{"id":"https://openalex.org/W2139473690","doi":"https://doi.org/10.1093/protein/gzl031","title":"A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration","display_name":"A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration","publication_year":2006,"publication_date":"2006-07-14","ids":{"openalex":"https://openalex.org/W2139473690","doi":"https://doi.org/10.1093/protein/gzl031","mag":"2139473690","pmid":"https://pubmed.ncbi.nlm.nih.gov/16868004"},"language":"en","primary_location":{"id":"doi:10.1093/protein/gzl031","doi":"https://doi.org/10.1093/protein/gzl031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/gzl031","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111798865","display_name":"Eva-Maria Krinner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.-M. Krinner","raw_affiliation_strings":["Micromet AG Staffelseestrasse 2, Munich, Germany","1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Micromet AG Staffelseestrasse 2, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083385273","display_name":"Julia Hepp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Hepp","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080867482","display_name":"Patrick Hoffmann","orcid":"https://orcid.org/0000-0002-1230-7945","observed_orcids":["https://orcid.org/0000-0002-1230-7945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Hoffmann","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017545125","display_name":"Sandra Bruckmaier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Bruckmaier","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111575974","display_name":"Laetitia Petersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laetitia Petersen","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089513179","display_name":"Silke Petsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silke Petsch","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043746027","display_name":"Larissa Parr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa Parr","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110241700","display_name":"Ioana Schuster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioana Schuster","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003981996","display_name":"Susanne Mangold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanne Mangold","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066873098","display_name":"Grit Lorenczewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grit Lorenczewski","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105906281","display_name":"Petra Lutterb\u00fcse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petra Lutterb\u00fcse","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105805868","display_name":"Stefan Buziol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Buziol","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106240499","display_name":"Inessa Hochheim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inessa Hochheim","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012850788","display_name":"J\u00f6rg Volkland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00f6rg Volkland","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041306331","display_name":"Michael M\u00f8lh\u00f8j","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M\u00f8lh\u00f8j","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015406859","display_name":"Mirnalini Sriskandarajah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirnalini Sriskandarajah","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110241699","display_name":"Markus Strasser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Strasser","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069106447","display_name":"Christian Itin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Itin","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107639473","display_name":"Andreas Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Wolf","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056806070","display_name":"Amartya Basu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39454813","display_name":"Enzon Pharmaceuticals (United States)","ror":"https://ror.org/050prqy77","country_code":"US","type":"company","lineage":["https://openalex.org/I39454813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amartya Basu","raw_affiliation_strings":["2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA","institution_ids":["https://openalex.org/I39454813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102762884","display_name":"Karen Yang","orcid":"https://orcid.org/0000-0003-2688-3609","observed_orcids":["https://orcid.org/0000-0003-2688-3609"]},"institutions":[{"id":"https://openalex.org/I39454813","display_name":"Enzon Pharmaceuticals (United States)","ror":"https://ror.org/050prqy77","country_code":"US","type":"company","lineage":["https://openalex.org/I39454813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Yang","raw_affiliation_strings":["2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA","institution_ids":["https://openalex.org/I39454813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110343071","display_name":"David R. Filpula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39454813","display_name":"Enzon Pharmaceuticals (United States)","ror":"https://ror.org/050prqy77","country_code":"US","type":"company","lineage":["https://openalex.org/I39454813"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Filpula","raw_affiliation_strings":["2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Enzon Pharmaceuticals20 Kingsbridge Road, Piscataway, NJ 08854-3969, USA","institution_ids":["https://openalex.org/I39454813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023895322","display_name":"Poul S\u00f8rensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2197358","display_name":"Leo Pharma (Australia)","ror":"https://ror.org/00vvs5b96","country_code":"AU","type":"company","lineage":["https://openalex.org/I2197358","https://openalex.org/I4210124980","https://openalex.org/I4210165112"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Poul S\u00f8rensen","raw_affiliation_strings":["3LEO Pharma A/S, Industriparken 55DK-2750 Ballerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3LEO Pharma A/S, Industriparken 55DK-2750 Ballerup, Denmark","institution_ids":["https://openalex.org/I2197358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008627097","display_name":"Peter Kufer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Kufer","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058901224","display_name":"Patrick A. Baeuerle","orcid":"https://orcid.org/0009-0006-7117-2784","observed_orcids":["https://orcid.org/0009-0006-7117-2784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Baeuerle","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066304227","display_name":"Tobias Raum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Raum","raw_affiliation_strings":["1Micromet AGStaffelseestr. 