{"id":"https://openalex.org/W2139385164","doi":"https://doi.org/10.1039/c1md00159k","title":"Cytotoxic activity, cell imaging and photocleavage of DNA induced by a Pt(ii) cyclophane bearing 1,2 diamino ethane as a terminal ligand","display_name":"Cytotoxic activity, cell imaging and photocleavage of DNA induced by a Pt(ii) cyclophane bearing 1,2 diamino ethane as a terminal ligand","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2139385164","doi":"https://doi.org/10.1039/c1md00159k","mag":"2139385164"},"language":"en","primary_location":{"id":"doi:10.1039/c1md00159k","doi":"https://doi.org/10.1039/c1md00159k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1md00159k","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Niraj Kumari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Niraj Kumari","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060184973","display_name":"Brajesh Kumar Maurya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Brajesh Kumar Maurya","raw_affiliation_strings":["Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047891238","display_name":"Raj Kumar Koiri","orcid":"https://orcid.org/0000-0002-1258-5160","observed_orcids":["https://orcid.org/0000-0002-1258-5160"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raj Kumar Koiri","raw_affiliation_strings":["Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071367897","display_name":"Surendra Kumar Trigun","orcid":"https://orcid.org/0000-0002-5655-9618","observed_orcids":["https://orcid.org/0000-0002-5655-9618"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Surendra Kumar Trigun","raw_affiliation_strings":["Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology Section, Centre of Advanced Studies in Zoology, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011486337","display_name":"Saripella Srikrishna","orcid":"https://orcid.org/0000-0002-6019-1588","observed_orcids":["https://orcid.org/0000-0002-6019-1588"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srikrishna Saripella","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039443789","display_name":"Michael P. Coogan","orcid":"https://orcid.org/0000-0003-2568-9337","observed_orcids":["https://orcid.org/0000-0003-2568-9337"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael P. Coogan","raw_affiliation_strings":["Department of Chemistry, Cardiff University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Cardiff University, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060996790","display_name":"Lallan Mishra","orcid":"https://orcid.org/0000-0003-2420-3323","observed_orcids":["https://orcid.org/0000-0003-2420-3323"]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Lallan Mishra","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060996790"],"corresponding_institution_ids":["https://openalex.org/I91357014"],"apc_list":null,"apc_paid":null,"fwci":1.6209,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82831469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"12","first_page":"1208","last_page":"1208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platinum-ii-complexes","display_name":"platinum(II) complexes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cyclophanes","display_name":"cyclophanes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.7200000286102295},{"id":"https://openalex.org/keywords/photocleavage","display_name":"photocleavage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cellular-imaging","display_name":"cell imaging","score":0.7110000252723694},{"id":"https://openalex.org/keywords/fluorophores","display_name":"fluorophores","score":0.6480000019073486},{"id":"https://openalex.org/keywords/ethidium-bromide-fluorescence","display_name":"ethidium bromide fluorescence","score":0.597000002861023},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2776907736","wikidata":"https://www.wikidata.org/wiki/Q408634","display_name":"Ethidium bromide","level":3,"score":0.8069919943809509},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7283790111541748},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7090122103691101},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7008926272392273},{"id":"https://openalex.org/C137824038","wikidata":"https://www.wikidata.org/wiki/Q175562","display_name":"Intercalation (chemistry)","level":2,"score":0.6726217865943909},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.6521139740943909},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6481122970581055},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.49297165870666504},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.45734429359436035},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4129890203475952},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.39382046461105347},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3335055708885193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19627591967582703},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18366780877113342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12873965501785278},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08662411570549011},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/c1md00159k","doi":"https://doi.org/10.1039/c1md00159k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1md00159k","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},{"id":"pmh:oai:eprints.lancs.ac.uk:62483","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/62483/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:17269","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/17269/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W277762786","https://openalex.org/W1586119447","https://openalex.org/W1590106897","https://openalex.org/W1768982165","https://openalex.org/W1964315121","https://openalex.org/W1965612889","https://openalex.org/W1967066076","https://openalex.org/W1967247384","https://openalex.org/W1971920947","https://openalex.org/W1983067951","https://openalex.org/W1989651677","https://openalex.org/W1995691835","https://openalex.org/W1998202001","https://openalex.org/W1999622831","https://openalex.org/W2007013745","https://openalex.org/W2010380674","https://openalex.org/W2012188873","https://openalex.org/W2013011950","https://openalex.org/W2015621995","https://openalex.org/W2024085704","https://openalex.org/W2033487696","https://openalex.org/W2034233680","https://openalex.org/W2040178224","https://openalex.org/W2041564013","https://openalex.org/W2043065633","https://openalex.org/W2043610941","https://openalex.org/W2048168597","https://openalex.org/W2054862649","https://openalex.org/W2070219679","https://openalex.org/W2073142182","https://openalex.org/W2076701053","https://openalex.org/W2079771508","https://openalex.org/W2082106291","https://openalex.org/W2085238957","https://openalex.org/W2087492305","https://openalex.org/W2089012870","https://openalex.org/W2094630676","https://openalex.org/W2114918609","https://openalex.org/W2120064876","https://openalex.org/W2145538324","https://openalex.org/W2146563007","https://openalex.org/W2150303730","https://openalex.org/W2152745328","https://openalex.org/W2152777853","https://openalex.org/W2952670656","https://openalex.org/W4245397386","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2031117956","https://openalex.org/W2363450053","https://openalex.org/W1972070288","https://openalex.org/W1965538704","https://openalex.org/W3159490845","https://openalex.org/W2061737829","https://openalex.org/W2330687298","https://openalex.org/W2150714055","https://openalex.org/W2565125725","https://openalex.org/W2906988846"],"abstract_inverted_index":{"A":[0],"PtII":[1],"complex":[2],"[{Pt(en)L}2]\u00b74PF6":[3],"(Ptcyp)":[4],"(LH2":[5],"=":[6,9],"N,N\u2032-bis(salicylidene)-p-phenylenediamine,":[7],"en":[8],"1,2-diamino":[10],"ethane)":[11],"shows":[12],"high":[13],"cytotoxicity":[14],"against":[15,21],"HeLa":[16,146],"cells":[17,25],"(IC50\u201411.5":[18],"\u03bcM)":[19],"and":[20,53,133,171],"Dalton's":[22],"lymphoma":[23],"(DL)":[24],"(IC50\u20140.65":[26],"nM);":[27],"UV-vis":[28],"titration":[29,49],"of":[30,50,75,120,139,154,158,162],"Ptcyp":[31,52,61,82,113,155],"with":[32,63,110,176],"calf":[33],"thymus":[34],"DNA":[35,39,91,96,122,131,136],"(CT-DNA)":[36],"demonstrated":[37],"its":[38,174],"binding,":[40],"which":[41],"could":[42],"be":[43],"further":[44],"quantified":[45],"by":[46,65],"competitive":[47],"fluorescence":[48],"DNA,":[51],"ethidium":[54],"bromide.":[55],"Circular":[56],"dichroism":[57],"studies":[58,143],"suggest":[59],"that":[60,81],"interacts":[62],"CT-DNA":[64],"intercalation":[66],"in":[67,97,105,123,151,168],"an":[68,106,124],"aqueous":[69,107,125],"medium":[70],"containing":[71],"a":[72,87,93,101],"minimum":[73],"amount":[74],"DMSO.":[76],"Agarose":[77],"gel":[78],"electrophoresis":[79],"showed":[80],"is":[83,114],"able":[84,115],"to":[85,100,116],"convert":[86],"supercoiled":[88,121],"pBR322":[89],"plasmid":[90],"into":[92],"nicked":[94],"circular":[95],"DMSO,":[98],"but":[99],"much":[102],"lower":[103],"extent":[104],"medium.":[108,126],"However,":[109],"UV":[111,134],"irradiation,":[112],"cause":[117],"concentration-dependent":[118],"nicking":[119],"These":[127],"findings":[128],"indicate":[129],"the":[130,145,152,159],"binding":[132],"exposure-dependent":[135],"cleavage":[137],"properties":[138],"Ptcyp.":[140],"Cell":[141],"imaging":[142,170],"using":[144],"cell":[147,169],"line":[148],"carried":[149],"out":[150],"presence":[153],"represent":[156],"one":[157],"first":[160],"examples":[161],"Pt":[163],"complexes":[164],"applied":[165],"as":[166],"fluorophores":[167],"strongly":[172],"support":[173],"interaction":[175],"DNA.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}