{"id":"https://openalex.org/W2139305702","doi":null,"title":"Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal.","display_name":"Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal.","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2139305702","mag":"2139305702","pmid":"https://pubmed.ncbi.nlm.nih.gov/20388955"},"language":"en","primary_location":{"id":"pmid:20388955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20388955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061869584","display_name":"Yuji Naito","orcid":"https://orcid.org/0000-0001-5443-788X","observed_orcids":["https://orcid.org/0000-0001-5443-788X"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Naito","raw_affiliation_strings":["Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan. ynaito@koto.kpu-m.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan. ynaito@koto.kpu-m.ac.jp","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043670524","display_name":"Tomohisa Takagi","orcid":"https://orcid.org/0000-0002-6119-4828","observed_orcids":["https://orcid.org/0000-0002-6119-4828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Takagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057254057","display_name":"Tomoko Oya\u2010Ito","orcid":"https://orcid.org/0000-0001-6921-4566","observed_orcids":["https://orcid.org/0000-0001-6921-4566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Oya-Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055955455","display_name":"Hitomi Okada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Okada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088432056","display_name":"Takahiro Suzuki","orcid":"https://orcid.org/0000-0001-6179-0614","observed_orcids":["https://orcid.org/0000-0001-6179-0614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110784358","display_name":"Ikuhiro Hirata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Hirata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Hirai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Hirai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084648926","display_name":"Kazuhiko Uchiyama","orcid":"https://orcid.org/0000-0001-5210-167X","observed_orcids":["https://orcid.org/0000-0001-5210-167X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Uchiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059287690","display_name":"Osamu Handa","orcid":"https://orcid.org/0000-0003-2228-0405","observed_orcids":["https://orcid.org/0000-0003-2228-0405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Handa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055822025","display_name":"K\u00f4ji Uchida","orcid":"https://orcid.org/0000-0003-3894-5299","observed_orcids":["https://orcid.org/0000-0003-3894-5299","https://orcid.org/0000-0003-2029-1768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Uchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108522725","display_name":"Toshikazu Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yoshikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5956,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77768526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"60 Suppl 7","issue":null,"first_page":"123","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gastric-ulcer-healing","display_name":"gastric ulcer healing","score":0.8130000233650208},{"id":"https://openalex.org/keywords/peroxiredoxin-6","display_name":"peroxiredoxin 6","score":0.9179999828338623},{"id":"https://openalex.org/keywords/argpyrimidine","display_name":"argpyrimidine","score":0.6570000052452087},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acetic-acid-induced-gastric-ulcer","display_name":"acetic acid-induced gastric ulcer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dicarbonyl-compounds","display_name":"dicarbonyl compounds","score":0.753000020980835},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6290000081062317},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2778592357","wikidata":"https://www.wikidata.org/wiki/Q903881","display_name":"Methylglyoxal","level":3,"score":0.9944459795951843},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6928181648254395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5201480984687805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5187128186225891},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5055422782897949},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4879898428916931},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.48098886013031006},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4668107032775879},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45501792430877686},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4480672776699066},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.43711942434310913},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.42955368757247925},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