{"id":"https://openalex.org/W2139379034","doi":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","title":"A Role for Hydrogen Peroxide in the Pro\u2010apoptotic Effects of Photodynamic Therapy","display_name":"A Role for Hydrogen Peroxide in the Pro\u2010apoptotic Effects of Photodynamic Therapy","publication_year":2009,"publication_date":"2009-07-21","ids":{"openalex":"https://openalex.org/W2139379034","doi":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","mag":"2139379034","pmid":"https://pubmed.ncbi.nlm.nih.gov/19659920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2783742"},"language":"en","primary_location":{"id":"doi:10.1111/j.1751-1097.2009.00589.x","doi":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2783742","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Price","raw_affiliation_strings":["Cancer Biology Program, Wayne State University School of Medicine, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074971628","display_name":"Stanley R. Terlecky","orcid":"https://orcid.org/0000-0003-3690-7467","observed_orcids":["https://orcid.org/0000-0003-3690-7467"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley R. Terlecky","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001063598","display_name":"David H. Kessel","orcid":"https://orcid.org/0000-0002-3221-9299","observed_orcids":["https://orcid.org/0000-0002-3221-9299"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Kessel","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001063598"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":4.7688,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.95081558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"85","issue":"6","first_page":"1491","last_page":"1496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8539999723434448},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/p388-leukemia-cells","display_name":"P388 leukemia cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.7559999823570251},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.9470000267028809},{"id":"https://openalex.org/keywords/3-amino-1-2-4-triazole","display_name":"3-amino-1,2,4-triazole","score":0.8949999809265137},{"id":"https://openalex.org/keywords/2-2-bipyridine","display_name":"2,2'-bipyridine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.9065380096435547},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8445104956626892},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.8345905542373657},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7832671403884888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7176423072814941},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.7010990977287292},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.6391516327857971},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.6352739334106445},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5504204630851746},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5293551087379456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35423389077186584},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3460710942745209},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3093639016151428},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.30011001229286194},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.29378819465637207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17777419090270996},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000640","descriptor_name":"Amitrole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1751-1097.2009.00589.x","doi":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.2009.00589.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"pmid:19659920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19659920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and photobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2783742","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2783742","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Photochem Photobiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2783742","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2783742","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Photochem Photobiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1815773126","display_name":null,"funder_award_id":"CA-23378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1937655988","display_name":"Modes of cell death initiated by photodynamic therapy","funder_award_id":"R01CA023378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2831771084","display_name":null,"funder_award_id":"GM058905-11","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4787017749","display_name":"Initiative for Maximizing Student Development Program at Wayne State University","funder_award_id":"R25GM058905","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W146759131","https://openalex.org/W1559829329","https://openalex.org/W1836033269","https://openalex.org/W1916661321","https://openalex.org/W1970748148","https://openalex.org/W1976100892","https://openalex.org/W1988362185","https://openalex.org/W1995191054","https://openalex.org/W2000745911","https://openalex.org/W2004283265","https://openalex.org/W2007606855","https://openalex.org/W2041108504","https://openalex.org/W2042778264","https://openalex.org/W2046428993","https://openalex.org/W2047985404","https://openalex.org/W2056135909","https://openalex.org/W2066834429","https://openalex.org/W2082060324","https://openalex.org/W2084072384","https://openalex.org/W2096251967","https://openalex.org/W2102684933","https://openalex.org/W2114108892","https://openalex.org/W2147929482","https://openalex.org/W2154679334","https://openalex.org/W2315250335","https://openalex.org/W2325862576"],"related_works":["https://openalex.org/W2086558686","https://openalex.org/W2247621497","https://openalex.org/W1975698338","https://openalex.org/W2027838449","https://openalex.org/W2161159672","https://openalex.org/W172704629","https://openalex.org/W2081559176","https://openalex.org/W3208788457","https://openalex.org/W2286306770","https://openalex.org/W2078500257"],"abstract_inverted_index":{"Although":[0],"the":[1,26,52,57,76,136,142],"first":[2],"reactive":[3],"oxygen":[4,18],"species":[5],"(ROS)":[6],"formed":[7],"during":[8,156],"irradiation":[9,157],"of":[10,29,54,72,81,98,125,144,154,158],"photosensitized":[11,159],"cells":[12,111,160],"is":[13],"almost":[14],"invariably":[15],"singlet":[16],"molecular":[17],"(1O2),":[19],"other":[20],"ROS":[21],"have":[22],"been":[23],"implicated":[24],"in":[25,56,62,116,135,141],"phototoxic":[27],"effects":[28],"photodynamic":[30],"therapy":[31],"(PDT).":[32],"Among":[33],"these":[34],"are":[35],"superoxide":[36],"anion":[37],"radical":[38,45],"(*O2(-)),":[39],"hydrogen":[40],"peroxide":[41],"(H2O2)":[42],"and":[43,112],"hydroxyl":[44],"(*OH).":[46],"In":[47],"this":[48],"study,":[49],"we":[50],"investigated":[51],"role":[53],"H2O2":[55,74,145,155],"pro-apoptotic":[58],"response":[59],"to":[60,87,109,146,162],"PDT":[61,163],"murine":[63],"leukemia":[64],"P388":[65],"cells.":[66],"A":[67,118],"primary":[68],"route":[69],"for":[70],"detoxification":[71],"cellular":[73],"involves":[75],"peroxisomal":[77],"enzyme":[78],"catalase.":[79],"Inhibition":[80],"catalase":[82,102],"activity":[83],"by":[84,96],"3-amino-1,2,4-triazole":[85],"led":[86],"an":[88,99],"increased":[89],"apoptotic":[90],"response.":[91],"PDT-induced":[92],"apoptosis":[93],"was":[94,106,121],"impaired":[95],"addition":[97,124],"exogenous":[100],"recombinant":[101],"analog":[103],"(CAT-skl)":[104],"that":[105,129,139,152],"specifically":[107],"designed":[108],"enter":[110],"more":[113],"efficiently":[114],"localize":[115],"peroxisomes.":[117],"similar":[119],"effect":[120],"observed":[122],"upon":[123],"2,2'-bipyridine,":[126],"a":[127,133],"reagent":[128],"can":[130],"chelate":[131],"Fe+2,":[132],"co-factor":[134],"Fenton":[137],"reaction":[138],"results":[140,149],"conversion":[143],"*OH.":[147],"These":[148],"provide":[150],"evidence":[151],"formation":[153],"contributes":[161],"efficacy.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
