{"id":"https://openalex.org/W2139290108","doi":"https://doi.org/10.2174/138920010794328869","title":"Influence of Dietary Substances on Intestinal Drug Metabolism and Transport","display_name":"Influence of Dietary Substances on Intestinal Drug Metabolism and Transport","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W2139290108","doi":"https://doi.org/10.2174/138920010794328869","mag":"2139290108","pmid":"https://pubmed.ncbi.nlm.nih.gov/21189136"},"language":"en","primary_location":{"id":"doi:10.2174/138920010794328869","doi":"https://doi.org/10.2174/138920010794328869","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920010794328869","pdf_url":"http://www.eurekaselect.com/article/13034","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/13034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018111384","display_name":"Christina S. Won","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina S. Won","raw_affiliation_strings":["Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569, USA","Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7569, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7569, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011810695","display_name":"Nicholas H. Oberlies","orcid":"https://orcid.org/0000-0002-0354-8464","observed_orcids":["https://orcid.org/0000-0002-0354-8464"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas H. Oberlies","raw_affiliation_strings":["Department of Chemistry and Biochemistry , University of North Carolina at Greensboro , Greensboro , NC 27402-6170 USA","Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402-6170 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry , University of North Carolina at Greensboro , Greensboro , NC 27402-6170 USA","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402-6170 USA","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083433629","display_name":"Mary F. Paine","orcid":"https://orcid.org/0000-0002-3331-1839","observed_orcids":["https://orcid.org/0000-0002-3331-1839"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary F. Paine","raw_affiliation_strings":["Division of Pharmacotherapy and Experimental Therapeutics , Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7569 USA","Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics , Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7569 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569 USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083433629"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":4.1668,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.93189491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"9","first_page":"778","last_page":"792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-drug-metabolism","display_name":"intestinal drug metabolism","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intestinal-drug-transport","display_name":"intestinal drug transport","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fruit-juice","display_name":"fruit juice","score":0.7720000147819519},{"id":"https://openalex.org/keywords/grapefruit-juice","display_name":"grapefruit juice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp3a-inhibition","display_name":"CYP3A inhibition","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cranberry-juice","display_name":"cranberry juice","score":0.8500000238418579},{"id":"https://openalex.org/keywords/orange-juice","display_name":"orange juice","score":0.5329999923706055},{"id":"https://openalex.org/keywords/esterase","display_name":"esterase","score":0.578000009059906},{"id":"https://openalex.org/keywords/sulfotransferase","display_name":"sulfotransferase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6763615012168884},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5919238924980164},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.5323513150215149},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5062800645828247},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.48364317417144775},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.46506670117378235},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.44798097014427185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.447584331035614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38806506991386414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3106345534324646},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/138920010794328869","doi":"https://doi.org/10.2174/138920010794328869","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920010794328869","pdf_url":"http://www.eurekaselect.com/article/13034","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmid:21189136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21189136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3034088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Curr Drug Metab","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2174/138920010794328869","doi":"https://doi.org/10.2174/138920010794328869","is_oa":true,"landing_page_url":"https://doi.org/10.2174/138920010794328869","pdf_url":"http://www.eurekaselect.com/article/13034","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4340343398","display_name":null,"funder_award_id":"R01 