37294313311576843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34614986181259155},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17366039752960205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15517958998680115},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09990426898002625}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011765","descriptor_name":"Pyruvaldehyde","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011765","descriptor_name":"Pyruvaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013830","descriptor_name":"Thiadiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053778","descriptor_name":"Thiazolidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054465","descriptor_name":"Peroxiredoxin VI","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054465","descriptor_name":"Peroxiredoxin VI","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20388955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20388955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2139305702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20388955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W12798589","https://openalex.org/W75294861","https://openalex.org/W346850762","https://openalex.org/W1968609884","https://openalex.org/W1976685070","https://openalex.org/W1980643281","https://openalex.org/W1988913833","https://openalex.org/W1993143422","https://openalex.org/W1995002748","https://openalex.org/W2002654604","https://openalex.org/W2009938201","https://openalex.org/W2017947908","https://openalex.org/W2019122701","https://openalex.org/W2044864054","https://openalex.org/W2051205138","https://openalex.org/W2059804383","https://openalex.org/W2066098276","https://openalex.org/W2082487229","https://openalex.org/W2095224264","https://openalex.org/W2123748067","https://openalex.org/W2131569045","https://openalex.org/W2143118702","https://openalex.org/W2143372650","https://openalex.org/W2143573248","https://openalex.org/W2318776101"],"related_works":["https://openalex.org/W2153448761","https://openalex.org/W2364281932","https://openalex.org/W2614770231","https://openalex.org/W1976685070","https://openalex.org/W1987764743","https://openalex.org/W2340768617","https://openalex.org/W3030889939","https://openalex.org/W2018232602","https://openalex.org/W2095092413","https://openalex.org/W7171653682"],"abstract_inverted_index":{"Methylglyoxal":[0],"is":[1],"a":[2,54,68,210],"reactive":[3],"dicarbonyl":[4],"compound":[5],"produced":[6,78],"from":[7],"cellular":[8],"glycolytic":[9],"intermediates":[10],"that":[11],"reacts":[12],"non-enzymatically":[13],"with":[14,169,202],"proteins":[15,52,184,217],"to":[16,32,48,88,97,148,221],"form":[17],"products":[18],"such":[19],"as":[20,53],"argpyrimidine":[21],"at":[22],"arginine":[23],"residue.":[24],"The":[25,133],"aim":[26],"of":[27,36,42,57,72,83,85,92,101,105,131,135,181,212,216,235,238,244],"the":[28,34,39,50,80,89,93,99,129,167,179,186,200,206,222,232,236,242],"present":[29,207],"study":[30,208],"was":[31,65,141,163,196],"investigate":[33],"role":[35],"methylglyoxal":[37,106,214,239],"in":[38,45,144,157,160,185,227],"delayed":[40,152,223],"healing":[41,226],"gastric":[43,75,109,136,188,191,224,246],"ulcer":[44,110,137,153,158,225],"diabetes,":[46,228],"and":[47,74,127,193,229],"identify":[49],"methylglyoxal-modified":[51],"target":[55],"molecule":[56],"this":[58,194],"modification.":[59],"Using":[60],"male":[61],"C57BL/6":[62],"mice,":[63,150],"diabetes":[64],"induced":[66],"by":[67,79,166,199],"single":[69],"i.p.":[70],"injection":[71,130],"streptozotocin":[73],"ulcers":[76],"were":[77,113],"focal":[81],"application":[82],"40%":[84],"acetic":[86],"acid":[87],"serosal":[90],"surface":[91],"stomach.":[94],"In":[95,204],"order":[96],"evaluate":[98],"effect":[100],"OPB-9195,":[102],"an":[103],"inhibitor":[104,237],"modification,":[107],"on":[108,138],"healing,":[111],"mice":[112,146,162],"given":[114],"orally":[115],"OPB-9195":[116,170],"(30":[117],"mg/kg)":[118],"twice":[119],"daily":[120],"for":[121,241],"14":[122],"days,":[123],"one":[124],"week":[125],"before":[126],"after":[128],"streptozotocin.":[132],"area":[134,159],"day":[139],"7":[140],"significantly":[142,164],"increased":[143,213],"diabetic":[145,161,187,245],"compared":[147],"non-diabetic":[149],"indicating":[151],"healing.":[154],"This":[155],"increase":[156],"reversed":[165],"treatment":[168,201,243],"without":[171],"affecting":[172],"blood":[173],"glucose":[174],"levels.":[175],"Proteomics":[176],"analysis":[177],"showed":[178],"methylglyoxal-modification":[180],"peroxiredoxin":[182,219],"6":[183,220],"mucosa":[189],"around":[190],"ulcer,":[192],"modification":[195,215,240],"markedly":[197],"inhibited":[198],"OPB-9195.":[203],"conclusion,":[205],"suggests":[209],"link":[211],"including":[218],"also":[230],"shows":[231],"therapeutic":[233],"potential":[234],"ulcers.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
