{"id":"https://openalex.org/W2139367012","doi":"https://doi.org/10.1002/ana.410390304","title":"Intramuscular interferon beta\u20101a for disease progression in relapsing multiple sclerosis","display_name":"Intramuscular interferon beta\u20101a for disease progression in relapsing multiple sclerosis","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2139367012","doi":"https://doi.org/10.1002/ana.410390304","mag":"2139367012","pmid":"https://pubmed.ncbi.nlm.nih.gov/8602746"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410390304","doi":"https://doi.org/10.1002/ana.410390304","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410390304","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lawrence D. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence D. Jacobs","raw_affiliation_strings":["Department of Neurology, Buffalo General Hospital, New York 14203, USA","William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Buffalo General Hospital, New York 14203, USA","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","institution_ids":["https://openalex.org/I4210157091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113855659","display_name":"Diane L. Cookfair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289499695","display_name":"Women & Children's Hospital of Buffalo","ror":"https://ror.org/00kg66g91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289499695"]},{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane L. Cookfair","raw_affiliation_strings":["MSCRG Data Management and Statistical Center, Department of Neurology, The Buffalo General Hospital, Buffalo","Women and Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSCRG Data Management and Statistical Center, Department of Neurology, The Buffalo General Hospital, Buffalo","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Women and Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I1289499695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066298482","display_name":"Richard A. Rudick","orcid":"https://orcid.org/0000-0002-7051-1602","observed_orcids":["https://orcid.org/0000-0002-7051-1602"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Rudick","raw_affiliation_strings":["Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111667085","display_name":"Robert M. Herndon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]},{"id":"https://openalex.org/I2799453855","display_name":"Legacy Good Samaritan Medical Center","ror":"https://ror.org/05msy3z48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I163879017","https://openalex.org/I2799453855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Herndon","raw_affiliation_strings":["Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, OR","Legacy Clinical Research and Technology Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, OR","institution_ids":["https://openalex.org/I2799453855"]},{"raw_affiliation_string":"Legacy Clinical Research and Technology Center","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756331","display_name":"John R. Richert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Richert","raw_affiliation_strings":["Department of Neurology, Georgetown University Medical Center, Washington, DC","GEORGETOWN UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091736003","display_name":"Andres \u039c. Salazar","orcid":"https://orcid.org/0000-0003-1723-691X","observed_orcids":["https://orcid.org/0000-0003-1723-691X"]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres M. Salazar","raw_affiliation_strings":["Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110681074","display_name":"Jill S. Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill S. Fischer","raw_affiliation_strings":["Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108421987","display_name":"Donald E. Goodkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E. Goodkin","raw_affiliation_strings":["University of California ar San Francisco/Mount Zion Multiple Sclerosis Center, San Francisco, CA","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California ar San Francisco/Mount Zion Multiple Sclerosis Center, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112144793","display_name":"Carl V. Granger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl V. Granger","raw_affiliation_strings":["Department of Rehabilitation Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY","SUNY Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"SUNY Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109117161","display_name":"Jack H. Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack H. Simon","raw_affiliation_strings":["Department of Radiology-MRI, University of Colorado Health Sciences Center, Denver, CO","University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology-MRI, University of Colorado Health Sciences Center, Denver, CO","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023056842","display_name":"John J. Alam","orcid":"https://orcid.org/0000-0002-1285-1115","observed_orcids":["https://orcid.org/0000-0002-1285-1115"]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Alam","raw_affiliation_strings":["Biogen, Inc, Cambridge, MA","Biogen IDEC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen, Inc, Cambridge, MA","institution_ids":["https://openalex.org/I1297540436"]},{"raw_affiliation_string":"Biogen IDEC","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113479977","display_name":"David M. Bartoszak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Bartoszak","raw_affiliation_strings":["Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057706417","display_name":"DENNIS N. BOURDETTE","orcid":"https://orcid.org/0000-0002-1312-8615","observed_orcids":["https://orcid.org/0000-0002-1312-8615"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis N. Bourdette","raw_affiliation_strings":["Department of Neurology, Oregon Health Sciences University, Portland, OR","Department of Neurology Oregon Health Sciences University Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Oregon Health Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Neurology Oregon Health Sciences University Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016129652","display_name":"Jonathan Braiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Braiman","raw_affiliation_strings":["Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110291890","display_name":"Carol M. Brownscheidle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol M. Brownscheidle","raw_affiliation_strings":["William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","Buffalo Genetal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Buffalo Genetal Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049008083","display_name":"Michael E. Coats","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Coats","raw_affiliation_strings":["Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067317369","display_name":"STANLEY L. COHAN","orcid":"https://orcid.org/0000-0002-9568-346X","observed_orcids":["https://orcid.org/0000-0002-9568-346X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley L. Cohan","raw_affiliation_strings":["Department of Neurology, Georgetown University Medical Center, Washington, DC","GEORGETOWN UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"GEORGETOWN UNIVERSITY","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113581696","display_name":"David S. Dougherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Dougherty","raw_affiliation_strings":["Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","Walter Reed Army Institute of Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Walrer Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Institute of Research","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103451142","display_name":"Revere Philip Kinkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Revere P. Kinkel","raw_affiliation_strings":["Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008608095","display_name":"Michele K Mass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799453855","display_name":"Legacy Good Samaritan Medical Center","ror":"https://ror.org/05msy3z48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I163879017","https://openalex.org/I2799453855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele K. Mass","raw_affiliation_strings":["Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, OR","institution_ids":["https://openalex.org/I2799453855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109350722","display_name":"Frederick E. Munschauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick E. Munschauer","raw_affiliation_strings":["William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","Buffalo Genetal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Buffalo Genetal Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542401","display_name":"Roger L. Priore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289499695","display_name":"Women & Children's Hospital of Buffalo","ror":"https://ror.org/00kg66g91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289499695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger L. Priore","raw_affiliation_strings":["Women and Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women and Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I1289499695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108095048","display_name":"Patrick M. Pullicino","orcid":"https://orcid.org/0000-0001-6865-8333","observed_orcids":["https://orcid.org/0000-0001-6865-8333"]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Pullicino","raw_affiliation_strings":["William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","Buffalo Genetal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William C. Baird Multiple Sclerosis Research Center, Millard Fillmore Health Sysrem, and the Department of Neuroloby, The Buffalo General Hospital, Buffalo","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Buffalo Genetal Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109558909","display_name":"Barbara Scherokman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Scherokman","raw_affiliation_strings":["Department of Neurology, Kaiser Permanente Medical Cenrer, Springfield, VA","Kaiser Permanente"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kaiser Permanente Medical Cenrer, Springfield, VA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"Kaiser Permanente","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075596287","display_name":"Bianca Weinstock\u2010Guttman","orcid":"https://orcid.org/0000-0001-6732-151X","observed_orcids":["https://orcid.org/0000-0001-6732-151X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bianca Weinstock\u2010Guttman","raw_affiliation_strings":["Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023553606","display_name":"Ruth H. Whitham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth H. Whitham","raw_affiliation_strings":["Department of Neurology, Oregon Health Sciences University, Portland, OR","Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Oregon Health Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210157091"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":83.2959,"has_fulltext":false,"cited_by_count":2450,"citation_normalized_percentile":{"value":0.99991884,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"39","issue":"3","first_page":"285","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta-1a","display_name":"interferon beta-1a","score":0.9390000104904175},{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.859000027179718},{"id":"https://openalex.org/keywords/expanded-disability-status-scale","display_name":"Expanded Disability Status Scale","score":0.9229999780654907},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.703000009059906},{"id":"https://openalex.org/keywords/gadolinium-enhancing-lesions","display_name":"gadolinium-enhancing lesions","score":0.9160000085830688},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.5879999995231628},{"id":"https://openalex.org/keywords/physical-disability","display_name":"physical disability","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8451672792434692},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8354000449180603},{"id":"https://openalex.org/C2780892749","wikidata":"https://www.wikidata.org/wiki/Q929518","display_name":"Expanded Disability Status Scale","level":3,"score":0.724325954914093},{"id":"https://openalex.org/C2908698914","wikidata":"https://www.wikidata.org/wiki/Q2450337","display_name":"Interferon