{"id":"https://openalex.org/W2139463181","doi":null,"title":"The Role of Complex Chromosome Translocations in Leukemia","display_name":"The Role of Complex Chromosome Translocations in Leukemia","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2139463181","mag":"2139463181"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/6297","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6297","pdf_url":"https://run.unl.pt/bitstreams/6b7bf694-ceb3-4203-800a-216c5211d844/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://run.unl.pt/bitstreams/6b7bf694-ceb3-4203-800a-216c5211d844/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103561791","display_name":"Luis Miguel Ramos Vieira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Luis Miguel Ramos Vieira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103561791"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.27250000834465027,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.7900000214576721},{"id":"https://openalex.org/keywords/fusion-genes","display_name":"fusion genes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5659999847412109},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.5109999775886536},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-reactivation","display_name":"tumor suppressor gene reactivation","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.8907220363616943},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7582339644432068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6772134900093079},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6096535325050354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5933389067649841},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5679965019226074},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4525274336338043},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42166972160339355},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4181728959083557},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/6297","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6297","pdf_url":"https://run.unl.pt/bitstreams/6b7bf694-ceb3-4203-800a-216c5211d844/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:2139463181","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/6297/1/Vieira%20Luis%20TD%202011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/6297","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6297","pdf_url":"https://run.unl.pt/bitstreams/6b7bf694-ceb3-4203-800a-216c5211d844/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310654","display_name":"Indian National Science Academy","ror":"https://ror.org/051475v86"},{"id":"https://openalex.org/F4320323424","display_name":"Universidade de Lisboa","ror":"https://ror.org/01c27hj86"},{"id":"https://openalex.org/F4320327240","display_name":"Liga Portuguesa Contra o Cancro","ror":"https://ror.org/03r31ar10"},{"id":"https://openalex.org/F4320330265","display_name":"Associa\u00e7\u00e3o Portuguesa Contra a Leucemia","ror":"https://ror.org/05r4c0z09"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139463181.pdf","grobid_xml":"https://content.openalex.org/works/W2139463181.grobid-xml"},"referenced_works_count":367,"referenced_works":["https://openalex.org/W2537449","https://openalex.org/W11426206","https://openalex.org/W15453418","https://openalex.org/W34311289","https://openalex.org/W62930271","https://openalex.org/W68963654","https://openalex.org/W114795016","https://openalex.org/W123071911","https://openalex.org/W130111970","https://openalex.org/W134398319","https://openalex.org/W136408922","https://openalex.org/W176998439","https://openalex.org/W186546807","https://openalex.org/W200623202","https://openalex.org/W206592526","https://openalex.org/W221180449","https://openalex.org/W249585176","https://openalex.org/W753987688","https://openalex.org/W1486674271","https://openalex.org/W1