{"id":"https://openalex.org/W2139458363","doi":"https://doi.org/10.1093/gerona/60.4.425","title":"Age-Related Decline in Actomyosin Function","display_name":"Age-Related Decline in Actomyosin Function","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2139458363","doi":"https://doi.org/10.1093/gerona/60.4.425","mag":"2139458363","pmid":"https://pubmed.ncbi.nlm.nih.gov/15933379"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/60.4.425","doi":"https://doi.org/10.1093/gerona/60.4.425","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/60.4.425","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087234662","display_name":"Ewa Pr\u00f3chniewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Prochniewicz","raw_affiliation_strings":["Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA. ewa@ddt.biochem.umn.edu","Department of Biochemistry University of Minnesota Minneapolis, Mn. 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA. ewa@ddt.biochem.umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Biochemistry University of Minnesota Minneapolis, Mn. 55455 USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063616345","display_name":"David Dale Thomas","orcid":"https://orcid.org/0000-0002-8822-2040","observed_orcids":["https://orcid.org/0000-0002-8822-2040","https://orcid.org/0000-0001-5739-0992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. D. Thomas","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology, and Biophysics , and","Chemical and Structural Biology (TMED)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology, and Biophysics , and","institution_ids":[]},{"raw_affiliation_string":"Chemical and Structural Biology (TMED)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088219712","display_name":"LaDora V. Thompson","orcid":"https://orcid.org/0000-0002-6481-9029","observed_orcids":["https://orcid.org/0000-0002-6481-9029"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. V. Thompson","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation , University of Minnesota , Minneapolis","Physical Therapy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation , University of Minnesota , Minneapolis","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Physical Therapy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087234662"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":1.8584,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.84616688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"60","issue":"4","first_page":"425","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-aging","display_name":"muscle aging","score":0.7200000286102295},{"id":"https://openalex.org/keywords/actomyosin-atpase","display_name":"actomyosin ATPase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/heavy-meromyosin","display_name":"heavy meromyosin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cysteine-reactivity","display_name":"cysteine reactivity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/actin-activated-atpase","display_name":"actin-activated ATPase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C102091540","wikidata":"https://www.wikidata.org/wiki/Q5695264","display_name":"Heavy meromyosin","level":3,"score":0.8749469518661499},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.8652713298797607},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.732053816318512},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6095559000968933},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5677177906036377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5476691722869873},{"id":"https://openalex.org/C2778021804","wikidata":"https://www.wikidata.org/wiki/Q13359586","display_name":"Myosin ATPase","level":4,"score":0.5149182081222534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4947311580181122},{"id":"https://openalex.org/C18923293","wikidata":"https://www.wikidata.org/wiki/Q6819942","display_name":"Meromyosin","level":5,"score":0.41955459117889404},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.393882155418396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32069289684295654},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.302262544631958},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.17818427085876465},{"id":"https://openalex.org/C15954220","wikidata":"https://www.wikidata.org/wiki/Q24780076","display_name":"Myosin head","level":4,"score":0.11496540904045105}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015879","descriptor_name":"Myosin Subfragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gerona/60.4.425","doi":"https://doi.org/10.1093/gerona/60.4.425","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/60.4.425","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmid:15933379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15933379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.336.5785","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.336.5785","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedgerontology.oxfordjournals.org/content/60/4/425.