{"id":"https://openalex.org/W2139341329","doi":"https://doi.org/10.1080/01926230601072327","title":"Urothelial Carcinogenesis in the Urinary Bladder of Male Rats Treated with Muraglitazar, a PPAR\u03b1/\u03b3 Agonist: Evidence for Urolithiasis as the Inciting Event in the Mode of Action","display_name":"Urothelial Carcinogenesis in the Urinary Bladder of Male Rats Treated with Muraglitazar, a PPAR\u03b1/\u03b3 Agonist: Evidence for Urolithiasis as the Inciting Event in the Mode of Action","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2139341329","doi":"https://doi.org/10.1080/01926230601072327","mag":"2139341329","pmid":"https://pubmed.ncbi.nlm.nih.gov/17178691"},"language":"en","primary_location":{"id":"doi:10.1080/01926230601072327","doi":"https://doi.org/10.1080/01926230601072327","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01926230601072327","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1080/01926230601072327","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1080/01926230601072327","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108527689","display_name":"Mark A. Dominick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark A. Dominick","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016575790","display_name":"Melvin R. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin R. White","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069300682","display_name":"Thomas P. Sanderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Sanderson","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049781812","display_name":"Terry Van Vleet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry van Vleet","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029395581","display_name":"Samuel M. Cohen","orcid":"https://orcid.org/0000-0002-5047-0962","observed_orcids":["https://orcid.org/0000-0002-5047-0962"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel M. Cohen","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024906356","display_name":"Lora L. Arnold","orcid":"https://orcid.org/0000-0001-6797-7578","observed_orcids":["https://orcid.org/0000-0001-6797-7578"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora E. Arnold","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marty Cano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marty Cano","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006974776","display_name":"Sarah H. Tannehill\u2010Gregg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Tannehill-Gregg","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026356154","display_name":"Jeffrey D. Moehlenkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Moehlenkamp","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059577451","display_name":"Crystal R. Waites","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal R. Waites","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064720074","display_name":"Beth E. Schilling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E. Schilling","raw_affiliation_strings":["Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety Evaluation, Bristol-Myers Squibb Co., Evansville, Indiana 47721, USA","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108527689"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.6659,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.91185679,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"34","issue":"7","first_page":"903","last_page":"920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muraglitazar","display_name":"muraglitazar","score":0.996999979019165},{"id":"https://openalex.org/keywords/urothelial-carcinogenesis","display_name":"urothelial carcinogenesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8130000233650208},{"id":"https://openalex.org/keywords/urolithiasis","display_name":"urolithiasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-citrate","display_name":"urinary citrate","score":0.7379999756813049},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.6859999895095825},{"id":"https://openalex.org/keywords/calcium-oxalate-crystals","display_name":"calcium oxalate crystals","score":0.8019999861717224},{"id":"https://openalex.org/keywords/urothelial-proliferation","display_name":"urothelial proliferation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6907581090927124},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6403639912605286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6315093040466309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5619762539863586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5606337189674377},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.556511402130127},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.48268556594848633},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.46258020401000977},{"id":"https://openalex.org/C2777540882","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelium","level":3,"score":0.46217814087867737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.243859201669693},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14650660753250122}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010070","descriptor_name":"Oxalates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013052","descriptor_name":"Spectrometry, X-Ray Emission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019459","descriptor_name":"Urothelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052878","descriptor_name":"Urolithiasis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D052878","descriptor_name":"Urolithiasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/01926230601072327","doi":"https://doi.org/10.1080/01926230601072327","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01926230601072327","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1080/01926230601072327","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:17178691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17178691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/01926230601072327","doi":"https://doi.org/10.1080/01926230601072327","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01926230601072327","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1080/01926230601072327","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139341329.pdf","grobid_xml":"https://content.openalex.org/works/W2139341329.