{"id":"https://openalex.org/W2139331206","doi":"https://doi.org/10.1186/1748-717x-6-56","title":"Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells","display_name":"Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells","publication_year":2011,"publication_date":"2011-05-30","ids":{"openalex":"https://openalex.org/W2139331206","doi":"https://doi.org/10.1186/1748-717x-6-56","mag":"2139331206","pmid":"https://pubmed.ncbi.nlm.nih.gov/21624128","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123574"},"language":"en","primary_location":{"id":"doi:10.1186/1748-717x-6-56","doi":"https://doi.org/10.1186/1748-717x-6-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-56","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-56","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-56","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071677886","display_name":"Chia\u2010Yuan Liu","orcid":"https://orcid.org/0000-0001-9752-4430","observed_orcids":["https://orcid.org/0000-0001-9752-4430"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Yuan Liu","raw_affiliation_strings":["Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088487","display_name":"Hsun\u2010Shuo Chang","orcid":"https://orcid.org/0000-0003-2745-139X","observed_orcids":["https://orcid.org/0000-0003-2745-139X"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsun-Shuo Chang","raw_affiliation_strings":["Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065659619","display_name":"Ih\u2010Sheng Chen","orcid":"https://orcid.org/0000-0002-9191-6529","observed_orcids":["https://orcid.org/0000-0002-9191-6529"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ih-Sheng Chen","raw_affiliation_strings":["Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607320","display_name":"Chih\u2010Jen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Jen Chen","raw_affiliation_strings":["Section of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103417835","display_name":"Ming-Ling Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Ling Hsu","raw_affiliation_strings":["Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043985731","display_name":"Shu\u2010Ling Fu","orcid":"https://orcid.org/0000-0003-2895-225X","observed_orcids":["https://orcid.org/0000-0003-2895-225X"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shu-Ling Fu","raw_affiliation_strings":["Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100731675","display_name":"Yu-Jen Chen","orcid":"https://orcid.org/0000-0001-9794-8938","observed_orcids":["https://orcid.org/0000-0001-9794-8938","https://orcid.org/0000-0002-1953-4614"]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu-Jen Chen","raw_affiliation_strings":["Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan","Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan","Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043985731","https://openalex.org/A5100731675","https://openalex.org/A5111607320"],"corresponding_institution_ids":["https://openalex.org/I2802753785","https://openalex.org/I4387156312"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":1.526,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.79275256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"56","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/costunolide","display_name":"costunolide","score":1.0},{"id":"https://openalex.org/keywords/sesquiterpene-lactones","display_name":"sesquiterpene lactones","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.953000009059906},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9929999709129333},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.875},{"id":"https://openalex.org/keywords/histone-h3-phosphorylation","display_name":"histone H3 phosphorylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cdc25c","display_name":"Cdc25C","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7187638282775879},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6402901411056519},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6053878664970398},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5414526462554932},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.5256482362747192},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.504226565361023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4418541193008423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4361153841018677},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.4332893490791321},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3984167277812958},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3371715545654297},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32862621545791626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12356087565422058}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D029562","descriptor_name":"Magnoliaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1748-717x-6-56","doi":"https://doi.org/10.1186/1748-717x-6-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-56","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-56","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2139787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21624128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21624128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation oncology (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3123574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3123574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiat Oncol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.290.2557","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.2557","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/00/a4/Radiat_Oncol_2011_May_30_6_56.