{"id":"https://openalex.org/W2139290077","doi":"https://doi.org/10.1186/1745-6215-15-192","title":"The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial","display_name":"The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W2139290077","doi":"https://doi.org/10.1186/1745-6215-15-192","mag":"2139290077","pmid":"https://pubmed.ncbi.nlm.nih.gov/24885600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4050098"},"language":"en","primary_location":{"id":"doi:10.1186/1745-6215-15-192","doi":"https://doi.org/10.1186/1745-6215-15-192","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-15-192","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/1745-6215-15-192","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/1745-6215-15-192","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039329214","display_name":"Ram\u00f3n Rodrigo","orcid":"https://orcid.org/0000-0003-1724-571X","observed_orcids":["https://orcid.org/0000-0003-1724-571X"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ram\u00f3n Rodrigo","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. rrodrigo@med.uchile.cl","Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. rrodrigo@med.uchile.cl","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063037743","display_name":"Daniel Hasson","orcid":"https://orcid.org/0000-0003-1833-700X","observed_orcids":["https://orcid.org/0000-0003-1833-700X"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Daniel Hasson","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064738887","display_name":"Juan Carlos Prieto","orcid":"https://orcid.org/0000-0001-8706-0775","observed_orcids":["https://orcid.org/0000-0001-8706-0775"]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Juan C Prieto","raw_affiliation_strings":["Cardiovascular Department, University of Chile Clinical Hospital, Santiago, Chile","Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Department, University of Chile Clinical Hospital, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]},{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020061528","display_name":"G Dussaillant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Gast\u00f3n Dussaillant","raw_affiliation_strings":["Cardiovascular Department, University of Chile Clinical Hospital, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Department, University of Chile Clinical Hospital, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102053144","display_name":"Crist\u00f3bal Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Crist\u00f3bal Ramos","raw_affiliation_strings":["Department of Radiology, University of Chile Clinical Hospital, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chile Clinical Hospital, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069959004","display_name":"Lucio Le\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156682","display_name":"Hospital San Borja Arriar\u00e1n","ror":"https://ror.org/04qdwp261","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210156682"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Lucio Le\u00f3n","raw_affiliation_strings":["Cardiovascular Center, San Borja Arriar\u00e1n Clinical Hospital, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, San Borja Arriar\u00e1n Clinical Hospital, Santiago, Chile","institution_ids":["https://openalex.org/I4210156682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004347979","display_name":"Javier G\u00e1rate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156682","display_name":"Hospital San Borja Arriar\u00e1n","ror":"https://ror.org/04qdwp261","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210156682"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Javier G\u00e1rate","raw_affiliation_strings":["Cardiovascular Center, San Borja Arriar\u00e1n Clinical Hospital, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, San Borja Arriar\u00e1n Clinical Hospital, Santiago, Chile","institution_ids":["https://openalex.org/I4210156682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085964422","display_name":"Nicol\u00e1s Valls","orcid":"https://orcid.org/0000-0002-3664-5770","observed_orcids":["https://orcid.org/0000-0002-3664-5770"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Valls","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113894249","display_name":"Juan Guillermo Gormaz","orcid":"https://orcid.org/0000-0003-3424-4807","observed_orcids":["https://orcid.org/0000-0003-3424-4807"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Juan G Gormaz","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039329214"],"corresponding_institution_ids":["https://openalex.org/I69737025"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.5603,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.850738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"192","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.06800000369548798,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9449999928474426},{"id":"https://openalex.org/keywords/percutaneous-transluminal-coronary-angioplasty","display_name":"percutaneous transluminal coronary angioplasty","score":0.8690000176429749},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.6859999895095825},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myocardial-infarct-size","display_name":"myocardial infarct size","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"cardiac