{"id":"https://openalex.org/W2139458220","doi":null,"title":"Preparation, characterization and tableting of cilnidipine solid dispersions.","display_name":"Preparation, characterization and tableting of cilnidipine solid dispersions.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2139458220","mag":"2139458220","pmid":"https://pubmed.ncbi.nlm.nih.gov/23625441"},"language":"en","primary_location":{"id":"pmid:23625441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23625441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W2139458220"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004475174","display_name":"Liandong Hu","orcid":"https://orcid.org/0000-0002-9436-6913","observed_orcids":["https://orcid.org/0000-0002-9436-6913"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liandong Hu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Hebei University, Baoding, China. hbupharm@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Hebei University, Baoding, China. hbupharm@126.com","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082431022","display_name":"Weihua Song","orcid":"https://orcid.org/0009-0003-0003-1077","observed_orcids":["https://orcid.org/0009-0003-0003-1077","https://orcid.org/0009-0002-7882-3018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weihua Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Niu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Niu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090312827","display_name":"Kuiliang Jiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuiliang Jiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057063139","display_name":"Zheng Jia","orcid":"https://orcid.org/0000-0003-2476-2969","observed_orcids":["https://orcid.org/0000-0003-2476-2969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2281,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.45430142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"3","first_page":"629","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cilnidipine","display_name":"cilnidipine","score":1.0},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tablet-compression","display_name":"tablet compression","score":0.5889999866485596},{"id":"https://openalex.org/keywords/granulation","display_name":"granulation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.8069999814033508},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/poloxamer","display_name":"poloxamer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dissolution-enhancement","display_name":"dissolution enhancement","score":0.6470000147819519},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8659999966621399},{"id":"https://openalex.org/keywords/drug-polymer-interactions","display_name":"drug-polymer interactions","score":0.6769999861717224},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tablet-stability","display_name":"tablet stability","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2779849058","wikidata":"https://www.wikidata.org/wiki/Q7673462","display_name":"Tableting","level":2,"score":0.8964841365814209},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7765699625015259},{"id":"https://openalex.org/C2780077769","wikidata":"https://www.wikidata.org/wiki/Q413433","display_name":"Polyvinylpyrrolidone","level":2,"score":0.7620038986206055},{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.7171863913536072},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7169137597084045},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6373793482780457},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.6265437602996826},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.6091391444206238},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.5365875363349915},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5050333142280579},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.48991769552230835},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.4761795401573181},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.27382558584213257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23464363813400269},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.16474398970603943},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16028615832328796},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.09970629215240479},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.05326065421104431},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004095","descriptor_name":"Dihydropyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011205","descriptor_name":"Povidone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011208","descriptor_name":"Powders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23625441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23625441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:2139458220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23625441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1616865606","https://openalex.org/W1970806274","https://openalex.org/W1974127508","https://openalex.org/W1980615171","https://openalex.org/W1982610021","https://openalex.org/W1994255325","https://openalex.org/W2014082975","https://openalex.org/W2014227114","https://openalex.org/W2017326295","https://openalex.org/W2023049080","https://openalex.org/W2023820004","https://openalex.org/W2030078063","https://openalex.org/W2040432233","https://openalex.org/W2053855315","https://openalex.org/W2056777469","https://openalex.org/W2061991556","https://openalex.org/W2067326253","https://openalex.org/W2069955378","https://openalex.org/W2071360611","https://openalex.org/W2078814811","https://openalex.org/W2081912897","https://openalex.org/W2082567539"],"related_works":["https://openalex.org/W2362584684","https://openalex.org/W4386401561","https://openalex.org/W4319015193","https://openalex.org/W862113153","https://openalex.org/W2271803704","https://openalex.org/W2130404973","https://openalex.org/W4283165138","https://openalex.org/W4414571439","https://openalex.org/W2371458646","https://openalex.org/W2064003257"],"abstract_inverted_index":{"Solid":[0],"dispersion":[1,71,122,139,175,202],"technique":[2,23,203],"has":[3],"been":[4],"developed":[5],"many":[6,25],"years":[7],"for":[8,29,204],"improving":[9],"solubility":[10],"of":[11,35,51,76,154],"water-insoluble":[12,53],"drugs,":[13],"aiming":[14],"to":[15,40,46,62,89,119,164,200],"achieve":[16],"a":[17],"better":[18,183],"oral":[19],"bioavailability.":[20],"However,":[21],"this":[22,52],"exhibits":[24],"inconveniences":[26],"when":[27,162],"used":[28,68,86],"large-scale":[30],"tableting":[31,66,180],"procedures.":[32],"The":[33,93,113,134,173],"objective":[34],"current":[36],"research":[37],"work":[38],"was":[39,60,117,127],"develop":[41],"cilnidipine":[42],"solid":[43,70,91,97,121,138,155,174,201],"dispersions":[44,156],"(SDs)":[45],"improve":[47],"the":[48,64,96,125,131,141,159,190],"dissolution":[49,132,149,160,187],"behaviors":[50],"drug.":[54],"Moreover,":[55],"an":[56],"innovative":[57],"granulation":[58,115],"method":[59,116,181],"designed":[61,114],"simplify":[63],"traditional":[65,194],"technology":[67],"in":[69,95,178,193],"technique.":[72],"Three":[73],"different":[74],"kinds":[75],"polymers,":[77],"polyethylene":[78],"glycol":[79],"(PEG),":[80],"polyvinylpyrrolidone":[81],"(PVP)":[82],"and":[83,110,124,148,167,186],"poloxamer,":[84],"were":[85,99],"as":[87],"carriers":[88],"prepare":[90,120],"dispersions.":[92],"interactions":[94],"state":[98],"characterized":[100],"by":[101],"differential":[102],"scanning":[103],"calorimetry":[104],"(DSC),":[105],"powder":[106],"X-ray":[107],"diffraction":[108],"(PXRD)":[109],"FT-IR":[111],"spectroscopy.":[112],"employed":[118],"tablets":[123,176,191],"formulation":[126],"optimized":[128],"through":[129],"investigating":[130],"behaviors.":[133],"results":[135],"indicated":[136],"PEG":[137],"showed":[140],"best":[142],"effect":[143],"both":[144],"on":[145],"physical":[146,170],"characterizations":[147],"studies.":[150],"Furthermore,":[151],"all":[152],"type":[153],"significantly":[157],"improved":[158],"rates":[161],"compared":[163],"pure":[165],"drug":[166],"its":[168],"corresponding":[169],"mixture":[171],"(PM).":[172],"prepared":[177,192],"simplified":[179],"exhibited":[182],"operability,":[184],"stability":[185],"behavior":[188],"than":[189],"ways,":[195],"which":[196],"brought":[197],"more":[198],"opportunities":[199],"industrial":[205],"production.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}