{"id":"https://openalex.org/W2139343412","doi":"https://doi.org/10.1200/jco.2007.15.0672","title":"Gefitinib Versus Vinorelbine in Chemotherapy-Na\u00efve Elderly Patients With Advanced Non\u2013Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study","display_name":"Gefitinib Versus Vinorelbine in Chemotherapy-Na\u00efve Elderly Patients With Advanced Non\u2013Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study","publication_year":2008,"publication_date":"2008-09-08","ids":{"openalex":"https://openalex.org/W2139343412","doi":"https://doi.org/10.1200/jco.2007.15.0672","mag":"2139343412","pmid":"https://pubmed.ncbi.nlm.nih.gov/18779612"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.15.0672","doi":"https://doi.org/10.1200/jco.2007.15.0672","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.15.0672","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008403882","display_name":"Lucio Crin\u00f2","orcid":"https://orcid.org/0000-0001-5745-6429","observed_orcids":["https://orcid.org/0000-0001-5745-6429"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Lucio Crin\u00f2","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001928949","display_name":"Federico Cappuzzo","orcid":"https://orcid.org/0000-0002-6295-6767","observed_orcids":["https://orcid.org/0000-0002-6295-6767"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Federico Cappuzzo","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088240085","display_name":"Petr Zatloukal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Petr Zatloukal","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060572768","display_name":"Martin Reck","orcid":"https://orcid.org/0000-0002-5336-9739","observed_orcids":["https://orcid.org/0000-0002-5336-9739"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Martin Reck","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004795208","display_name":"Milo\u0161 Pe\u0161ek","orcid":"https://orcid.org/0000-0002-4664-7614","observed_orcids":["https://orcid.org/0000-0002-4664-7614"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Milos Pesek","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109952896","display_name":"Joyce Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Joyce C. Thompson","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080217735","display_name":"Hugo E. R. Ford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Hugo E.R. Ford","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071851332","display_name":"Fred R. Hirsch","orcid":"https://orcid.org/0000-0002-6885-1894","observed_orcids":["https://orcid.org/0000-0002-6885-1894"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Fred R. Hirsch","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024045160","display_name":"Marileila Varella\u2010Garcia","orcid":"https://orcid.org/0000-0002-2310-5863","observed_orcids":["https://orcid.org/0000-0002-2310-5863"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Marileila Varella-Garcia","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046261528","display_name":"Serban Ghiorghiu","orcid":"https://orcid.org/0009-0006-6879-9113","observed_orcids":["https://orcid.org/0009-0006-6879-9113"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Serban Ghiorghiu","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080144494","display_name":"Emma L. Duffield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Emma L. Duffield","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113649204","display_name":"Alison A. Armour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Alison A. Armour","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042329520","display_name":"Georgina Speake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Georgina Speake","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111916766","display_name":"Michael H. Cullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I2803076161","display_name":"Fakultn\u00ed nemocnice Bulovka","ror":"https://ror.org/009e9xr64","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I2803076161"]},{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Michael Cullen","raw_affiliation_strings":["From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Perugia Hospital, Perugia; and Instituto Clinico Humanitas Istituto di Recovero e Cura a Carattere Scientifico, Rozzano, Italy; Third Faculty of Medicine, Charles University, Faculty Hospital Bulovka and Postgraduate Medical Institute, Prague; and Charles University Medical Faculty, Plzen, Czech Republic; Hospital Grobhansdorf, Gro\u03b2hansdorf, Germany; Birmingham Heartlands Hospital; Queen Elizabeth Hospital, Birmingham; Cambridge University Hospitals National","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I2799307867","https://openalex.org/I2803076161","https://openalex.org/I4210104666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":30.5594,"has_fulltext":false,"cited_by_count":214,"citation_normalized_percentile":{"value":0.99799797,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"26","issue":"26","first_page":"4253","last_page":"4260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":1.0},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.972000002861023},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/egfr-gene-copy-number","display_name":"EGFR gene copy number","score":0.8960000276565552},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9369999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9350000023841858},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pulmonary-symptoms","display_name":"pulmonary symptoms","score":0.7599999904632568},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.7250000238418579},{"id":"https://openalex.org/keywords/egfr-mutation-status","display_name":"EGFR mutation