{"id":"https://openalex.org/W2139393303","doi":"https://doi.org/10.1200/jco.1999.17.5.1349","title":"Comparative Efficacy of Adjuvant Chemotherapy in Patients With Dukes' B Versus Dukes' C Colon Cancer: Results From Four National Surgical Adjuvant Breast and Bowel Project Adjuvant Studies (C-01, C-02, C-03, and C-04)","display_name":"Comparative Efficacy of Adjuvant Chemotherapy in Patients With Dukes' B Versus Dukes' C Colon Cancer: Results From Four National Surgical Adjuvant Breast and Bowel Project Adjuvant Studies (C-01, C-02, C-03, and C-04)","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2139393303","doi":"https://doi.org/10.1200/jco.1999.17.5.1349","mag":"2139393303","pmid":"https://pubmed.ncbi.nlm.nih.gov/10334518"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1999.17.5.1349","doi":"https://doi.org/10.1200/jco.1999.17.5.1349","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1999.17.5.1349","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082509731","display_name":"Eleftherios P. Mamounas","orcid":"https://orcid.org/0000-0002-9476-2553","observed_orcids":["https://orcid.org/0000-0002-9476-2553"]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleftherios Mamounas","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA 15212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]},{"raw_affiliation_string":"National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA 15212, USA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045097225","display_name":"Sam Wieand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Wieand","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055013606","display_name":"Norman Wolmark","orcid":"https://orcid.org/0000-0001-7156-1110","observed_orcids":["https://orcid.org/0000-0001-7156-1110"]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Wolmark","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064069772","display_name":"Harry D. Bear","orcid":"https://orcid.org/0000-0002-7632-9019","observed_orcids":["https://orcid.org/0000-0002-7632-9019"]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry D. Bear","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111770497","display_name":"James N. Atkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N. Atkins","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022637417","display_name":"Kyunghee Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyunghee Song","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108541048","display_name":"Judy M. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Jones","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025094543","display_name":"Howard E. Rockette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162844","display_name":"NSABP Foundation","ror":"https://ror.org/05e2f9085","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Rockette","raw_affiliation_strings":["From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210162844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162844"],"apc_list":null,"apc_paid":null,"fwci":12.4116,"has_fulltext":false,"cited_by_count":527,"citation_normalized_percentile":{"value":0.99181737,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"17","issue":"5","first_page":"1349","last_page":"1349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.7397000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.7397000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.2524000108242035,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dukes-c-colon-cancer","display_name":"Dukes' C colon cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6159999966621399},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/levamisole","display_name":"levamisole","score":0.9559999704360962},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8399999737739563},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.936660885810852},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6581686735153198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5886568427085876},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5554434657096863},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5303025245666504},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5258824229240417},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.46772468090057373},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45460835099220276},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.4528142809867859},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4233013391494751},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4128301739692688},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36081206798553467},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.15349215269088745}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012673","descriptor_name":"Semustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012673","descriptor_name":"Semustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012673","descriptor_name":"Semustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1999.17.5.1349","doi":"https://doi.org/10.1200/jco.1999.17.5.1349","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1999.17.5.1349","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:10334518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10334518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1289999116","display_name":"COOPERATIVE