{"id":"https://openalex.org/W2139285272","doi":"https://doi.org/10.1002/jbm.a.35128","title":"Novel porous scaffolds of pH responsive chitosan/carrageenan-based polyelectrolyte complexes for tissue engineering","display_name":"Novel porous scaffolds of pH responsive chitosan/carrageenan-based polyelectrolyte complexes for tissue engineering","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2139285272","doi":"https://doi.org/10.1002/jbm.a.35128","mag":"2139285272","pmid":"https://pubmed.ncbi.nlm.nih.gov/24677767"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.35128","doi":"https://doi.org/10.1002/jbm.a.35128","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.35128","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. V. Araujo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. V. Araujo","raw_affiliation_strings":["Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials, University of Cambridge, Cambridge, CB3 0FS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials, University of Cambridge, Cambridge, CB3 0FS, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047543321","display_name":"Natalia Davidenko","orcid":"https://orcid.org/0000-0002-5489-6629","observed_orcids":["https://orcid.org/0000-0002-5489-6629"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Davidenko","raw_affiliation_strings":["Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054865034","display_name":"M. Danner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Danner","raw_affiliation_strings":["Biophysical Chemistry, Institute of Physical Chemistry; University of Heidelberg; Heidelberg 69120 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysical Chemistry, Institute of Physical Chemistry; University of Heidelberg; Heidelberg 69120 Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041541061","display_name":"Ruth Elizabeth Cameron","orcid":"https://orcid.org/0000-0003-1573-4923","observed_orcids":["https://orcid.org/0000-0003-1573-4923"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. E. Cameron","raw_affiliation_strings":["Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079785884","display_name":"Serena M. Best","orcid":"https://orcid.org/0000-0001-7866-8607","observed_orcids":["https://orcid.org/0000-0001-7866-8607"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. M. Best","raw_affiliation_strings":["Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science & Metallurgy, Cambridge Centre for Medical Materials; University of Cambridge; Cambridge CB3 0FS United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":2.9176,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91342721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"102","issue":"12","first_page":"n/a","last_page":"n/a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyelectrolyte-complexes","display_name":"polyelectrolyte complexes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carrageenan","display_name":"carrageenan","score":1.0},{"id":"https://openalex.org/keywords/ph-responsive-materials","display_name":"pH-responsive materials","score":0.8019999861717224},{"id":"https://openalex.org/keywords/porous-scaffolds","display_name":"porous scaffolds","score":0.9810000061988831},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.6850000023841858},{"id":"https://openalex.org/keywords/scaffold-mechanical-properties","display_name":"scaffold mechanical properties","score":0.6650000214576721},{"id":"https://openalex.org/keywords/water-uptake","display_name":"water absorption","score":0.7419999837875366},{"id":"https://openalex.org/keywords/reprecipitation","display_name":"reprecipitation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.8157393336296082},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7243894338607788},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.715012788772583},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6535276174545288},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6333072781562805},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6238321661949158},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.6092717051506042},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5727344155311584},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.5532066226005554},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.503567636013031},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.49941158294677734},{"id":"https://openalex.org/C168314062","wikidata":"https://www.wikidata.org/wiki/Q2550696","display_name":"Absorption of