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:39e03b2c0b874c5eb2c620f7d0043eab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/39e03b2c0b874c5eb2c620f7d0043eab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Radiation Oncology, Vol 6, Iss 1, p 56 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1748-717x-6-56","doi":"https://doi.org/10.1186/1748-717x-6-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-56","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-56","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139331206.pdf","grobid_xml":"https://content.openalex.org/works/W2139331206.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W120664136","https://openalex.org/W1968060268","https://openalex.org/W1981052658","https://openalex.org/W1994193851","https://openalex.org/W2004765046","https://openalex.org/W2006109398","https://openalex.org/W2015751526","https://openalex.org/W2024477087","https://openalex.org/W2029055742","https://openalex.org/W2037789689","https://openalex.org/W2043152000","https://openalex.org/W2044772744","https://openalex.org/W2046653234","https://openalex.org/W2082297130","https://openalex.org/W2082427958","https://openalex.org/W2096592126","https://openalex.org/W2101995865","https://openalex.org/W2122622542","https://openalex.org/W2126505493","https://openalex.org/W2134648911","https://openalex.org/W2135712365","https://openalex.org/W2137493748","https://openalex.org/W2151463580","https://openalex.org/W2154745425","https://openalex.org/W2158179506","https://openalex.org/W2164792557","https://openalex.org/W4232711777","https://openalex.org/W4243964059","https://openalex.org/W4244944373","https://openalex.org/W4302561293"],"related_works":["https://openalex.org/W7099702824","https://openalex.org/W2289927885","https://openalex.org/W2903935909","https://openalex.org/W2057643815","https://openalex.org/W3013063052","https://openalex.org/W7006761181","https://openalex.org/W6939479327","https://openalex.org/W3132000767","https://openalex.org/W2401735392","https://openalex.org/W3005073422"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"work":[2],"aimed":[3],"to":[4,180,188],"investigate":[5],"the":[6,92,148,194,217],"effect":[7,219],"of":[8,23,47,69,72,94,133,150,207,220],"costunolide,":[9],"a":[10,99],"sesquiterpene":[11],"lactone":[12],"isolated":[13],"from":[14],"Michelia":[15],"compressa,":[16],"on":[17],"cell":[18,37,40,73,198],"cycle":[19,41],"distribution":[20],"and":[21,61,79,119,163,196],"radiosensitivity":[22],"human":[24,223],"hepatocellular":[25],"carcinoma":[26],"(HCC)":[27],"cells.":[28,96,168,204,225],"METHODS:":[29],"The":[30,110],"assessment":[31],"used":[32],"in":[33,112,166,202],"this":[34,208],"study":[35],"included:":[36],"viability":[38,93,195],"assay,":[39],"analysis":[42],"by":[43,53,58,67,76,82,107],"DNA":[44,108],"histogram,":[45],"expression":[46,71,149],"phosphorylated":[48,113,151,155,159],"histone":[49,114],"H3":[50,115],"(Ser":[51,116,157],"10)":[52],"flow":[54],"cytometer,":[55],"mitotic":[56,64,120,173],"index":[57,121],"Liu's":[59],"stain":[60],"morphological":[62],"observation,":[63],"spindle":[65,136],"alignment":[66],"immunofluorescence":[68],"alpha-tubulin,":[70],"cycle-related":[74],"proteins":[75],"Western":[77],"blotting,":[78],"radiation":[80,182],"survival":[81],"clonogenic":[83],"assay.":[84],"RESULTS:":[85],"Our":[86],"results":[87],"show":[88],"that":[89],"costunolide":[90,175,215],"reduced":[91],"HA22T/VGH":[95,167,177],"It":[97],"caused":[98],"rapid":[100],"G2/M":[101],"arrest":[102,197],"at":[103,127,144,200],"4":[104],"hours":[105],"shown":[106],"histogram.":[109],"increase":[111],"10)-positive":[117],"cells":[118,124,141,179],"indicates":[122],"costunolide-treated":[123],"are":[125,142],"arrested":[126],"mitosis,":[128],"not":[129],"G2,":[130],"phase.":[131],"Immunofluorescence":[132],"alpha-tubulin":[134],"for":[135,211],"formation":[137],"further":[138],"demonstrated":[139],"these":[140],"halted":[143],"metaphase.":[145],"Costunolide":[146,191],"up-regulated":[147],"Chk2":[152],"(Thr":[153],"68),":[154],"Cdc25c":[156],"216),":[158],"Cdk1":[160],"(Tyr":[161],"15)":[162],"cyclin":[164],"B1":[165],"At":[169],"optimal":[170],"condition":[171],"causing":[172],"arrest,":[174],"sensitized":[176],"HCC":[178,224],"ionizing":[181],"with":[183],"sensitizer":[184],"enhancement":[185],"ratio":[186],"up":[187],"1.9.":[189],"CONCLUSIONS:":[190],"could":[192],"reduce":[193],"cycling":[199],"mitosis":[201],"hepatoma":[203],"Logical":[205],"exploration":[206],"mitosis-arresting":[209],"activity":[210],"cancer":[212],"therapeutics":[213],"shows":[214],"enhanced":[216],"killing":[218],"radiotherapy":[221],"against":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