GROUP OUTREACH PROGRAM","funder_award_id":"5u10ca039086-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2532722453","display_name":"NSABP COMMUNITY CLINICAL ONCOLOGY PROGRAM RESEARCH BASE - OPERATIONS CENTER","funder_award_id":"U10CA037377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3045883153","display_name":null,"funder_award_id":"NCIU10CA39086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3946127998","display_name":null,"funder_award_id":"NCI-U10-CA-37377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G427032950","display_name":null,"funder_award_id":"NCIU10CA12027","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G952999087","display_name":"NATIONAL SURGICAL ADJUVANT BREAST AND BOWEL PROJECT","funder_award_id":"U10CA012027","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1769344090","https://openalex.org/W1840481440","https://openalex.org/W1884213330","https://openalex.org/W1962875322","https://openalex.org/W2002678771","https://openalex.org/W2016791396","https://openalex.org/W2032930680","https://openalex.org/W2053827853","https://openalex.org/W2067028787","https://openalex.org/W2106147539","https://openalex.org/W2150000105","https://openalex.org/W2159848047","https://openalex.org/W2258204764","https://openalex.org/W2275576700","https://openalex.org/W2277639422","https://openalex.org/W2313857605","https://openalex.org/W4233272864","https://openalex.org/W4250091029"],"related_works":["https://openalex.org/W7100710374","https://openalex.org/W4231713950","https://openalex.org/W1975404145","https://openalex.org/W4244645965","https://openalex.org/W2979016188","https://openalex.org/W2133526876","https://openalex.org/W2016791396","https://openalex.org/W2026095947","https://openalex.org/W2155820060","https://openalex.org/W2366642865"],"abstract_inverted_index":{"PURPOSE:":[0],"Although":[1],"the":[2,44,47,59,147,185,196,212,234,262,290,315,344],"benefit":[3,19,37,330,358],"from":[4,38,280,331,359],"adjuvant":[5,39,63,88,97,133,163,169,174,332],"chemotherapy":[6,40,64,89,238,333,360],"has":[7,20],"been":[8,21],"clearly":[9],"established":[10],"in":[11,23,53,69,199,225,247,259,286,308],"patients":[12,24,32,110,197,222,272,298,311,355],"with":[13,25,33,50,91,95,141,157,168,178,184,325,338],"Dukes'":[14,26,34,54,67,106,205,227,230,256,270,275,296,302,309,326,353],"C":[15,55,109,231,276,303],"colon":[16,328],"cancer,":[17],"such":[18],"questioned":[22],"B":[27,35,107,206,228,271,297,310,327,354],"disease.":[28],"To":[29],"determine":[30],"whether":[31],"disease":[36],"and":[41,76,83,108,111,116,121,136,165,176,180,183,190,215,229,258,334],"to":[42,66,357],"evaluate":[43],"magnitude":[45],"of":[46,62,150,155,187,195,237,255,314,319,343,348],"benefit,":[48],"compared":[49,86,132,146,162,173],"that":[51,85],"observed":[52,245],"patients,":[56],"we":[57],"examined":[58,285],"relative":[60,235],"efficacy":[61,236],"according":[65],"stage":[68],"four":[70,103,128,201,210,282],"sequential":[71],"National":[72],"Surgical":[73],"Adjuvant":[74],"Breast":[75],"Bowel":[77],"Project":[78],"trials":[79,104,202,283],"(C-01,":[80],"C-02,":[81],"C-03,":[82],"C-04)":[84],"different":[87],"regimens":[90],"each":[92],"other":[93,349],"or":[94,250,267,317,346],"no":[96],"treatment.":[98],"PATIENTS":[99],"AND":[100],"METHODS:":[101],"The":[102,118,305],"included":[105,198],"were":[112,124,284],"conducted":[113],"between":[114],"1977":[115],"1990.":[117],"eligibility":[119],"criteria":[120],"follow-up":[122],"requirements":[123],"similar":[125],"for":[126,220,269,274,295,301],"all":[127,209,221,281],"trials.":[129],"Protocol":[130,144,160,171],"C-01":[131],"semustine,":[134],"vincristine,":[135],"fluorouracil":[137],"(5-FU)":[138],"(MOF":[139],"regimen)":[140],"operation":[142,158],"alone.":[143,159],"C-02":[145],"perioperative":[148],"administration":[149],"a":[151,287],"portal":[152],"venous":[153],"infusion":[154],"5-FU":[156,164,175,179],"C-03":[161],"leucovorin":[166],"(LV)":[167],"MOF.":[170],"C-04":[172],"LV":[177],"levamisole":[181],"(LEV)":[182],"combination":[186],"5-FU,":[188],"LV,":[189],"LEV.":[191],"RESULTS:":[192],"Forty-one":[193],"percent":[194],"these":[200],"had":[203],"resected":[204],"tumors.":[207],"In":[208],"studies,":[211],"overall,":[213],"disease-free,":[214],"recurrence-free":[216],"survival":[217,252],"improvement":[218],"noted":[219],"was":[223,239,242,264,293],"evident":[224],"both":[226],"patients.":[232,277,304],"When":[233,278],"examined,":[240],"there":[241],"always":[243],"an":[244],"reduction":[246,263,292,307],"mortality,":[248],"recurrence,":[249],"disease-free":[251],"event,":[253],"irrespective":[254,313],"stage,":[257],"most":[260],"instances,":[261],"as":[265,273],"great":[266],"greater":[268],"data":[279],"combined":[288],"analysis,":[289],"mortality":[291,306],"30%":[294],"versus":[299],"18%":[300],"occurred":[312],"presence":[316,345],"absence":[318,347],"adverse":[320],"prognostic":[321,351],"factors.":[322],"CONCLUSION:":[323],"Patients":[324],"cancer":[329],"should":[335],"be":[336],"presented":[337],"this":[339],"treatment":[340],"option.":[341],"Regardless":[342],"clinical":[350],"factors,":[352],"seem":[356],"administration.":[361]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":22}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}