{"id":"https://openalex.org/W2139335752","doi":"https://doi.org/10.1210/jc.2012-3389","title":"Maternal Hypothyroxinemia in Early Pregnancy Predicts Reduced Performance in Reaction Time Tests in 5- to 6-Year-Old Offspring","display_name":"Maternal Hypothyroxinemia in Early Pregnancy Predicts Reduced Performance in Reaction Time Tests in 5- to 6-Year-Old Offspring","publication_year":2013,"publication_date":"2013-02-13","ids":{"openalex":"https://openalex.org/W2139335752","doi":"https://doi.org/10.1210/jc.2012-3389","mag":"2139335752","pmid":"https://pubmed.ncbi.nlm.nih.gov/23408575"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2012-3389","doi":"https://doi.org/10.1210/jc.2012-3389","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2012-3389","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044527100","display_name":"Martijn J.J. Finken","orcid":"https://orcid.org/0000-0002-6589-9788","observed_orcids":["https://orcid.org/0000-0002-6589-9788"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Martijn J. J. Finken","raw_affiliation_strings":["Department of Pediatric Endocrinology (M.J.J.F., J.R.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Endocrinology (M.J.J.F., J.R.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059834108","display_name":"Manon van Eijsden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148356","display_name":"GGD Amsterdam","ror":"https://ror.org/04gbbq803","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210088893","https://openalex.org/I4210148356"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Manon van Eijsden","raw_affiliation_strings":["Department of Epidemiology Documentation and Health Promotion (M.v.E., E.M.L.), Public Health Service Amsterdam, Amsterdam 1018 WT, The Netherlands","Department of Health Sciences (M.v.E.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Documentation and Health Promotion (M.v.E., E.M.L.), Public Health Service Amsterdam, Amsterdam 1018 WT, The Netherlands","institution_ids":["https://openalex.org/I4210148356"]},{"raw_affiliation_string":"Department of Health Sciences (M.v.E.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013431808","display_name":"Eva M. Loomans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193700539","display_name":"Tilburg University","ror":"https://ror.org/04b8v1s79","country_code":"NL","type":"education","lineage":["https://openalex.org/I193700539"]},{"id":"https://openalex.org/I4210148356","display_name":"GGD Amsterdam","ror":"https://ror.org/04gbbq803","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210088893","https://openalex.org/I4210148356"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eva M. Loomans","raw_affiliation_strings":["Department of Developmental Psychology (E.M.L.), Tilburg University, Tilburg 5000 LE, The Netherlands","Department of Epidemiology Documentation and Health Promotion (M.v.E., E.M.L.), Public Health Service Amsterdam, Amsterdam 1018 WT, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Psychology (E.M.L.), Tilburg University, Tilburg 5000 LE, The Netherlands","institution_ids":["https://openalex.org/I193700539"]},{"raw_affiliation_string":"Department of Epidemiology Documentation and Health Promotion (M.v.E., E.M.L.), Public Health Service Amsterdam, Amsterdam 1018 WT, The Netherlands","institution_ids":["https://openalex.org/I4210148356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007255877","display_name":"Tanja G. M. Vrijkotte","orcid":"https://orcid.org/0000-0003-3641-4048","observed_orcids":["https://orcid.org/0000-0003-3641-4048"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tanja G. M. Vrijkotte","raw_affiliation_strings":["Department of Public Health (T.G.M.V.), Academic Medical Center\u2013University of Amsterdam, Amsterdam 1100 DD, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health (T.G.M.V.), Academic Medical Center\u2013University of Amsterdam, Amsterdam 1100 DD, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042812382","display_name":"Joost Rotteveel","orcid":"https://orcid.org/0000-0001-7635-564X","observed_orcids":["https://orcid.org/0000-0001-7635-564X"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost Rotteveel","raw_affiliation_strings":["Department of Pediatric Endocrinology (M.J.J.F., J.R.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Endocrinology (M.J.J.F., J.R.), VU University Medical Center, Amsterdam 1007 MB, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044527100"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":10.3776,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.98641675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"98","issue":"4","first_page":"1417","last_page":"1426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-hypothyroxinemia","display_name":"maternal hypothyroxinemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/maternal-thyroid-function","display_name":"maternal thyroid