{"id":"https://openalex.org/W2139370035","doi":"https://doi.org/10.1093/ejo/cjs108","title":"Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials","display_name":"Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2139370035","doi":"https://doi.org/10.1093/ejo/cjs108","mag":"2139370035","pmid":"https://pubmed.ncbi.nlm.nih.gov/23376899"},"language":"en","primary_location":{"id":"doi:10.1093/ejo/cjs108","doi":"https://doi.org/10.1093/ejo/cjs108","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ejo/cjs108","pdf_url":null,"source":{"id":"https://openalex.org/S64889221","display_name":"European Journal of Orthodontics","issn_l":"0141-5387","issn":["0141-5387","1460-2210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European Journal of Orthodontics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/89566/1/cjs108.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066448929","display_name":"Nikolaos Pandis","orcid":"https://orcid.org/0000-0003-0258-468X","observed_orcids":["https://orcid.org/0000-0003-0258-468X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"N. Pandis","raw_affiliation_strings":["* Department of Orthodontics and Dentofacial Orthopedics, Dental School, Medical Faculty, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"* Department of Orthodontics and Dentofacial Orthopedics, Dental School, Medical Faculty, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045126942","display_name":"Tanya Walsh","orcid":"https://orcid.org/0000-0001-7003-8854","observed_orcids":["https://orcid.org/0000-0001-7003-8854"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Walsh","raw_affiliation_strings":["School of Dentistry, University of Manchester, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, University of Manchester, UK#TAB#","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066432422","display_name":"Argy Polychronopoulou","orcid":"https://orcid.org/0000-0002-9336-5089","observed_orcids":["https://orcid.org/0000-0002-9336-5089"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Polychronopoulou","raw_affiliation_strings":["Department of Community and Preventive Dentistry, School of Dentistry, University of Athens, Greece, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community and Preventive Dentistry, School of Dentistry, University of Athens, Greece, and","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046625222","display_name":"Christos Katsaros","orcid":"https://orcid.org/0000-0001-5545-6740","observed_orcids":["https://orcid.org/0000-0001-5545-6740"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Katsaros","raw_affiliation_strings":["Department of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland,","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017555255","display_name":"Theodore Eliades","orcid":"https://orcid.org/0000-0003-2313-4979","observed_orcids":["https://orcid.org/0000-0003-2313-4979","https://orcid.org/0000-0002-7452-9711"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T. Eliades","raw_affiliation_strings":["Department of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland,","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3250,"currency":"GBP","value_usd":4286},"apc_paid":null,"fwci":5.5989,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.97271672,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"35","issue":"6","first_page":"783","last_page":"789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/split-mouth-design","display_name":"split-mouth design","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sample-size-efficiency","display_name":"sample size efficiency","score":0.7239999771118164},{"id":"https://openalex.org/keywords/carryover-effects","display_name":"residual effects","score":0.8009999990463257},{"id":"https://openalex.org/keywords/period-effects","display_name":"period effects","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intrapatient-variability","display_name":"intrapatient variability","score":0.5519999861717224},{"id":"https://openalex.org/keywords/clustered-data","display_name":"clustered data","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.6020371317863464},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5925613641738892},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5677451491355896},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5631409883499146},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5627841353416443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5366916060447693},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.47786515951156616},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.47250258922576904},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4282693564891815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3395189642906189},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20966163277626038},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16242191195487976},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.12958741188049316},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D016382","descriptor_name":"Orthodontic Appliance Design","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1093/ejo/cjs108","doi":"https://doi.org/10.1093/ejo/cjs108","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ejo/cjs108","pdf_url":null,"source":{"id":"https://openalex.org/S64889221","display_name":"European Journal of Orthodontics","issn_l":"0141-5387","issn":["0141-5387","1460-2210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European Journal of Orthodontics","raw_type":"journal-article"},{"id":"pmid:23376899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23376899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of orthodontics","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/64772d62-35e0-4332-b260-17d88f84d716","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/64772d62-35e0-4332-b260-17d88f84d716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pandis, N, Walsh, T, Polychronopoulou, A, Katsaros, C & Eliades, T 2013, 'Split-mouth designs in orthodontics: An overview with applications to orthodontic clinical trials', European Journal of Orthodontics, vol. 35, no. 6, pp. 783-789. https://doi.org/10.1093/ejo/cjs108","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:89566","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/89566/1/cjs108.