{"id":"https://openalex.org/W2139348853","doi":"https://doi.org/10.1053/j.seminoncol.2004.09.011","title":"Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity","display_name":"Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2139348853","doi":"https://doi.org/10.1053/j.seminoncol.2004.09.011","mag":"2139348853","pmid":"https://pubmed.ncbi.nlm.nih.gov/15599852"},"language":"en","primary_location":{"id":"doi:10.1053/j.seminoncol.2004.09.011","doi":"https://doi.org/10.1053/j.seminoncol.2004.09.011","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.seminoncol.2004.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S77180905","display_name":"Seminars in Oncology","issn_l":"0093-7754","issn":["0093-7754","1532-8708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139348853"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1053/j.seminoncol.2004.09.011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076901251","display_name":"Maura L. Gillison","orcid":"https://orcid.org/0000-0002-8145-5749","observed_orcids":["https://orcid.org/0000-0002-8145-5749"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maura L. Gillison","raw_affiliation_strings":["Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076901251"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714","https://openalex.org/I4210164401"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":4.6788,"has_fulltext":false,"cited_by_count":552,"citation_normalized_percentile":{"value":0.97744361,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"31","issue":"6","first_page":"744","last_page":"754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hpv-associated-head-and-neck-squamous-cell-carcinoma","display_name":"HPV-associated head and neck squamous cell carcinoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/tonsillar-cancer","display_name":"tonsillar carcinoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9929999709129333},{"id":"https://openalex.org/keywords/viral-carcinogenesis","display_name":"viral oncogenesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sexual-behavior","display_name":"sexual behavior","score":0.48100000619888306},{"id":"https://openalex.org/keywords/human-papillomavirus-vaccine","display_name":"HPV vaccine","score":0.8159999847412109},{"id":"https://openalex.org/keywords/oncoprotein","display_name":"oncoprotein","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8237677216529846},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6419562697410583},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6259450912475586},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5787518620491028},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5403561592102051},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5251134037971497},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.4512374699115753},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4303932785987854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37531420588493347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3685346245765686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3177797198295593},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.2713389992713928}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1053/j.seminoncol.2004.09.011","doi":"https://doi.org/10.1053/j.seminoncol.2004.09.011","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.seminoncol.2004.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S77180905","display_name":"Seminars in Oncology","issn_l":"0093-7754","issn":["0093-7754","1532-8708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Oncology","raw_type":"journal-article"},{"id":"pmid:15599852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15599852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1053/j.seminoncol.2004.09.011","doi":"https://doi.org/10.1053/j.seminoncol.2004.09.011","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.seminoncol.2004.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S77180905","display_name":"Seminars in Oncology","issn_l":"0093-7754","issn":["0093-7754","1532-8708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G663269820","display_name":"HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERS","funder_award_id":"R01DE013121","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W49088703","https://openalex.org/W71485610","https://openalex.org/W109846877","https://openalex.org/W162091646","https://openalex.org/W1524258017","https://openalex.org/W1541833203","https://openalex.org/W1566505170","https://openalex.org/W1575443246","https://openalex.org/W1585242242","https://openalex.org/W1591691859","https://openalex.org/W1603405467","https://openalex.org/W1660800498","https://openalex.org/W1782090758","https://openalex.org/W1783393452","https://openalex.org/W1796807968","https://openalex.org/W1825875625","https://openalex.org/W1919309487","https://openalex.org/W1963487632","https://openalex.org/W1963625854","https://openalex.org/W1966768800","https://openalex.org/W1967773428","https://openalex.org/W1967960141","https://openalex.org/W1972529789","https://openalex.org/W1972533259","https://openalex.org/W1974711039","https://openalex.org/W1976933756","https://openalex.org/W1979476737","https://openalex.org/W1981279361","https://openalex.org/W1982046131","https://openalex.org/W1989586626","https://openalex.org/W1992450511","https://openalex.org/W1993044734","https://openalex.org/W1993154457","https://openalex.org/W1994130188","https://openalex.org/W1996017378","https://openalex.org/W1998218812","https://openalex.org/W1999587521","https://openalex.org/W2000063139","https://openalex.org/W2000067413","https://openalex.org/W2002611375","https://openalex.org/W2003651076","https://openalex.org/W2005029249","https://openalex.org/W2008004857","https://openalex.org/W2010585539","https://openalex.org/W2011271315","https://openalex.org/W