{"id":"https://openalex.org/W2139443876","doi":"https://doi.org/10.1002/mnfr.201000310","title":"Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin","display_name":"Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin","publication_year":2010,"publication_date":"2010-10-11","ids":{"openalex":"https://openalex.org/W2139443876","doi":"https://doi.org/10.1002/mnfr.201000310","mag":"2139443876","pmid":"https://pubmed.ncbi.nlm.nih.gov/20938993"},"language":"en","primary_location":{"id":"doi:10.1002/mnfr.201000310","doi":"https://doi.org/10.1002/mnfr.201000310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201000310","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition &amp; Food Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139443876"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085796637","display_name":"Vandita Kakkar","orcid":"https://orcid.org/0000-0002-3325-781X","observed_orcids":["https://orcid.org/0000-0002-3325-781X","https://orcid.org/0000-0003-4757-2666"]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vandita Kakkar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India","institution_ids":["https://openalex.org/I51452335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043183412","display_name":"Sukhjit Singh","orcid":"https://orcid.org/0000-0002-2039-492X","observed_orcids":["https://orcid.org/0000-0002-2039-492X"]},"institutions":[{"id":"https://openalex.org/I107947710","display_name":"Panacea Biotec (India)","ror":"https://ror.org/01ew11x49","country_code":"IN","type":"company","lineage":["https://openalex.org/I107947710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sukhjit Singh","raw_affiliation_strings":["Formulation Development, Panacea Biotec Ltd, Lalru, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation Development, Panacea Biotec Ltd, Lalru, Punjab, India","institution_ids":["https://openalex.org/I107947710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008264042","display_name":"Dinesh Singla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107947710","display_name":"Panacea Biotec (India)","ror":"https://ror.org/01ew11x49","country_code":"IN","type":"company","lineage":["https://openalex.org/I107947710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh Singla","raw_affiliation_strings":["Formulation Development, Panacea Biotec Ltd, Lalru, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation Development, Panacea Biotec Ltd, Lalru, Punjab, India","institution_ids":["https://openalex.org/I107947710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060053377","display_name":"Indu Pal Kaur","orcid":"https://orcid.org/0000-0002-1237-2974","observed_orcids":["https://orcid.org/0000-0002-1237-2974"]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Indu Pal Kaur","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India","institution_ids":["https://openalex.org/I51452335"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060053377"],"corresponding_institution_ids":["https://openalex.org/I51452335"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":12.4735,"has_fulltext":false,"cited_by_count":362,"citation_normalized_percentile":{"value":0.99777424,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"55","issue":"3","first_page":"495","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.3212999999523163,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8289999961853027},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5019999742507935},{"id":"https://openalex.org/keywords/microemulsification","display_name":"microemulsification","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.824999988079071},{"id":"https://openalex.org/keywords/rat-plasma","display_name":"rat plasma","score":0.4490000009536743},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9742509126663208},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9205620884895325},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.907850980758667},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6878028512001038},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6382817029953003},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.624304473400116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5983222723007202},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5730004906654358},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5688666105270386},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5500714182853699},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4961486756801605},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.468837171792984},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.43031755089759827},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2551703453063965},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18947145342826843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15843307971954346},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07829007506370544},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.05634036660194397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mnfr.201000310","doi":"https://doi.org/10.1002/mnfr.201000310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201000310","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition &amp; Food Research","raw_type":"journal-article"},{"id":"pmid:20938993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20938993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular nutrition & food research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1506756493","https://openalex.org/W1828339576","https://openalex.org/W1964896591","https://openalex.org/W1966352701","https://openalex.org/W1971120211","https://openalex.org/W1976194786","https://openalex.org/W1977755432","https://openalex.org/W1998841796","https://openalex.org/W2008382270","https://openalex.org/W2020143653","https://openalex.org/W2026012172","https://openalex.org/W2029336804","https://openalex.org/W2033390870","https://openalex.org/W2038796248","https://openalex.org/W2040350223","https://openalex.org/W2047069988","https://openalex.org/W2054189154","https://openalex.org/W2079005682","https://openalex.org/W2086626740","https://openalex.org/W2088242076","https://openalex.org/W2092032160","https://openalex.org/W2093388479","https://openalex.org/W2115586774","https://openalex.org/W2128863256","https://openalex.org/W2131357228","https://openalex.org/W2142404968","https://openalex.org/W2148628183","https://openalex.org/W2162838846","https://openalex.org/W2496791304"],"related_works":["https://openalex.org/W1589827172","https://openalex.org/W2554695056","https://openalex.org/W2606614729","https://openalex.org/W2318602638","https://openalex.org/W2037602102","https://openalex.org/W7223469956","https://openalex.org/W2966052837","https://openalex.org/W2330477112","https://openalex.org/W2045474438","https://openalex.org/W1533261454"],"abstract_inverted_index":{"SCOPE:":[0],"Curcumin,":[1],"a":[2,15,40,49,100,131],"molecule":[3],"with":[4,14,31,58,174],"pluripharmacological":[5],"properties,":[6],"was":[7,46,72,78,95],"loaded":[8],"into":[9],"solid":[10,27],"lipid":[11,28],"nanoparticles":[12,29],"(SLNs)":[13],"view":[16],"to":[17,81,176],"improve":[18],"its":[19,187],"oral":[20,112],"bioavailability":[21],"(BA).":[22],"METHODS":[23],"AND":[24],"RESULTS:":[25],"Curcumin-loaded":[26],"(C-SLNs)":[30],"an":[32],"average":[33],"particle":[34,88],"size":[35,89],"of":[36,44,62,93,102,114,168],"134.6":[37],"nm":[38],"and":[39,77,90,119,123,157,162,180,193],"total":[41],"drug":[42,60,66],"content":[43,92],"92.33\u00b11.63%":[45],"produced":[47],"using":[48,130],"microemulsification":[50],"technique.":[51],"The":[52,68],"particles":[53],"were":[54],"spherical":[55],"in":[56,69,87,135,143,185,196],"shape,":[57],"high":[59],"entrapment":[61],"81.92\u00b12.91%":[63],"at":[64,105,147,152,160,170],"10%":[65],"loading.":[67],"vitro":[70],"release":[71],"predominantly":[73],"by":[74],"diffusion":[75],"phenomenon":[76],"prolonged":[79],"up":[80],"7":[82],"days.":[83],"No":[84],"significant":[85,139],"variation":[86],"curcumin":[91,126],"C-SLNs":[94,115,169],"observed,":[96],"upon":[97],"storage,":[98],"over":[99],"period":[101],"12":[103],"months":[104],"5\u00b13\u00b0C.":[106],"In":[107],"vivo":[108],"pharmacokinetics":[109],"performed":[110],"after":[111,166],"administration":[113,167],"(50,":[116],"25,":[117],"12.5":[118,161],"1":[120,153],"mg/kg":[121],"dose)":[122],"(free)":[124],"solubilized":[125],"(C-S;":[127],"50":[128,148],"mg/kg),":[129],"validated":[132],"LC-MS/MS":[133],"method":[134],"rat":[136],"plasma":[137],"revealed":[138],"improvement":[140],"(at":[141],"p<0.05)":[142],"BA":[144,182],"(39":[145],"times":[146,151,159],"mg/kg;":[149,154],"155":[150],"and,":[155],"59":[156],"32":[158],"25":[163],"mg/kg,":[164],"respectively)":[165],"all":[171],"the":[172],"doses":[173],"respect":[175],"C-S.":[177],"CONCLUSIONS:":[178],"Enhanced":[179],"reliable":[181],"will":[183],"help":[184],"establishing":[186],"therapeutic":[188],"usefulness":[189],"especially":[190],"for":[191],"neurodegenerative":[192],"cancerous":[194],"disorders":[195],"humans.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
