{"id":"https://openalex.org/W2139396663","doi":"https://doi.org/10.1016/j.febslet.2007.04.045","title":"ER chaperones in mammalian development and human diseases","display_name":"ER chaperones in mammalian development and human diseases","publication_year":2007,"publication_date":"2007-04-25","ids":{"openalex":"https://openalex.org/W2139396663","doi":"https://doi.org/10.1016/j.febslet.2007.04.045","mag":"2139396663","pmid":"https://pubmed.ncbi.nlm.nih.gov/17481612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2040386"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2007.04.045","doi":"https://doi.org/10.1016/j.febslet.2007.04.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.04.045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.04.045","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139396663"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.04.045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081919984","display_name":"Min Ni","orcid":"https://orcid.org/0000-0002-4587-1622","observed_orcids":["https://orcid.org/0000-0002-4587-1622"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Ni","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, United States","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100686480","display_name":"Amy Shiu Lee","orcid":"https://orcid.org/0000-0002-0378-5443","observed_orcids":["https://orcid.org/0000-0002-0378-5443"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy S. Lee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9176, United States","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100686480"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":3.9536,"has_fulltext":false,"cited_by_count":753,"citation_normalized_percentile":{"value":0.95886889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"581","issue":"19","first_page":"3641","last_page":"3651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9449999928474426},{"id":"https://openalex.org/keywords/er-chaperones","display_name":"ER chaperones","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mammalian-development","display_name":"mammalian development","score":0.7929999828338623},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.6980000138282776},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pdi","display_name":"PDI","score":0.8550000190734863},{"id":"https://openalex.org/keywords/erp72","display_name":"ERp72","score":0.9629999995231628},{"id":"https://openalex.org/keywords/calnexin","display_name":"calnexin","score":1.0},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":1.0},{"id":"https://openalex.org/keywords/edem","display_name":"EDEM","score":0.9980000257492065},{"id":"https://openalex.org/keywords/herp","display_name":"Herp","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sil1","display_name":"SIL1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p58ipk","display_name":"p58IPK","score":0.9419999718666077},{"id":"https://openalex.org/keywords/er-homeostasis","display_name":"ER homeostasis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.7139999866485596},{"id":"https://openalex.org/keywords/er-signaling","display_name":"ER signaling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C130361206","wikidata":"https://www.wikidata.org/wiki/Q908443","display_name":"Calnexin","level":4,"score":0.9708201289176941},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.9473792910575867},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.9037584662437439},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7959190607070923},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6568672060966492},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5821936726570129},{"id":"https://openalex.org/C141109615","wikidata":"https://www.wikidata.org/wiki/Q5137430","display_name":"Co-chaperone","level":5,"score":0.5189599394798279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4856621026992798},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.41530799865722656},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.41409897804260254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28228968381881714},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.24497616291046143},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17837610840797424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13832828402519226},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048788","descriptor_name":"Growth and Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.febslet.2007.04.045","doi":"https://doi.org/10.1016/j.febslet.2007.04.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.04.045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.04.045","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:17481612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17481612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2040386","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2040386/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2007.04.045","doi":"https://doi.org/10.1016/j.febslet.2007.04.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.04.045","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.04.045","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2557829145","display_name":"Stress Induction of Glucose Regulated Protein GRP78/BiP","funder_award_id":"R01CA027607","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3917761238","display_name":null,"funder_award_id":"CA27607","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5837264668","display_name":"MECHANISM OF ANTI-APOPTOTIC FUNCTION OF