{"id":"https://openalex.org/W2139271966","doi":"https://doi.org/10.1152/ajpheart.00328.2005","title":"Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction","display_name":"Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction","publication_year":2005,"publication_date":"2005-07-02","ids":{"openalex":"https://openalex.org/W2139271966","doi":"https://doi.org/10.1152/ajpheart.00328.2005","mag":"2139271966","pmid":"https://pubmed.ncbi.nlm.nih.gov/15994860"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00328.2005","doi":"https://doi.org/10.1152/ajpheart.00328.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00328.2005","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045787325","display_name":"Xichun Yu","orcid":"https://orcid.org/0000-0001-6760-3410","observed_orcids":["https://orcid.org/0000-0001-6760-3410"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xichun Yu","raw_affiliation_strings":["Dept. of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108223058","display_name":"Shijun Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shijun Huang","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008809646","display_name":"Eugene S. Patterson","orcid":"https://orcid.org/0000-0001-9666-2348","observed_orcids":["https://orcid.org/0000-0001-9666-2348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene Patterson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050862574","display_name":"Marion W. Garrett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion W. Garrett","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenneth M. Kaufman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth M. Kaufman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030911572","display_name":"Jordan Patrick Metcalf","orcid":"https://orcid.org/0000-0003-4359-5270","observed_orcids":["https://orcid.org/0000-0003-4359-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan P. Metcalf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108695632","display_name":"Meili Zhu","orcid":"https://orcid.org/0000-0002-7337-6549","observed_orcids":["https://orcid.org/0000-0002-7337-6549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meili Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112749096","display_name":"Samuel Terence Dunn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel T. Dunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045687177","display_name":"David C. Kem","orcid":"https://orcid.org/0000-0001-8142-7767","observed_orcids":["https://orcid.org/0000-0001-8142-7767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Kem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2976,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81539911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"289","issue":"5","first_page":"H1960","last_page":"H1967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grk2","display_name":"GRK2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ventricular-tachyarrhythmia","display_name":"ventricular tachyarrhythmia","score":0.9179999828338623},{"id":"https://openalex.org/keywords/border-zone","display_name":"border zone","score":0.5080000162124634},{"id":"https://openalex.org/keywords/coronary-artery-ligation","display_name":"coronary artery ligation","score":0.906000018119812},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9490000009536743},{"id":"https://openalex.org/keywords/grk5","display_name":"GRK5","score":0.703000009059906},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7979999780654907},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C78976303","wikidata":"https://www.wikidata.org/wiki/Q14907967","display_name":"Beta adrenergic receptor kinase","level":4,"score":0.8177813291549683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6091586351394653},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.577130913734436},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5726569294929504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5353178381919861},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.47625160217285156},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.4426887333393097},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.42662858963012695},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.4136175513267517},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31274503469467163},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054774","descriptor_name":"G-Protein-Coupled Receptor Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.00328.2005","doi":"https://doi.org/10.1152/ajpheart.00328.