status","score":0.40700000524520874},{"id":"https://openalex.org/keywords/egfr-exon-19-deletion","display_name":"EGFR exon 19 deletion","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.9813544750213623},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9437543153762817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8491801023483276},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7291673421859741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6954208612442017},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6741860508918762},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5707377195358276},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4952644407749176},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4845260977745056},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.46679410338401794},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44560256600379944},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.37478333711624146},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.29781144857406616},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2910993695259094},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.10668942332267761},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.09433737397193909}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2007.15.0672","doi":"https://doi.org/10.1200/jco.2007.15.0672","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.15.0672","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18779612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18779612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1970476748","https://openalex.org/W1988442083","https://openalex.org/W1995002313","https://openalex.org/W2006994284","https://openalex.org/W2014725195","https://openalex.org/W2043696829","https://openalex.org/W2083547960","https://openalex.org/W2105258029","https://openalex.org/W2106585301","https://openalex.org/W2107304950","https://openalex.org/W2115178301","https://openalex.org/W2120718661","https://openalex.org/W2121389354","https://openalex.org/W2123857987","https://openalex.org/W2129793485","https://openalex.org/W2137009016","https://openalex.org/W2139248078","https://openalex.org/W2140872365","https://openalex.org/W2146404049","https://openalex.org/W2153477391","https://openalex.org/W2161821474","https://openalex.org/W2168431047"],"related_works":["https://openalex.org/W1977244201","https://openalex.org/W2244253797","https://openalex.org/W2589801121","https://openalex.org/W2149095868","https://openalex.org/W2064456374","https://openalex.org/W2084871859","https://openalex.org/W2612042782","https://openalex.org/W7025077711","https://openalex.org/W2519936770","https://openalex.org/W2372227088"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"phase":[2],"II,":[3],"open-label,":[4],"parallel-group":[5],"study":[6],"compared":[7],"gefitinib":[8,32,103,116,222,235],"with":[9,15,221,225,245,253],"vinorelbine":[10,37,109,226,237,263],"in":[11,93,238,240],"chemotherapy-na\u00efve":[12],"elderly":[13,243],"patients":[14,23,187,244],"advanced":[16,246],"non-small-cell":[17],"lung":[18],"cancer":[19],"(NSCLC).":[20],"METHODS:":[21],"Chemotherapy-na\u00efve":[22],"(age":[24],">or=":[25],"70":[26],"years)":[27],"were":[28,61,99,119,142,171,189,193,212,257],"randomly":[29,100],"assigned":[30,101],"to":[31,102,108,124,133,147,158,198,207,217],"(250":[33],"mg/d":[34],"orally)":[35],"or":[36,107],"(30":[38],"mg/m(2)":[39],"infusion":[40],"on":[41],"days":[42],"1":[43],"and":[44,77,128,138,149,153,160,168,173,177,179,202,236],"8":[45],"of":[46,70],"a":[47],"21-day":[48],"cycle).":[49],"The":[50],"primary":[51],"end":[52,59,80],"point":[53],"was":[54,230,250],"progression-free":[55],"survival":[56,63],"(PFS).":[57],"Secondary":[58],"points":[60,81],"overall":[62],"(OS),":[64],"objective":[65],"response":[66],"rate":[67],"(ORR),":[68],"quality":[69],"life":[71],"(QOL),":[72],"pulmonary":[73],"symptom":[74],"improvement":[75,167],"(PSI),":[76],"tolerability.":[78],"Exploratory":[79],"included":[82],"epidermal":[83],"growth":[84],"factor":[85],"receptor":[86],"(EGFR)":[87],"gene":[88],"copy":[89],"number":[90],"by":[91],"fluorescent":[92],"situ":[94],"hybridization":[95],"(FISH).":[96],"RESULTS:":[97],"Patients":[98],"(n":[104,110],"=":[105,111],"97)":[106],"99).":[112],"Hazard":[113],"ratios":[114],"(HR;":[115],"v":[117],"vinorelbine)":[118],"1.19":[120],"(95%":[121,130,144,155,195,204],"CI,":[122,131,145,156,196,205],"0.85":[123],"1.65)":[125],"for":[126,135,200,209],"PFS":[127,201],"0.98":[129],"0.66":[132],"1.47)":[134],"OS.":[136,210],"ORR":[137],"disease":[139],"control":[140],"rates":[141,170],"3.1%":[143],"0.6":[146],"8.8)":[148],"43.3%":[150],"(for":[151,162,175,181],"gefitinib)":[152,176],"5.1%":[154],"1.7":[157],"11.4)":[159],"53.5%":[161],"vinorelbine),":[163,182],"respectively.":[164,183],"Overall":[165],"QOL":[166],"PSI":[169],"24.3%":[172],"36.6%":[174],"10.9%":[178],"31.0%":[180],"In":[184],"the":[185],"54":[186],"who":[188,256],"EGFR":[190,258],"FISH-positive,":[191],"HRs":[192],"3.13":[194],"1.45":[197],"6.76)":[199],"2.88":[203],"1.21":[206],"6.83)":[208],"There":[211,229],"fewer":[213],"treatment-related":[214],"grade":[215],"3":[216],"5":[218],"adverse":[219],"events":[220],"(12.8%)":[223],"than":[224,264],"(41.7%).":[227],"CONCLUSION:":[228],"no":[231],"statistical":[232],"difference":[233],"between":[234],"efficacy":[239],"chemotherapy-na\u00efve,":[241],"unselected":[242],"NSCLC,":[247],"but":[248],"there":[249],"better":[251],"tolerability":[252],"gefitinib.":[254],"Individuals":[255],"FISH-positive":[259],"benefited":[260],"more":[261],"from":[262,265],"gefitinib;":[266],"this":[267],"unexpected":[268],"finding":[269],"requires":[270],"further":[271],"study.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}