{"id":"https://openalex.org/W2139473713","doi":"https://doi.org/10.1016/j.amjcard.2005.06.009","title":"Effects of Statins on 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Beyond Low-Density Lipoprotein Cholesterol","display_name":"Effects of Statins on 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Beyond Low-Density Lipoprotein Cholesterol","publication_year":2005,"publication_date":"2005-07-15","ids":{"openalex":"https://openalex.org/W2139473713","doi":"https://doi.org/10.1016/j.amjcard.2005.06.009","mag":"2139473713","pmid":"https://pubmed.ncbi.nlm.nih.gov/16126020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684977"},"language":"en","primary_location":{"id":"doi:10.1016/j.amjcard.2005.06.009","doi":"https://doi.org/10.1016/j.amjcard.2005.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjcard.2005.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S185186944","display_name":"The American Journal of Cardiology","issn_l":"0002-9149","issn":["0002-9149","1879-1913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Cardiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139473713"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC2684977","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010397554","display_name":"James K. Liao","orcid":"https://orcid.org/0000-0001-9679-4252","observed_orcids":["https://orcid.org/0000-0001-9679-4252"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James K. Liao","raw_affiliation_strings":["Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA. jliao@rics.bwh.harvard.edu","Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA. jliao@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010397554"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":3.819,"has_fulltext":false,"cited_by_count":311,"citation_normalized_percentile":{"value":0.95530086,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"96","issue":"5","first_page":"24","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":1.0},{"id":"https://openalex.org/keywords/hmg-coa-reductase-inhibition","display_name":"HMG-CoA reductase inhibition","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.656000018119812},{"id":"https://openalex.org/keywords/ras-gtpase","display_name":"Ras GTPase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rac-gtpase","display_name":"Rac GTPase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-isoprenylation","display_name":"isoprenylation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9319999814033508},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-stability","display_name":"atherosclerotic plaque stability","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.921999990940094},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6809999942779541},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6677384376525879},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5104297995567322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4940533936023712},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4508979320526123},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.44417861104011536},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.43994730710983276},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43332308530807495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3983449637889862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31130316853523254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29013144969940186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22319826483726501},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1911582052707672}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.amjcard.2005.06.009","doi":"https://doi.org/10.1016/j.amjcard.2005.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjcard.2005.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S185186944","display_name":"The American Journal of Cardiology","issn_l":"0002-9149","issn":["0002-9149","1879-1913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Cardiology","raw_type":"journal-article"},{"id":"pmid:16126020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16126020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1443251","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2684977","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2684977","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2684977/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Cardiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1443251","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2684977","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G168696995","display_name":null,"funder_award_id":"NS10828","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2736144214","display_name":"INACTIVATION OF DELAYED RECTIFIER POTASSIUM CHANNELS","funder_award_id":"F32NS010828","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6792122379","display_name":"Activation of eNOS by Steroid Hormones","funder_award_id":"R01HL070274","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6826798685","display_name":"Lipoproteins Effect on G Protein Function","funder_award_id":"R01HL052233","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7043998098","display_name":"Role of PI3-Kinase in Estrogen-induced eNOS Activation","funder_award_id":"R01DK062729","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8285010786","display_name":"Interdepartmental Stroke Program","funder_award_id":"P50NS010828","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8379051808","display_name":"Interdepartmental Stroke Program","funder_award_id":"P01NS010828","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W112355453","https://openalex.org/W424467158","https://openalex.org/W589142326","https://openalex.org/W1479880028","https://openalex.org/W1516421005","https://openalex.org/W1525331105","https://openalex.org/W1537398036","https://openalex.org/W1597787921","https://openalex.org/W1607892649","https://openalex.org/W1678800844","https://openalex.org/W1922625321","https://openalex.org/W1965418020","https://openalex.org/W1966936568","https://openalex.org/W1967310696","https://openalex.org/W1967506330","https://openalex.org/W1968144530","https://openalex.org/W1971163980","https://openalex.org/W1971797638","https://openalex.org/W1974812650","https://openalex.org/W1978644984","https://openalex.org/W1980123375","https://openalex.org/W1988126593","https://openalex.org/W1998984591","https://openalex.org/W2005515164","https://openalex.org/W2008037275","https://openalex.org/W2014237668","https://openalex.org/W2014243580","https://openalex.org/W2019463117","https://openalex.org/W2021090126","https://openalex.org/W2022109882","https://openalex.org/W2026167566","https://openalex.org/W2027415701","https://openalex.org/W2029491963","https://openalex.org/W2031185570","https://openalex.org/W2032022098","https://openalex.org/W2034916016","https://openalex.org/W2035059839","https://openalex.org/W2036145275","https://openalex.org/W2036787121","https://openalex.org/W2039358229","https://openalex.org/W2041075406","https://openalex.org/W2042928998","https://openalex.org/W2045063002","https://openalex.org/W2045829491","https://openalex.org/W2052055930","https://openalex.org/W2052704549","https://openalex.org/W2055718645","https://openalex.org/W2057518721","https://openalex.org/W2058610272","https://openalex.org/W2060376917","https://openalex.org/W2063842926","https://openalex.org/W2069600859","https://openalex.org/W2071124826","https://openalex.org/W2076834039","https://openalex.org/W2077792958","https://openalex.org/W2081394289","https://openalex.org/W2083687847","https://openalex.org/W2084231836","https://openalex.org/W2085728170","https://openalex.org/W2089406251","https://openalex.org/W2092145002","https://openalex.org/W2092368086","https://openalex.org/W2094247279","https://openalex.org/W2096791952","https://openalex.org/W2098946775","https://openalex.org/W2103015914","https://openalex.org/W2103636227","https://openalex.org/W2109068464","https://openalex.org/W2110106971","https://openalex.org/W2111045845","https://openalex.org/W2112098540","https://openalex.org/W2112698709","https://openalex.org/W2112728084","https://openalex.org/W2117264102","https://openalex.org/W2121165964","https://openalex.org/W2123005135","https://openalex.org/W2134080458","https://openalex.org/W2134627002","https://openalex.org/W2144188723","https://openalex.org/W2145053304","https://openalex.org/W2145448066","https://openalex.org/W2145653235","https://openalex.org/W2148637873","https://openalex.org/W2151458606","https://openalex.org/W2151718749","https://openalex.org/W2153390391","https://openalex.org/W2153986804","https://openalex.org/W2154746915","https://openalex.org/W2155598961","https://openalex.org/W2155853522","https://openalex.org/W2159449551","https://openalex.org/W2160152341","https://openalex.org/W2160852038","https://openalex.org/W2162975453","https://openalex.org/W2163792427","https://openalex.org/W2176511881","https://openalex.org/W2315575691","https://openalex.org/W2315618879","https://openalex.org/W2316243284","https://openalex.org/W2316376271","https://openalex.org/W2319834083","https://openalex.org/W2322095705","https://openalex.org/W2331959986","https://openalex.org/W2338977280","https://openalex.org/W2416388175","https://openalex.org/W2435772150","https://openalex.org/W2569568519","https://openalex.org/W2608539973","https://openalex.org/W4230285830","https://openalex.org/W4236017105","https://openalex.org/W4237306139","https://openalex.org/W4254363271","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2098946775","https://openalex.org/W2145653235","https://openalex.org/W127809968","https://openalex.org/W2033554531","https://openalex.org/W2161503442","https://openalex.org/W1990114889","https://openalex.org/W2095101852","https://openalex.org/W2002676488","https://openalex.org/W1982283178","https://openalex.org/W2187666047"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