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00328.2005","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:15994860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15994860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W934559764","https://openalex.org/W1545609286","https://openalex.org/W1935443268","https://openalex.org/W1969663023","https://openalex.org/W1976334012","https://openalex.org/W1998813642","https://openalex.org/W2009674445","https://openalex.org/W2011506135","https://openalex.org/W2013518345","https://openalex.org/W2015557754","https://openalex.org/W2017952516","https://openalex.org/W2023645046","https://openalex.org/W2034449515","https://openalex.org/W2040377097","https://openalex.org/W2043698693","https://openalex.org/W2044840865","https://openalex.org/W2054695602","https://openalex.org/W2055375040","https://openalex.org/W2070446231","https://openalex.org/W2070952976","https://openalex.org/W2071040174","https://openalex.org/W2090020265","https://openalex.org/W2091014584","https://openalex.org/W2094065595","https://openalex.org/W2101007077","https://openalex.org/W2112223772","https://openalex.org/W2122143586","https://openalex.org/W2125468282","https://openalex.org/W2129491311","https://openalex.org/W2133318395","https://openalex.org/W2137154189","https://openalex.org/W2138077682","https://openalex.org/W2155432244","https://openalex.org/W2166819175","https://openalex.org/W2329735057","https://openalex.org/W2417148432","https://openalex.org/W2441738042","https://openalex.org/W2614496215"],"related_works":["https://openalex.org/W2152617844","https://openalex.org/W2009674445","https://openalex.org/W2128720796","https://openalex.org/W2977993316","https://openalex.org/W2155007822","https://openalex.org/W2004112280","https://openalex.org/W2137086434","https://openalex.org/W4411077428","https://openalex.org/W1780228535","https://openalex.org/W1976875145"],"abstract_inverted_index":{"Arrhythmia-prone":[0],"subepicardial":[1],"border":[2],"zone":[3],"(EBZ)":[4,154],"tissue":[5,77,214],"demonstrates":[6],"decreased":[7,47,111],"G":[8],"protein":[9],"receptor":[10],"kinase":[11],"2":[12],"(GRK2)":[13],"activity":[14],"and":[15,92,106,155,174,223],"increased":[16],"sensitivity":[17],"to":[18,48,122,137,198],"isoproterenol":[19],"6-24":[20],"h":[21,114],"after":[22],"coronary":[23],"artery":[24],"ligation":[25],"(CAL)":[26],"in":[27,45,52,115,131,192,196,209,211],"the":[28,31,38,84,98,127,132,147,193,206],"dog.":[29],"With":[30],"use":[32,85,99],"of":[33,43,50,75,86,100,129,143,161,170,185],"a":[34,53,87],"semiquantitative":[35],"immunofluorescence":[36],"technique,":[37],"relative":[39,121],"fluorescence":[40],"intensity":[41],"(RF)":[42],"GRK2":[44,82,93,105,130,162,210],"EBZ":[46,116,133],"24%":[49],"that":[51,126,181,205,224],"remote":[54],"site":[55],"(RS)":[56],"(P":[57],"<":[58],"0.01,":[59],"n":[60],"=":[61,118],"30":[62],"cells":[63],"from":[64,78],"3":[65],"dogs),":[66],"whereas":[67],"GRK5":[68,107],"RF":[69,91],"did":[70],"not":[71,110],"change.":[72],"Confocal":[73],"studies":[74],"cardiac":[76,187,212],"transgenic":[79],"mice":[80],"overexpressing":[81],"validated":[83],"semilogarithmic":[88],"relationship":[89],"between":[90],"activity.":[94],"As":[95],"shown":[96],"with":[97,146,228],"quantitative":[101],"real-time":[102],"RT-PCR,":[103],"both":[104],"mRNA":[108],"were":[109],"at":[112,163],"24":[113,164],"(n":[117],"6":[119],"dogs)":[120],"RS":[123],"control,":[124],"indicating":[125],"decrease":[128,208],"is":[134,226],"likely":[135],"due":[136],"posttranscriptional":[138],"degradation":[139],"following":[140],"CAL.":[141],"Pretreatment":[142],"six":[144],"dogs":[145],"selective":[148],"proteasome":[149,221],"inhibitor":[150],"bortezomib":[151],"provided":[152],"100%":[153],"50%":[156],"(infarct)":[157],"protection":[158],"against":[159,231],"loss":[160],"h.":[165],"There":[166],"was":[167],"an":[168],"absence":[169],"rapid":[171,176],"(>300":[172],"beats/min)":[173,178],"very":[175],"(>360":[177],"ventricular":[179,233],"triplets":[180],"are":[182],"highly":[183],"predictive":[184],"sudden":[186],"death":[188],"during":[189],"ECG":[190],"monitoring":[191],"bortezomib-pretreated":[194],"animals":[195],"contrast":[197],"nonpretreated":[199],"infarcted":[200],"animals.":[201],"We":[202],"have":[203],"demonstrated":[204],"dramatic":[207],"ischemic":[213],"can":[215],"be":[216],"largely":[217],"blocked":[218],"by":[219],"prior":[220],"blockade":[222],"this":[225],"associated":[227],"significant":[229],"cardioprotection":[230],"malignant":[232],"tachyarrhythmias.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