magnetic resonance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/chilean-patients","display_name":"Chilean patients","score":0.4819999933242798},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.35199999809265137},{"id":"https://openalex.org/keywords/latin-america-and-the-caribbean","display_name":"Latin America and the Caribbean","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9417634606361389},{"id":"https://openalex.org/C2780326628","wikidata":"https://www.wikidata.org/wiki/Q539795","display_name":"Angioplasty","level":2,"score":0.7749648094177246},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7244413495063782},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.630490779876709},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5735433101654053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5702934861183167},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5687807202339172},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.4976535141468048},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46407344937324524},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.09798231720924377},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06071031093597412},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002677","descriptor_name":"Chile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006785","descriptor_name":"Hospitals, University","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062645","descriptor_name":"Percutaneous Coronary Intervention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1186/1745-6215-15-192","doi":"https://doi.org/10.1186/1745-6215-15-192","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-15-192","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/1745-6215-15-192","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3037826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4050098","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4050098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4050098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmid:24885600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24885600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.643.7817","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.643.7817","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.trialsjournal.com/content/pdf/1745-6215-15-192.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3264905","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3264905","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TRIALS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/137932","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/137932","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TRIALS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/129564","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/129564","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1186/1745-6215-15-192","doi":"https://doi.org/10.1186/1745-6215-15-192","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-15-192","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/1745-6215-15-192","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139290077.pdf","grobid_xml":"https://content.openalex.org/works/W2139290077.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W177678132","https://openalex.org/W183841710","https://openalex.org/W185955167","https://openalex.org/W201398293","https://openalex.org/W281504690","https://openalex.org/W1237385790","https://openalex.org/W1489783301","https://openalex.org/W1493556752","https://openalex.org/W1520292841","https://openalex.org/W1525641289","https://openalex.org/W1534026557","https://openalex.org/W1537037257","https://openalex.org/W1541055999","https://openalex.org/W1922087192","https://openalex.org/W1934994215","https://openalex.org/W1966137962","https://openalex.org/W1973472942","https://openalex.org/W1975083648","https://openalex.org/W1981962455","https://openalex.org/W1983855526","https://openalex.org/W1984358837","https://openalex.org/W1984470467","https://openalex.org/W1987631282","https://openalex.org/W1990617236","https://openalex.org/W1991661996","https://openalex.org/W1996746173","https://openalex.org/W2000874404","https://openalex.org/W2002439304","https://openalex.org/W2005991281","https://openalex.org/W2006891221","https://openalex.org/W2009652531","https://openalex.org/W2010928297","https://openalex.org/W2014320017","https://openalex.org/W2021294790","https://openalex.org/W2021383532","https://openalex.org/W2022567628","https://openalex.org/W2027278652","https://openalex.org/W2027832422","https://openalex.org/W2027967898","https://openalex.org/W2035981171","https://openalex.org/W2043355876","https://openalex.org/W2045729275","https://openalex.org/W2050744280","https://openalex.org/W2052217128","https://openalex.org/W2053717115","https://openalex.org/W2055992885","https://openalex.org/W2057200756","https://openalex.org/W2064612214","https://openalex.org/W2068626411","https://openalex.org/W2074800090","https://openalex.org/W2083668480","https://openalex.org/W2085025223","https://openalex.org/W2087549039","https://openalex.org/W2088466977","https://openalex.org/W2091712060","https://openalex.org/W2093051132","https://openalex.org/W2095135990","https://openalex.org/W2095592188","https://openalex.org/W2097867305","https://openalex.org/W2099869131