498241445","https://openalex.org/W1499500424","https://openalex.org/W1502230814","https://openalex.org/W1506478892","https://openalex.org/W1519519905","https://openalex.org/W1524671781","https://openalex.org/W1546217975","https://openalex.org/W1551547047","https://openalex.org/W1554600230","https://openalex.org/W1555266286","https://openalex.org/W1555771060","https://openalex.org/W1556421650","https://openalex.org/W1559842321","https://openalex.org/W1560910443","https://openalex.org/W1578441131","https://openalex.org/W1579421676","https://openalex.org/W1583265575","https://openalex.org/W1587672801","https://openalex.org/W1612954127","https://openalex.org/W1806091569","https://openalex.org/W1832766035","https://openalex.org/W1839183617","https://openalex.org/W1866691507","https://openalex.org/W1894088929","https://openalex.org/W1950580345","https://openalex.org/W1963789659","https://openalex.org/W1963850857","https://openalex.org/W1964834498","https://openalex.org/W1965007670","https://openalex.org/W1965388358","https://openalex.org/W1966155874","https://openalex.org/W1966347912","https://openalex.org/W1968092959","https://openalex.org/W1968525362","https://openalex.org/W1968640966","https://openalex.org/W1969137587","https://openalex.org/W1969177408","https://openalex.org/W1969987028","https://openalex.org/W1970060467","https://openalex.org/W1970228704","https://openalex.org/W1970360609","https://openalex.org/W1970861610","https://openalex.org/W1972113189","https://openalex.org/W1973162373","https://openalex.org/W1973304621","https://openalex.org/W1973394001","https://openalex.org/W1975983904","https://openalex.org/W1976286290","https://openalex.org/W1976631985","https://openalex.org/W1977046269","https://openalex.org/W1977852852","https://openalex.org/W1978803683","https://openalex.org/W1979187335","https://openalex.org/W1979214589","https://openalex.org/W1979629243","https://openalex.org/W1980206664","https://openalex.org/W1980311558","https://openalex.org/W1980568348","https://openalex.org/W1980720313","https://openalex.org/W1980743356","https://openalex.org/W1981044274","https://openalex.org/W1981915872","https://openalex.org/W1982640053","https://openalex.org/W1983171249","https://openalex.org/W1983308047","https://openalex.org/W1983359974","https://openalex.org/W1985530443","https://openalex.org/W1986658762","https://openalex.org/W1987163216","https://openalex.org/W1987676683","https://openalex.org/W1988639913","https://openalex.org/W1988683043","https://openalex.org/W1990301753","https://openalex.org/W1990737203","https://openalex.org/W1991052769","https://openalex.org/W1991408379","https://openalex.org/W1991665028","https://openalex.org/W1991688171","https://openalex.org/W1992563036","https://openalex.org/W1992628946","https://openalex.org/W1993703063","https://openalex.org/W1994345557","https://openalex.org/W1995369623","https://openalex.org/W1996148535","https://openalex.org/W1996412960","https://openalex.org/W1997012271","https://openalex.org/W1997863961","https://openalex.org/W1998593414","https://openalex.org/W1999048322","https://openalex.org/W1999690223","https://openalex.org/W2001731280","https://openalex.org/W2001943565","https://openalex.org/W2002210336","https://openalex.org/W2002240494","https://openalex.org/W2002654245","https://openalex.org/W2002782759","https://openalex.org/W2005391462","https://openalex.org/W2005413198","https://openalex.org/W2005981464","https://openalex.org/W2006518962","https://openalex.org/W2007573003","https://openalex.org/W2008018118","https://openalex.org/W2008601218","https://openalex.org/W2009307227","https://openalex.org/W2009697099","https://openalex.org/W2010207364","https://openalex.org/W2010330552","https://openalex.org/W2010428440","https://openalex.org/W2012160343","https://openalex.org/W2012668185","https://openalex.org/W2013299344","https://openalex.org/W2014525