{"id":"https://openalex.org/W2139456115","doi":"https://doi.org/10.2337/dc07-1485","title":"Fetal Programming of Type 2 Diabetes","display_name":"Fetal Programming of Type 2 Diabetes","publication_year":2007,"publication_date":"2007-09-28","ids":{"openalex":"https://openalex.org/W2139456115","doi":"https://doi.org/10.2337/dc07-1485","mag":"2139456115","pmid":"https://pubmed.ncbi.nlm.nih.gov/17901535"},"language":"en","primary_location":{"id":"doi:10.2337/dc07-1485","doi":"https://doi.org/10.2337/dc07-1485","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc07-1485","pdf_url":"https://diabetesjournals.org/care/article-pdf/30/10/2754/595967/zdc01007002754.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/care/article-pdf/30/10/2754/595967/zdc01007002754.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040057155","display_name":"Chittaranjan Sakerlal Yajnik","orcid":"https://orcid.org/0000-0002-2911-2378","observed_orcids":["https://orcid.org/0000-0002-2911-2378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chittaranjan S. Yajnik","raw_affiliation_strings":["From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614101","display_name":"Koumudi Godbole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koumudi Godbole","raw_affiliation_strings":["From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012733676","display_name":"Suhas Otiv","orcid":"https://orcid.org/0000-0003-3011-1759","observed_orcids":["https://orcid.org/0000-0003-3011-1759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suhas R. Otiv","raw_affiliation_strings":["From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046682362","display_name":"Himangi Lubree","orcid":"https://orcid.org/0000-0002-7473-2859","observed_orcids":["https://orcid.org/0000-0002-7473-2859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Himangi G. Lubree","raw_affiliation_strings":["From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3057,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87647967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"30","issue":"10","first_page":"2754","last_page":"2755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-programming","display_name":"fetal programming","score":0.9459999799728394},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intrauterine-environment","display_name":"intrauterine environment","score":0.7889999747276306},{"id":"https://openalex.org/keywords/thrifty-phenotype","display_name":"thrifty phenotype","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fetal-origins-hypothesis","display_name":"fetal origins hypothesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/diabetic-mothers","display_name":"diabetic mothers","score":0.5040000081062317},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.968999981880188},{"id":"https://openalex.org/keywords/diabetes-prevention","display_name":"diabetes prevention","score":0.4830000102519989},{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6840171217918396},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.644438624382019},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6284189820289612},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5751457810401917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5105754137039185},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.4498603940010071},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44362184405326843},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.44031932950019836},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4280139207839966},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41144847869873047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3380681872367859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32816895842552185},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3233959674835205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27199605107307434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2708625793457031}],"mesh":[{"descriptor_ui":"D001800","descriptor_name":"Blood Specimen Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001800","descriptor_name":"Blood Specimen Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001800","descriptor_name":"Blood Specimen Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/dc07-1485","doi":"https://doi.org/10.2337/dc07-1485","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc07-1485","pdf_url":"https://diabetesjournals.org/care/article-pdf/30/10/2754/595967/zdc01007002754.