{"id":"https://openalex.org/W2139451307","doi":"https://doi.org/10.1002/anie.201410341","title":"Application of Fragment\u2010Based Screening to the Design of Inhibitors of Escherichia coli DsbA","display_name":"Application of Fragment\u2010Based Screening to the Design of Inhibitors of Escherichia coli DsbA","publication_year":2014,"publication_date":"2014-12-30","ids":{"openalex":"https://openalex.org/W2139451307","doi":"https://doi.org/10.1002/anie.201410341","mag":"2139451307","pmid":"https://pubmed.ncbi.nlm.nih.gov/25556635"},"language":"en","primary_location":{"id":"doi:10.1002/anie.201410341","doi":"https://doi.org/10.1002/anie.201410341","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.201410341","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Application_of_fragment-based_screening_to_the_design_of_inhibitors_of_Escherichia_coli_DsbA/22919375","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063975231","display_name":"Luke A. Adams","orcid":"https://orcid.org/0000-0002-8481-9819","observed_orcids":["https://orcid.org/0000-0002-8481-9819"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Luke A. Adams","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057292937","display_name":"Pooja Sharma","orcid":"https://orcid.org/0000-0002-0387-9669","observed_orcids":["https://orcid.org/0000-0002-0387-9669","https://orcid.org/0009-0001-1172-9935"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Pooja Sharma","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039402896","display_name":"Biswaranjan Mohanty","orcid":"https://orcid.org/0000-0002-6921-343X","observed_orcids":["https://orcid.org/0000-0002-6921-343X"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Biswaranjan Mohanty","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064917701","display_name":"Olga V. Ilyichova","orcid":"https://orcid.org/0000-0001-6947-6216","observed_orcids":["https://orcid.org/0000-0001-6947-6216"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Olga V. Ilyichova","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074537606","display_name":"Mark D. Mulcair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark D. Mulcair","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010417984","display_name":"Martin L Williams","orcid":"https://orcid.org/0000-0002-9483-3008","observed_orcids":["https://orcid.org/0000-0002-9483-3008"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Martin L. Williams","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054312298","display_name":"Ellen C. Gleeson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ellen C. Gleeson","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019644976","display_name":"Makrina Totsika","orcid":"https://orcid.org/0000-0003-2468-0293","observed_orcids":["https://orcid.org/0000-0003-2468-0293"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Makrina Totsika","raw_affiliation_strings":["Present address: Institute of Health and Biomedical, Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059 (Australia)","School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address: Institute of Health and Biomedical, Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059 (Australia)","institution_ids":["https://openalex.org/I160993911"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046053517","display_name":"B.C. Doak","orcid":"https://orcid.org/0000-0001-8422-675X","observed_orcids":["https://orcid.org/0000-0001-8422-675X"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bradley C. Doak","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015605647","display_name":"Sofia Caria","orcid":"https://orcid.org/0000-0001-7289-2093","observed_orcids":["https://orcid.org/0000-0001-7289-2093"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sofia Caria","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059014679","display_name":"Kieran A. Rimmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kieran Rimmer","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102999227","display_name":"James Horne","orcid":"https://orcid.org/0000-0002-1935-2378","observed_orcids":["https://orcid.org/0000-0002-1935-2378"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James Horne","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052850179","display_name":"Stephen R. Shouldice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen R. Shouldice","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058633286","display_name":"Mansha Vazirani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mansha Vazirani","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066354519","display_name":"Stephen J. Headey","orcid":"https://orcid.org/0000-0001-8015-7064","observed_orcids":["https://orcid.org/0000-0001-8015-7064"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen J. Headey","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080303596","display_name":"Brent R. Plumb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brent R. Plumb","raw_affiliation_strings":["Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040201335","display_name":"Jennifer L. Martin","orcid":"https://orcid.org/0000-0002-9225-8863","observed_orcids":["https://orcid.org/0000-0002-9225-8863","https://orcid.org/0009-0004-5596-5720"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer L. Martin","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041973018","display_name":"Bego\u00f1a Heras","orcid":"https://orcid.org/0000-0003-3469-7988","observed_orcids":["https://orcid.org/0000-0003-3469-7988"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Bego\u00f1a Heras","raw_affiliation_strings":["Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Present address: La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 (Australia)","Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Present address: La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 (Australia)","institution_ids":["https://openalex.org/I196829312"]},{"raw_affiliation_string":"Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034908235","display_name":"Jamie S. Simpson","orcid":"https://orcid.org/0000-0002-8894-422X","observed_orcids":["https://orcid.org/0000-0002-8894-422X"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jamie S. Simpson","raw_affiliation_strings":["Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040684603","display_name":"Martin J. Scanlon","orcid":"https://orcid.org/0000-0002-9230-7506","observed_orcids":["https://orcid.org/0000-0002-9230-7506"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Martin J. Scanlon","raw_affiliation_strings":["Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Begon\u0303a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Jamie S. Simpson, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Martin J. Scanlon, Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052 (Australia) http://www.pharm.monash.