722","https://openalex.org/W2014625060","https://openalex.org/W2015547415","https://openalex.org/W2016086822","https://openalex.org/W2016401533","https://openalex.org/W2016790281","https://openalex.org/W2017209956","https://openalex.org/W2017792463","https://openalex.org/W2019649241","https://openalex.org/W2020092689","https://openalex.org/W2020252485","https://openalex.org/W2024727395","https://openalex.org/W2024775232","https://openalex.org/W2025383376","https://openalex.org/W2025749030","https://openalex.org/W2026611875","https://openalex.org/W2027613124","https://openalex.org/W2028211858","https://openalex.org/W2028472887","https://openalex.org/W2028757834","https://openalex.org/W2028959752","https://openalex.org/W2029355672","https://openalex.org/W2029510600","https://openalex.org/W2029878366","https://openalex.org/W2030928908","https://openalex.org/W2031201681","https://openalex.org/W2031325108","https://openalex.org/W2031701701","https://openalex.org/W2032528208","https://openalex.org/W2033594965","https://openalex.org/W2034269086","https://openalex.org/W2034892057","https://openalex.org/W2036180570","https://openalex.org/W2036296056","https://openalex.org/W2036383641","https://openalex.org/W2036862498","https://openalex.org/W2037010155","https://openalex.org/W2037257344","https://openalex.org/W2038430021","https://openalex.org/W2038538605","https://openalex.org/W2038960013","https://openalex.org/W2040396943","https://openalex.org/W2041200806","https://openalex.org/W2041715533","https://openalex.org/W2042052098","https://openalex.org/W2042883018","https://openalex.org/W2043073544","https://openalex.org/W2043122788","https://openalex.org/W2043372546","https://openalex.org/W2044496404","https://openalex.org/W2045924548","https://openalex.org/W2046448239","https://openalex.org/W2046892081","https://openalex.org/W2047591593","https://openalex.org/W2047973654","https://openalex.org/W2048593270","https://openalex.org/W2049145190","https://openalex.org/W2049791242","https://openalex.org/W2049964729","https://openalex.org/W2050557699","https://openalex.org/W2052214869","https://openalex.org/W2052477944","https://openalex.org/W2052855224","https://openalex.org/W2053310263","https://openalex.org/W2054113320","https://openalex.org/W2055852018","https://openalex.org/W2056560239","https://openalex.org/W2056885584","https://openalex.org/W2058330063","https://openalex.org/W2059340669","https://openalex.org/W2059410642","https://openalex.org/W2060017952","https://openalex.org/W2060833726","https://openalex.org/W2061036706","https://openalex.org/W2061573957","https://openalex.org/W2061851471","https://openalex.org/W2062743311","https://openalex.org/W2063083122","https://openalex.org/W2065458378","https://openalex.org/W2065567658","https://openalex.org/W2066982873","https://openalex.org/W2067181050","https://openalex.org/W2067684423","https://openalex.org/W2068728784","https://openalex.org/W2068735449","https://openalex.org/W2068774331","https://openalex.org/W2069058583","https://openalex.org/W2069963403","https://openalex.org/W2070169840","https://openalex.org/W2070426601","https://openalex.org/W2070560261","https://openalex.org/W2070704649","https://openalex.org/W2071036762","https://openalex.org/W2071040646","https://openalex.org/W2072233408","https://openalex.org/W2072233737","https://openalex.org/W2072419001","https://openalex.org/W2072583409","https://openalex.org/W2075731157","https://openalex.org/W2075731214","https://openalex.org/W2076372887","https://openalex.org/W2077605748","https://openalex.org/W2079604568","https://openalex.org/W2081571977","https://openalex.org/W2082112437","https://openalex.org/W2082151996","https://openalex.org/W2082606971","https://openalex.org/W2083047689","https://openalex.org/W2083275000","https://openalex.org/W2083971818","https://openalex.org/W2084041698","https://openalex.org/W2085124463","