{"id":"https://openalex.org/W2139484960","doi":"https://doi.org/10.1136/thx.39.8.588","title":"Bronchial responsiveness to hyperventilation in children with asthma: inhibition by ipratropium bromide.","display_name":"Bronchial responsiveness to hyperventilation in children with asthma: inhibition by ipratropium bromide.","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W2139484960","doi":"https://doi.org/10.1136/thx.39.8.588","mag":"2139484960","pmid":"https://pubmed.ncbi.nlm.nih.gov/6236576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1020510"},"language":"en","primary_location":{"id":"doi:10.1136/thx.39.8.588","doi":"https://doi.org/10.1136/thx.39.8.588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.39.8.588","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/39/8/588.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/39/8/588.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111979562","display_name":"N M Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Wilson","raw_affiliation_strings":["From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 OHS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203"]},{"raw_affiliation_string":"Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 OHS","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113781131","display_name":"Caroline M. S. Dixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Dixon","raw_affiliation_strings":["From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067954882","display_name":"Michael A Silverman","orcid":"https://orcid.org/0000-0001-6967-4917","observed_orcids":["https://orcid.org/0000-0001-6967-4917"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Silverman","raw_affiliation_strings":["From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801748203"],"apc_list":null,"apc_paid":null,"fwci":0.3945,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64568586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"39","issue":"8","first_page":"588","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"hyperventilation","score":0.859000027179718},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7160000205039978},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ipratropium-bromide","display_name":"ipratropium bromide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimuscarinic-agents","display_name":"antimuscarinic agents","score":0.6589999794960022},{"id":"https://openalex.org/keywords/isocapnic-hyperventilation","display_name":"isocapnic hyperventilation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5109999775886536},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2780532441","wikidata":"https://www.wikidata.org/wiki/Q424294","display_name":"Ipratropium bromide","level":4,"score":0.9898584485054016},{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.9737632870674133},{"id":"https://openalex.org/C2909577894","wikidata":"https://www.wikidata.org/wiki/Q424294","display_name":"Ipratropium","level":4,"score":0.858156144618988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8536477088928223},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7012038230895996},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6768199801445007},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6534563302993774},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.577547013759613},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5006983280181885},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.45843204855918884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23102882504463196},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2220386564731598},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001250","descriptor_name":"Asthma, Exercise-Induced","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001250","descriptor_name":"Asthma, Exercise-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001286","descriptor_name":"Atropine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006985","descriptor_name":"Hyperventilation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009241","descriptor_name":"Ipratropium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/thx.39.8.588","doi":"https://doi.org/10.1136/thx.39.8.588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.39.8.588","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/39/8/588.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1020510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1020510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"pmid:6236576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6236576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1136/thx.39.8.588","doi":"https://doi.org/10.1136/thx.39.8.588","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.39.8.588","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/39/8/588.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139484960.pdf","grobid_xml":"https://content.openalex.org/works/W2139484960.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1699817888","https://openalex.org/W1751385251","https://openalex.org/W1934334043","https://openalex.org/W2008613350","https://openalex.org/W2009604455","https://openalex.org/W2025452840","https://openalex.org/W2033304363","https://openalex.org/W2060866039","https://openalex.org/W2073174752","https://openalex.org/W2075028746","https://openalex.org/W2080650174","https://openalex.org/W2097665064","https://openalex.org/W2106454406","https://openalex.org/W2110574979","https://openalex.org/W2111897397","https://openalex.org/W2112360320","https://openalex.org/W2146049100","https://openalex.org/W2412989419"],"related_works":["https://openalex.org/W2416499209","https://openalex.org/W2028268802","https://openalex.org/W85876467","https://openalex.org/W2105286600","https://openalex.org/W2043522586","https://openalex.org/W2109469343","https://openalex.org/W1985751774","https://openalex.org/W2039467264","https://openalex.org/W2028632754","https://openalex.org/W1993744895"],"abstract_inverted_index":{"Isocapnic":[0],"hyperventilation":[1,69,128],"dose":[2,99,107],"response":[3,30],"curves":[4],"were":[5],"constructed":[6],"for":[7,47,111,120],"11":[8],"asthmatic":[9],"children":[10,81],"before":[11,31],"and":[12,32,45,55,82],"after":[13,33],"pretreatment":[14],"with":[15],"placebo":[16,34],"or":[17,86,129],"ipratropium":[18,75,101,109],"bromide,":[19],"40-1500":[20],"micrograms":[21,78,85],"given":[22],"by":[23,74,83,97],"inhalation,":[24],"on":[25],"three":[26],"separate":[27],"days.":[28],"The":[29,92,106],"was":[35,60,72,95,113],"highly":[36],"reproducible":[37],"(within":[38],"subject":[39],"coefficient":[40],"of":[41,49,62,100,108],"variation":[42],"7.5%,":[43],"18%,":[44],"22%":[46],"intervals":[48],"two":[50,53,57],"hours,":[51],"within":[52],"weeks,":[54],"over":[56],"weeks).":[58],"It":[59],"independent":[61],"baseline":[63,130],"lung":[64,131],"function.":[65,132],"Complete":[66],"protection":[67,112],"against":[68],"induced":[70],"asthma":[71],"achieved":[73],"bromide":[76],"40":[77],"in":[79,88],"six":[80],"200":[84],"more":[87],"a":[89],"further":[90],"four.":[91],"remaining":[93],"child":[94],"unaffected":[96],"any":[98],"up":[102],"to":[103,116,124,127],"1500":[104],"micrograms.":[105],"required":[110],"better":[114],"related":[115],"the":[117],"subjects'":[118],"requirement":[119],"regular":[121],"medication":[122],"than":[123],"their":[125],"sensitivity":[126]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
