{"id":"https://openalex.org/W2139388314","doi":"https://doi.org/10.1128/jb.01375-09","title":"Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains","display_name":"Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains","publication_year":2009,"publication_date":"2009-12-19","ids":{"openalex":"https://openalex.org/W2139388314","doi":"https://doi.org/10.1128/jb.01375-09","mag":"2139388314","pmid":"https://pubmed.ncbi.nlm.nih.gov/20023032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2812960"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01375-09","doi":"https://doi.org/10.1128/jb.01375-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01375-09","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2812960","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Karen M. Daly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen M. Daly","raw_affiliation_strings":["Department of Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018551532","display_name":"Mathew Upton","orcid":"https://orcid.org/0000-0003-4287-6396","observed_orcids":["https://orcid.org/0000-0003-4287-6396"]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mathew Upton","raw_affiliation_strings":["Department of Medical Microbiology, School of Translational Medicine, School of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, School of Translational Medicine, School of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom","institution_ids":["https://openalex.org/I2801926401","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083505562","display_name":"Stephanie Kate Sandiford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephanie K. Sandiford","raw_affiliation_strings":["Department of Medical Microbiology, School of Translational Medicine, School of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, School of Translational Medicine, School of Medicine, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom","institution_ids":["https://openalex.org/I2801926401","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005085411","display_name":"Lorraine A. Draper","orcid":"https://orcid.org/0000-0002-6910-9317","observed_orcids":["https://orcid.org/0000-0002-6910-9317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorraine A. Draper","raw_affiliation_strings":["Department of Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034730864","display_name":"Philip A. Wescombe","orcid":"https://orcid.org/0000-0001-8754-6265","observed_orcids":["https://orcid.org/0000-0001-8754-6265"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Philip A. Wescombe","raw_affiliation_strings":["BLIS Technologies Ltd., Centre for Innovation, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BLIS Technologies Ltd., Centre for Innovation, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051869070","display_name":"Ralph W. Jack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Ralph W. Jack","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091619722","display_name":"Paula M. O\u2019Connor","orcid":"https://orcid.org/0000-0001-6462-2077","observed_orcids":["https://orcid.org/0000-0001-6462-2077"]},"institutions":[{"id":"https://openalex.org/I141766778","display_name":"Teagasc - The Irish Agriculture and Food Development Authority","ror":"https://ror.org/03sx84n71","country_code":"IE","type":"facility","lineage":["https://openalex.org/I141766778"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paula M. O'Connor","raw_affiliation_strings":["Teagasc Moorepark Food Research Centre, Fermoy, Cork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teagasc Moorepark Food Research Centre, Fermoy, Cork","institution_ids":["https://openalex.org/I141766778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053719183","display_name":"Angela S. Rossney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Angela Rossney","raw_affiliation_strings":["National Methicillin-Resistant Staphylococcus aureus (MRSA) Reference Laboratory, Saint James's Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Methicillin-Resistant Staphylococcus aureus (MRSA) Reference Laboratory, Saint James's Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014079362","display_name":"Friedrich G\u00f6tz","orcid":"https://orcid.org/0000-0002-2042-0518","observed_orcids":["https://orcid.org/0000-0002-2042-0518","https://orcid.org/0000-0002-4574-0278"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich Go\u0308tz","raw_affiliation_strings":["Microbial Genetics, University of Tu\u0308bingen, Tu\u0308bingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbial Genetics, University of Tu\u0308bingen, Tu\u0308bingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047441756","display_name":"Colin Hill","orcid":"https://orcid.org/0000-0002-8527-1445","observed_orcids":["https://orcid.org/0000-0002-8527-1445"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Colin Hill","raw_affiliation_strings":["Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","Department of Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"Department of Microbiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050465932","display_name":"Paul D. Cotter","orcid":"https://orcid.org/0000-0002-5465-9068","observed_orcids":["https://orcid.org/0000-0002-5465-9068"]},"institutions":[{"id":"https://openalex.org/I141766778","display_name":"Teagasc - The Irish Agriculture and Food Development Authority","ror":"https://ror.org/03sx84n71","country_code":"IE","type":"facility","lineage":["https://openalex.org/I141766778"]},{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Paul D. Cotter","raw_affiliation_strings":["Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","Teagasc Moorepark Food Research Centre, Fermoy, Cork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"Teagasc