function","score":0.7490000128746033},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.7400000095367432},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.902999997138977},{"id":"https://openalex.org/keywords/response-speed","display_name":"response speed","score":0.6809999942779541},{"id":"https://openalex.org/keywords/reaction-time","display_name":"reaction time","score":0.8360000252723694},{"id":"https://openalex.org/keywords/response-inhibition","display_name":"response inhibition","score":0.6430000066757202},{"id":"https://openalex.org/keywords/visual-motor-skills","display_name":"visuomotor skills","score":0.8539999723434448},{"id":"https://openalex.org/keywords/response-selection","display_name":"response selection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/child-cognitive-performance","display_name":"child cognitive performance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.6489999890327454},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.6209999918937683},{"id":"https://openalex.org/keywords/prenatal-thyroid-hormone-exposure","display_name":"prenatal thyroid hormone exposure","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8996216654777527},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6982088685035706},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6656591296195984},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6290084719657898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6071953773498535},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.6054266095161438},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.5226345062255859},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4366966485977173},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.43093788623809814},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4207199811935425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3941075801849365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3790719509124756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07625865936279297},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D016241","descriptor_name":"Child of Impaired Parents","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1210/jc.2012-3389","doi":"https://doi.org/10.1210/jc.2012-3389","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2012-3389","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:tilburguniversity.edu:openaire_cris_publications/5c13b94b-0fc6-4ac7-8376-c67838c1495d","doi":null,"is_oa":false,"landing_page_url":"https://research.tilburguniversity.edu/en/publications/5c13b94b-0fc6-4ac7-8376-c67838c1495d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401490","display_name":"Research portal (Tilburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193700539","host_organization_name":"Tilburg University","host_organization_lineage":["https://openalex.org/I193700539"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Finken, M J J, van Eijsden, M, Loomans, E M, Vrijkotte, T G M & Rotteveel, J 2013, 'Maternal hypothyroxinemia in early pregnancy predicts reduced performance in reaction time tests in 5- to 6-year-old offspring', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 4, pp. 1417-1426. https://doi.org/10.1210/jc.2012-3389","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:23408575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23408575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/91a7e054-2fac-4b19-9ef2-b52fa0b21f57","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/91a7e054-2fac-4b19-9ef2-b52fa0b21f57","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Finken, M J J, van Eijsden, M, Loomans, E M, Vrijkotte, T G M & Rotteveel, J 2013, 'Maternal hypothyroxinemia in early pregnancy predicts reduced performance in reaction time tests in 5- to 6-year-old offspring', Journal of clinical endocrinology and metabolism, vol. 98, no. 4, pp. 1417-1426. https://doi.org/10.1210/jc.2012-3389","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d3e35781-b6c7-4572-ae47-504721e6d3b7","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/d3e35781-b6c7-4572-ae47-504721e6d3b7","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Finken, M J J, van Eijsden, M, Loomans, E M, Vrijkotte, T G M & Rotteveel, J 2013, 'Maternal Hypothyroxinemia in Early Pregnancy Predicts Reduced Performance in Reaction Time Tests in 5-to 6-Year-Old Offspring', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 4, pp. 1417-1426. https://doi.org/10.1210/jc.2012-3389","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvt:oai:tilburguniversity.edu:publications/5c13b94b-0fc6-4ac7-8376-c67838c1495d","doi":null,"is_oa":false,"landing_page_url":"https://research.tilburguniversity.edu/en/publications/5c13b94b-0fc6-4ac7-8376-c67838c1495d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Endocrinology and Metabolism, 98(4), 1417 - 1426. ENDOCRINE SOC","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/4ba4c58b-8937-4e36-899c-bc5ae245914a","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/maternal-hypothyroxinemia-in-early-pregnancy-predicts-reduced-performance-in-reaction-time-tests-in-5-to-6yearold-offspring(4ba4c58b-8937-4e36-899c-bc5ae245914a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of