{"id":"https://openalex.org/W2139461601","doi":null,"title":"Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development.","display_name":"Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development.","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2139461601","mag":"2139461601","pmid":"https://pubmed.ncbi.nlm.nih.gov/9019159"},"language":"en","primary_location":{"id":"pmid:9019159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9019159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Comparative Study"},"parent_works":[],"lineage":["https://openalex.org/W2139461601"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026295223","display_name":"E C Shugart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E C Shugart","raw_affiliation_strings":["Department of Biology, University of Virginia, Charlottesville 22903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Virginia, Charlottesville 22903, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057301281","display_name":"A S Levenson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Levenson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079837378","display_name":"C M Constance","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Constance","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037719660","display_name":"Robert M. Umek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Umek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.08,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.73955081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"12","first_page":"1541","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/3t3-l1-cells","display_name":"3T3-L1 cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.7329999804496765},{"id":"https://openalex.org/keywords/gas1","display_name":"GAS1","score":0.6779999732971191},{"id":"https://openalex.org/keywords/gas6","display_name":"Gas6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.718999981880188},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.8330000042915344},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.878000020980835},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8731987476348877},{"id":"https://openalex.org/C2778021510","wikidata":"https://www.wikidata.org/wiki/Q3756837","display_name":"Gadd45","level":5,"score":0.6478023529052734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.617530882358551},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5139567255973816},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.5129046440124512},{"id":"https://openalex.org/C172811965","wikidata":"https://www.wikidata.org/wiki/Q21110911","display_name":"GAS6","level":4,"score":0.4446917176246643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43682098388671875},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4200579524040222},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4101375937461853},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39531952142715454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3198157548904419},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.28242266178131104},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2433866560459137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24322634935379028},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.16640743613243103},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000097642","descriptor_name":"GADD45 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009185","descriptor_name":"Myelin Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009185","descriptor_name":"Myelin Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9019159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9019159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.498.7121","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.7121","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/6/12/1541.pdf","raw_type":"text"},{"id":"mag:2139461601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9019159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1595843384","https://openalex.org/W1831056283","https://openalex.org/W1856001636","https://openalex.org/W1861749169","https://openalex.org/W1932653806","https://openalex.org/W1980673019","https://openalex.org/W1988059168","https://openalex.org/W2003406123","https://openalex.org/W2009046213","https://openalex.org/W2023722762","https://openalex.org/W2048515321","https://openalex.org/W2071692398","https://openalex.org/W2091990033","https://openalex.org/W2101127398","https://openalex.org/W2115583464","https://openalex.org/W2134812217","https://openalex.org/W2136066768","https://openalex.org/W2140798038","https://openalex.org/W2150073376","https://openalex.org/W2165868580","https://openalex.org/W2168415166"],"related_works":["https://openalex.org/W1963018426","https://openalex.org/W2107237943","https://openalex.org/W2024841285","https://openalex.org/W2047842226","https://openalex.org/W3176080305","https://openalex.org/W2043551694","https://openalex.org/W2003616094","https://openalex.org/W2033870866","https://openalex.org/W2368403475"],"abstract_inverted_index":{"The":[0],"characterization":[1],"of":[2,37,52,70,80,125,142],"growth":[3,13,22,38,42,54,60,81,115,127,151],"arrest-associated":[4,61,152],"genes":[5,48,62,73,153],"has":[6],"revealed":[7],"that":[8,133,150],"cells":[9,21],"actively":[10],"suppress":[11],"mitotic":[12,126],"in":[14,77,91,100,108,132],"response":[15,109],"to":[16,31,110,121],"extracellular":[17],"signals.":[18],"Mouse":[19],"3T3-L1":[20,53],"arrest":[23,55,82,128],"at":[24],"multiple":[25],"distinct":[26],"points":[27],"during":[28,138],"terminal":[29],"differentiation":[30],"adipocytes.":[32,98],"We":[33],"examined":[34],"the":[35,71,122,139,146],"expression":[36,131,147],"arrest-specific":[39],"(gas)":[40],"and":[41,44,56,87,96,104,129],"arrest-":[43],"DNA":[45],"damage-inducible":[46],"(gadd)":[47],"as":[49],"a":[50,78,162],"function":[51],"adipocyte":[57,67],"development.":[58,68],"These":[59],"are":[63,74,89,106,154],"differentially":[64],"expressed":[65,76,90,137],"throughout":[66,161],"Some":[69],"gas/gadd":[72,130],"preferentially":[75,136],"subset":[79],"states.":[83],"In":[84],"contrast,":[85],"gas1":[86,103],"gas3":[88,105],"serum-starved":[92],"adipoblasts,":[93,95],"contact-inhibited":[94],"post-mitotic":[97,101],"However,":[99],"adipocytes,":[102],"induced":[107],"nutrient":[111],"deprivation,":[112],"not":[113],"altered":[114],"status.":[116],"gas6":[117,134],"is":[118,135],"an":[119],"exception":[120],"general":[123],"concordance":[124],"clonal":[140],"expansion":[141],"postconfluent":[143],"adipoblasts.":[144],"Combined,":[145],"patterns":[148],"indicate":[149],"regulated":[155],"by":[156],"numerous":[157],"signal":[158],"transduction":[159],"pathways":[160],"discrete":[163],"developmental":[164],"transition.":[165]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}