{"id":"https://openalex.org/W2139267199","doi":"https://doi.org/10.1002/bdra.20762","title":"Oral clefts and maternal biomarkers of folate\u2010dependent one\u2010carbon metabolism in utah","display_name":"Oral clefts and maternal biomarkers of folate\u2010dependent one\u2010carbon metabolism in utah","publication_year":2011,"publication_date":"2011-02-02","ids":{"openalex":"https://openalex.org/W2139267199","doi":"https://doi.org/10.1002/bdra.20762","mag":"2139267199","pmid":"https://pubmed.ncbi.nlm.nih.gov/21290562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4703080"},"language":"en","primary_location":{"id":"doi:10.1002/bdra.20762","doi":"https://doi.org/10.1002/bdra.20762","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bdra.20762","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bdra.20762","source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bdra.20762","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028394515","display_name":"Ronald G. Munger","orcid":"https://orcid.org/0000-0002-2381-5355","observed_orcids":["https://orcid.org/0000-0002-2381-5355"]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald G. Munger","raw_affiliation_strings":["Department of Nutrition, Dietetics, and Food Sciences, Center for Epidemiologic Studies, Utah State University, Logan, UT 84322, USA. ron.munger@usu.edu","Center for Epidemiologic Studies, Utah State University","Department of Nutrition, Dietetics, and Food Sciences, Utah State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics, and Food Sciences, Center for Epidemiologic Studies, Utah State University, Logan, UT 84322, USA. ron.munger@usu.edu","institution_ids":["https://openalex.org/I121980950"]},{"raw_affiliation_string":"Center for Epidemiologic Studies, Utah State University","institution_ids":["https://openalex.org/I121980950"]},{"raw_affiliation_string":"Department of Nutrition, Dietetics, and Food Sciences, Utah State University","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060651507","display_name":"Tsunenobu Tamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsunenobu Tamura","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103393287","display_name":"Kelley E. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley E. Johnston","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021724364","display_name":"Marcia L. Feldkamp","orcid":"https://orcid.org/0000-0001-9171-7848","observed_orcids":["https://orcid.org/0000-0001-9171-7848"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210122884","display_name":"Utah Department of Health","ror":"https://ror.org/034de1n65","country_code":"US","type":"government","lineage":["https://openalex.org/I4210122884","https://openalex.org/I4405272622"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia L. Feldkamp","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine","Utah Birth Defect Network, Utah Department of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Utah Birth Defect Network, Utah Department of Health","institution_ids":["https://openalex.org/I4210122884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103561639","display_name":"Roxane Pfister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roxane Pfister","raw_affiliation_strings":["Center for Epidemiologic Studies, Utah State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Epidemiologic Studies, Utah State University","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Cutler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Cutler","raw_affiliation_strings":["Center for Epidemiologic Studies, Utah State University","Department of Mathematics and Statistics, Utah State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Epidemiologic Studies, Utah State University","institution_ids":["https://openalex.org/I121980950"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, Utah State University","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076632096","display_name":"Maureen A. Murtaugh","orcid":"https://orcid.org/0000-0001-5281-0302","observed_orcids":["https://orcid.org/0000-0001-5281-0302"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen A. Murtaugh","raw_affiliation_strings":["Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012216196","display_name":"John C. Carey","orcid":"https://orcid.org/0000-0002-6007-8518","observed_orcids":["https://orcid.org/0000-0002-6007-8518"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210122884","display_name":"Utah Department of Health","ror":"https://ror.org/034de1n65","country_code":"US","type":"government","lineage":["https://openalex.org/I4210122884","https://openalex.org/I4405272622"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Carey","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine","Utah Birth Defect Network, Utah Department of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Utah Birth Defect Network, Utah Department of Health","institution_ids":["https://openalex.org/I4210122884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028394515"],"corresponding_institution_ids":["https://openalex.org/I121980950"],"apc_list":null,"apc_paid":null,"fwci":2.1984,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87696543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"91","issue":"3","first_page":"153","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orofacial-clefts","display_name":"orofacial clefts","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cleft-lip-with-or-without-cleft-palate","display_name":"cleft lip with or without cleft palate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cleft-palate","display_name":"cleft palate","score":0.925000011920929},{"id":"https://openalex.org/keywords/maternal-folate-intake","display_name":"maternal folate intake","score":0.7670000195503235},{"id":"https://openalex.org/keywords/plasma-folate","display_name":"plasma folate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/red-blood-cell-folate","display_name":"red blood cell folate","score":1.0},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.8640000224113464},{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9769999980926514},{"id":"https://openalex.org/keywords/folate-metabolism-disorders","display_name":"folate metabolism