{"id":"https://openalex.org/W2139392626","doi":null,"title":"Detection and analysis of cancer genes amplified from bone material of a Scythian royal burial in Arzhan near Tuva, Siberia.","display_name":"Detection and analysis of cancer genes amplified from bone material of a Scythian royal burial in Arzhan near Tuva, Siberia.","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2139392626","mag":"2139392626","pmid":"https://pubmed.ncbi.nlm.nih.gov/18225581"},"language":"en","primary_location":{"id":"pmid:18225581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060504547","display_name":"Thilo Schlott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thilo Schlott","raw_affiliation_strings":["Department of Pathology, Georg August Universitaet, Goettingen, Germany. thiloschlott@web.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Georg August Universitaet, Goettingen, Germany. thiloschlott@web.de","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107825404","display_name":"Helmut Eiffert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Eiffert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082097144","display_name":"Tyede H. Schmidt\u2010Schultz","orcid":"https://orcid.org/0000-0002-9788-1662","observed_orcids":["https://orcid.org/0000-0002-9788-1662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tyede Schmidt-Schultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Melanie Gebhardt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie Gebhardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053378230","display_name":"Hermann Parzinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hermann Parzinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102890186","display_name":"Michael Schultz","orcid":"https://orcid.org/0000-0001-5028-2497","observed_orcids":["https://orcid.org/0000-0001-5028-2497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8532,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.8974625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"27","issue":"6B","first_page":"4117","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13409","display_name":"Paleopathology and ancient diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology (arts and humanities)"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T13409","display_name":"Paleopathology and ancient diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology (arts and humanities)"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10087","display_name":"Archaeology and ancient environmental studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3302","display_name":"Archeology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ancient-dna","display_name":"ancient DNA","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8029999732971191},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.6790000200271606},{"id":"https://openalex.org/keywords/gadd153","display_name":"GADD153","score":0.8479999899864197},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9359999895095825},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.9760000109672546},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8379999995231628},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.3310000002384186},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6719086170196533},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6588748693466187},{"id":"https://openalex.org/C189338579","wikidata":"https://www.wikidata.org/wiki/Q290447","display_name":"Ancient DNA","level":3,"score":0.6122457981109619},{"id":"https://openalex.org/C152037538","wikidata":"https://www.wikidata.org/wiki/Q676092","display_name":"Paleopathology","level":2,"score":0.5581324696540833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5488867163658142},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.444241464138031},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43623971939086914},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41015422344207764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4054836928844452},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36082351207733154},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1602523922920227},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.15613806247711182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11651235818862915},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000885","descriptor_name":"Anthropology, Physical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012800","descriptor_name":"Siberia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025803","descriptor_name":"Tumor Suppressor Protein p14ARF","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18225581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/49636","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/49636","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W96509206","https://openalex.org/W1507315481","https://openalex.org/W1639710168","https://openalex.org/W2013367562","https://openalex.org/W2051306456","https://openalex.org/W2104169173","https://openalex.org/W2115314035","https://openalex.org/W2125770629","https://openalex.org/W2135068319","https://openalex.org/W3188357708"],"related_works":["https://openalex.org/W6986161886","https://openalex.org/W2350837039","https://openalex.org/W2106518050","https://openalex.org/W7042325306","https://openalex.org/W2013936016","https://openalex.org/W2093798885","https://openalex.org/W2276419286","https://openalex.org/W2010638944","https://openalex.org/W2127373151","https://openalex.org/W2156346173"],"abstract_inverted_index":{"Molecular":[0],"paleopathology":[1],"has":[2],"become":[3],"an":[4,25,173],"emerging":[5],"field":[6],"that":[7,127],"helps":[8],"to":[9,98,132,143,152],"characterize":[10],"molecular":[11],"markers":[12],"of":[13,28,53,61,77,95,101,116,163,182],"past":[14],"disease.":[15],"Especially":[16],"highly":[17],"sensitive":[18],"genetic":[19],"techniques":[20],"such":[21],"as":[22],"PCR":[23,69,111],"are":[24],"important":[26,146],"means":[27],"unraveling":[29],"changes":[30],"in":[31,157],"ancient":[32,158],"DNA":[33,81,106,136,156],"extracted":[34],"from":[35,50,107,138],"bone":[36,48,140,159],"tissue,":[37],"teeth":[38],"and":[39,58,84,177],"mummified":[40],"soft":[41],"tissue.":[42],"In":[43,122],"the":[44,51,78,93,99,108,117,180],"present":[45],"study,":[46],"excavated":[47],"material":[49],"skeleton":[52],"a":[54,62],"Scythian":[55],"sovereign,":[56],"morphologically":[57],"immunohistochemically":[59],"suspicious":[60],"metastatic":[63],"prostate":[64,183],"carcinoma,":[65],"was":[66],"analyzed":[67],"by":[68],"for":[70],"amplifiable":[71],"human":[72,79,135],"gene":[73,83,88],"sequences.":[74],"Short":[75],"sequences":[76,115,166],"GADD153":[80],"repair":[82],"p53":[85],"tumor":[86,119],"suppressor":[87,120],"were":[89],"detectable":[90],"which":[91],"revealed":[92],"absence":[94],"mutations":[96],"according":[97],"data":[100,125],"automatic":[102],"sequencing.":[103],"Using":[104],"bisulfite-treated":[105],"bone,":[109],"methylation-specific":[110],"detected":[112],"hypermethylated":[113,164],"promoter":[114],"p14ARF":[118,165],"gene.":[121],"summary,":[123],"these":[124],"show":[126],"it":[128],"is":[129],"possible:":[130],"a)":[131],"amply":[133],"short":[134],"stretches":[137],"2,500-year-old":[139],"material,":[141],"b)":[142],"detect":[144,153],"tumorigenetically":[145],"genes":[147],"within":[148],"this":[149,170],"DNA,":[150],"c)":[151],"epigenetically":[154],"modified":[155],"material.":[160],"The":[161],"finding":[162],"merits":[167],"attention":[168],"because":[169],"may":[171,178],"indicate":[172],"intraosseal":[174],"neoplastic":[175],"process":[176],"corroborate":[179],"hypothesis":[181],"cancer.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}