GRP78/BiP","funder_award_id":"R01CA111700","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139396663.pdf"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W65868975","https://openalex.org/W150569175","https://openalex.org/W277055403","https://openalex.org/W1607176255","https://openalex.org/W1861594661","https://openalex.org/W1955583657","https://openalex.org/W1964706050","https://openalex.org/W1965552134","https://openalex.org/W1965785232","https://openalex.org/W1966923623","https://openalex.org/W1966996818","https://openalex.org/W1968659980","https://openalex.org/W1969809609","https://openalex.org/W1972110853","https://openalex.org/W1973766996","https://openalex.org/W1974207791","https://openalex.org/W1975987422","https://openalex.org/W1979158821","https://openalex.org/W1979193480","https://openalex.org/W1981551685","https://openalex.org/W1984098639","https://openalex.org/W1986166825","https://openalex.org/W1993822183","https://openalex.org/W1993966022","https://openalex.org/W1995483143","https://openalex.org/W1996600144","https://openalex.org/W1997500225","https://openalex.org/W1998026822","https://openalex.org/W1998166048","https://openalex.org/W2000237287","https://openalex.org/W2000504232","https://openalex.org/W2000859982","https://openalex.org/W2002439304","https://openalex.org/W2002965337","https://openalex.org/W2004816473","https://openalex.org/W2009107269","https://openalex.org/W2009664225","https://openalex.org/W2011714134","https://openalex.org/W2012986282","https://openalex.org/W2014002820","https://openalex.org/W2016983085","https://openalex.org/W2018850937","https://openalex.org/W2021206670","https://openalex.org/W2021727296","https://openalex.org/W2022087931","https://openalex.org/W2022680168","https://openalex.org/W2024645138","https://openalex.org/W2026799689","https://openalex.org/W2027077104","https://openalex.org/W2031088196","https://openalex.org/W2033482754","https://openalex.org/W2035623537","https://openalex.org/W2038481055","https://openalex.org/W2042294920","https://openalex.org/W2043387126","https://openalex.org/W2043825401","https://openalex.org/W2046013379","https://openalex.org/W2048796991","https://openalex.org/W2050502538","https://openalex.org/W2053885962","https://openalex.org/W2057556028","https://openalex.org/W2060388817","https://openalex.org/W2061424386","https://openalex.org/W2061774676","https://openalex.org/W2062378136","https://openalex.org/W2065022563","https://openalex.org/W2067018477","https://openalex.org/W2068572725","https://openalex.org/W2070715459","https://openalex.org/W2070750261","https://openalex.org/W2071084328","https://openalex.org/W2071273959","https://openalex.org/W2072185042","https://openalex.org/W2072610101","https://openalex.org/W2073820480","https://openalex.org/W2075110126","https://openalex.org/W2076359042","https://openalex.org/W2076759214","https://openalex.org/W2079566392","https://openalex.org/W2082698485","https://openalex.org/W2084276537","https://openalex.org/W2091582420","https://openalex.org/W2096539811","https://openalex.org/W2096915343","https://openalex.org/W2097494460","https://openalex.org/W2098022329","https://openalex.org/W2099386409","https://openalex.org/W2101758144","https://openalex.org/W2104209182","https://openalex.org/W2104985991","https://openalex.org/W2105628355","https://openalex.org/W2112286580","https://openalex.org/W2112682006","https://openalex.org/W2113027160","https://openalex.org/W2114082039","https://openalex.org/W2117631316","https://openalex.org/W2117986250","https://openalex.org/W2119902047","https://openalex.org/W2120103843","https://openalex.org/W2121576917","https://openalex.org/W2123174753","https://openalex.org/W2127647346","https://openalex.org/W2128720297","https://openalex.org/W2128788229","https://openalex.org/W2129058679","https://openalex.org/W2129695436","https://openalex.org/W2133425838","https://openalex.org/W2134153385","https://openalex.org/W2135429740","https://openalex.org/W2135913162","https://openalex.org/W2137368432","https://openalex.org/W2137570167","https://openalex.org/W2139786644","https://openalex.org/W2139993962","https://openalex.org/W2144259103","https://openalex.org/W2146394074","https://openalex.org/W2148172443","https://openalex.org/W2152163817","https://openalex.org/W2152398979","https://openalex.org/W2156617634","https://openalex.org/W2163374884","https://openalex.org/W2163411496","https://openalex.org/W2163470744","https://openalex.org/W2164783065","https://openalex.org/W2166153014","https://openalex.org/W2166158038","https://openalex.org/W2167688505","https://openalex.org/W2168065678","https://openalex.org/W2168987973","https://openalex.org/W2169879031","https://openalex.org/W2170117828","https://openalex.org/W2184268422","https://openalex.org/W2271977180","https://openalex.org/W2319326268","https://openalex.org/W2324841714","https://openalex.org/W2342150662","https://openalex.org/W2404936681","https://openalex.org/W2789068030","https://openalex.org/W3024054742"],"related_works":["https://openalex.org/W2049085322","https://openalex.org/W2045380517","https://openalex.org/W2155884826","https://openalex.org/W7144932348","https://openalex.org/W2135336113","https://openalex.org/W7139354537","https://openalex.org/W2615587765","https://openalex.org/W7133002313","https://openalex.org/W7097660391","https://openalex.org/W1980280323"],"abstract_inverted_index":{"The":[0],"field":[1],"of":[2,20,51,61,76,100,128],"endoplasmic":[3],"reticulum":[4],"(ER)":[5],"stress":[6],"in":[7,31,54,64,95,132],"mammalian":[8],"cells":[9,26],"has":[10],"expanded":[11],"rapidly":[12],"during":[13],"the":[14,21,55,72,101,112,115,125,129],"past":[15],"decade,":[16],"contributing":[17],"to":[18,27,29,66],"understanding":[19],"molecular":[22,40],"pathways":[23],"that":[24],"allow":[25],"adapt":[28],"perturbations":[30],"ER":[32,41,62,67,130],"homeostasis.":[33],"One":[34],"major":[35],"mechanism":[36],"is":[37],"mediated":[38],"by":[39],"chaperones":[42,116,131],"which":[43],"are":[44,104,117],"critical":[45],"not":[46],"only":[47],"for":[48,59,123],"quality":[49],"control":[50],"proteins":[52],"processed":[53],"ER,":[56],"but":[57],"also":[58],"regulation":[60],"signaling":[63],"response":[65],"stress.":[68],"Here,":[69],"we":[70],"summarized":[71],"properties":[73],"and":[74,87,90,92,97],"functions":[75],"GRP78/BiP,":[77],"GRP94/gp96,":[78],"GRP170/ORP150,":[79],"GRP58/ERp57,":[80],"PDI,":[81],"ERp72,":[82],"calnexin,":[83],"calreticulin,":[84],"EDEM,":[85],"Herp":[86],"co-chaperones":[88],"SIL1":[89],"P58(IPK)":[91],"their":[93],"role":[94],"development":[96],"diseases.":[98],"Many":[99],"new":[102],"insights":[103],"derived":[105],"from":[106],"recently":[107],"constructed":[108],"mouse":[109],"models":[110],"where":[111],"genes":[113],"encoding":[114],"genetically":[118],"altered,":[119],"providing":[120],"invaluable":[121],"tools":[122],"examining":[124],"physiological":[126],"involvement":[127],"vivo.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":42},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":41},{"year":2014,"cited_by_count":49},{"year":2013,"cited_by_count":62},{"year":2012,"cited_by_count":62}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