https://openalex.org/W2086622664","https://openalex.org/W2087283266","https://openalex.org/W2087479365","https://openalex.org/W2087616883","https://openalex.org/W2088038595","https://openalex.org/W2088854268","https://openalex.org/W2089483984","https://openalex.org/W2089988801","https://openalex.org/W2090450792","https://openalex.org/W2090656848","https://openalex.org/W2090977067","https://openalex.org/W2091545623","https://openalex.org/W2091720445","https://openalex.org/W2091824666","https://openalex.org/W2092329569","https://openalex.org/W2093216476","https://openalex.org/W2093708765","https://openalex.org/W2094233558","https://openalex.org/W2095184701","https://openalex.org/W2095592851","https://openalex.org/W2096753123","https://openalex.org/W2098174216","https://openalex.org/W2103158448","https://openalex.org/W2105984992","https://openalex.org/W2107436056","https://openalex.org/W2107728441","https://openalex.org/W2107755237","https://openalex.org/W2108925373","https://openalex.org/W2112033407","https://openalex.org/W2112087352","https://openalex.org/W2112613857","https://openalex.org/W2114570899","https://openalex.org/W2115524556","https://openalex.org/W2115702003","https://openalex.org/W2116878961","https://openalex.org/W2117002977","https://openalex.org/W2117073299","https://openalex.org/W2118823453","https://openalex.org/W2119749554","https://openalex.org/W2120359322","https://openalex.org/W2121619780","https://openalex.org/W2122038874","https://openalex.org/W2122417713","https://openalex.org/W2124098316","https://openalex.org/W2125661033","https://openalex.org/W2126665281","https://openalex.org/W2129465811","https://openalex.org/W2131195660","https://openalex.org/W2131377263","https://openalex.org/W2131385589","https://openalex.org/W2134453935","https://openalex.org/W2134460656","https://openalex.org/W2134990614","https://openalex.org/W2137114892","https://openalex.org/W2137493698","https://openalex.org/W2139255055","https://openalex.org/W2139447006","https://openalex.org/W2139839349","https://openalex.org/W2140707292","https://openalex.org/W2141324982","https://openalex.org/W2142039491","https://openalex.org/W2144664431","https://openalex.org/W2144927409","https://openalex.org/W2145262679","https://openalex.org/W2145483085","https://openalex.org/W2145872206","https://openalex.org/W2146505525","https://openalex.org/W2148379368","https://openalex.org/W2150498320","https://openalex.org/W2151438417","https://openalex.org/W2152532651","https://openalex.org/W2153715492","https://openalex.org/W2154025598","https://openalex.org/W2155373892","https://openalex.org/W2155469435","https://openalex.org/W2157973267","https://openalex.org/W2158035710","https://openalex.org/W2158714788","https://openalex.org/W2159453741","https://openalex.org/W2161371522","https://openalex.org/W2163775178","https://openalex.org/W2165551378","https://openalex.org/W2169398518","https://openalex.org/W2169704861","https://openalex.org/W2170471663","https://openalex.org/W2171023100","https://openalex.org/W2171915984","https://openalex.org/W2172101787","https://openalex.org/W2184391500","https://openalex.org/W2203103700","https://openalex.org/W2204038861","https://openalex.org/W2247260304","https://openalex.org/W2255054567","https://openalex.org/W2255761522","https://openalex.org/W2279693825","https://openalex.org/W2280905264","https://openalex.org/W2281287090","https://openalex.org/W2294291334","https://openalex.org/W2302051571","https://openalex.org/W2314667854","https://openalex.org/W2315785769","https://openalex.org/W2328556759","https://openalex.org/W2338753933","https://openalex.org/W2339359539","https://openalex.org/W2346531348","https://openalex.org/W2370704489","https://openalex.org/W2396904655","https://openalex.org/W2399416293","https://openalex.org/W2399642221","https://openalex.org/W2400947496","https://openalex.org/W2406125215","https