{"id":"https://openalex.org/W2139306913","doi":"https://doi.org/10.1371/journal.pone.0103929","title":"Neurochemical Pathways That Converge on Thalamic Trigeminovascular Neurons: Potential Substrate for Modulation of Migraine by Sleep, Food Intake, Stress and Anxiety","display_name":"Neurochemical Pathways That Converge on Thalamic Trigeminovascular Neurons: Potential Substrate for Modulation of Migraine by Sleep, Food Intake, Stress and Anxiety","publication_year":2014,"publication_date":"2014-08-04","ids":{"openalex":"https://openalex.org/W2139306913","doi":"https://doi.org/10.1371/journal.pone.0103929","mag":"2139306913","pmid":"https://pubmed.ncbi.nlm.nih.gov/25090640","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4121288"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0103929","doi":"https://doi.org/10.1371/journal.pone.0103929","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103929","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103929&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103929&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063820823","display_name":"Rodrigo Noseda","orcid":"https://orcid.org/0000-0002-9641-4691","observed_orcids":["https://orcid.org/0000-0002-9641-4691"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rodrigo Noseda","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074532419","display_name":"Vanessa Kainz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Kainz","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091764355","display_name":"David Borsook","orcid":"https://orcid.org/0000-0001-9825-0064","observed_orcids":["https://orcid.org/0000-0001-9825-0064"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Borsook","raw_affiliation_strings":["Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016966448","display_name":"Rami Burstein","orcid":"https://orcid.org/0000-0003-3763-8916","observed_orcids":["https://orcid.org/0000-0003-3763-8916"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami Burstein","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063820823"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":8.142,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.98157221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"8","first_page":"e103929","last_page":"e103929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.996999979019165},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melanin-concentrating-hormone","display_name":"melanin-concentrating hormone","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.7490000128746033},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9229999780654907},{"id":"https://openalex.org/keywords/juxtacellular-labeling","display_name":"juxtacellular labeling","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7742294669151306},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6588028073310852},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6163992881774902},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5623548626899719},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.4875008761882782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4641382098197937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30875885486602783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2919257879257202},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19816023111343384},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007028","descriptor_name":"Hypothalamic Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010907","descriptor_name":"Pituitary Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014276","descriptor_name":"Trigeminal Nerve","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014276","descriptor_name":"Trigeminal Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0103929","doi":"https://doi.org/10.1371/journal.pone.0103929","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103929","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103929&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3092251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4121288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4121288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4121288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25090640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25090640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.778.2423","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.778.2423","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e8/ad/pone.0103929.PMC4121288.pdf","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/12785968","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:817e9bae51ba4f36a15b38d32b9ce483","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/817e9bae51ba4f36a15b38d32b9ce483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 8, p e103929 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1126774","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Neurochemical_Pathways_That_Converge_on_Thalamic_Trigeminovascular_Neurons_Potential_Substrate_for_Modulation_of_Migraine_by_Sleep_Food_Intake_Stress_and_Anxiety_/1126774","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0103929","doi":"https://doi.org/10.1371/journal.pone.0103929","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103929","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103929&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3826360290","display_name":"Migraine pathophysiology: neural basis of photophobia","funder_award_id":"R01NS069847","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6582778642","display_name":"Photophobia during migraine: sensory, autonomic and emotional responses to