GM077482","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000138430","display_name":null,"funder_award_id":"R01 GM077482","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139290108.pdf","grobid_xml":"https://content.openalex.org/works/W2139290108.grobid-xml"},"referenced_works_count":176,"referenced_works":["https://openalex.org/W12336950","https://openalex.org/W19162607","https://openalex.org/W133504488","https://openalex.org/W170367701","https://openalex.org/W188682155","https://openalex.org/W610377616","https://openalex.org/W1507209789","https://openalex.org/W1508531867","https://openalex.org/W1571439721","https://openalex.org/W1574320663","https://openalex.org/W1577340174","https://openalex.org/W1581747141","https://openalex.org/W1593292368","https://openalex.org/W1736805871","https://openalex.org/W1783939843","https://openalex.org/W1805104149","https://openalex.org/W1870905795","https://openalex.org/W1875260420","https://openalex.org/W1963543020","https://openalex.org/W1967690927","https://openalex.org/W1968235034","https://openalex.org/W1968570995","https://openalex.org/W1970359870","https://openalex.org/W1971075428","https://openalex.org/W1971435003","https://openalex.org/W1974574813","https://openalex.org/W1975655486","https://openalex.org/W1976254032","https://openalex.org/W1978638504","https://openalex.org/W1978681746","https://openalex.org/W1983143306","https://openalex.org/W1984494391","https://openalex.org/W1984788901","https://openalex.org/W1985343529","https://openalex.org/W1985731196","https://openalex.org/W1985949266","https://openalex.org/W1988641769","https://openalex.org/W1988678216","https://openalex.org/W1991048885","https://openalex.org/W1991072079","https://openalex.org/W1991103860","https://openalex.org/W1996271918","https://openalex.org/W1997024394","https://openalex.org/W1997545624","https://openalex.org/W1997987760","https://openalex.org/W1998183843","https://openalex.org/W1999021046","https://openalex.org/W2001062722","https://openalex.org/W2001783064","https://openalex.org/W2003556240","https://openalex.org/W2008135430","https://openalex.org/W2011801812","https://openalex.org/W2012290584","https://openalex.org/W2012621927","https://openalex.org/W2013822904","https://openalex.org/W2014002195","https://openalex.org/W2015782988","https://openalex.org/W2017498050","https://openalex.org/W2017644723","https://openalex.org/W2019215800","https://openalex.org/W2021399896","https://openalex.org/W2021986001","https://openalex.org/W2023731023","https://openalex.org/W2028657603","https://openalex.org/W2031096662","https://openalex.org/W2031627853","https://openalex.org/W2032069645","https://openalex.org/W2032217537","https://openalex.org/W2034615747","https://openalex.org/W2035019909","https://openalex.org/W2035309742","https://openalex.org/W2036206567","https://openalex.org/W2042250774","https://openalex.org/W2043056355","https://openalex.org/W2044814201","https://openalex.org/W2044868753","https://openalex.org/W2045070031","https://openalex.org/W2045567622","https://openalex.org/W2046336496","https://openalex.org/W2046788693","https://openalex.org/W2046874836","https://openalex.org/W2048106894","https://openalex.org/W2055274038","https://openalex.org/W2057409619","https://openalex.org/W2059142487","https://openalex.org/W2061248294","https://openalex.org/W2063194647","https://openalex.org/W2064401742","https://openalex.org/W2069544769","https://openalex.org/W2071190197","https://openalex.org/W2072044044","https://openalex.org/W2073981836","https://openalex.org/W2074179782","https://openalex.org/W2075854392","https://openalex.org/W2076194172","https://openalex.org/W2076993862","https://openalex.org/W2077510533","https://openalex.org/W2078592585","https://openalex.org/W2080003869","https://openalex.org/W2081329598","https://openalex.org/W2081583413","https://openalex.org/W2083654973","https://openalex.org/W2086883786","https://openalex.org/W2089363473","https://openalex.org/W2090386521","https://openalex.org/W2091249983","https://openalex.org/W2093611658","https://openalex.org/W2096784741","https://openalex.org/W2096967528","https://openalex.org/W2097742807","https://openalex.org/W2098006674","https://openalex.org/W2102710726","https://openalex.org/W2104559404","https://openalex.org/W2104693453","https://openalex.org/W2106497978","https://openalex.org/W2109257139","https://openalex.org/W2109634724","https://openalex.org/W2111668019","https://openalex.org/W2113899561","https://openalex.org/W2118664900","https://openalex.org/W2120418349","https://openalex.org/W2122227604","https://openalex.org/W2122659074","https://openalex.org/W2122784936","https://openalex.org/W2124945212","https://openalex.org/W2134431157","https://openalex.org/W2135037873","https://openalex.org/W2135856635","https://openalex.org/W2137790072","https://openalex.org/W2139700614","https://openalex.org/W2141913676","https://openalex.org/W2142573506","https://openalex.org/W2144815258","https://openalex.org/W2145484821","https://openalex.org/W2146282338","https://openalex.org/W2148070209","https://openalex.org/W2148321787","https://openalex.org/W2150840665","https://openalex.org/W2153714617","https