://openalex.org/W2407118965","https://openalex.org/W2410341681","https://openalex.org/W2410506455","https://openalex.org/W2412126852","https://openalex.org/W2414626961","https://openalex.org/W2418152262","https://openalex.org/W2418643325","https://openalex.org/W2419612626","https://openalex.org/W2431946899","https://openalex.org/W2464335533","https://openalex.org/W3113814835","https://openalex.org/W4232374197","https://openalex.org/W4252203505","https://openalex.org/W7098492624"],"related_works":["https://openalex.org/W4319984793","https://openalex.org/W4402310014","https://openalex.org/W2125440568","https://openalex.org/W2013467569","https://openalex.org/W1503303237","https://openalex.org/W1560910443","https://openalex.org/W41704235","https://openalex.org/W2118836772","https://openalex.org/W2032340333","https://openalex.org/W2023256994"],"abstract_inverted_index":{"A":[0,565,629,853,944,1367],"tumorig\u00e9nese":[1],"\u00e9":[2,113,558,789,803,913,1258],"um":[3,92,106,163,187,246,533,663,784,974,998,1042,1054,1082,1108,1124,1135,1150,1251,1275,1300,1330],"processo":[4,96],"de":[5,18,25,48,56,68,73,88,105,109,124,136,162,165,171,178,191,207,213,221,249,259,265,272,274,294,303,323,336,363,372,378,411,418,433,435,446,460,473,487,497,501,512,524,532,546,548,578,600,604,613,625,657,659,688,702,716,736,744,751,761,764,773,786,836,839,842,872,898,918,932,934,962,973,980,987,1030,1045,1069,1084,1087,1103,1123,1156,1167,1175,1179,1208,1215,1246,1256,1290,1303,1315,1338,1380,1392,1394,1402],"transforma\u00e7\u00e3o":[6],"celular":[7,376,589,640,725,819,942,1086,1139,1363,1407],"que":[8,31,86,132,149,180,185,200,224,368,443,521,554,619,670,685,769,788,832,868,895,908,915,956,1025,1034,1040,1091,1164,1187,1223,1238,1243,1260,1383],"se":[9,225,444,1036],"desenrola":[10],"tipicamente":[11],"em":[12,148,194,414,478,561,602,611,646,692,696,1047,1146,1158,1177,1385],"v\u00e1rias":[13],"etapas.":[14],"Os":[15,1378],"diferentes":[16,169,292,334,795,1078,1322],"n\u00edveis":[17,931,1191,1231],"evolu\u00e7\u00e3o":[19],"tumoral":[20,242],"resultam":[21,87],"da":[22,54,62,345,374,485,568,571,590,595,632,666,971,1067,1110,1117,1119,1127,1137,1152,1199,1213,1281,1285,1361,1405],"acumula\u00e7\u00e3o":[23],"sucessiva":[24],"muta\u00e7\u00f5es":[26,42],"gen\u00e9ticas":[27],"numa":[28,115,805,1038],"c\u00e9lula":[29],"normal":[30,1289],"lhe":[32],"conferem":[33],"uma":[34,60,150,175,228,406,575,623,723,759,843,848,910,928,940,954,1070,1316],"vantagem":[35],"selectiva":[36],"no":[37,95,240,367,480,526,862,879,884,920,1004,1347,1352],"respectivo":[38],"meio":[39],"tecidular.":[40],"As":[41,1411],"podem":[43,698,1371,1396],"manifestar-se":[44],"sob":[45,102],"a":[46,59,103,144,218,279,299,328,342,431,456,464,530,581,608,636,642,649,662,674,677,712,792,810,823,833,903,916,978,1007,1051,1092,1131,1134,1143,1173,1188,1197,1206,1239,1261,1390,1400],"forma":[47,104,710],"altera\u00e7\u00f5es":[49,74,266,961],"nucleot\u00eddicas":[50],"pontuais":[51],"ao":[52,720,858],"n\u00edvel":[53],"sequ\u00eancia":[55,500,531,569],"DNA,":[57],"levando":[58],"desregula\u00e7\u00e3o":[61,1401],"fun\u00e7\u00e3o":[63,119,229,911],"prote\u00edca":[64],"ou":[65,71,77,188,1196],"\u00e0":[66,160,538],"forma\u00e7\u00e3o":[67,161,204,793,1391],"prote\u00ednas":[69,715,1024],"n\u00e3o-funcionais,":[70],"atrav\u00e9s":[72,656,841,970,1122,1210,1284],"cromoss\u00f3micas":[75,90,131,183,276,694,1306],"num\u00e9ricas":[76],"estruturais.":[78],"Na":[79],"leucemia,":[80,697],"por":[81,808,821,966,1101],"exemplo,":[82],"os":[83,122,154,211,383,416,495,686,749,828,985,1160],"genes":[84,99,206,355,434,515,703,735,775,867,1014,1264,1393,1403],"h\u00edbridos":[85],"transloca\u00e7\u00f5es":[89,130,182,275,390,427,450,693,1305,1386],"desempenham":[91],"importante":[93,230,1278],"papel":[94,236,263,352,470,1058,1252],"tumorig\u00e9nico.":[97],"Estes":[98,682],"s\u00e3o":[100],"transcritos":[101],"RNA":[107,660,1155],"mensageiro":[108],"fus\u00e3o,":[110,1395],"o":[111,235,253,258,261,351,522,555,896,1115,1165,1244,1359],"qual":[112,863],"traduzido":[114,804],"prote\u00edna":[116,572,582,624,633,806,1120],"h\u00edbrida":[117],"com":[118,129,291,422,430,455,482,543,580,711,748,756,860,922,950,960,984,1107,1130,1205,1219,1228,1321,1389],"oncog\u00e9nica.":[120],"Frequentemente,":[121],"subtipos":[123,170],"doen\u00e7a":[125,295,955],"leuc\u00e9mica":[126],"est\u00e3o":[127,201,215,1203],"associados":[128,217,290],"envolvem":[133,186],"2":[134,866,1344,1374],"pontos":[135,190,212,271,322,417,472,496,511,687,750,986,1337,1379],"quebra":[137,192,214,273,324,474,498,513,525,689,752,988,1381],"recorrentes":[138],"e":[139,157,313,333,377,399,424,440,452,463,517,606,641,676,778,838,882,992,1020,1064,1266,1312,1314,1350],"espec\u00edficos.":[140],"\u00c9":[141],"disto":[142],"exemplo":[143],"leucemia":[145,300,308,457,465],"miel\u00f3ide":[146,309,466],"cr\u00f3nica,":[147],"transloca\u00e7\u00e3o":[151,407,844,1317],"rec\u00edproca":[152],"entre":[153,382],"cromossomas":[155,505,990],"9":[156,774,881],"22":[158],"conduz":[159],"gene":[164,556,621,654,781,906,1060,1097],"fus\u00e3o":[166,436,717],"BCR-ABL1.":[167],"Em":[168,348,1113,1295,1325],"doen\u00e7a,":[172],"existe":[173],"tamb\u00e9m":[174,216,1329],"pequena":[176],"propor\u00e7\u00e3o":[177],"casos":[179,349,385,421,730,1326],"apresenta":[181],"complexas,":[184],"mais":[189,1232],"adicionais":[193,268,475],"outras":[195],"localiza\u00e7\u00f5es":[196],"gen\u00f3micas":[197,239],"al\u00e9m":[198],"das":[199,449,644,714,794,812,1077,1292,1334,1364],"implicadas":[202],"na":[203,231,499,507,585,700,766,771,798,814,851,875,1061,1065,1075,1279],"dos":[205,321,353,471,503,510,705,930,1190,1226,1263,1336],"fus\u00e3o.":[208,737],"Por":[209],"vezes,":[210],"delec\u00e7\u00f5es":[219,412,743,982,1046],"extensas":[220,413],"material":[222],"gen\u00e9tico":[223],"pensa":[226],"terem":[227],"tumorig\u00e9nese.":[232],"No":[233,401,754,994,1182],"entanto,":[234],"destas":[237],"regi\u00f5es":[238,1335],"desenvolvimento":[241],"n\u00e3o":[243,317,732],"tem":[244],"sido":[245],"motivo":[247],"recorrente":[248],"estudo.":[250],"Neste":[251,826,968],"contexto,":[252,827],"objectivo":[254,282],"desta":[255,709],"disserta\u00e7\u00e3o":[256,1299],"foi":[257,325,357,404,476,519,946],"determinar":[260],"potencial":[262],"tumorig\u00e9nico":[264],"g\u00e9nicas":[267],"ocorridas":[269],"nos":[270,514,989],"complexas.":[277],"Para":[278],"prossecu\u00e7\u00e3o":[280],"do":[281,587,597,638,651,653,679,817,891,905,1057,1094,1096,1154,1193,1211,1234,1237,1269,1287],"proposto,":[283],"foram":[284,493,733],"estudados":[285,731],"5":[286,384],"rearranjos":[287,447],"cromoss\u00f3micos":[288],"distintos":[289],"tipos":[293],"hematol\u00f3gica":[296],"maligna,":[297],"nomeadamente":[298,366,395,438],"linfobl\u00e1stica":[301,458],"aguda":[302,459],"c\u00e9lulas":[304,461,542,645,813,1178,1225,1365],"B":[305,462],"(2":[306],"casos),":[307],"aguda,":[310,467],"neoplasma":[311],"mieloproliferativo":[312],"s\u00edndrome":[314],"mielodispl\u00e1sico/neoplasma":[315],"ieloproliferativo,":[316],"classific\u00e1vel.":[318],"O":[319,469,780],"mapeamento":[320],"efectuado":[326],"utilizando":[327,361],"hibrida\u00e7\u00e3o":[329],"fluorescente":[330],"in":[331,359,616,1099,1140],"situ":[332],"metodologias":[335],"biologia":[337],"molecular,":[338],"tendo":[339],"como":[340,889,926,1027,1253,1398],"base":[341],"informa\u00e7\u00e3o":[343],"inicial":[344],"an\u00e1lise":[346,566,1341],"citogen\u00e9tica.":[347],"seleccionados,":[350],"novos":[354],"candidatos":[356],"avaliado":[358],"vitro":[360],"modelos":[362],"linhas":[364,614],"celulares,":[365,1162],"respeita":[369],"\u00e0s":[370],"fun\u00e7\u00f5es":[371],"controlo":[373],"prolifera\u00e7\u00e3o":[375,643,667,675,724,824,941,1062,1111,1138