clinical endocrinology and metabolism, 98(4), 1417 - 1426. The Endocrine Society","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/d3e35781-b6c7-4572-ae47-504721e6d3b7","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/d3e35781-b6c7-4572-ae47-504721e6d3b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Endocrinology and Metabolism, 98(4), 1417 - 1426. The Endocrine Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","score":0.6200000047683716,"display_name":"No poverty"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1589270353","https://openalex.org/W1977677577","https://openalex.org/W1982665255","https://openalex.org/W1989898590","https://openalex.org/W2000822484","https://openalex.org/W2014703340","https://openalex.org/W2027794280","https://openalex.org/W2042324638","https://openalex.org/W2042842358","https://openalex.org/W2052693888","https://openalex.org/W2053164315","https://openalex.org/W2066397765","https://openalex.org/W2067989581","https://openalex.org/W2088426508","https://openalex.org/W2096550472","https://openalex.org/W2097728159","https://openalex.org/W2114529504","https://openalex.org/W2115056443","https://openalex.org/W2121794894","https://openalex.org/W2122237405","https://openalex.org/W2122447116","https://openalex.org/W2127701834","https://openalex.org/W2138527530","https://openalex.org/W2148883945","https://openalex.org/W2152279142","https://openalex.org/W2153203681","https://openalex.org/W2156715881","https://openalex.org/W2157581450","https://openalex.org/W2161291997","https://openalex.org/W2170972205","https://openalex.org/W2334882251","https://openalex.org/W2416307508","https://openalex.org/W4240837091"],"related_works":["https://openalex.org/W2496469184","https://openalex.org/W2016258313","https://openalex.org/W1996322489","https://openalex.org/W2105558110","https://openalex.org/W4237091814","https://openalex.org/W2133577258","https://openalex.org/W1980117820","https://openalex.org/W1982821560","https://openalex.org/W1984669348","https://openalex.org/W2954242942"],"abstract_inverted_index":{"CONTEXT:":[0],"Overt":[1],"hypothyroidism":[2],"in":[3,11,24,32,69,166,185,202,252,255],"pregnant":[4],"women":[5],"is":[6],"associated":[7,173,197],"with":[8,174,198,229],"poorer":[9],"neurodevelopment":[10],"their":[12,73,109],"children.":[13],"Findings":[14],"from":[15,103],"studies":[16],"investigating":[17],"the":[18,25,62,65,94,104,167,239,242],"effect":[19,63,218],"of":[20,41,45,64,82,96,125,170,219,241,262],"less":[21],"severe":[22],"impairments":[23],"maternal":[26,66,163,234],"thyroid":[27,67],"function":[28],"on":[29,72,221,226],"cognitive":[30,47,75],"functioning":[31],"offspring":[33,256],"are":[34],"difficult":[35],"to":[36,60,79,100,130,259],"interpret":[37],"for":[38,211],"a":[39,89,121,141,175,186,199],"number":[40],"reasons,":[42],"including":[43],"lack":[44],"objective":[46],"tests,":[48],"preschool":[49],"age":[50,124],"at":[51,77,120,238,257],"assessment,":[52],"and":[53,108,116,156,214,249],"small":[54],"sample":[55],"sizes.":[56],"OBJECTIVE:":[57],"We":[58],"aimed":[59],"assess":[61],"status":[68],"early":[70],"pregnancy":[71],"offspring's":[74],"performance":[76,137],"5":[78,258],"6":[80,260],"years":[81,261],"age.":[83,263],"DESIGN":[84],"AND":[85],"PARTICIPANTS:":[86],"This":[87],"was":[88,138,172,195,224],"prospective":[90],"study":[91],"that":[92,145],"included":[93],"data":[95],"1765":[97],"healthy":[98],"5-":[99],"6-year-old":[101],"children":[102],"Amsterdam":[105],"Born":[106],"Children":[107],"Development":[110],"study.":[111],"Maternal":[112,160],"serum":[113],"free":[114,164,235],"T4":[115,165,236],"TSH":[117,230],"were":[118],"obtained":[119],"median":[122],"gestational":[123],"90":[126],"(interquartile":[127],"range,":[128],"83":[129],"100)":[131],"days.":[132],"MAIN":[133],"OUTCOME":[134],"MEASURES:":[135],"Cognitive":[136],"tested":[139],"using":[140],"computerized":[142],"assessment":[143],"program":[144],"measured":[146],"response":[147,149,154,157,183,203,247,253],"speed,":[148],"speed":[150,184,248,254],"stability,":[151],"visuomotor":[152],"skills,":[153],"selection,":[155],"inhibition.":[158],"RESULTS:":[159],"hypothyroxinemia":[161,220],"(ie,":[162],"lowest":[168],"10%":[169],"distribution)":[171],"41.3":[176],"(95%":[177],"confidence":[178],"interval,":[179],"20.3-62.4)":[180],"ms":[181],"slower":[182,246],"simple":[187],"reaction":[188],"time":[189],"task.":[190],"In":[191],"this":[192],"test,":[193],"it":[194],"also":[196],"decreased":[200,250],"stability":[201,251],"speed.":[204],"The":[205,217],"relations":[206],"found":[207],"persisted":[208],"after":[209],"adjustment":[210],"family":[212],"background":[213],"perinatal":[215],"conditions.":[216],"these":[222],"outcomes":[223],"dependent":[225],"its":[227],"interaction":[228],"level.":[231],"CONCLUSIONS:":[232],"Lower":[233],"concentration":[237],"end":[240],"first":[243],"trimester":[244],"predicted":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}