://openalex.org/W2154399286","https://openalex.org/W2154889565","https://openalex.org/W2155309314","https://openalex.org/W2155413505","https://openalex.org/W2155904074","https://openalex.org/W2157345824","https://openalex.org/W2157352621","https://openalex.org/W2158291672","https://openalex.org/W2158425599","https://openalex.org/W2161022754","https://openalex.org/W2161349247","https://openalex.org/W2162794787","https://openalex.org/W2164113828","https://openalex.org/W2167309323","https://openalex.org/W2167450468","https://openalex.org/W2167832449","https://openalex.org/W2168253316","https://openalex.org/W2171836350","https://openalex.org/W2172224337","https://openalex.org/W2218594318","https://openalex.org/W2276173953","https://openalex.org/W2325262598","https://openalex.org/W2413095708","https://openalex.org/W2552691388","https://openalex.org/W2793278280","https://openalex.org/W3148113551","https://openalex.org/W4248503022","https://openalex.org/W4248760913","https://openalex.org/W4249306916","https://openalex.org/W4255035631","https://openalex.org/W4255582288","https://openalex.org/W4299439956","https://openalex.org/W4392233546","https://openalex.org/W6675002225","https://openalex.org/W6677014070","https://openalex.org/W6683006774","https://openalex.org/W7157302148"],"related_works":["https://openalex.org/W2352350815","https://openalex.org/W2991030316","https://openalex.org/W2908757458","https://openalex.org/W2112528869","https://openalex.org/W2189230703","https://openalex.org/W2254638634","https://openalex.org/W2369345461","https://openalex.org/W1544500465","https://openalex.org/W2359925514","https://openalex.org/W3186621756"],"abstract_inverted_index":{"Successful":[0],"delivery":[1],"of":[2,16,39,74,99,140,151,163,216,219,229],"promising":[3],"new":[4,93],"chemical":[5],"entities":[6],"via":[7],"the":[8,33,61,79,136],"oral":[9],"route":[10],"is":[11,32,78,145,169,200],"rife":[12],"with":[13],"challenges,":[14],"some":[15,130],"which":[17,83],"cannot":[18],"be":[19],"explained":[20],"or":[21],"foreseen":[22],"during":[23],"drug":[24,43,215,240],"development.":[25],"Further":[26],"complicating":[27],"an":[28],"already":[29,95],"multifaceted":[30],"problem":[31],"obvious,":[34],"yet":[35],"often":[36,177],"overlooked,":[37],"effect":[38],"dietary":[40,48,172,212,257],"substances":[41,173],"on":[42],"disposition":[44],"and":[45,68,94,103,115,166,185,196,214],"response.":[46],"Some":[47],"substances,":[49],"particularly":[50],"fruit":[51,84,118,243],"juices,":[52,85],"have":[53,120,132],"been":[54,121],"shown":[55,122],"to":[56,64,92,123,135,148,154,159,202],"inhibit":[57,124],"biochemical":[58],"processes":[59,126],"in":[60,127,141,183],"intestine,":[62,247],"leading":[63],"altered":[65],"pharmacokinetic":[66],"(PK),":[67],"potentially":[69],"pharmacodynamic":[70],"(PD),":[71],"outcomes.":[72],"Inhibition":[73,98],"intestinal":[75,100],"CYP3A-mediated":[76],"metabolism":[77],"major":[80],"mechanism":[81],"by":[82],"including":[86],"grapefruit":[87,245],"juice,":[88,244,246],"enhances":[89],"systemic":[90],"exposure":[91],"marketed":[96],"drugs.":[97],"non-CYP3A":[101],"enzymes":[102],"apically-located":[104],"transport":[105],"proteins":[106],"represent":[107],"recently":[108],"identified":[109],"mechanisms":[110,168],"that":[111,181],"can":[112],"alter":[113],"PK":[114],"PD.":[116],"Several":[117],"juices":[119],"these":[125,220],"vitro,":[128],"but":[129],"interactions":[131,237],"not":[133],"translated":[134],"clinic.":[137],"The":[138],"lack":[139,150],"vitro-in":[142],"vivo":[143],"concordance":[144],"due":[146],"largely":[147],"a":[149,210],"rigorous":[152],"methods":[153],"elucidate":[155],"causative":[156],"ingredients":[157,180],"prior":[158],"clinical":[160,194,224],"testing.":[161],"Identification":[162],"specific":[164],"components":[165],"underlying":[167],"challenging,":[170],"as":[171],"frequently":[174],"contain":[175],"multiple,":[176],"unknown,":[178],"bioactive":[179],"vary":[182],"composition":[184],"bioactivity.":[186],"A":[187],"translational":[188],"research":[189],"approach,":[190],"combining":[191],"expertise":[192],"from":[193],"pharmacologists":[195],"natural":[197],"products":[198],"chemists,":[199],"needed":[201],"develop":[203],"robust":[204],"models":[205,221],"describing":[206],"PK/PD":[207],"relationships":[208],"between":[209],"given":[211],"substance":[213,236],"interest.":[217],"Validation":[218],"through":[222],"well-designed":[223],"trials":[225],"would":[226],"facilitate":[227],"development":[228],"common":[230],"practice":[231],"guidelines":[232],"for":[233],"managing":[234],"drug-dietary":[235],"appropriately.":[238],"Keywords:":[239],"interaction,":[241],"food,":[242],"metabolism,":[248],"transport,":[249],"Bioavailability,":[250],"PK,":[251],"PD,":[252],"DDIs,":[253],"pharmacodynamics,":[254],"pharmacotherapy,":[255],"calcium,":[256],"substance,":[258],"aging,":[259],"Citrus":[260,262],"maxima,":[261],"sinensis,":[263],"Cyclosporine,":[264],"Nilotinib,":[265],"Cmax,":[266],"Cranberry":[267],"Juice,":[268,276],"INR,":[269],"Punica":[270],"granatum,":[271],"Esterase,":[272],"PNPA,":[273],"Sulfotransferase,":[274],"Orange":[275],"PK-PD":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}