","https://openalex.org/W2102085357","https://openalex.org/W2102340455","https://openalex.org/W2104807853","https://openalex.org/W2106607991","https://openalex.org/W2108045872","https://openalex.org/W2110163647","https://openalex.org/W2116984449","https://openalex.org/W2118296121","https://openalex.org/W2118747132","https://openalex.org/W2128476480","https://openalex.org/W2131412683","https://openalex.org/W2132679226","https://openalex.org/W2135289666","https://openalex.org/W2136009429","https://openalex.org/W2137635355","https://openalex.org/W2143266144","https://openalex.org/W2148428120","https://openalex.org/W2148879813","https://openalex.org/W2150742641","https://openalex.org/W2150843985","https://openalex.org/W2155603952","https://openalex.org/W2157183439","https://openalex.org/W2160998626","https://openalex.org/W2168595038","https://openalex.org/W2169256012","https://openalex.org/W2170990838","https://openalex.org/W2174121794","https://openalex.org/W2193143775","https://openalex.org/W2334679219","https://openalex.org/W2398005929","https://openalex.org/W2399228814","https://openalex.org/W2409909042","https://openalex.org/W2482663060","https://openalex.org/W2595053147","https://openalex.org/W3170020307","https://openalex.org/W4205653014"],"related_works":["https://openalex.org/W2128476480","https://openalex.org/W2754558285","https://openalex.org/W1982586055","https://openalex.org/W2034548788","https://openalex.org/W2504841287","https://openalex.org/W7097697134","https://openalex.org/W2015277554","https://openalex.org/W3201600641","https://openalex.org/W2029823871","https://openalex.org/W201398293"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"myocardial":[2,40,85,144,280],"infarction":[3,145],"(AMI)":[4],"is":[5,110,153,206,276,332],"the":[6,18,35,45,65,178,182,194,255,307,310,319],"leading":[7],"cause":[8],"of":[9,34,38,44,75,127,168,188,257,286,289,309,313],"mortality":[10],"worldwide.":[11],"Oxidative":[12],"stress":[13],"has":[14,24],"been":[15,25,298],"involved":[16],"in":[17,21,99,124,327,336],"ischemia-reperfusion":[19,66,271],"injury":[20],"AMI.":[22,107],"It":[23],"suggested":[26],"that":[27,53],"reperfusion":[28,76,320],"accounts":[29],"for":[30,148,199,239],"up":[31],"to":[32,48,88,102,260,278,305,334],"50%":[33],"final":[36],"size":[37,98],"a":[39,42,111,157],"infarct,":[41],"part":[43],"damage":[46,77,321],"likely":[47],"be":[49,139,250],"prevented.Therefore,":[50],"we":[51],"propose":[52],"antioxidant":[54,91,242],"reinforcement":[55],"through":[56],"vitamins":[57,92,189,314],"C":[58,93,163,190,291,315],"and":[59,94,131,191,193,217,229,237,246,265,316],"E":[60,95,170,295,317],"supplementation":[61],"should":[62],"protect":[63],"against":[64,318],"damage,":[67,245],"thus":[68],"decreasing":[69],"infarct":[70,97,207,281],"size.The":[71],"PREVEC":[72,302],"Trial":[73,303],"(Prevention":[74],"associated":[78],"with":[79,142,146,235,293],"percutaneous":[80,103,149],"coronary":[81,104,150,203,221,233],"angioplasty":[82,105,179,234,275],"following":[83],"acute":[84,143],"infarction)":[86],"seeks":[87,304],"evaluate":[89],"whether":[90],"reduce":[96],"patients":[100],"subjected":[101],"after":[106,202,220,232,263],"METHODS/DESIGN:":[108],"This":[109],"randomized,":[112],"1:1,":[113],"double-blind,":[114],"placebo-controlled":[115],"clinical":[116],"trial.The":[117],"study":[118],"takes":[119],"place":[120],"at":[121,252,254,266],"two":[122],"centers":[123],"Chile:":[125],"University":[126],"Chile":[128],"Clinical":[129,135],"Hospital":[130],"San":[132],"Borja":[133],"Arriar\u00e1n":[134],"Hospital.The":[136],"subjects":[137],"will":[138,249],"134":[140],"adults":[141],"indication":[147],"angioplasty.This":[151],"intervention":[152],"being":[154],"performed":[155],"as":[156],"pilot":[158],"study,":[159],"involving":[160],"high-dose":[161],"vitamin":[162,169,290,294],"infusion":[164],"plus":[165],"oral":[166,186],"administration":[167],"(Vitamin-treatment":[171],"group)":[172,176],"or":[173],"placebo":[174,198],"(Control":[175],"during":[177,274,323],"procedure.":[180],"Afterward,":[181],"Vitamin-treatment":[183],"group":[184,196],"receives":[185,197],"doses":[187,288],"E,":[192],"Control":[195],"84":[200,218,230],"days":[201,219,231],"angioplasty.Primary":[204],"outcome":[205],"size,":[208],"assessed":[209],"by":[210],"cardiac":[211],"magnetic":[212],"resonance":[213],"(CMR),":[214],"measured":[215,227,251],"6":[216,228,259],"angioplasty.Secondary":[222],"outcomes":[223],"are":[224],"ejection":[225],"fraction,":[226],"CMR,":[236],"biomarkers":[238],"oxidative":[240],"stress,":[241],"status,":[243],"heart":[244],"inflammation,":[247],"which":[248],"baseline,":[253],"onset":[256],"reperfusion,":[258],"8":[261],"hours":[262],"revascularization,":[264],"hospital":[267],"discharge.":[268],"DISCUSSION:":[269],"The":[270,283,301,330],"event":[272],"occurring":[273],"known":[277],"increase":[279],"size.":[282],"cardioprotective":[284],"benefits":[285],"high":[287],"combined":[292],"have":[296],"not":[297],"fully":[299],"explored.":[300],"determine":[306],"suitability":[308],"therapeutic":[311],"use":[312],"produced":[322],"angioplasty.Patient":[324],"recruitment":[325],"opened":[326],"February":[328],"2013.":[329],"trial":[331],"scheduled":[333],"end":[335],"March":[337],"2016.":[338],"TRIAL":[339],"REGISTRATION:":[340],"ISRCTN56034553.":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