,1207,1362,1406],"regula\u00e7\u00e3o":[379,586,1066],"transcricional.":[380],"De":[381,1217],"estudados,":[386],"quatro":[387],"deles":[388],"evidenciaram":[389],"complexas":[391,695,1307,1387],"envolvendo":[392],"3":[393,504,729,1011],"cromossomas,":[394],"t(12;21;5)(p13;q22;q13),":[396],"t(12;6;15)(p13;p24~25;q22),":[397],"t(9;11;19)(p22;q23;p13)":[398],"t(X;20;16)(p11;q13;q23).":[400],"caso":[402,481,755,859,921],"remanescente,":[403],"observada":[405],"dic\u00eantrica":[408,1318],"dic(9;12)(p11;p11)":[409],"acompanhada":[410],"ambos":[415,1159],"quebra.":[419,1339],"Nos":[420,727],"t(12;21;5)":[423],"t(9;11;19)":[425,1311],"as":[426,1224],"estavam":[428,887],"associadas":[429,454,747,983,1320,1388],"presen\u00e7a":[432,979],"recorrentes,":[437],"TV6(12p13)-RUNX1(21q22)":[439],"TLL(11q23)-MLLT3(9p22),":[441],"indicando":[442,1163],"tratavam":[445],"complexos":[448],"t(12;21)":[451],"t(9;11)":[453],"respectivamente.":[468],"estudado":[477],"detalhe":[479],"t(9;11;19).":[483,544],"Atrav\u00e9s":[484,545,594],"metodologia":[486],"long":[488],"distance":[489],"inverse-polymerase":[490],"chain":[491,551],"reaction,":[492],"identificados":[494,734],"DNA":[502,598,765],"envolvidos":[506],"transloca\u00e7\u00e3o.":[508],"Al\u00e9m":[509],"MLL":[516],"MLLT3,":[518],"observado":[520],"local":[523],"cromossoma":[527,880,885,995,1005,1348,1353],"19":[528,1349],"interrompeu":[529],"novo":[534],"gene,":[535,999],"designado":[536],"CCDC94,conduzindo":[537],"sua":[539,1128],"haplo-insufici\u00eancia":[540,701,917,1262,1356],"nas":[541],"ensaios":[547,1161],"reverse":[549],"transcription-polymerase":[550],"reaction":[552],"verific\u00e1mos":[553,1090,1222],"CCDC94":[557,573,601,634,655,671,1346],"expresso":[559],"ubiquitariamente":[560],"tecidos":[562],"humanos":[563],"normais.":[564],"inform\u00e1tica":[567],"prevista":[570],"indicou":[574],"elevada":[576],"identidade":[577],"amino\u00e1cidos":[579],"cwf16,":[583],"envolvida":[584],"ciclo":[588,639,680,818],"levedura":[591],"Schizosaccharomyces":[592],"pombe.":[593],"clonagem":[596],"complementar":[599],"vectores":[603],"express\u00e3o,":[605],"ap\u00f3s":[607],"transfec\u00e7\u00e3o":[609],"destes":[610,1369],"culturas":[612],"celulares":[615],"vitro,":[617,1100],"observ\u00e1mos":[618],"este":[620],"codifica":[622,783],"localiza\u00e7\u00e3o":[626],"exclusivamente":[627],"nuclear.":[628],"express\u00e3o":[630,904,933,1068,1174,1291],"ect\u00f3pica":[631],"diminuiu":[635],"progress\u00e3o":[637,678],"cultura.":[647],"Inversamente,":[648],"supress\u00e3o":[650,1093],"transcrito":[652,1095,1194,1235],"interfer\u00eancia":[658,1102],"conduziu":[661,1133],"aumento":[664,1109,1136,1151,1212,1360],"significativo":[665],"celular,":[668],"confirmando":[669],"regula":[672,901],"negativamente":[673,902,1172],"celular.":[681,825,1112],"resultados":[683,829,1185],"mostram":[684,1186],"adicionais,":[690,1382],"presentes":[691],"resultar":[699],"controladores":[704,1404],"mecanismos":[706],"proliferativos,":[707],"cooperando":[708],"ac\u00e7\u00e3o":[713,849],"para":[718,791,870,939],"proporcionar":[719],"clone":[721],"leuc\u00e9mico":[722],"descontrolada.":[726],"restantes":[728],"Ao":[738],"inv\u00e9s,":[739],"todos":[740],"aqueles":[741],"apresentaram":[742],"extens\u00e3o":[745],"vari\u00e1vel":[746],"cromoss\u00f3micos.":[753],"t(12;6;15),":[757,1310],"identific\u00e1mos":[758,977],"delec\u00e7\u00e3o":[760,1008],"1.2":[762],"megabases":[763],"banda":[767],"12p13":[768],"resultou":[770],"elimina\u00e7\u00e3o":[772],"incluindo":[776,1050,1308],"ETV6":[777,782,837,883],"CDKN1B.":[779],"factor":[785,897,1166,1245],"transcri\u00e7\u00e3o":[787,873,899,1168,1247],"essencial":[790,952,1283],"linhagens":[796,1079],"hematopoi\u00e9ticas":[797],"medula":[799],"\u00f3ssea,":[800],"enquanto":[801,1003],"CDKN1B":[802],"respons\u00e1vel":[807],"bloquear":[809],"entrada":[811],"fase":[815],"G1":[816],"