{"id":"https://openalex.org/W2139327784","doi":"https://doi.org/10.1038/sj.bjc.6605180","title":"MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition","display_name":"MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W2139327784","doi":"https://doi.org/10.1038/sj.bjc.6605180","mag":"2139327784","pmid":"https://pubmed.ncbi.nlm.nih.gov/19603033","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2720211"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6605180","doi":"https://doi.org/10.1038/sj.bjc.6605180","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605180","pdf_url":"https://www.nature.com/articles/6605180.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6605180.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085320682","display_name":"Xiu-Yun Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Ding","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA","Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052355807","display_name":"Azizah B. Mohd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Mohd","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97333, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97333, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102807732","display_name":"Zhiqing Huang","orcid":"https://orcid.org/0000-0002-0598-3742","observed_orcids":["https://orcid.org/0000-0002-0598-3742"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Huang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023191265","display_name":"Tsukasa Baba","orcid":"https://orcid.org/0000-0003-0066-3747","observed_orcids":["https://orcid.org/0000-0003-0066-3747"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Baba","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012995919","display_name":"Marcus Q. Bernardini","orcid":"https://orcid.org/0000-0001-7022-8308","observed_orcids":["https://orcid.org/0000-0001-7022-8308","https://orcid.org/0000-0002-8572-0271"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Q Bernardini","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804507","display_name":"Herbert Kim Lyerly","orcid":"https://orcid.org/0000-0002-0063-4770","observed_orcids":["https://orcid.org/0000-0002-0063-4770"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H K Lyerly","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA","Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038248146","display_name":"Andrew Berchuck","orcid":"https://orcid.org/0000-0002-1940-1467","observed_orcids":["https://orcid.org/0000-0002-1940-1467"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Berchuck","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233781","display_name":"Susan K. Murphy","orcid":"https://orcid.org/0000-0001-8298-7272","observed_orcids":["https://orcid.org/0000-0001-8298-7272"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S K Murphy","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089561047","display_name":"Andrew B. Buermeyer","orcid":"https://orcid.org/0000-0003-4502-4666","observed_orcids":["https://orcid.org/0000-0003-4502-4666"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Buermeyer","raw_affiliation_strings":["Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97333, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97333, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089632095","display_name":"Gayathri R. Devi","orcid":"https://orcid.org/0000-0001-9158-7289","observed_orcids":["https://orcid.org/0000-0001-9158-7289"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G R Devi","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA","Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, 27710, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089632095"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.9999,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.73417113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"2","first_page":"269","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mlh1","display_name":"MLH1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.7480000257492065},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7799999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.9240000247955322},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9269999861717224},{"id":"https://openalex.org/keywords/xiap-inhibitors","display_name":"XIAP inhibitors","score":0.6850000023841858},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6990000009536743},{"id":"https://openalex.org/keywords/platinum-sensitivity","display_name":"platinum sensitivity","score":0.4429999887943268},{"id":"https://openalex.org/keywords/dna-damage-induced-apoptosis","display_name":"DNA damage-induced apoptosis","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.9701926708221436},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7291933298110962},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6781331896781921},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6282846927642822},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.6122417449951172},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4661591947078705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44618552923202515},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43569421768188477},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3199824094772339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26766645908355713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07953542470932007},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07369700074195862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04007357358932495}],"mesh":[{"descriptor_ui":"D000070957","descriptor_name":"MutL Protein Homolog 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051745","descriptor_name":"Protein Kinase C-delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6605180","doi":"https://doi.org/10.1038/sj.bjc.6605180","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605180","pdf_url":"https://www.nature.com/articles/6605180.