{"id":"https://openalex.org/W2139363724","doi":"https://doi.org/10.1093/bioinformatics/btg433","title":"Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function","display_name":"Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function","publication_year":2004,"publication_date":"2004-01-22","ids":{"openalex":"https://openalex.org/W2139363724","doi":"https://doi.org/10.1093/bioinformatics/btg433","mag":"2139363724","pmid":"https://pubmed.ncbi.nlm.nih.gov/14990444"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btg433","doi":"https://doi.org/10.1093/bioinformatics/btg433","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg433","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027374744","display_name":"Daehee Hwang","orcid":"https://orcid.org/0000-0002-7553-0044","observed_orcids":["https://orcid.org/0000-0002-7553-0044","https://orcid.org/0000-0003-3608-0885","https://orcid.org/0000-0003-1038-9200"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daehee Hwang","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059565523","display_name":"George Stephanopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering Massachusetts Institute of Technology Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0000-0003-3054-2727","observed_orcids":["https://orcid.org/0000-0003-3054-2727","https://orcid.org/0009-0003-7693-8206"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Chan","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, 1257 EB East Lansing, MI 48824, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, 1257 EB East Lansing, MI 48824, USA#TAB#","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027374744"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":1.1836,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.75724251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"4","first_page":"487","last_page":"499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.482699990272522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.26440000534057617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inverse-modeling","display_name":"inverse modeling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.6399999856948853},{"id":"https://openalex.org/keywords/intracellular-lipids","display_name":"intracellular lipids","score":0.6830000281333923},{"id":"https://openalex.org/keywords/urea-synthesis","display_name":"urea synthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bioartificial-liver","display_name":"bioartificial liver","score":0.722000002861023},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.640999972820282},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.43799999356269836},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.5581585764884949},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5491589903831482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5487674474716187},{"id":"https://openalex.org/C129880937","wikidata":"https://www.wikidata.org/wiki/Q677023","display_name":"Multiprotocol Label Switching","level":3,"score":0.5344122648239136},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.44862064719200134},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.44129183888435364},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3249627947807312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2617529332637787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2592794895172119},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.15182983875274658},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14526653289794922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11093983054161072},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.0},{"id":"https://openalex.org/C5119721","wikidata":"https://www.wikidata.org/wiki/Q220501","display_name":"Quality of service","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004779","descriptor_name":"Environment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004780","descriptor_name":"Environment, Controlled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btg433","doi":"https://doi.org/10.1093/bioinformatics/btg433","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btg433","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:14990444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14990444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Comparative Study"},{"id":"pmh:oai:oasis.postech.ac.kr:2014.oak/26540","doi":null,"is_oa":false,"landing_page_url":"https://oasis.postech.ac.kr/handle/2014.oak/26540","pdf_url":null,"source":{"id":"https://openalex.org/S4306401965","display_name":"Open Access System for Information Sharing (Pohang University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123900574","host_organization_name":"Pohang University of Science and Technology","host_organization_lineage":["https://openalex.org/I123900574"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1481834144","https://openalex.org/W1487444668","https://openalex.org/W1780532214","https://openalex.org/W1966089218","https://openalex.org/W1972078123","https://openalex.org/W1992366665","https://openalex.org/W2015436473","https://openalex.org/W2017829333","https://openalex.org/W2037100052","https://openalex.org/W2062530492","https://openalex.org/W2067609325","https://openalex.org/W2067928373","https://openalex.org/W2073696580","https://openalex.org/W2080479180","https://openalex.org/W2107570767","https://openalex.org/W2109302907","https://openalex.org/W2112440119","https://openalex.org/W2133199783","https://openalex.org/W2139144784","https://openalex.org/W2139818522","https://openalex.org/W2155834859","https://openalex.org/W2158863190"],"related_works":["https://openalex.org/W2109302907","https://openalex.org/W2131635217","https://openalex.org/W773180494","https://openalex.org/W2246123902","https://openalex.org/W7011609217","https://openalex.org/W2134778891","https://openalex.org/W2995441630","https://openalex.org/W2076716065","https://openalex.org/W2049642322","https://openalex.org/W3157934862"],"abstract_inverted_index":{"MOTIVATIONS:":[0],"Tissue":[1],"engineering":[2],"constitutes":[3],"an":[4,54,65],"important":[5],"field":[6],"with":[7,83,118],"its":[8,86],"potential":[9],"of":[10,45,53,100,106,127,156,195,209],"addressing":[11],"the":[12,31,46,49,59,91,114,136,167,175,186,191,201],"current":[13],"shortage":[14],"in":[15,85],"organ":[16],"availability.":[17],"To":[18,123],"successfully":[19],"develop":[20],"tissue-engineered":[21,67],"organs,":[22],"it":[23],"is":[24],"crucial":[25],"to":[26,29,39,72,95,111,134,148,154,189,199],"understand":[27],"how":[28,77,174],"maintain":[30],"cells":[32,50,78],"under":[33],"conditions":[34],"that":[35],"maximize":[36],"their":[37,41],"ability":[38],"perform":[40],"physiological":[42],"roles,":[43],"regardless":[44],"environment,":[47],"whether":[48],"are":[51,71,178],"part":[52],"extracorporeal":[55],"system,":[56],"such":[57],"as":[58],"bioartificial":[60],"liver":[61],"assist":[62],"device,":[63],"or":[64],"implantable":[66],"device.":[68],"Our":[69],"goals":[70],"(1)":[73,166],"provide":[74],"insight":[75],"into":[76],"will":[79],"behave":[80],"when":[81],"confronted":[82],"changes":[84],"environment":[87],"and":[88,120,152,159,172,193],"(2)":[89,173],"determine":[90,190],"optimal":[92,207],"environmental":[93,107,150,170,196],"factors":[94,108,151,171,197],"achieve":[96],"a":[97,141],"desired":[98],"level":[99],"cellular":[101,210],"function.":[102],"RESULTS:":[103],"Diverse":[104],"sets":[105],"were":[109],"used":[110,133],"systematically":[112],"perturb":[113],"metabolic":[115,125,129,137,176],"behavior":[116],"associated":[117],"pre-conditioning":[119],"plasma":[121],"supplementation.":[122],"probe":[124],"state":[126],"hepatocytes,":[128],"flux":[130],"analysis":[131],"was":[132],"obtain":[135,200],"profile.":[138],"We":[139],"applied":[140],"multi-block":[142],"partial":[143],"least":[144],"square":[145],"(MPLS)":[146],"model":[147,164,188],"relate":[149],"fluxes":[153],"levels":[155,208],"intracellular":[157],"lipids":[158],"urea":[160],"synthesis.":[161],"The":[162],"MPLS":[163,187],"identified:":[165],"most":[168,202],"influential":[169],"pathways":[177],"altered":[179],"by":[180],"these":[181],"factors.":[182],"Finally,":[183],"we":[184],"inverted":[185],"concentrations":[192],"types":[194],"required":[198],"economical":[203],"solution":[204],"for":[205,212],"achieving":[206],"function":[211],"practical":[213],"situations.":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
