{"id":"https://openalex.org/W2139481981","doi":"https://doi.org/10.1016/j.juro.2007.03.028","title":"A Comparison of Hexaminolevulinate Fluorescence Cystoscopy and White Light Cystoscopy for the Detection of Carcinoma In Situ in Patients With Bladder Cancer: A Phase III, Multicenter Study","display_name":"A Comparison of Hexaminolevulinate Fluorescence Cystoscopy and White Light Cystoscopy for the Detection of Carcinoma In Situ in Patients With Bladder Cancer: A Phase III, Multicenter Study","publication_year":2007,"publication_date":"2007-05-12","ids":{"openalex":"https://openalex.org/W2139481981","doi":"https://doi.org/10.1016/j.juro.2007.03.028","mag":"2139481981","pmid":"https://pubmed.ncbi.nlm.nih.gov/17499291"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2007.03.028","doi":"https://doi.org/10.1016/j.juro.2007.03.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2007.03.028","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075327765","display_name":"Yves Fradet","orcid":"https://orcid.org/0000-0002-7581-2500","observed_orcids":["https://orcid.org/0000-0002-7581-2500"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yves Fradet","raw_affiliation_strings":["L\u2019Hotel-Dieu de Qu\u00e9bec, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Province de Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u2019Hotel-Dieu de Qu\u00e9bec, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec, Province de Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I4210121051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109496116","display_name":"Herbert Barton Grossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Barton Grossman","raw_affiliation_strings":["University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071741514","display_name":"Leonard G. Gomella","orcid":"https://orcid.org/0000-0002-9466-489X","observed_orcids":["https://orcid.org/0000-0002-9466-489X"]},"institutions":[{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Gomella","raw_affiliation_strings":["Thomas Jefferson Medical Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Jefferson Medical Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2799360765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048604566","display_name":"Seth P. Lerner","orcid":"https://orcid.org/0000-0002-6379-2581","observed_orcids":["https://orcid.org/0000-0002-6379-2581"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Lerner","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050663947","display_name":"Michael S. Cookson","orcid":"https://orcid.org/0000-0001-8678-0551","observed_orcids":["https://orcid.org/0000-0001-8678-0551"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Cookson","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105471397","display_name":"David Mois Albala","orcid":"https://orcid.org/0000-0003-0178-3695","observed_orcids":["https://orcid.org/0000-0003-0178-3695"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Albala","raw_affiliation_strings":["Duke University Medical Center, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113852569","display_name":"Michael J. Droller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Droller","raw_affiliation_strings":["Mount Sinai Medical Center, New York, New York on behalf of the PC B302/01 Study Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Medical Center, New York, New York on behalf of the PC B302/01 Study Group","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"PC B302/01 Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PC B302/01 Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":24.2436,"has_fulltext":false,"cited_by_count":311,"citation_normalized_percentile":{"value":0.99729641,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"178","issue":"1","first_page":"68","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-cystoscopy","display_name":"fluorescence cystoscopy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/white-light-cystoscopy","display_name":"white light cystoscopy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bladder-carcinoma-in-situ","display_name":"bladder carcinoma in situ","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7170000076293945},{"id":"https://openalex.org/keywords/blue-light-cystoscopy","display_name":"blue light cystoscopy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/papillary-bladder-cancer","display_name":"papillary bladder cancer","score":0.46700000762939453},{"id":"https://openalex.org/keywords/intravesical-instillation","display_name":"intravesical instillation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/targeted-biopsy","display_name":"targeted biopsy","score":0.4359999895095825},{"id":"https://openalex.org/keywords/diagnostic-accuracy-comparison","display_name":"diagnostic accuracy comparison","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2778769751","wikidata":"https://www.wikidata.org/wiki/Q246090","display_name":"Cystoscopy","level":3,"score":0.9380115270614624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9242293238639832},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.7968978881835938},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6865342259407043},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4593759775161743},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.44235560297966003},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42821845412254333},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.41921624541282654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2849079370498657},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.26880985498428345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16576656699180603}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003558","descriptor_name":"Cystoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2007.03.028","doi":"https://doi.org/10.1016/j.juro.2007.03.