{"id":"https://openalex.org/W2139335516","doi":"https://doi.org/10.1016/j.ad.2014.09.001","title":"Assessment of the Efficacy and Safety of a Combination of 2 Topical Retinoids (RetinSphere) in Maintaining Post-Treatment Response of Acne to Oral Isotretinoin","display_name":"Assessment of the Efficacy and Safety of a Combination of 2 Topical Retinoids (RetinSphere) in Maintaining Post-Treatment Response of Acne to Oral Isotretinoin","publication_year":2014,"publication_date":"2014-10-11","ids":{"openalex":"https://openalex.org/W2139335516","doi":"https://doi.org/10.1016/j.ad.2014.09.001","mag":"2139335516","pmid":"https://pubmed.ncbi.nlm.nih.gov/25306870"},"language":"en","primary_location":{"id":"doi:10.1016/j.ad.2014.09.001","doi":"https://doi.org/10.1016/j.ad.2014.09.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ad.2014.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S2755888424","display_name":"Actas Dermo-Sifiliogr\u00e1ficas","issn_l":"0001-7310","issn":["0001-7310","1578-2190","1695-4734"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Actas Dermo-Sifiliogr\u00e1ficas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014031829","display_name":"Maria Teresa Truchuelo","orcid":"https://orcid.org/0000-0002-9691-0476","observed_orcids":["https://orcid.org/0000-0002-9691-0476"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M.T. Truchuelo","raw_affiliation_strings":["University Ram\u00f3n y Cajal Hospital, Madrid, Spain. Electronic address: maytetd@yahoo.es","University Ram\u00f3n y Cajal Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Ram\u00f3n y Cajal Hospital, Madrid, Spain. Electronic address: maytetd@yahoo.es","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"University Ram\u00f3n y Cajal Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085929090","display_name":"Natalia Jim\u00e9nez","orcid":"https://orcid.org/0000-0003-3376-9660","observed_orcids":["https://orcid.org/0000-0003-3376-9660"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N. Jim\u00e9nez","raw_affiliation_strings":["University Ram\u00f3n y Cajal Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Ram\u00f3n y Cajal Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112679384","display_name":"Daudi R. Mavura","orcid":"https://orcid.org/0000-0002-4637-7239","observed_orcids":["https://orcid.org/0000-0002-4637-7239"]},"institutions":[{"id":"https://openalex.org/I4210136876","display_name":"Kilimanjaro Christian Medical Centre","ror":"https://ror.org/04knhza04","country_code":"TZ","type":"healthcare","lineage":["https://openalex.org/I4210136876"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"D. Mavura","raw_affiliation_strings":["Regional Dermatology Training Centre Kilimanjaro Christion Medical Center, Moshi, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Dermatology Training Centre Kilimanjaro Christion Medical Center, Moshi, Tanzania","institution_ids":["https://openalex.org/I4210136876"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061250464","display_name":"Pedro Ja\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Ja\u00e9n","raw_affiliation_strings":["University Ram\u00f3n y Cajal Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Ram\u00f3n y Cajal Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210161852"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014031829"],"corresponding_institution_ids":["https://openalex.org/I4210161852"],"apc_list":{"value":2080,"currency":"USD","value_usd":2080},"apc_paid":null,"fwci":0.3422,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.58418923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"106","issue":"2","first_page":"126","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-retinoids","display_name":"topical retinoids","score":0.9350000023841858},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.8019999861717224},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acne-relapse","display_name":"acne relapse","score":0.6740000247955322},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.781000018119812},{"id":"https://openalex.org/keywords/lesion-count","display_name":"lesion count","score":0.546999990940094},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.5410000085830688},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776285725","wikidata":"https://www.wikidata.org/wiki/Q287029","display_name":"Isotretinoin","level":3,"score":0.9317431449890137},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8966293334960938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7395752668380737},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6916680335998535},{"id":"https://openalex.org/C2777140388","wikidata":"https://www.wikidata.org/wiki/Q352348","display_name":"Adapalene","level":5,"score":0.4107142686843872},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08602261543273926},{"id":"https://openalex.org/C2778885487","wikidata":"https://www.wikidata.org/wiki/Q411424","display_name":"Benzoyl peroxide","level":4,"score":0.04314124584197998},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060046","descriptor_name":"Maintenance Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ad.2014.09.001","doi":"https://doi.org/10.1016/j.ad.2014.09.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ad.2014.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S2755888424","display_name":"Actas Dermo-Sifiliogr\u00e1ficas","issn_l":"0001-7310","issn":["0001-7310","1578-2190","1695-4734"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Actas Dermo-Sifiliogr\u00e1ficas","raw_type":"journal-article"},{"id":"pmid:25306870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25306870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Actas dermo-sifiliograficas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W73624071","https://openalex.org/W1498225944","https://openalex.org/W1505438741","https://openalex.org/W1894495389","https://openalex.org/W1953690218","https://openalex.org/W1969067090","https://openalex.org/W2001937481","https://openalex.org/W2018910750","https://openalex.org/W2041976282","https://openalex.org/W2043157381","https://openalex.org/W2055610347","https://openalex.org/W2058499720","https://openalex.org/W2069107618","https://openalex.org/W2073711421","https://openalex.org/W2116713827","https://openalex.org/W2128264864","https://openalex.org/W2146675394","https://openalex.org/W2150501649","https://openalex.org/W2154047770","https://openalex.org/W2288811259","https://openalex.org/W2972048158","https://openalex.org/W6629795827"],"related_works":["https://openalex.org/W2279590686","https://openalex.org/W2150501649","https://openalex.org/W2018910750","https://openalex.org/W4413877459","https://openalex.org/W4211052360","https://openalex.org/W2116713827","https://openalex.org/W7035345548","https://openalex.org/W2109196389","https://openalex.org/W4382499861","https://openalex.org/W1971557841"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}