W329662528","https://openalex.org/W644058104","https://openalex.org/W1265257573","https://openalex.org/W1491993932","https://openalex.org/W1965359675","https://openalex.org/W1974742309","https://openalex.org/W1978064491","https://openalex.org/W1991150541","https://openalex.org/W2000444716","https://openalex.org/W2010055592","https://openalex.org/W2025570004","https://openalex.org/W2063940607","https://openalex.org/W2080008757","https://openalex.org/W2085516849","https://openalex.org/W2086793358","https://openalex.org/W2090529961","https://openalex.org/W2127340198","https://openalex.org/W2129321368","https://openalex.org/W2166777876","https://openalex.org/W2267126247","https://openalex.org/W2317259161","https://openalex.org/W2330713242","https://openalex.org/W2333162405","https://openalex.org/W2442356882","https://openalex.org/W2510117822","https://openalex.org/W2606142120"],"related_works":["https://openalex.org/W2380255730","https://openalex.org/W2946104632","https://openalex.org/W2442220036","https://openalex.org/W2554355145","https://openalex.org/W2049680237","https://openalex.org/W2032967610","https://openalex.org/W2408821813","https://openalex.org/W2557428639","https://openalex.org/W1985675880","https://openalex.org/W1764546643"],"abstract_inverted_index":{"Allogeneic":[0],"stem":[1,49],"cell":[2,14],"transplantation":[3],"with":[4,58,79,195,224,245],"umbilical":[5],"cord":[6],"blood":[7],"(UCB)":[8],"cells":[9,32,50,100,123,166,187,198,218,249],"is":[10,24,179,188,250],"limited":[11],"by":[12],"the":[13,29,89,104,112,132,182,202],"dose":[15],"a":[16,71,109,225],"single":[17],"unit":[18],"provides":[19],"recipients.":[20],"Ex":[21],"vivo":[22,175],"expansion":[23,46,120,135,176],"one":[25],"strategy":[26],"to":[27,111,204,220],"increase":[28,141],"number":[30],"of":[31,47,121,134,177,184,192,215,228],"available":[33],"for":[34,45],"transplantation.":[35],"Aastrom":[36],"Biosciences":[37],"developed":[38],"an":[39],"automated":[40],"continuous":[41],"perfusion":[42],"culture":[43],"device":[44],"hematopoietic":[48],"(HSCs).":[51],"Cells":[52],"are":[53],"expanded":[54,102],"in":[55,103,129,146,152,159,210],"media":[56],"supplemented":[57],"fetal":[59],"bovine":[60],"serum,":[61,63],"horse":[62],"PIXY321,":[64],"flt-3":[65],"ligand,":[66],"and":[67,95,124,155,181],"erythropoietin.":[68],"We":[69],"performed":[70],"phase":[72,236],"1":[73],"trial":[74,90],"augmenting":[75,242],"conventional":[76,113],"UCB":[77,99,178,193,243,248],"transplants":[78,194,244],"ex":[80,174,185,196,216,246],"vivo-expanded":[81,186,197,217,247],"cells.":[82,164],"The":[83,138],"28":[84],"patients":[85],"were":[86,101],"enrolled":[87],"on":[88,115],"between":[91],"October":[92],"8,":[93],"1997":[94],"September":[96],"30,":[97],"1998.":[98],"device,":[105],"then":[106],"administered":[107],"as":[108],"boost":[110],"graft":[114],"posttransplantation":[116],"day":[117],"12.":[118],"While":[119],"total":[122],"colony-forming":[125],"units":[126],"(CFUs)":[127],"occurred":[128],"all":[130],"cases,":[131],"magnitude":[133],"varied":[136],"considerably.":[137],"median":[139,226],"fold":[140],"was":[142],"2.4":[143],"(range,":[144,150,157,231],"1.0-8.5)":[145],"nucleated":[147],"cells,":[148],"82":[149],"4.6-266.4)":[151],"CFU":[153],"granulocyte-macrophages,":[154],"0.5":[156],"0.09-2.45)":[158],"CD34+":[160],"lineage":[161],"negative":[162],"(lin-)":[163],"CD3+":[165],"did":[167,199],"not":[168,200],"expand":[169],"under":[170],"these":[171],"conditions.":[172],"Clinical-scale":[173],"feasible,":[180],"administration":[183],"well":[189],"tolerated.":[190],"Augmentation":[191],"alter":[201],"time":[203],"myeloid,":[205],"erythroid,":[206],"or":[207],"platelet":[208],"engraftment":[209,223],"21":[211],"evaluable":[212],"patients.":[213],"Recipients":[214],"continue":[219],"have":[221],"durable":[222],"follow-up":[227],"47":[229],"months":[230],"41-51":[232],"months).":[233],"A":[234],"randomized":[235],"2":[237],"study":[238],"will":[239],"determine":[240],"whether":[241],"beneficial.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":18}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}