light","funder_award_id":"R37NS079678","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6947892713","display_name":null,"funder_award_id":"NS-079687","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G707981973","display_name":null,"funder_award_id":"NS-069847","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139306913.pdf"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W15724495","https://openalex.org/W106141043","https://openalex.org/W1510072837","https://openalex.org/W1593351428","https://openalex.org/W1627229807","https://openalex.org/W1717129987","https://openalex.org/W1748089690","https://openalex.org/W1925492557","https://openalex.org/W1964887266","https://openalex.org/W1966779141","https://openalex.org/W1973662774","https://openalex.org/W1975983146","https://openalex.org/W1978734924","https://openalex.org/W1980514806","https://openalex.org/W1980603718","https://openalex.org/W1980890656","https://openalex.org/W1981723438","https://openalex.org/W1983064584","https://openalex.org/W1989388706","https://openalex.org/W1999331745","https://openalex.org/W2003135603","https://openalex.org/W2004124667","https://openalex.org/W2007502604","https://openalex.org/W2010716926","https://openalex.org/W2011834223","https://openalex.org/W2012337379","https://openalex.org/W2015724371","https://openalex.org/W2018760402","https://openalex.org/W2020317313","https://openalex.org/W2021155819","https://openalex.org/W2022652751","https://openalex.org/W2024348439","https://openalex.org/W2026206644","https://openalex.org/W2027180375","https://openalex.org/W2027364088","https://openalex.org/W2027740042","https://openalex.org/W2028129568","https://openalex.org/W2028311911","https://openalex.org/W2028474222","https://openalex.org/W2030531431","https://openalex.org/W2035235513","https://openalex.org/W2036329827","https://openalex.org/W2037438491","https://openalex.org/W2037718442","https://openalex.org/W2039912069","https://openalex.org/W2041677480","https://openalex.org/W2042203667","https://openalex.org/W2042416616","https://openalex.org/W2043417320","https://openalex.org/W2044723823","https://openalex.org/W2049040467","https://openalex.org/W2054355200","https://openalex.org/W2055886910","https://openalex.org/W2057621737","https://openalex.org/W2058159881","https://openalex.org/W2059148567","https://openalex.org/W2059590710","https://openalex.org/W2062594256","https://openalex.org/W2063841851","https://openalex.org/W2066848874","https://openalex.org/W2069091630","https://openalex.org/W2069255967","https://openalex.org/W2075792889","https://openalex.org/W2076495702","https://openalex.org/W2080199045","https://openalex.org/W2080328272","https://openalex.org/W2081593252","https://openalex.org/W2082119274","https://openalex.org/W2085499630","https://openalex.org/W2085530639","https://openalex.org/W2085867569","https://openalex.org/W2086831790","https://openalex.org/W2086834867","https://openalex.org/W2092002730","https://openalex.org/W2092148703","https://openalex.org/W2092993997","https://openalex.org/W2094605937","https://openalex.org/W2094676587","https://openalex.org/W2100751279","https://openalex.org/W2101578047","https://openalex.org/W2110705999","https://openalex.org/W2112575206","https://openalex.org/W2113334587","https://openalex.org/W2114808045","https://openalex.org/W2120905598","https://openalex.org/W2121330405","https://openalex.org/W2123517430","https://openalex.org/W2124673755","https://openalex.org/W2128792120","https://openalex.org/W2129357751","https://openalex.org/W2129928127","https://openalex.org/W2129965045","https://openalex.org/W2135826809","https://openalex.org/W2137074423","https://openalex.org/W2137303544","https://openalex.org/W2137422526","https://openalex.org/W2143609607","https://openalex.org/W2150442066","https://openalex.org/W2160442886","https://openalex.org/W2162347612","https://openalex.org/W2163815564","https://openalex.org/W2163934970","https://openalex.org/W2164701017","https://openalex.org/W2165892338","https://openalex.org/W2166745166","https://openalex.org/W2167169236","https://openalex.org/W2171502806","https://openalex.org/W2329765567","https://openalex.org/W2400800457"],"related_works":["https://openalex.org/W2613194071","https://openalex.org/W2036329827","https://openalex.org/W2022652751","https://openalex.org/W2034764120","https://openalex.org/W3090360480","https://openalex.org/W2113334587","https://openalex.org/W635707911","https://openalex.org/W4306770629","https://openalex.org/W2052886821","https://openalex.org/W2433934516"],"abstract_inverted_index":{"Dynamic":[0],"thalamic":[1,24,68,93,115],"regulation":[2],"of":[3,99,123,127,135,143,166,174],"sensory":[4],"signals":[5,177],"allows":[6],"the":[7,164,168,172,179,182],"cortex":[8,183],"to":[9,12,30,52,91,181,200],"adjust":[10],"better":[11],"rapidly":[13],"changing":[14,32],"behavioral,":[15,203],"physiological":[16],"and":[17,45,74,109,131,139,147,205],"environmental":[18],"demands.":[19],"To":[20,78],"fulfill":[21],"this":[22,81],"role,":[23],"neurons":[25,117],"must":[26],"themselves":[27],"be":[28,185],"subjected":[29],"constantly":[31],"modulatory":[33],"inputs":[34],"that":[35,114,171,193],"originate":[36],"in":[37,42,88],"multiple":[38],"neurochemical":[39],"pathways":[40],"involved":[41],"autonomic,":[43],"affective":[44],"cognitive":[46,204],"functions.":[47],"Our":[48],"overall":[49],"goal":[50],"is":[51,62],"define":[53],"an":[54],"anatomical":[55],"framework":[56],"for":[57,71],"conceptualizing":[58],"how":[59,72],"a":[60,66,89,97],"'decision'":[61],"made":[63],"on":[64],"whether":[65],"trigeminovascular":[67,94,116],"neuron":[69],"fires,":[70],"long,":[73],"at":[75],"what":[76],"frequency.":[77],"begin":[79],"answering":[80],"question,":[82],"we":[83,112],"determine":[84],"which":[85],"neuropeptides/neurotransmitters":[86],"are":[87,194],"position":[90],"modulate":[92],"neurons.":[95],"Using":[96],"combination":[98],"in-vivo":[100],"single-unit":[101],"recording,":[102],"juxtacellular":[103],"labeling":[104],"with":[105],"tetramethylrhodamine":[106],"dextran":[107],"(TMR)":[108],"in-vitro":[110],"immunohistochemistry,":[111],"found":[113],"were":[118],"surrounded":[119],"by":[120,187,196],"high":[121],"density":[122,134,142],"axons":[124,136,144,154],"containing":[125,137,145,155],"biomarkers":[126],"glutamate,":[128],"GABA,":[129],"dopamine":[130],"serotonin;":[132],"moderate":[133],"noradrenaline":[138],"histamine;":[140],"low":[141],"orexin":[146],"melanin":[148],"concentrating":[149],"hormone":[150],"(MCH);":[151],"but":[152],"not":[153],"CGRP,":[156],"serotonin":[157],"1D":[158],"receptor,":[159],"oxytocin":[160],"or":[161],"vasopressin.":[162],"In":[163],"context":[165],"migraine,":[167],"findings":[169],"suggest":[170],"transmission":[173],"headache-related":[175],"nociceptive":[176],"from":[178],"thalamus":[180],"may":[184],"modulated":[186],"opposing":[188],"forces":[189],"(i.e.,":[190],"facilitatory,":[191],"inhibitory)":[192],"governed":[195],"continuous":[197],"adjustments":[198],"needed":[199],"keep":[201],"physiological,":[202],"emotional":[206],"homeostasis.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}