Moorepark Food Research Centre, Fermoy, Cork","institution_ids":["https://openalex.org/I141766778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048633162","display_name":"R. Paul Ross","orcid":"https://orcid.org/0000-0003-4876-8839","observed_orcids":["https://orcid.org/0000-0003-4876-8839"]},"institutions":[{"id":"https://openalex.org/I141766778","display_name":"Teagasc - The Irish Agriculture and Food Development Authority","ror":"https://ror.org/03sx84n71","country_code":"IE","type":"facility","lineage":["https://openalex.org/I141766778"]},{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"R. Paul Ross","raw_affiliation_strings":["Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","Teagasc Moorepark Food Research Centre, Fermoy, Cork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"Teagasc Moorepark Food Research Centre, Fermoy, Cork","institution_ids":["https://openalex.org/I141766778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032975513","display_name":"John Robert Tagg","orcid":"https://orcid.org/0000-0001-9477-6579","observed_orcids":["https://orcid.org/0000-0001-9477-6579"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"John R. Tagg","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9001, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047441756","https://openalex.org/A5050465932"],"corresponding_institution_ids":["https://openalex.org/I141766778","https://openalex.org/I27577105"],"apc_list":null,"apc_paid":null,"fwci":5.0629,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.95554852,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"192","issue":"4","first_page":"1131","last_page":"1142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.13729999959468842,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/community-associated-mrsa","display_name":"community-acquired MRSA","score":0.8600000143051147},{"id":"https://openalex.org/keywords/bacteriocins","display_name":"bacteriocins","score":0.656000018119812},{"id":"https://openalex.org/keywords/panton-valentine-leukocidin","display_name":"Panton-Valentine leukocidin","score":0.890999972820282},{"id":"https://openalex.org/keywords/st8","display_name":"ST8","score":0.6859999895095825},{"id":"https://openalex.org/keywords/st80","display_name":"ST80","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gallidermin","display_name":"gallidermin","score":0.7049999833106995},{"id":"https://openalex.org/keywords/immunity-genes","display_name":"immunity genes","score":0.7509999871253967},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C132141352","wikidata":"https://www.wikidata.org/wiki/Q1724806","display_name":"Lantibiotics","level":4,"score":0.8968923091888428},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.848840594291687},{"id":"https://openalex.org/C115574571","wikidata":"https://www.wikidata.org/wiki/Q183119","display_name":"Bacteriocin","level":3,"score":0.8392088413238525},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7829592227935791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7751575112342834},{"id":"https://openalex.org/C2777805791","wikidata":"https://www.wikidata.org/wiki/Q16889545","display_name":"Leukocidin","level":5,"score":0.603647768497467},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5605284571647644},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5314242839813232},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5086430311203003},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.48162955045700073},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4257257580757141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38147425651550293},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.32580286264419556},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26311612129211426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2256433069705963}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005827","descriptor_name":"Genetics, Microbial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/jb.01375-09","doi":"https://doi.org/10.1128/jb.01375-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01375-09","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2812960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2812960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:20023032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20023032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.859.2132","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.859.2132","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.asm.org/content/192/4/1131.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b2c1575c-f8b1-4d15-a9ff-c19212120f81","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b2c1575c-f8b1-4d15-a9ff-c19212120f81","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Daly, K M, Upton, M, Sandiford, S K, Draper, L A, Wescombe, P A, Jack, R W, O'Connor, P M, Rossney, A, G\u00f6tz, F, Hill, C, Cotter, P D, Ross, R P & Tagg, J R 2010, 'Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains', Journal of Bacteriology, vol. 192, no. 4, pp. 1131-1142. https://doi.org/10.1128/JB.01375-09","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2812960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2812960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1605183800","display_name":"Peptide engineering of the two-component lantibiotic lacticin 3147: generating a blueprint for improved lantibiotic design","funder_award_id":"06/IN.1/B98","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320310371","display_name":"University of Otago","ror":"https://ror.org/01jmxt844"},{"id":"https://openalex.org/F4320311666","display_name":"Society for Applied