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W4465339","https://openalex.org/W44251087","https://openalex.org/W46855672","https://openalex.org/W94113292","https://openalex.org/W102437070","https://openalex.org/W148279663","https://openalex.org/W195199441","https://openalex.org/W209941844","https://openalex.org/W334103292","https://openalex.org/W1480899531","https://openalex.org/W1498999922","https://openalex.org/W1647126819","https://openalex.org/W1756303988","https://openalex.org/W1812285428","https://openalex.org/W1849423995","https://openalex.org/W1908444498","https://openalex.org/W1957106181","https://openalex.org/W1965138576","https://openalex.org/W1965682121","https://openalex.org/W1967398770","https://openalex.org/W1970522314","https://openalex.org/W1972248992","https://openalex.org/W1974876622","https://openalex.org/W1975293170","https://openalex.org/W1976936270","https://openalex.org/W1977767802","https://openalex.org/W1978125779","https://openalex.org/W1988805205","https://openalex.org/W1989863356","https://openalex.org/W1994937581","https://openalex.org/W1999868822","https://openalex.org/W2001177059","https://openalex.org/W2002880821","https://openalex.org/W2002915990","https://openalex.org/W2005598417","https://openalex.org/W2006440916","https://openalex.org/W2010110365","https://openalex.org/W2015458288","https://openalex.org/W2023721101","https://openalex.org/W2024438811","https://openalex.org/W2028869586","https://openalex.org/W2028910227","https://openalex.org/W2029456267","https://openalex.org/W2033204507","https://openalex.org/W2036744553","https://openalex.org/W2037140399","https://openalex.org/W2037890119","https://openalex.org/W2041062515","https://openalex.org/W2049692059","https://openalex.org/W2050885954","https://openalex.org/W2051241476","https://openalex.org/W2054556235","https://openalex.org/W2064921473","https://openalex.org/W2070184367","https://openalex.org/W2070399160","https://openalex.org/W2077396448","https://openalex.org/W2077577898","https://openalex.org/W2084099638","https://openalex.org/W2085524651","https://openalex.org/W2087367550","https://openalex.org/W2093079433","https://openalex.org/W2097170334","https://openalex.org/W2101477802","https://openalex.org/W2105267306","https://openalex.org/W2110209253","https://openalex.org/W2113328569","https://openalex.org/W2120875133","https://openalex.org/W2123832852","https://openalex.org/W2126739473","https://openalex.org/W2131406107","https://openalex.org/W2135401506","https://openalex.org/W2137535914","https://openalex.org/W2144009844","https://openalex.org/W2148011531","https://openalex.org/W2150985748","https://openalex.org/W2161241963","https://openalex.org/W2168142266","https://openalex.org/W2170834657","https://openalex.org/W2218557939","https://openalex.org/W2280004510","https://openalex.org/W2293248093","https://openalex.org/W2337504668","https://openalex.org/W2339962248","https://openalex.org/W2404726068","https://openalex.org/W2407510426","https://openalex.org/W2409753588","https://openalex.org/W2409886872","https://openalex.org/W2412167598","https://openalex.org/W2412908115","https://openalex.org/W4205205604","https://openalex.org/W4240449862"],"related_works":["https://openalex.org/W2118561897","https://openalex.org/W2134489589","https://openalex.org/W2131963215","https://openalex.org/W2156994876","https://openalex.org/W7099478501","https://openalex.org/W2097170334","https://openalex.org/W2168999134","https://openalex.org/W2081043740","https://openalex.org/W2156721436","https://openalex.org/W2791665297"],"abstract_inverted_index":{"Muraglitazar,":[0],"a":[1,56,83,155,171],"PPARalpha/gamma":[2],"agonist,":[3],"dose-dependently":[4],"increased":[5,129],"urinary":[6,168,228],"bladder":[7,157,229],"tumors":[8],"in":[9,65,102,109,126,161,234,244],"male":[10,33],"Harlan":[11],"Sprague-Dawley":[12],"(HSD)":[13],"rats":[14,35,81,163,190],"administered":[15],"5,":[16],"30,":[17],"or":[18,49,58,91,186],"50":[19,50],"mg/kg/day":[20],"for":[21,39],"up":[22,40],"to":[23,41,239],"2":[24],"years.":[25],"To":[26],"determine":[27],"the":[28,103,212],"mode":[29,226],"of":[30,46,97,105,116,204,227],"tumor":[31,230],"development,":[32],"HSD":[34],"were":[36,75,122,159,181],"treated":[37,80,162],"daily":[38],"21":[42],"months":[43],"at":[44],"doses":[45],"0,":[47],"1,":[48],"mg/kg":[51],"while":[52],"being":[53],"fed":[54,82,191],"either":[55],"normal":[57,84],"1%":[59],"NH4Cl-acidified":[60],"diet.":[61,187],"Muraglitazar-associated,":[62],"time-dependent":[63],"changes":[64,108],"urine":[66,86,195,235],"composition,":[67],"urothelial":[68,73,150,213],"mitogenesis":[69],"and":[70,72,79,118,140,142,152,167,216,241],"apoptosis,":[71],"morphology":[74],"assessed.":[76],"In":[77,188],"control":[78],"diet,":[85,194],"pH":[87,196],"was":[88,197],"generally":[89],">":[90],"=":[92],"6.5,":[93,200],"which":[94,201],"facilitates":[95],"formation":[96,203],"calcium-and":[98,205],"magnesium-containing":[99,206],"solids,":[100],"particularly":[101],"presence":[104],"other":[106],"prolithogenic":[107],"rat":[110],"urine.":[111],"Urinary":[112],"citrate,":[113],"an":[114,192,223],"inhibitor":[115],"lithogenesis,":[117],"soluble":[119],"calcium":[120,130,143,246],"concentrations":[121],"dose":[123],"dependently":[124],"decreased":[125],"association":[127],"with":[128,154,170],"phosphate":[131,138],"precipitate,":[132],"crystals":[133,139],"and/or":[134],"microcalculi;":[135],"magnesium":[136],"ammonium":[137],"aggregates;":[141],"oxalate-containing":[144],"thin,":[145],"rod-like":[146],"crystals.":[147],"Morphologically,":[148],"sustained":[149],"cytotoxicity":[151],"proliferation":[153],"ventral":[156],"predilection":[158],"noted":[160],"by":[164,175,183],"month":[165,176],"1":[166],"carcinomas":[169],"similar":[172],"distribution":[173],"occurred":[174],"9.":[177],"Urothelial":[178],"apoptotic":[179],"rates":[180],"unaffected":[182],"muraglitazar":[184],"treatment":[185],"muraglitazar-treated":[189],"acidified":[193],"invariably":[198],"<":[199],"inhibited":[202],"solids.":[207],"Moreover,":[208],"dietary":[209],"acidification":[210],"prevented":[211],"cytotoxic,":[214],"proliferative,":[215],"tumorigenic":[217],"responses.":[218],"Collectively,":[219],"these":[220],"data":[221],"support":[222],"indirect":[224],"pharmacologic":[225],"development":[231],"involving":[232],"alterations":[233],"composition":[236],"that":[237],"predispose":[238],"urolithiasis":[240],"associated":[242],"decreases":[243],"urine-soluble":[245],"concentrations.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