beta-1a","level":4,"score":0.698952317237854},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.650826632976532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6331856846809387},{"id":"https://openalex.org/C2910198813","wikidata":"https://www.wikidata.org/wiki/Q1851162","display_name":"Interferon beta-1b","level":4,"score":0.6243870258331299},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5793934464454651},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4846363663673401},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4245210289955139},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.42268335819244385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2740139365196228},{"id":"https://openalex.org/C2994247566","wikidata":"https://www.wikidata.org/wiki/Q2450337","display_name":"Interferon beta","level":3,"score":0.205269455909729},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19075199961662292},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410390304","doi":"https://doi.org/10.1002/ana.410390304","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410390304","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:8602746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8602746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1222886165","display_name":null,"funder_award_id":"R01 26321","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1252868590","https://openalex.org/W1966339678","https://openalex.org/W1972978214","https://openalex.org/W1979300931","https://openalex.org/W1991690574","https://openalex.org/W1994351520","https://openalex.org/W1995919639","https://openalex.org/W2000599573","https://openalex.org/W2007316542","https://openalex.org/W2011277573","https://openalex.org/W2012270273","https://openalex.org/W2013463599","https://openalex.org/W2017449946","https://openalex.org/W2020737415","https://openalex.org/W2021278130","https://openalex.org/W2041282815","https://openalex.org/W2063406928","https://openalex.org/W2073087131","https://openalex.org/W2076290236","https://openalex.org/W2087998058","https://openalex.org/W2090718971","https://openalex.org/W2112165124","https://openalex.org/W2126094059","https://openalex.org/W2130355701","https://openalex.org/W2135715920","https://openalex.org/W2139070714","https://openalex.org/W2151529161","https://openalex.org/W2165547142","https://openalex.org/W2167254455","https://openalex.org/W2230732737","https://openalex.org/W2240999260","https://openalex.org/W2246548868","https://openalex.org/W2321043971","https://openalex.org/W2928067445","https://openalex.org/W4210548604"],"related_works":["https://openalex.org/W2574627421","https://openalex.org/W2384957276","https://openalex.org/W2163394083","https://openalex.org/W4250963283","https://openalex.org/W2112246282","https://openalex.org/W2143134934","https://openalex.org/W2158113633","https://openalex.org/W2151273111","https://openalex.org/W2144120881","https://openalex.org/W1972538283"],"abstract_inverted_index":{"The":[0,36,92,131],"accepted":[1],"standard":[2],"treatment":[3,15,117,255],"of":[4,9,29,38,54,76,102,134,137,143,179,236,261],"relapsing":[5,55,63,228,262],"multiple":[6,56,64,229,263],"sclerosis":[7,65,230],"consists":[8],"medications":[10],"for":[11,16],"disease":[12,243],"symptoms,":[13],"including":[14],"acute":[17],"exacerbations.":[18],"However,":[19],"currently":[20],"there":[21],"is":[22],"no":[23,213],"therapy":[24],"that":[25],"alters":[26],"the":[27,49,108,135,141,149,155,196,234,258],"progression":[28,101,127],"physical":[30,238],"disability":[31,53,100],"associated":[32],"with":[33,62,161],"this":[34,39],"disease.":[35],"purpose":[37],"study":[40],"was":[41,86,96,146,200],"to":[42,98,124,218],"determine":[43],"whether":[44],"interferon":[45,77,156,162,208],"beta-1a":[46,116,163,221],"could":[47],"slow":[48],"progressive,":[50],"irreversible,":[51],"neurological":[52],"sclerosis.":[57,264],"Three":[58],"hundred":[59],"one":[60],"patients":[61,138,204,231],"were":[66,212],"randomized":[67],"into":[68],"a":[69,119,173,223],"double-blinded,":[70],"placebo-controlled,":[71],"multicenter":[72],"phase":[73],"III":[74],"trial":[75],"beta-1a.":[78],"Interferon":[79,115,220],"beta-1a,":[80],"6.0":[81],"million":[82],"units":[83],"(30":[84],"micrograms\u00bf,":[85],"administered":[87],"by":[88,140,232,246],"intramuscular":[89],"injection":[90],"weekly.":[91],"primary":[93],"outcome":[94],"variable":[95],"time":[97,123],"sustained":[99,125],"at":[103],"least":[104],"1.0":[105],"point":[106],"on":[107,183,249],"Kurtzke":[109],"Expanded":[110],"Disability":[111],"Status":[112],"Scale":[113],"(EDSS).":[114],"produced":[118],"significant":[120,224],"delay":[121],"in":[122,148,154,202,207,227],"EDSS":[126],"(p":[128,169],"=":[129,170],"0.02).":[130],"Kaplan-Meier":[132],"estimate":[133],"proportion":[136],"progressing":[139],"end":[142],"104":[144],"weeks":[145],"34.9%":[147],"placebo":[150],"group":[151],"and":[152,172,177,191,242],"21.9%":[153],"beta-1a-treated":[157,209],"group.":[158],"Patients":[159],"treated":[160],"also":[164],"had":[165,222],"significantly":[166,174],"fewer":[167],"exacerbations":[168],"0.03)":[171],"lower":[175],"number":[176],"volume":[178],"gadolinium-enhanced":[180,247],"brain":[181,250],"lesions":[182,248],"magnetic":[184,251],"resonance":[185,252],"images":[186],"(p-values":[187],"ranging":[188],"between":[189],"0.02":[190],"0.05).":[192],"Over":[193],"2":[194],"years,":[195],"annual":[197],"exacerbation":[198,240],"rate":[199],"0.90":[201],"placebo-treated":[203],"versus":[205],"0.61":[206],"patients.":[210],"There":[211],"major":[214],"adverse":[215],"events":[216],"related":[217],"treatment.":[219],"beneficial":[225],"impact":[226],"reducing":[233],"accumulation":[235],"permanent":[237],"disability,":[239],"frequency,":[241],"activity":[244],"measured":[245],"images.":[253],"This":[254],"may":[256],"alter":[257],"fundamental":[259],"course":[260]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":56},{"year":2018,"cited_by_count":43},{"year":2017,"cited_by_count":56},{"year":2016,"cited_by_count":79},{"year":2015,"cited_by_count":88},{"year":2014,"cited_by_count":87},{"year":2013,"cited_by_count":121},{"year":2012,"cited_by_count":106}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