Microbiology","ror":"https://ror.org/05qds0828"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320863","display_name":"University College Cork","ror":"https://ror.org/03265fv13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1523736689","https://openalex.org/W1525080113","https://openalex.org/W1548162677","https://openalex.org/W1566759157","https://openalex.org/W1571247924","https://openalex.org/W1716867421","https://openalex.org/W1848320945","https://openalex.org/W1970230095","https://openalex.org/W1972439422","https://openalex.org/W1977701349","https://openalex.org/W1982226630","https://openalex.org/W1991004031","https://openalex.org/W1991634127","https://openalex.org/W1993617346","https://openalex.org/W1995383789","https://openalex.org/W1997298634","https://openalex.org/W1997337616","https://openalex.org/W2003940898","https://openalex.org/W2005404275","https://openalex.org/W2013048005","https://openalex.org/W2013948180","https://openalex.org/W2026220836","https://openalex.org/W2026476282","https://openalex.org/W2040034507","https://openalex.org/W2042035526","https://openalex.org/W2044879187","https://openalex.org/W2058752732","https://openalex.org/W2061688904","https://openalex.org/W2067348974","https://openalex.org/W2067424225","https://openalex.org/W2072763959","https://openalex.org/W2089238458","https://openalex.org/W2092543902","https://openalex.org/W2096011773","https://openalex.org/W2097509506","https://openalex.org/W2099648162","https://openalex.org/W2104379180","https://openalex.org/W2104669367","https://openalex.org/W2106192001","https://openalex.org/W2106521502","https://openalex.org/W2108643808","https://openalex.org/W2110422600","https://openalex.org/W2113651812","https://openalex.org/W2115127793","https://openalex.org/W2115991524","https://openalex.org/W2118003399","https://openalex.org/W2118380403","https://openalex.org/W2118605696","https://openalex.org/W2119628653","https://openalex.org/W2120276613","https://openalex.org/W2122710851","https://openalex.org/W2124048377","https://openalex.org/W2125698629","https://openalex.org/W2133530652","https://openalex.org/W2133682043","https://openalex.org/W2134937983","https://openalex.org/W2140903449","https://openalex.org/W2143227116","https://openalex.org/W2146325980","https://openalex.org/W2148133809","https://openalex.org/W2148414127","https://openalex.org/W2154187341","https://openalex.org/W2155864378","https://openalex.org/W2158033863","https://openalex.org/W2161137494","https://openalex.org/W2161167549","https://openalex.org/W2162031862","https://openalex.org/W2163908033","https://openalex.org/W2165465840","https://openalex.org/W2171629802","https://openalex.org/W2171660616","https://openalex.org/W2171998389","https://openalex.org/W2172156934","https://openalex.org/W2783981376","https://openalex.org/W4233351338"],"related_works":["https://openalex.org/W2002726455","https://openalex.org/W7117561333","https://openalex.org/W2156815577","https://openalex.org/W4387728853","https://openalex.org/W2338114489","https://openalex.org/W1993617346","https://openalex.org/W2093412657","https://openalex.org/W2152203073","https://openalex.org/W4413449362","https://openalex.org/W2011758222"],"abstract_inverted_index":{"Lantibiotics":[0],"are":[1,27,40,171],"antimicrobial":[2,193],"peptides":[3],"that":[4,116,126,151,157,199],"have":[5],"been":[6],"the":[7,55,59,67,103,131,153,187,191],"focus":[8],"of":[9,58,69,78,84,109,143,148,165,173,177,195,201],"much":[10],"attention":[11],"in":[12,97,169],"recent":[13],"years":[14],"with":[15,90],"a":[16,73,107,120,205],"view":[17],"to":[18,48,54,130,186],"clinical,":[19],"veterinary,":[20],"and":[21,87,114,163,167],"food":[22,49],"applications.":[23],"Although":[24],"many":[25,158],"lantibiotics":[26,39],"produced":[28,41,137],"by":[29,42,138],"food-grade":[30],"bacteria":[31,33],"or":[32],"generally":[34],"regarded":[35],"as":[36],"safe,":[37],"some":[38],"pathogens":[43],"and,":[44],"rather":[45],"than":[46],"contributing":[47],"safety":[50],"and/or":[51],"health,":[52],"add":[53],"virulence":[56],"potential":[57],"producing":[60],"strains.":[61],"Indeed,":[62],"genome":[63],"sequencing":[64],"has":[65],"revealed":[66],"presence":[68],"genes":[70,118,180],"apparently":[71],"encoding":[72],"lantibiotic,":[74],"designated":[75],"Bsa":[76,127,178,196],"(bacteriocin":[77],"Staphylococcus":[79],"aureus),":[80],"among":[81],"clinical":[82],"isolates":[83,150],"S.":[85,93,140,160,211],"aureus":[86,94,141,161],"those":[88],"associated":[89],"community-acquired":[91,159,210],"methicillin-resistant":[92],"(MRSA)":[95],"infections":[96],"particular.":[98],"Here,":[99],"we":[100],"establish":[101],"for":[102],"first":[104],"time,":[105],"through":[106],"combination":[108],"reverse":[110],"genetics,":[111],"mass":[112],"spectrometry,":[113],"mutagenesis,":[115],"these":[117],"encode":[119],"functional":[121],"lantibiotic.":[122],"We":[123],"also":[124],"reveal":[125],"is":[128],"identical":[129],"previously":[132],"identified":[133],"bacteriocin":[134,203],"staphylococcin":[135],"Au-26,":[136],"an":[139],"strain":[142],"vaginal":[144],"origin.":[145],"Our":[146],"examination":[147],"MRSA":[149],"produce":[152],"Panton-Valentine":[154],"leukocidin":[155],"demonstrates":[156],"strains,":[162],"representatives":[164],"ST8":[166],"ST80":[168],"particular,":[170],"producers":[172],"Bsa.":[174],"While":[175],"possession":[176],"immunity":[179],"does":[181],"not":[182],"significantly":[183],"enhance":[184],"resistance":[185],"related":[188],"lantibiotic":[189],"gallidermin,":[190],"broad":[192],"spectrum":[194],"strongly":[197],"indicates":[198],"production":[200],"this":[202],"confers":[204],"competitive":[206],"ecological":[207],"advantage":[208],"on":[209],"aureus.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}