e,consequentemente,":[820],"travar":[822],"obtidos":[830],"indicam":[831],"perda":[834],"simult\u00e2nea":[835],"CDKN1B,":[840],"cromoss\u00f3mica":[845],"complexa,":[846],"constituiu":[847],"cooperativa":[850],"leucemog\u00e9nese.":[852],"mesma":[854],"no\u00e7\u00e3o":[855],"pode":[856,1170,1357],"aplicar-se":[857],"dic(9;12),":[861,1319],"pelo":[864],"menos":[865],"codificam":[869,1023],"factores":[871],"importantes":[874],"linhagem":[876],"hematopoi\u00e9tica,":[877],"PAX5":[878,900,919],"12,":[886],"deleccionados":[888],"resultado":[890],"rearranjo":[892,1270],"cromoss\u00f3mico.":[893],"Dado":[894,1033,1242],"FLT3,":[907,935],"desempenha":[909,1249],"pr\u00f3-proliferativa,":[912],"expect\u00e1vel":[914],"dic(9;12)":[923],"ter\u00e1":[924],"tido":[925],"consequ\u00eancia":[927,1399],"eleva\u00e7\u00e3o":[929],"contribuindo":[936],"deste":[937,1059],"modo":[938],"aumentada.":[943],"t(X;20;16)":[945],"identificada":[947],"num":[948],"doente":[949],"trombocit\u00e9mia":[951,1052,1088,1180,1282],"(TE),":[953],"est\u00e1":[957],"intimamente":[958],"relacionada":[959],"vias":[963],"intracelulares":[964],"reguladas":[965],"citocinas.":[967],"caso,":[969],"utiliza\u00e7\u00e3o":[972],"array":[975],"gen\u00f3mico,":[976],"pequenas":[981],"16":[991,996],"20.":[993],"apenas":[997],"MAF,":[1000,1267],"estava":[1001,1105],"deleccionado,":[1002],"20":[1006],"tinha":[1009],"abrangido":[1010],"genes.":[1012],"Dos":[1013],"deleccionados,":[1015],"dois":[1016],"deles,":[1017],"NFATC2":[1018,1035,1098,1121,1169,1236,1265,1351],"(20q13)":[1019],"MAF":[1021,1248],"(16q23),":[1022],"operam":[1026],"reguladores":[1028],"transcricionais":[1029],"citocinas":[1031,1293],"hematopoi\u00e9ticas.":[1032,1294],"localiza":[1037],"regi\u00e3o":[1039],"constitui":[1041],"alvo":[1043],"frequente":[1044],"neoplasmas":[1048,1323],"ieloproliferativos,":[1049],"essencial,efectu\u00e1mos":[1053],"estudo":[1055,1301,1331],"detalhado":[1056,1333],"megacarioc\u00edtica":[1063],"citocina":[1071],"hematopoi\u00e9tica":[1072],"(GM-CSF),":[1073],"implicada":[1074],"matura\u00e7\u00e3o":[1076],"miel\u00f3ides.":[1080],"Utilizando":[1081,1142],"modelo":[1083],"linha":[1085],"essencial,":[1089],"RNA,":[1104],"associada":[1106],"concord\u00e2ncia,":[1114],"bloqueio":[1116],"activa\u00e7\u00e3o":[1118],"inibidor":[1125],"espec\u00edfico":[1126],"interac\u00e7\u00e3o":[1129],"calcineurina,":[1132],"vitro.":[1141],"PCR":[1144],"quantitativa":[1145],"tempo":[1147],"real,":[1148],"detectou-se":[1149],"produ\u00e7\u00e3o":[1153,1214],"GM-CSF":[1157,1176],"regular":[1171,1254],"essencial.":[1181],"geral,":[1183],"estes":[1184,1220],"redu\u00e7\u00e3o":[1189,1198],"fisiol\u00f3gicos":[1192],"NFATC2,":[1195],"respectiva":[1200],"actividade":[1201],"proteica,":[1202],"relacionados":[1204],"megacariocitos":[1209],"GM-CSF.":[1216],"acordo":[1218],"resultados,":[1221],"doentes":[1227],"TE":[1229],"apresentam":[1230],"baixos":[1233],"popula\u00e7\u00e3o":[1240],"normal.":[1241],"igualmente":[1250],"transcricional":[1255],"citocinas,":[1257],"plaus\u00edvel":[1259],"resultante":[1268],"cromoss\u00f3mico":[1271],"complexo":[1272],"t(X;20;16),":[1273,1313],"teve":[1274],"efeito":[1276],"cooperativo":[1277],"patog\u00e9nese":[1280],"altera\u00e7\u00e3o":[1286],"padr\u00e3o":[1288],"s\u00edntese,":[1296],"efectu\u00e1mos":[1297,1328],"nesta":[1298],"citogen\u00e9tico":[1302],"4":[1304],"t(12;21;5),":[1309],"hematol\u00f3gicos.":[1324],"seleccionados":[1327],"molecular":[1332],"Esta":[1340],"permitiu-nos":[1342],"identificar":[1343],"genes,":[1345],"20,":[1354],"cuja":[1355],"promover":[1358],"leuc\u00e9micas.":[1366],"partir":[1368],"estudos":[1370],"ser":[1372],"retiradas":[1373],"no\u00e7\u00f5es":[1375],"principais:":[1376],"(i)":[1377],"ocorrem":[1384],"ter":[1397],"(e.g.,":[1408],"CCDC94);":[1409],"(ii)":[1410],"tran":[1412]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