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2720211","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2720211","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:19603033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19603033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6605180","doi":"https://doi.org/10.1038/sj.bjc.6605180","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605180","pdf_url":"https://www.nature.com/articles/6605180.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2167607012","display_name":"Short-Term Research Training for Minority Students","funder_award_id":"T35ES007316","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4288126918","display_name":"Reducing Susceptibility to Environmental Stress Throughout the Life Span","funder_award_id":"P30ES000210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G453209877","display_name":null,"funder_award_id":"2P30 CA14236-33","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7740459127","display_name":"DNA Mismatch Repair Functions in Tumor Suppression","funder_award_id":"R01CA100906","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914840","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139327784.pdf","grobid_xml":"https://content.openalex.org/works/W2139327784.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W236091721","https://openalex.org/W1546310056","https://openalex.org/W1549582007","https://openalex.org/W1557686543","https://openalex.org/W1604468403","https://openalex.org/W1688621929","https://openalex.org/W1878572665","https://openalex.org/W1914367223","https://openalex.org/W1920968130","https://openalex.org/W1982640212","https://openalex.org/W1996627105","https://openalex.org/W1997743035","https://openalex.org/W2005996125","https://openalex.org/W2006491498","https://openalex.org/W2007625252","https://openalex.org/W2013801793","https://openalex.org/W2024437197","https://openalex.org/W2033175510","https://openalex.org/W2035523654","https://openalex.org/W2037898576","https://openalex.org/W2050202644","https://openalex.org/W2056571940","https://openalex.org/W2058346921","https://openalex.org/W2060087150","https://openalex.org/W2080156248","https://openalex.org/W2083065276","https://openalex.org/W2083574780","https://openalex.org/W2087522387","https://openalex.org/W2104979289","https://openalex.org/W2107466456","https://openalex.org/W2110922298","https://openalex.org/W2112331024","https://openalex.org/W2115027988","https://openalex.org/W2124291667","https://openalex.org/W2124295966","https://openalex.org/W2125202200","https://openalex.org/W2126273255","https://openalex.org/W2126787895","https://openalex.org/W2130929934","https://openalex.org/W2134564769","https://openalex.org/W2136652583","https://openalex.org/W2137075269","https://openalex.org/W2161508400","https://openalex.org/W2165679731","https://openalex.org/W2170989872","https://openalex.org/W2171530407","https://openalex.org/W2210983941","https://openalex.org/W2274012164","https://openalex.org/W2316994976"],"related_works":["https://openalex.org/W2006491498","https://openalex.org/W4238522762","https://openalex.org/W2104979289","https://openalex.org/W2908121199","https://openalex.org/W2137075269","https://openalex.org/W1515049248","https://openalex.org/W2198758502","https://openalex.org/W2165679731","https://openalex.org/W2057316225","https://openalex.org/W1968202270"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,107,162],"X-linked":[2],"inhibitor":[3],"of":[4,16,109,128,153,165,195],"apoptosis":[5,10,47],"protein":[6],"(XIAP),":[7],"an":[8,192],"endogenous":[9],"suppressor,":[11],"can":[12],"determine":[13],"the":[14,20,36,126],"level":[15],"caspase":[17],"accumulation":[18],"and":[19,53,70,97,146,158,170],"resultant":[21],"response":[22,66,89,143],"to":[23,44,67,90,137,144,190,198],"apoptosis-inducing":[24],"agents":[25],"such":[26],"as":[27],"cisplatin":[28,49,91,147],"in":[29,72,87,95,117,121,173,178],"epithelial":[30],"ovarian":[31],"cancer":[32],"(EOC).":[33],"In":[34,57,124],"addition,":[35,125],"mismatch":[37],"repair":[38],"protein,":[39],"hMLH1,":[40],"has":[41],"been":[42],"linked":[43],"DNA":[45],"damage-induced":[46],"by":[48,50,93],"both":[51],"p53-dependent":[52],"-independent":[54],"mechanisms.":[55],"METHODS:":[56],"this":[58],"study,":[59],"hMLH1":[60,130,132],"expression":[61],"was":[62,84,115,148],"correlated":[63],"with":[64,102,150,155],"clinical":[65],"platinum":[68],"drugs":[69],"survival":[71],"advanced":[73],"stage":[74],"(III-IV)":[75],"EOC":[76,99,197],"patients.":[77],"We":[78],"then":[79],"investigated":[80],"whether":[81],"MLH1":[82,168],"loss":[83],"a":[85,139],"determinant":[86],"anti-apoptosis":[88],"mediated":[92],"XIAP":[94,156,166,186],"isogenic":[96],"established":[98],"cell":[100,113,171],"lines":[101],"differential":[103],"p53":[104],"status.":[105],"RESULTS:":[106],"percentage":[108],"cells":[110,119,175],"undergoing":[111],"cisplatin-induced":[112],"killing":[114],"higher":[116],"MLH1-proficient":[118,174],"than":[120],"MLH1-defective":[122,179],"cells.":[123,180],"presence":[127],"wild-type":[129],"or":[131],"re-expression":[133],"significantly":[134],"increased":[135,159,167],"sensitivity":[136],"6-thioguanine,":[138],"MMR-dependent":[140],"agent.":[141],"Cell-death":[142],"6-thioguanine":[145],"associated":[149],"significant":[151],"proteolysis":[152,169],"MLH1,":[154],"destabilisation":[157],"caspase-3":[160],"activity.":[161],"siRNA-mediated":[163],"inhibition":[164],"death":[172],"but":[176],"not":[177],"CONCLUSION:":[181],"These":[182],"data":[183],"suggest":[184],"that":[185],"inhibitors":[187],"may":[188],"prove":[189],"be":[191],"effective":[193],"means":[194],"sensitising":[196],"MLH1-dependent":[199],"apoptosis.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}