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:17901535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17901535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.2337/dc07-1485","doi":"https://doi.org/10.2337/dc07-1485","is_oa":true,"landing_page_url":"https://doi.org/10.2337/dc07-1485","pdf_url":"https://diabetesjournals.org/care/article-pdf/30/10/2754/595967/zdc01007002754.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139456115.pdf","grobid_xml":"https://content.openalex.org/works/W2139456115.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W604002767","https://openalex.org/W1515251958","https://openalex.org/W1971708895","https://openalex.org/W1974733694","https://openalex.org/W2005859246","https://openalex.org/W2009318817","https://openalex.org/W2021181997","https://openalex.org/W2028920300","https://openalex.org/W2054268817","https://openalex.org/W2066291102","https://openalex.org/W2069636519","https://openalex.org/W2070490017","https://openalex.org/W2077451861","https://openalex.org/W2096534598","https://openalex.org/W2099876016","https://openalex.org/W2100489386","https://openalex.org/W2110952210","https://openalex.org/W2125326407","https://openalex.org/W2151172803","https://openalex.org/W2153857443","https://openalex.org/W2158973793","https://openalex.org/W2160234571","https://openalex.org/W2314245815","https://openalex.org/W4247268240"],"related_works":["https://openalex.org/W3130264402","https://openalex.org/W2570482167","https://openalex.org/W2113926517","https://openalex.org/W4377139478","https://openalex.org/W2086030114","https://openalex.org/W3199081264","https://openalex.org/W2094181504","https://openalex.org/W2401500343","https://openalex.org/W2359664347","https://openalex.org/W2060212224"],"abstract_inverted_index":{"Hales":[0],"and":[1,73,142,164,170,178,231],"Barker":[2],"(1)":[3],"caused":[4],"a":[5,113,208,217],"paradigm":[6],"shift":[7],"in":[8,108,150,167,189,204,210,223],"our":[9],"thinking":[10],"about":[11],"diabetes":[12,28,119,173],"prevention":[13],"when":[14],"they":[15],"demonstrated":[16],"that":[17,64,193],"low":[18,99,126],"birth":[19,100],"weight":[20,101,107,127],"(due":[21],"to":[22,94,124],"growth":[23],"retardation)":[24],"predicted":[25],"type":[26,117],"2":[27,118],"(the":[29,180],"\u201cthrifty":[30],"phenotype\u201d":[31],"or":[32],"\u201cfetal":[33,181],"origins\u201d":[34],"hypothesis).":[35],"On":[36],"the":[37,65,69,79,86,89,130,133,137,148,155],"other":[38],"hand,":[39],"larger":[40],"babies":[41,102],"of":[42,50,116,139,157,172],"diabetic":[43],"mothers":[44],"are":[45,82,111,154,161],"also":[46],"at":[47,83,112],"higher":[48,114],"risk":[49,115,171],"diabetes,":[51],"apart":[52],"from":[53],"their":[54,165],"genetic":[55],"susceptibility":[56],"(\u201cfuel":[57],"mediated":[58],"teratogenesis\u201d)":[59],"(2,3).":[60],"A":[61,201],"concept":[62],"evolved":[63],"intrauterine":[66,87,140,168,194],"experiences":[67,81],"mold":[68],"fetal":[70,190],"systems":[71],"(\u201cprogramming\u201d)":[72],"influence":[74],"future":[75],"health":[76],"(4).":[77],"If":[78],"postnatal":[80],"variance":[84],"with":[85],"ones,":[88],"programmed":[90],"fetus":[91],"is":[92,135,192,213],"susceptible":[93],"disease":[95],"(5).":[96],"For":[97],"example,":[98],"who":[103,122],"put":[104],"on":[105,136,143],"excess":[106],"later":[109],"life":[110],"than":[120,147],"those":[121],"continue":[123],"be":[125,233],"(6).":[128],"In":[129],"programming":[131,191],"hypothesis,":[132],"focus":[134],"role":[138,166],"environment":[141,195],"gene-environment":[144],"interaction":[145],"rather":[146],"differences":[149],"gene":[151,198,205,229],"structure,":[152],"which":[153],"basis":[156],"conventional":[158],"genetics.":[159],"Genes":[160],"clearly":[162],"important,":[163],"development":[169],"was":[174],"highlighted":[175],"by":[176,221],"Hattersley":[177],"Tooke":[179],"insulin":[182],"hypothesis\u201d)":[183],"(7).":[184],"The":[185],"most":[186],"exciting":[187],"thought":[188],"may":[196],"modify":[197],"expression":[199,206],"permanently.":[200],"heritable":[202],"change":[203,209],"without":[207],"DNA":[211],"sequence":[212],"called":[214],"\u201cepigenetic\u201d":[215],"(8),":[216],"term":[218],"first":[219],"used":[220],"Waddington":[222],"developmental":[224],"biology.":[225],"Epigenetic":[226],"changes":[227],"alter":[228],"function":[230],"can":[232],"silencing":[234],"\u2026":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}