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2007.03.028","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:17499291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17499291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W107352192","https://openalex.org/W204377231","https://openalex.org/W1513986580","https://openalex.org/W1530812988","https://openalex.org/W1536690700","https://openalex.org/W1966499603","https://openalex.org/W1973495364","https://openalex.org/W1974874188","https://openalex.org/W2004951826","https://openalex.org/W2009824150","https://openalex.org/W2014053256","https://openalex.org/W2022970459","https://openalex.org/W2028478105","https://openalex.org/W2030695905","https://openalex.org/W2083322143","https://openalex.org/W2126903040","https://openalex.org/W2171930771","https://openalex.org/W2275614507","https://openalex.org/W2345634800","https://openalex.org/W2417342445","https://openalex.org/W2417853688","https://openalex.org/W2470130076","https://openalex.org/W3159164887","https://openalex.org/W4318751285"],"related_works":["https://openalex.org/W2028478105","https://openalex.org/W2155212834","https://openalex.org/W2116544863","https://openalex.org/W2331467019","https://openalex.org/W1485309517","https://openalex.org/W2069003115","https://openalex.org/W2603717423","https://openalex.org/W7096047593","https://openalex.org/W2072712510","https://openalex.org/W2084937791"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"compared":[2],"hexaminolevulinate":[3,39,54,143,168,197,215,258,298],"(Hexvix)":[4],"fluorescence":[5,55,144,169,299,318],"cystoscopy":[6,10,198,220,239,259,300,319,328],"with":[7,25,34,103,110,131,157,285,295,301,313,325],"white":[8,50,150,176,218,266,314,326],"light":[9,51,151,177,219,267,303,315,327],"for":[11,40,71],"detecting":[12],"carcinoma":[13,98,104,111,136,161,189,208,246,306],"in":[14,99,105,112,125,137,145,152,162,170,178,184,190,209,221,231,247,250,307,323,331],"situ.":[15],"MATERIALS":[16],"AND":[17],"METHODS:":[18],"In":[19,74,154,293],"this":[20,335],"multicenter":[21],"study":[22],"298":[23],"patients":[24,92,130,172,183,225,252,294],"known":[26],"or":[27,58,187,288],"suspected":[28],"bladder":[29,32,296,338],"cancer":[30,297],"underwent":[31],"instillation":[33,281],"50":[35],"ml":[36],"8":[37,232],"mM":[38],"1":[41,76,186],"hour.":[42],"Cystoscopy":[43],"was":[44,79,119,139,164,199,282],"then":[45,53],"performed,":[46],"first":[47],"using":[48],"standard":[49],"and":[52,69,108,114,147,173,260],"cystoscopy.":[56,316],"Lesions":[57],"suspicious":[59],"areas":[60],"identified":[61],"under":[62],"the":[63,128,155,202,228,332],"2":[64],"illumination":[65],"conditions":[66],"were":[67,193,212,255,263,271],"mapped":[68],"biopsied":[70],"histological":[72],"examination.":[73],"addition,":[75],"directed":[77,275],"biopsy":[78,124],"obtained":[80],"from":[81],"an":[82],"area":[83],"appearing":[84],"to":[85,329],"be":[86,311,321],"normal.":[87],"RESULTS:":[88],"Of":[89,127,241],"196":[90],"evaluable":[91],"29.6%":[93],"(58":[94],"of":[95,182,223,233,244,334,337],"196)":[96],"had":[97],"situ,":[100],"including":[101],"18":[102,129],"situ":[106,113,138,163,191,210,248,308],"alone,":[107],"35":[109],"concomitant":[115,133,158],"papillary":[116,134,159],"disease,":[117],"which":[118],"only":[120,141,148,166,174,195,273],"detected":[121,140,256,264,272],"on":[122,274],"random":[123],"5.":[126],"no":[132,286],"disease":[135,160],"by":[142,149,167,175,196,214,217,257,265],"4":[146],"4.":[153],"group":[156],"found":[165,194,213],"5":[171,270],"3.":[179],"The":[180],"proportion":[181],"whom":[185],"more":[188,207],"lesions":[192,211,249],"greater":[200],"than":[201,216],"hypothesized":[203],"5%":[204],"(p=0.0022).":[205],"Overall":[206],"22":[222],"58":[224,234,251],"(41.5%),":[226],"while":[227,269],"converse":[229],"occurred":[230],"(15.1%).":[235],"Biopsy":[236],"results":[237],"confirmed":[238],"findings.":[240],"a":[242],"total":[243],"113":[245],"104":[253],"(92%)":[254],"77":[261],"(68%)":[262],"cystoscopy,":[268],"visually":[276],"normal":[277],"mucosal":[278],"biopsy.":[279],"Hexaminolevulinate":[280,317],"well":[283],"tolerated":[284],"local":[287],"systemic":[289],"side":[290],"effects.":[291],"CONCLUSIONS:":[292],"blue":[302],"can":[304,320],"diagnose":[305],"that":[309],"may":[310],"missed":[312],"used":[322],"conjunction":[324],"aid":[330],"diagnosis":[333],"form":[336],"cancer.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":20}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