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.508.5641","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.508.5641","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biochem.umn.edu/Papers/actomyoold.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4655420370","display_name":null,"funder_award_id":"AR 32961","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5335815761","display_name":"Myosin Modifications in Aged Muscle","funder_award_id":"K02AG021626","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5697243406","display_name":null,"funder_award_id":"AG0121626","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8083826405","display_name":"Structual and Calcium Regulatory Proteins in Sarcopenia","funder_award_id":"R01AG017768","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W195327220","https://openalex.org/W1479573389","https://openalex.org/W1505092179","https://openalex.org/W1547929361","https://openalex.org/W1834586338","https://openalex.org/W1835931797","https://openalex.org/W1968430387","https://openalex.org/W1971257860","https://openalex.org/W1972506441","https://openalex.org/W1976171313","https://openalex.org/W1978683697","https://openalex.org/W1979496410","https://openalex.org/W1988435430","https://openalex.org/W1988592326","https://openalex.org/W1990201609","https://openalex.org/W1995090250","https://openalex.org/W1999789808","https://openalex.org/W2004159478","https://openalex.org/W2006370393","https://openalex.org/W2006668876","https://openalex.org/W2007740980","https://openalex.org/W2018978013","https://openalex.org/W2019877068","https://openalex.org/W2022703044","https://openalex.org/W2026145805","https://openalex.org/W2030189898","https://openalex.org/W2031832102","https://openalex.org/W2033349550","https://openalex.org/W2039863570","https://openalex.org/W2040863926","https://openalex.org/W2044225421","https://openalex.org/W2044629144","https://openalex.org/W2044791038","https://openalex.org/W2045913132","https://openalex.org/W2047911550","https://openalex.org/W2048453107","https://openalex.org/W2052791683","https://openalex.org/W2074069675","https://openalex.org/W2076731840","https://openalex.org/W2080932814","https://openalex.org/W2090836757","https://openalex.org/W2091442492","https://openalex.org/W2101983583","https://openalex.org/W2116675254","https://openalex.org/W2121233768","https://openalex.org/W2137904740","https://openalex.org/W2139292873","https://openalex.org/W2140994672","https://openalex.org/W2151552361","https://openalex.org/W2153435210","https://openalex.org/W2156047359","https://openalex.org/W2164066515","https://openalex.org/W2165151357","https://openalex.org/W2165655337","https://openalex.org/W2170483942","https://openalex.org/W2187446866","https://openalex.org/W2194177070","https://openalex.org/W2239178393","https://openalex.org/W2285480884","https://openalex.org/W2337007022","https://openalex.org/W2403158538","https://openalex.org/W4238376026"],"related_works":["https://openalex.org/W7095722345","https://openalex.org/W2095770867","https://openalex.org/W2783510876","https://openalex.org/W2156047359","https://openalex.org/W31325638","https://openalex.org/W2031832102","https://openalex.org/W2005998878","https://openalex.org/W2006668876","https://openalex.org/W2069710262","https://openalex.org/W2140434534"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,6,14,29,45,56,68,125,151],"molecular":[3],"basis":[4],"of":[5,31,67,74,110,127,144],"functional":[7,15],"decline":[8],"in":[9,23,113,124,130,137,140],"aging":[10,135],"muscle,":[11],"we":[12,54],"examined":[13],"(actomyosin":[16],"ATPase)":[17],"and":[18,25,36,60,76,80,84,92],"chemical":[19,138],"(cysteine":[20],"content)":[21],"changes":[22,139],"actin":[24,61,75,91],"myosin":[26,49,141,153],"purified":[27],"from":[28,78,96,105],"muscles":[30],"young":[32,81,106],"(4-":[33],"to":[34,39],"12-month-old)":[35],"old":[37,79,97],"(27-":[38],"35-month-old)":[40],"Fisher":[41],"344":[42],"rats.":[43,82,107],"Using":[44],"soluble,":[46],"catalytically":[47],"active":[48],"fragment,":[50],"heavy":[51],"meromyosin":[52],"(HMM),":[53],"determined":[55],"maximum":[57],"rate":[58],"(V(max))":[59],"concentration":[62],"at":[63],"half":[64],"V(max)":[65,83],"(K(m))":[66],"actomyosin":[69],"ATPase,":[70],"using":[71],"four":[72],"combinations":[73],"HMM":[77,93,114],"K(m)":[85],"were":[86,94,103],"significantly":[87,115],"lower":[88],"when":[89,100],"both":[90,101],"obtained":[95,104],"rats":[98],"than":[99],"proteins":[102],"The":[108],"number":[109,126],"reactive":[111,128],"cysteines":[112,129],"decreased":[116],"with":[117],"age,":[118],"but":[119],"no":[120],"change":[121],"was":[122],"detected":[123],"actin.":[131],"We":[132],"conclude":[133],"that":[134,146],"results":[136],"(probably":[142],"oxidation":[143],"cysteines)":[145],"have":[147],"inhibitory":[148],"effects":[149],"on":[150],"actin-activated":[152],"ATPase.":[154]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}