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/89566/1/cjs108.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European Journal of Orthodontics, 35(6):783-789.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doc.rero.ch:290596","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/290596/files/cjs108.pdf","pdf_url":"http://doc.rero.ch/record/290596/files/cjs108.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:doi:10.7892/boris.39984","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/112434","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:39984","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/39984/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European journal of orthodontics, 35(6), pp. 783-789. Oxford University Press 10.1093/ejo/cjs108 &lt;http://dx.doi.org/10.1093/ejo/cjs108&gt;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/99953","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/99953","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pandis, N., Walsh, T., Polychronopoulou, A., Katsaros, C., & Eliades, T. (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European Journal of Orthodontics, 35, 783\u2013789. https://doi.org/10.1093/ejo/cjs108","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-89566","doi":"https://doi.org/10.5167/uzh-89566","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-89566","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:89566","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/89566/1/cjs108.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/89566/1/cjs108.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pandis, Nikolaos; Walsh, Tanya; Polychronopoulou, Argy; Katsaros, Christos; Eliades, Theodore (2013). Split-mouth designs in orthodontics: an overview with applications to orthodontic clinical trials. European Journal of Orthodontics, 35(6):783-789.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W42191289","https://openalex.org/W122888204","https://openalex.org/W1525161423","https://openalex.org/W1985516458","https://openalex.org/W1986215651","https://openalex.org/W1986927305","https://openalex.org/W1991362225","https://openalex.org/W2000945677","https://openalex.org/W2027785799","https://openalex.org/W2032541700","https://openalex.org/W2033890227","https://openalex.org/W2036767052","https://openalex.org/W2039964888","https://openalex.org/W2059796825","https://openalex.org/W2061623382","https://openalex.org/W2075873328","https://openalex.org/W2079154667","https://openalex.org/W2080709576","https://openalex.org/W2087425662","https://openalex.org/W2095468291","https://openalex.org/W2135160177","https://openalex.org/W2139000771","https://openalex.org/W2156868484","https://openalex.org/W2163424852","https://openalex.org/W2221506788","https://openalex.org/W2307997912","https://openalex.org/W4292229870"],"related_works":["https://openalex.org/W2118307558","https://openalex.org/W2156868484","https://openalex.org/W1975031021","https://openalex.org/W1141198286","https://openalex.org/W2725956138","https://openalex.org/W3128414373","https://openalex.org/W2905943575","https://openalex.org/W2079154667","https://openalex.org/W3096369442","https://openalex.org/W2157170665"],"abstract_inverted_index":{"Split-mouth":[0],"designs":[1],"first":[2],"appeared":[3],"in":[4,8,22,64,98],"dental":[5],"clinical":[6,100],"trials":[7],"the":[9,28,45,55,72,90,118,130,143],"late":[10],"sixties.":[11],"The":[12],"main":[13],"advantage":[14],"of":[15,24,44,47,92,117],"this":[16,93],"study":[17],"design":[18,94],"is":[19,83,95],"its":[20],"efficiency":[21,91],"terms":[23],"sample":[25],"size":[26],"as":[27,31],"patients":[29,70,138],"act":[30],"their":[32],"own":[33],"controls.":[34],"Cited":[35],"disadvantages":[36],"relate":[37],"to":[38,50,146],"carry-across":[39],"effects,":[40],"contamination":[41],"or":[42],"spilling":[43],"effects":[46,53,105,136],"one":[48],"intervention":[49,109,122],"another,":[51],"period":[52,104],"if":[54],"interventions":[56],"are":[57],"delivered":[58],"at":[59],"different":[60],"time":[61],"periods,":[62],"difficulty":[63],"finding":[65],"similar":[66],"comparison":[67],"sites":[68,110],"within":[69,137],"and":[71,106,124,133],"requirement":[73],"for":[74,128,142],"more":[75],"complex":[76],"data":[77],"analysis.":[78],"Although":[79],"some":[80],"additional":[81],"thought":[82],"required":[84],"when":[85],"utilizing":[86],"a":[87,114],"split-mouth":[88],"design,":[89,121],"attractive,":[96],"particularly":[97],"orthodontic":[99],"studies":[101],"where":[102],"carry-across,":[103],"dissimilarity":[107],"between":[108],"does":[111],"not":[112],"pose":[113],"problem.":[115],"Selection":[116],"appropriate":[119],"research":[120],"protocol":[123],"statistical":[125],"method":[126],"accounting":[127],"both":[129],"reduced":[131],"variability":[132],"potential":[134],"clustering":[135],"should":[139],"be":[140,147],"considered":[141],"trial":[144],"results":[145],"valid.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
