{"id":"https://openalex.org/W2139279258","doi":"https://doi.org/10.1016/j.ejmech.2005.05.004","title":"The molecular mechanisms involved in the cytotoxicity of alkannin derivatives","display_name":"The molecular mechanisms involved in the cytotoxicity of alkannin derivatives","publication_year":2005,"publication_date":"2005-06-30","ids":{"openalex":"https://openalex.org/W2139279258","doi":"https://doi.org/10.1016/j.ejmech.2005.05.004","mag":"2139279258","pmid":"https://pubmed.ncbi.nlm.nih.gov/15992967"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2005.05.004","doi":"https://doi.org/10.1016/j.ejmech.2005.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2005.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085490427","display_name":"Haiqiang Wu","orcid":"https://orcid.org/0000-0003-3979-7304","observed_orcids":["https://orcid.org/0000-0003-3979-7304"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Qiang Wu","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017464022","display_name":"Zhi\u2010Shu Huang","orcid":"https://orcid.org/0000-0002-6211-5482","observed_orcids":["https://orcid.org/0000-0002-6211-5482"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Shu Huang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089135718","display_name":"Xianzhang Bu","orcid":"https://orcid.org/0000-0002-3015-6634","observed_orcids":["https://orcid.org/0000-0002-3015-6634"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian-Zhang Bu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108931586","display_name":"Yudong Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Dong Shen","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051789651","display_name":"Zhu-Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu-Lin Zhang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011402439","display_name":"Bing\u2010Fen Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing-Fen Xie","raw_affiliation_strings":["Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102984726","display_name":"Zongchao Liu","orcid":"https://orcid.org/0000-0002-7331-7987","observed_orcids":["https://orcid.org/0000-0002-7331-7987"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Chao Liu","raw_affiliation_strings":["Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102283710","display_name":"Lian\u2010Quan Gu","orcid":"https://orcid.org/0000-0002-8176-4576","observed_orcids":["https://orcid.org/0000-0002-8176-4576"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lian-Quan Gu","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104303859","display_name":"A.S.C. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Albert S.C. Chan","raw_affiliation_strings":["Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017464022","https://openalex.org/A5102283710"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"12","first_page":"1341","last_page":"1345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oxidative-potential","display_name":"oxidative potential","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hydroquinone","display_name":"hydroquinone","score":0.8309999704360962},{"id":"https://openalex.org/keywords/quinones","display_name":"quinones","score":0.6439999938011169},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8339999914169312},{"id":"https://openalex.org/keywords/leaving-groups","display_name":"leaving groups","score":0.7710000276565552},{"id":"https://openalex.org/keywords/human-cancer-cell-lines","display_name":"human cancer cell lines","score":0.8709999918937683},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9412071108818054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.918800413608551},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.58799809217453},{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.5316752791404724},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4720362424850464},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4474126696586609},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.44111478328704834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29481279850006104},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.253034383058548},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ejmech.2005.05.004","doi":"https://doi.org/10.1016/j.ejmech.2005.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2005.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:15992967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15992967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/29953","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10397/29953","pdf_url":null,"source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal/Magazine Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322598","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W645592279","https://openalex.org/W1920829488","https://openalex.org/W1966590073","https://openalex.org/W1974357631","https://openalex.org/W1979424160","https://openalex.org/W1985800632","https://openalex.org/W1992437051","https://openalex.org/W2004899865","https://openalex.org/W2008113699","https://openalex.org/W2010205595","https://openalex.org/W2014972401","https://openalex.org/W2020214814","https://openalex.org/W2030945380","https://openalex.org/W2032615493","https://openalex.org/W2038027948","https://openalex.org/W2060013516","https://openalex.org/W2064796841","https://openalex.org/W2066555080","https://openalex.org/W2071956026","https://openalex.org/W2080122170","https://openalex.org/W2082358969","https://openalex.org/W2084034161","https://openalex.org/W2935752444","https://openalex.org/W2949956729"],"related_works":["https://openalex.org/W2955723887","https://openalex.org/W2076622078","https://openalex.org/W1977925984","https://openalex.org/W2056306868","https://openalex.org/W1985800632","https://openalex.org/W2054787847","https://openalex.org/W2092570341","https://openalex.org/W1990153597","https://openalex.org/W2161240269","https://openalex.org/W2057895864"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