2, 81477 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet AGStaffelseestr. 2, 81477 Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4656,"currency":"USD","value_usd":4656},"apc_paid":null,"fwci":1.6794,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82494407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"19","issue":"10","first_page":"461","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-chain-antibody","display_name":"single-chain antibody","score":0.9010000228881836},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.8669999837875366},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.796999990940094},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/polyethylene-glycol-conjugation","display_name":"polyethylene glycol conjugation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/circulating-half-life","display_name":"serum half-life","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antibody-stability","display_name":"antibody stability","score":0.6859999895095825},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.5920000076293945},{"id":"https://openalex.org/keywords/antibody-therapy","display_name":"antibody therapy","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7288408279418945},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6521676778793335},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6091656684875488},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5631262063980103},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.5412968397140503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5329609513282776},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4729466438293457},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4643094539642334},{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.4641628861427307},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.4511305093765259},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.44548383355140686},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41337841749191284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2694215476512909},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2684561014175415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22212734818458557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09112656116485596},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007128","descriptor_name":"Immunoglobulin Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/protein/gzl031","doi":"https://doi.org/10.1093/protein/gzl031","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/gzl031","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},{"id":"pmid:16868004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16868004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein engineering, design & selection : PEDS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067115135","https://openalex.org/W2737757003","https://openalex.org/W2486686769","https://openalex.org/W2069493168","https://openalex.org/W2078896755","https://openalex.org/W1587083983","https://openalex.org/W3012380983","https://openalex.org/W2078160959","https://openalex.org/W169546206","https://openalex.org/W4318332856"],"abstract_inverted_index":{"GM-CSF":[0,17,70,115],"(granulocyte-macrophage":[1],"colony":[2],"stimulating":[3],"factor)":[4],"plays":[5],"a":[6,34,45,56,87,130,152,167,175,198,220,226],"central":[7],"role":[8],"in":[9,22,157,170],"inflammatory":[10,26],"processes.":[11],"Treatment":[12],"with":[13,51,71,86,208],"antibodies":[14],"neutralizing":[15,68,159],"murine":[16],"showed":[18,197],"significant":[19,168],"therapeutic":[20],"effects":[21],"mouse":[23,191],"models":[24],"of":[25,55,74,80,97,161,184,203,225],"diseases.":[27,234],"We":[28],"constructed":[29],"by":[30],"phage":[31],"display":[32],"technology":[33],"human":[35,41,46,69,78,88,108,114,233],"scFv,":[36,163],"which":[37,112],"could":[38],"potently":[39],"neutralize":[40],"GM-CSF.":[42],"At":[43],"first,":[44],"V(L)":[47,79],"repertoire":[48],"was":[49,66,83,135],"combined":[50,85],"the":[52,94,98,138,156,162,182,185,193,212],"V(H)":[53,89,101],"domain":[54,102],"parental":[57,99],"GM-CSF-neutralizing":[58,141],"rat":[59,100],"antibody.":[60],"One":[61],"dominant":[62],"rat/human":[63],"scFv":[64,142,186,195,214,217],"clone":[65,82],"selected,":[67,111],"an":[72,145],"IC50":[73],"7.3":[75],"nM.":[76],"The":[77,91],"this":[81],"then":[84],"repertoire.":[90],"latter":[92],"preserved":[93],"CDR":[95],"3":[96],"to":[103,137,174,230],"retain":[104],"binding":[105,171],"specificity.":[106],"Several":[107],"scFvs":[109],"were":[110],"neutralized":[113],"at":[116,187],"low":[117],"nanomolar":[118],"concentrations":[119],"(IC50":[120],">":[121],"or":[122],"=":[123],"2.6":[124],"nM).":[125],"To":[126],"increase":[127],"serum":[128],"half-life,":[129],"branched":[131],"40":[132],"kDa":[133],"PEG-polymer":[134],"coupled":[136],"most":[139],"potent":[140],"(3077)":[143],"via":[144],"additional":[146],"C-terminal":[147],"cysteine.":[148],"PEG":[149],"conjugation":[150],"had":[151],"negligible":[153],"effect":[154],"on":[155],"vitro":[158],"potential":[160,221],"although":[164],"it":[165],"caused":[166],"drop":[169],"affinity":[172],"owing":[173],"reduced":[176],"on-rate.":[177],"It":[178],"also":[179],"significantly":[180,199],"increased":[181],"stability":[183],"elevated":[188],"temperatures.":[189],"In":[190],"experiments,":[192],"PEGylated":[194,216],"3077":[196,218],"prolonged":[200],"elimination":[201],"half-life":[202],"59":[204],"h":[205,210],"as":[206],"compared":[207],"2":[209],"for":[211,223],"unconjugated":[213],"version.":[215],"is":[219],"candidate":[222],"development":[224],"novel":[227],"antibody":[228],"therapy":[229],"treat":[231],"pro-inflammatory":[232]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