2012340177","https://openalex.org/W2014201296","https://openalex.org/W2014784517","https://openalex.org/W2017883975","https://openalex.org/W2019961694","https://openalex.org/W2021250272","https://openalex.org/W2022788823","https://openalex.org/W2026798637","https://openalex.org/W2028084128","https://openalex.org/W2028732613","https://openalex.org/W2033310811","https://openalex.org/W2033483225","https://openalex.org/W2033713678","https://openalex.org/W2035468785","https://openalex.org/W2036225741","https://openalex.org/W2036591675","https://openalex.org/W2036743876","https://openalex.org/W2037874314","https://openalex.org/W2038957829","https://openalex.org/W2041246059","https://openalex.org/W2044907977","https://openalex.org/W2045059362","https://openalex.org/W2046215123","https://openalex.org/W2048026376","https://openalex.org/W2048468323","https://openalex.org/W2053704077","https://openalex.org/W2054690110","https://openalex.org/W2056373000","https://openalex.org/W2058346499","https://openalex.org/W2060934494","https://openalex.org/W2065675351","https://openalex.org/W2069776260","https://openalex.org/W2072452325","https://openalex.org/W2074557458","https://openalex.org/W2074838903","https://openalex.org/W2077680786","https://openalex.org/W2081081421","https://openalex.org/W2082904105","https://openalex.org/W2085187651","https://openalex.org/W2086474036","https://openalex.org/W2088457548","https://openalex.org/W2094296784","https://openalex.org/W2095043719","https://openalex.org/W2096041050","https://openalex.org/W2101196984","https://openalex.org/W2107853891","https://openalex.org/W2111659395","https://openalex.org/W2111662371","https://openalex.org/W2111805332","https://openalex.org/W2116220899","https://openalex.org/W2120360742","https://openalex.org/W2120403825","https://openalex.org/W2126060901","https://openalex.org/W2126290488","https://openalex.org/W2128364457","https://openalex.org/W2129645590","https://openalex.org/W2132205266","https://openalex.org/W2135623224","https://openalex.org/W2138307859","https://openalex.org/W2139788029","https://openalex.org/W2141872609","https://openalex.org/W2142579389","https://openalex.org/W2143789052","https://openalex.org/W2146407376","https://openalex.org/W2147467272","https://openalex.org/W2147774152","https://openalex.org/W2149166037","https://openalex.org/W2152889813","https://openalex.org/W2153043270","https://openalex.org/W2153560947","https://openalex.org/W2153981408","https://openalex.org/W2165279145","https://openalex.org/W2166992099","https://openalex.org/W2168104423","https://openalex.org/W2170019502","https://openalex.org/W2170238921","https://openalex.org/W2179791758","https://openalex.org/W2312584840","https://openalex.org/W2332240411","https://openalex.org/W2342166036","https://openalex.org/W2419603697","https://openalex.org/W2465174048","https://openalex.org/W2465253711","https://openalex.org/W2886259079","https://openalex.org/W6606594704","https://openalex.org/W6631465928","https://openalex.org/W6633966275","https://openalex.org/W6636093777","https://openalex.org/W6637133696","https://openalex.org/W6653967621","https://openalex.org/W6676663479","https://openalex.org/W6677932070","https://openalex.org/W6681103461","https://openalex.org/W6681154495","https://openalex.org/W6682588768","https://openalex.org/W6717196754"],"related_works":["https://openalex.org/W2003411071","https://openalex.org/W2099281944","https://openalex.org/W1496516226","https://openalex.org/W2052849145","https://openalex.org/W2077272882","https://openalex.org/W2118216306","https://openalex.org/W2189074201","https://openalex.org/W2000536126","https://openalex.org/W2094896092","https://openalex.org/W2599441995"],"abstract_inverted_index":{"There":[0,32],"is":[1,33,65,147],"currently":[2],"sufficient":[3],"evidence":[4,125],"to":[5,95,135,152],"conclude":[6],"that":[7,83],"human":[8,47],"papillomavirus":[9],"(HPV)":[10],"plays":[11],"a":[12,18,34,45,89,127],"role":[13,128],"in":[14,131,138],"the":[15,115,123,139,165],"pathogenesis":[16],"of":[17,21,58,73,106,143,155,170],"distinct":[19],"subset":[20],"head":[22],"and":[23,36,49,75,110,119,168],"neck":[24],"squamous":[25],"cell":[26],"cancers":[27,53],"(HNSCC),":[28],"particularly":[29],"tonsillar":[30],"cancers.":[31],"strong":[35],"consistent":[37,78],"association":[38],"between":[39],"high-risk":[40],"HPV":[41,86,130],"types,":[42],"specifically":[43],"HPV16,":[44],"known":[46],"carcinogen,":[48],"these":[50],"distinctive":[51],"oropharyngeal":[52,107],"with":[54,79,100],"molecular":[55],"characteristics":[56],"indicative":[57],"viral":[59,116],"oncogene":[60],"function.":[61],"Risk":[62],"for":[63,103,126,129,149,164],"HPV-HNSCC":[64],"increased":[66,101],"by":[67],"certain":[68],"sexual":[69],"behaviors":[70],"after":[71],"consideration":[72],"alcohol":[74],"tobacco":[76],"exposure,":[77],"an":[80],"extensive":[81],"literature":[82],"has":[84,97],"established":[85],"infection":[87],"as":[88],"sexually":[90],"transmitted":[91],"disease.":[92,145],"Furthermore,":[93],"exposure":[94],"HPV16":[96],"been":[98],"associated":[99],"risk":[102],"subsequent":[104],"development":[105],"cancer.":[108],"Prophylactic":[109],"therapeutic":[111],"vaccines":[112],"targeted":[113],"against":[114],"capsid":[117],"components":[118],"oncoproteins":[120],"will":[121],"provide":[122],"ultimate":[124],"HNSCC,":[132],"if":[133],"demonstrated":[134],"be":[136],"effective":[137],"prevention":[140],"or":[141],"therapy":[142],"this":[144,156],"It":[146],"time":[148],"clinician":[150],"scientists":[151],"translate":[153],"knowledge":[154],"newly":[157],"recognized":[158],"disease":[159],"entity":[160],"into":[161],"potential":[162],"applications":[163],"prevention,":[166],"detection,":[167],"treatment":[169],"HPV-HNSCC.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":43},{"year":2012,"cited_by_count":53}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
