{"id":"https://openalex.org/W2139283055","doi":null,"title":"Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II.","display_name":"Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II.","publication_year":1973,"publication_date":"1973-08-01","ids":{"openalex":"https://openalex.org/W2139283055","mag":"2139283055","pmid":"https://pubmed.ncbi.nlm.nih.gov/4737200"},"language":"en","primary_location":{"id":"pmid:4737200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4737200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052168544","display_name":"Paul L. Chello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Chello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5104110678","display_name":"Joseph R. Bertino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Bertino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8592,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.97644829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"8","first_page":"1898","last_page":"904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-methyltetrahydrofolate","display_name":"5-methyltetrahydrofolate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hydroxocobalamin","display_name":"hydroxocobalamin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/transcobalamin-ii","display_name":"transcobalamin II","score":1.0},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9309999942779541},{"id":"https://openalex.org/keywords/l5178y-mouse-lymphoma-cells","display_name":"L5178Y cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/methionine-biosynthesis","display_name":"methionine biosynthesis","score":0.875},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.703000009059906},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.6430000066757202},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.7941058278083801},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.7773690223693848},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.6568769216537476},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.5378102660179138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4659629166126251},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4482279121875763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219141900539398},{"id":"https://openalex.org/C80315684","wikidata":"https://www.wikidata.org/wiki/Q2737583","display_name":"Methionine synthase","level":4,"score":0.4102349579334259},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3662676215171814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3594748377799988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3414697051048279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1821390688419342},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1346525251865387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003036","descriptor_name":"Cobalt Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:4737200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4737200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1973-2476","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1973/1477","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1973","raw_type":"text"},{"id":"mag:2139283055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4737200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W79959270","https://openalex.org/W88056638","https://openalex.org/W140209867","https://openalex.org/W199006581","https://openalex.org/W1461954287","https://openalex.org/W1505630620","https://openalex.org/W1507677151","https://openalex.org/W1994078420","https://openalex.org/W1996034180","https://openalex.org/W2002774684","https://openalex.org/W2007072103","https://openalex.org/W2023820998","https://openalex.org/W2039951410","https://openalex.org/W2040997218","https://openalex.org/W2066078380","https://openalex.org/W2068386013","https://openalex.org/W2133804704","https://openalex.org/W2141108922","https://openalex.org/W2290953407","https://openalex.org/W2434062470","https://openalex.org/W2441631823"],"related_works":["https://openalex.org/W1593840348","https://openalex.org/W2003193311","https://openalex.org/W195566432","https://openalex.org/W2005928169","https://openalex.org/W1491639452","https://openalex.org/W2010416533","https://openalex.org/W2290564246","https://openalex.org/W2135888822","https://openalex.org/W2320045004","https://openalex.org/W2059394089"],"abstract_inverted_index":{"Summary":[0],"L5178Y":[2],"mouse":[3],"leukemia":[4],"cells":[5,47],"in":[6,210,222],"tissue":[7],"culture":[8,136],"required":[9,216],"a":[10,27,36,74,86,113,171],"minimum":[11],"of":[12,30,39,82,89,115,120,139,143,193,225],"10.0":[13],"mg":[14,20,163],"l-methionine":[15,59,213],"per":[16,23,165],"liter":[17,24,166],"and":[18,122,230],"1.0":[19],"folic":[21,42,78],"acid":[22,43],"to":[25,32,50,91,134,147,169,173,195],"maintain":[26],"division":[28,87,175],"time":[29,88,176],"10":[31,90],"10.5":[33,92],"hr":[34,93],"during":[35],"72-hr":[37],"period":[38],"growth.":[40,65,150],"When":[41,130],"was":[44,60,63,68,101,132,145,167],"withheld,":[45,61],"the":[46,104,135,140,152,183,191,205,223],"underwent":[48],"three":[49],"four":[51],"divisions":[52],"before":[53],"growth":[54,109],"stopped.":[55],"In":[56,97],"contrast,":[57,98],"when":[58,99],"there":[62],"no":[64],"N5-Formyltetrahydrofolate":[67],"200":[69],"times":[70],"more":[71],"effective":[72],"as":[73,103],"folate":[75,105,198],"source":[76],"than":[77],"acid.":[79],"A":[80],"level":[81,114],"0.005":[83,123,162],"mg/liter":[84,124],"supported":[85],"for":[94,177,190,217],"72":[95,178],"hr.":[96,179],"N5-methyltetrahydrofolate":[100,144,164,194],"used":[102],"source,":[106],"only":[107],"slight":[108],"occurred,":[110],"even":[111,221],"at":[112],"0.5":[116],"mg/liter.":[117],"Lower":[118],"levels":[119,142],"0.05":[121],"were":[125,154],"without":[126],"growth-promoting":[127],"effect.":[128],"hydroxycobalamin":[131],"added":[133],"medium,":[137],"each":[138],"above":[141],"able":[146,168],"support":[148,170,182],"moderate":[149],"If":[151],"medium":[153],"further":[155],"supplemented":[156],"with":[157],"transcobalamin":[158,228],"II":[159],"plus":[160],"hydroxycobalamin,":[161,227],"10-":[172],"10.5-hr":[174],"These":[180],"data":[181],"concept":[184],"that":[185],"vitamin":[186],"B12":[187],"is":[188,215],"necessary":[189],"conversion":[192],"other":[196],"active":[197],"coenzymes,":[199],"presumably":[200],"via":[201],"methionine":[202],"biosynthesis":[203],"through":[204],"enzyme":[206],"N5-methyltetrahydrofolate-homocysteine":[207],"transmethylase.":[208],"However,":[209],"this":[211],"system,":[212],"supplementation":[214],"optimum":[218],"cell":[219],"growth,":[220],"presence":[224],"N5-methyltetrahydrofolate,":[226],"II,":[229],"dl-homocysteine.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