water","level":2,"score":0.45498600602149963},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4250923991203308},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32793834805488586},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3145335614681244},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.22498729825019836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19895803928375244},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16672521829605103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.35128","doi":"https://doi.org/10.1002/jbm.a.35128","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.35128","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:24677767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24677767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1977894565","https://openalex.org/W1983808608","https://openalex.org/W1989868983","https://openalex.org/W1996602995","https://openalex.org/W1998405097","https://openalex.org/W2003867481","https://openalex.org/W2006053978","https://openalex.org/W2006632334","https://openalex.org/W2010245042","https://openalex.org/W2014726972","https://openalex.org/W2019978468","https://openalex.org/W2020796788","https://openalex.org/W2021900697","https://openalex.org/W2029268792","https://openalex.org/W2031061338","https://openalex.org/W2034854042","https://openalex.org/W2038296497","https://openalex.org/W2041581549","https://openalex.org/W2045637724","https://openalex.org/W2048332300","https://openalex.org/W2049305057","https://openalex.org/W2050657698","https://openalex.org/W2051006191","https://openalex.org/W2055996272","https://openalex.org/W2056014442","https://openalex.org/W2058781927","https://openalex.org/W2059058513","https://openalex.org/W2061761744","https://openalex.org/W2071425043","https://openalex.org/W2072018844","https://openalex.org/W2073738844","https://openalex.org/W2079395601","https://openalex.org/W2080198935","https://openalex.org/W2081921549","https://openalex.org/W2088630991","https://openalex.org/W2090243647","https://openalex.org/W2099108227","https://openalex.org/W2103722820","https://openalex.org/W2103745164","https://openalex.org/W2113494020","https://openalex.org/W2115908870","https://openalex.org/W2120234986","https://openalex.org/W2121303316","https://openalex.org/W2121356794","https://openalex.org/W2129004006","https://openalex.org/W2129358933","https://openalex.org/W2139457077","https://openalex.org/W2140966992","https://openalex.org/W2142591131","https://openalex.org/W2153532131","https://openalex.org/W2159210886","https://openalex.org/W2169803852","https://openalex.org/W2412284627","https://openalex.org/W2520543507"],"related_works":["https://openalex.org/W2924879017","https://openalex.org/W2335321220","https://openalex.org/W4389537923","https://openalex.org/W2908522428","https://openalex.org/W2173458511","https://openalex.org/W2021900697","https://openalex.org/W2025188750","https://openalex.org/W2087607285","https://openalex.org/W2765125506","https://openalex.org/W2050657698"],"abstract_inverted_index":{"Polyelectrolyte":[0],"complexes":[1],"(PECs)":[2],"represent":[3],"promising":[4,231],"materials":[5,244],"for":[6,23,232],"drug":[7],"delivery":[8],"and":[9,64,75,123,143,156,180,198],"tissue":[10,233],"engineering":[11,234],"applications.":[12],"These":[13],"substances":[14],"are":[15],"obtained":[16,177],"in":[17,91,109,188,206],"aqueous":[18],"medium":[19],"without":[20],"the":[21,31,41,54,84,92,96,103,107,113,133,148,161,168,189,207,212,219,227,239],"need":[22],"crosslinking":[24],"agents.":[25],"PECs":[26,59,108,134],"can":[27],"be":[28,164],"produced":[29,52,135],"through":[30,53],"combination":[32],"of":[33,56,61,70,83,95,106,117,141,154,241],"oppositely":[34],"charged":[35],"medical":[36],"grade":[37],"polymers,":[38],"which":[39],"include":[40],"stimuli":[42],"responsive":[43,243],"ones.":[44],"In":[45,101],"this":[46],"work,":[47],"three-dimensional":[48],"porous":[49],"scaffolds":[50,97,176,192,229],"were":[51,78,98,136],"lyophilization":[55],"pH":[57,104,115,139,149,169,242],"sensitive":[58,185],"made":[60],"chitosan":[62],"(CS)":[63],"carrageenan":[65],"(CRG).":[66],"CS:CRG":[67,208],"molar":[68,209],"ratios":[69,210],"1:1":[71],"(CSCRG1),":[72],"2:1":[73],"(CSCRG2),":[74],"3:1":[76],"(CSCRG3)":[77],"used.":[79],"The":[80,175,204],"chemical":[81],"compositions":[82],"PECs,":[85],"as":[86,88,147],"well":[87],"their":[89],"influence":[90],"final":[93],"structure":[94],"meticulously":[99],"studied.":[100],"addition,":[102],"responsiveness":[105],"a":[110],"range":[111],"including":[112],"physiological":[114,121,247],"values":[116,140,153,171],"7.4":[118,142],"(simulating":[119,125],"normal":[120],"conditions)":[122],"4.5":[124],"inflammatory":[126],"response)":[127],"was":[128],"assessed.":[129],"Results":[130],"showed":[131],"that":[132,237],"stable":[137,245],"at":[138,246],"under":[144,223],"but":[145],"dissolved":[146],"increased":[150],"to":[151,170,173,186,194],"nonphysiological":[152],"9":[155],"11.":[157],"However,":[158],"after":[159],"dissolution,":[160],"PEC":[162,228],"could":[163],"reprecipitated":[165],"by":[166],"decreasing":[167],"close":[172],"4.5.":[174],"presented":[178],"large":[179],"interconnected":[181],"pores,":[182],"being":[183],"equally":[184],"changes":[187],"pH.":[190],"CSCRG1":[191],"appeared":[193],"have":[195],"higher":[196,200,220],"hydrophilicity":[197],"therefore":[199],"water":[201],"absorption":[202],"capacity.":[203],"increase":[205],"improved":[211],"scaffold":[213],"mechanical":[214],"properties,":[215],"with":[216],"CSCRG3":[217],"presenting":[218],"compressive":[221],"modulus":[222],"wet":[224],"conditions.":[225,248],"Overall,":[226],"appear":[230],"related":[235],"applications":[236],"require":[238],"use":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