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Bego\u00f1a Heras, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072 (Australia)","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034908235","https://openalex.org/A5040684603","https://openalex.org/A5041973018"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I196829312","https://openalex.org/I4405277047","https://openalex.org/I56590836"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":2.1277,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.87401822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"7","first_page":"2179","last_page":"2184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dsba","display_name":"DsbA","score":0.9350000023841858},{"id":"https://openalex.org/keywords/thiol-disulfide-oxidoreductase","display_name":"thiol-disulfide oxidoreductase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fragment-based-screening","display_name":"fragment screening","score":0.8769999742507935},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8399999737739563},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/anti-virulence-agents","display_name":"anti-virulence agents","score":0.8040000200271606},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.5619999766349792},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bacterial-motility-inhibition","display_name":"bacterial motility inhibition","score":0.703000009059906},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.36500000953674316},{"id":"https://openalex.org/keywords/active-site-binding","display_name":"active site binding","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2775951584","wikidata":"https://www.wikidata.org/wiki/Q5309954","display_name":"DsbA","level":5,"score":0.9976193308830261},{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.7903743982315063},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7801550030708313},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5970651507377625},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5285302996635437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49726012349128723},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.488677054643631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48531121015548706},{"id":"https://openalex.org/C5098756","wikidata":"https://www.wikidata.org/wiki/Q1641611","display_name":"Protein disulfide-isomerase","level":3,"score":0.4162681996822357},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4118831753730774},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3927795886993408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3380643129348755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06565666198730469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019704","descriptor_name":"Protein Disulfide-Isomerases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019704","descriptor_name":"Protein Disulfide-Isomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1002/anie.201410341","doi":"https://doi.org/10.1002/anie.201410341","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.201410341","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:25556635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:ecite.utas.edu.au:97111","doi":null,"is_oa":false,"landing_page_url":"http://ecite.utas.edu.au/97111","pdf_url":null,"source":{"id":"https://openalex.org/S4306401569","display_name":"eCite Digital Repository (University of Tasmania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129801699","host_organization_name":"University of Tasmania","host_organization_lineage":["https://openalex.org/I129801699"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Refereed Article"},{"id":"pmh:oai:alma61RMIT.INST:11247659220001341","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.201410341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/22919375","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Application_of_fragment-based_screening_to_the_design_of_inhibitors_of_Escherichia_coli_DsbA/22919375","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/27518001","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Application_of_fragment-based_screening_to_the_design_of_inhibitors_of_Escherichia_coli_DsbA/27518001","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/123559","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10072/123559","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"mag:1597475210","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/85958/","pdf_url":null,"source":{"id":"https://openalex.org/S4306510308","display_name":"Faculty of Health; Institute of Health and Biomedical Innovation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Health; Institute of Health and Biomedical Innovation","raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/22919375","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Application_of_fragment-based_screening_to_the_design_of_inhibitors_of_Escherichia_coli_DsbA/22919375","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7274636149","display_name":"New approaches to the treatment of gram negative bacterial infections","funder_award_id":"1009785","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1494453098","https://openalex.org/W1516963632","https://openalex.org/W1538438083","https://openalex.org/W1965596686","https://openalex.org/W1965642811","https://openalex.org/W1969183021","https://openalex.org/W1973843350","https://openalex.org/W1983714092","https://openalex.org/W2003516462","https://openalex.org/W2011062217","https://openalex.org/W2036357948","https://openalex.org/W2043510671","https://openalex.org/W2058647917","https://openalex.org/W2060816398","https://openalex.org/W2076228622","https://openalex.org/W2091213797","https://openalex.org/W2118917248","https://openalex.org/W2119581735","https://openalex.org/W2129360809","https://openalex.org/W2139574393","https://openalex.org/W2146312832","https://openalex.org/W2165496299"],"related_works":["https://openalex.org/W2576947058","https://openalex.org/W2980949744","https://openalex.org/W3147350888","https://openalex.org/W1987467962","https://openalex.org/W2035703715","https://openalex.org/W7134247255","https://openalex.org/W2488867217","https://openalex.org/W2028801868","https://openalex.org/W2891079993","https://openalex.org/W1586236771"],"abstract_inverted_index":{"The":[0],"thiol-disulfide":[1],"oxidoreductase":[2],"enzyme":[3],"DsbA":[4,17,44,69,83,118,133],"catalyzes":[5],"the":[6,12,26,40,90,125,129,138],"formation":[7],"of":[8,14,28,31,49,74,76,110,114,140],"disulfide":[9],"bonds":[10],"in":[11,22,85,101],"periplasm":[13],"Gram-negative":[15],"bacteria.":[16],"substrates":[18],"include":[19],"proteins":[20,33],"involved":[21],"bacterial":[23,93,148],"virulence.":[24,149],"In":[25,87],"absence":[27],"DsbA,":[29],"many":[30],"these":[32,77],"do":[34],"not":[35],"fold":[36],"correctly,":[37],"which":[38,104],"renders":[39],"bacteria":[41],"avirulent.":[42],"Thus":[43],"is":[45,105],"a":[46],"critical":[47],"mediator":[48],"virulence":[50],"and":[51],"inhibitors":[52,115],"may":[53,134],"act":[54,145],"as":[55],"antivirulence":[56],"agents.":[57],"Biophysical":[58],"screening":[59],"has":[60],"been":[61],"employed":[62],"to":[63,68,117,124,137],"identify":[64],"fragments":[65,78],"that":[66,81,120,132,144],"bind":[67,122],"from":[70],"Escherichia":[71],"coli.":[72],"Elaboration":[73],"one":[75],"produced":[79],"compounds":[80,91,143],"inhibit":[82,92],"activity":[84],"vitro.":[86],"cell-based":[88],"assays,":[89],"motility,":[94],"but":[95],"have":[96],"no":[97],"effect":[98],"on":[99],"growth":[100],"liquid":[102],"culture,":[103],"consistent":[106],"with":[107],"selective":[108],"inhibition":[109],"DsbA.":[111],"Crystal":[112],"structures":[113],"bound":[116],"indicate":[119],"they":[121],"adjacent":[123],"active":[126],"site.":[127],"Together,":[128],"data":[130],"suggest":[131],"be":[135],"amenable":[136],"development":[139],"novel":[141],"antibacterial":[142],"by":[146],"inhibiting":[147]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