disorders","score":0.7200000286102295},{"id":"https://openalex.org/keywords/utah","display_name":"Utah","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.8614383339881897},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.743837833404541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7410596013069153},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7215665578842163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.541601836681366},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.4943668842315674},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4431614875793457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3976190388202667},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3671134114265442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15230980515480042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1371196210384369}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002971","descriptor_name":"Cleft Lip","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014589","descriptor_name":"Utah","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014589","descriptor_name":"Utah","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014589","descriptor_name":"Utah","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/bdra.20762","doi":"https://doi.org/10.1002/bdra.20762","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bdra.20762","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bdra.20762","source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},{"id":"pmid:21290562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21290562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part A, Clinical and molecular teratology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3679494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4703080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4703080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4703080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Birth Defects Res A Clin Mol Teratol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/bdra.20762","doi":"https://doi.org/10.1002/bdra.20762","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bdra.20762","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bdra.20762","source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G155649734","display_name":"NUTRIENT BIOMARKERS, GENES AND OROFACIAL CLEFTS","funder_award_id":"R01HD039061","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2063023724","display_name":null,"funder_award_id":"1R21-DE016877","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5376269337","display_name":"MATERNAL METABOLIC DISORDERS AND THE PREVENTION OF ORAL CLEFT BIRTH DEFECTS","funder_award_id":"U01DD000698","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G8421215672","display_name":null,"funder_award_id":"1UO1DD000698","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G8455084159","display_name":"Nutrition and Oral Clefts in Asia: Planning Grant","funder_award_id":"R21DE016877","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G900635416","display_name":null,"funder_award_id":"5-RO1-HD39061","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320309198","display_name":"Utah State University","ror":"https://ror.org/00h6set76"},{"id":"https://openalex.org/F4320310050","display_name":"University of Utah","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139267199.pdf"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1971550901","https://openalex.org/W1986819584","https://openalex.org/W1987814479","https://openalex.org/W1989793230","https://openalex.org/W2008734402","https://openalex.org/W2049317020","https://openalex.org/W2060173287","https://openalex.org/W2067546738","https://openalex.org/W2072723939","https://openalex.org/W2077551742","https://openalex.org/W2082550546","https://openalex.org/W2102674553","https://openalex.org/W2124314873","https://openalex.org/W2130773424","https://openalex.org/W2141397120","https://openalex.org/W2155870343","https://openalex.org/W2157304866","https://openalex.org/W2157577918","https://openalex.org/W2158258051","https://openalex.org/W2164465963","https://openalex.org/W2197747455","https://openalex.org/W2326564641","https://openalex.org/W2337949001","https://openalex.org/W2353425685","https://openalex.org/W2394814908","https://openalex.org/W2592050191","https://openalex.org/W2601068201","https://openalex.org/W2917426357","https://openalex.org/W4206832593","https://openalex.org/W4237533794","https://openalex.org/W4255114350"],"related_works":["https://openalex.org/W78637109","https://openalex.org/W3000534148","https://openalex.org/W4416996185","https://openalex.org/W2467027563","https://openalex.org/W2157304866","https://openalex.org/W2164465963","https://openalex.org/W4400930417","https://openalex.org/W153652412","https://openalex.org/W2130773424","https://openalex.org/W3095218835"],"abstract_inverted_index":{"BACKGROUND:":[0],"Maternal":[1,18],"folate":[2,22,26,201,242],"intake":[3],"and":[4,24,35,49,67,103,151,160,173,175,194,211,217,222],"related":[5],"biomarkers":[6],"have":[7],"been":[8],"inconsistently":[9],"associated":[10,204],"with":[11,46,61,100,124,154,167,183,205],"a":[12,43,184,245],"risk":[13,121,166,208],"of":[14,20,54,122,170,209,241,250],"oral":[15],"clefts.":[16,251],"METHODS:":[17],"concentrations":[19,224],"plasma":[21,28,37],"(PF)":[23],"erythrocyte":[25],"(EF),":[27],"pyridoxal-5'-phosphate":[29],"(PLP;":[30],"active":[31],"vitamin":[32],"B(6)":[33],")":[34],"total":[36],"homocysteine":[38],"(tHcy)":[39],"were":[40,112,138],"measured":[41],"in":[42,75,97,108,145,181,214,247],"Utah":[44],"study":[45],"347":[47],"cases":[48,150],"469":[50],"controls.":[51],"RESULTS:":[52],"Risk":[53],"all":[55],"clefts":[56],"combined,":[57],"including":[58],"cleft":[59,64,68,165],"lip":[60],"or":[62,142,238],"without":[63],"palate":[65,69],"(CL/P)":[66],"only":[70],"(CP),":[71],"was":[72,127,178,203],"65%":[73],"lower":[74,128],"the":[76,98,115,190,212,248],"highest":[77,116],"versus":[78,117,186],"lowest":[79,118],"PF":[80],"quartile":[81],"(odds":[82],"ratio":[83],"[OR],":[84],"0.35;":[85],"95%":[86,131],"confidence":[87],"interval":[88,157,188],"[CI],":[89],"0.23-0.53;":[90],"p-trend":[91],"<":[92,106],"0.001).":[93],"Results":[94],"remained":[95],"significant":[96,139],"subgroups":[99],"isolated":[101],"CL/P":[102],"CP":[104,123],"(p-trend":[105],"0.001":[107],"each).":[109],"EF":[110],"results":[111],"similar.":[113],"In":[114],"PLP":[119,141,174],"quartile,":[120],"other":[125,136],"malformations":[126],"(OR,":[129],"0.25;":[130],"CI,":[132],"0.07-0.95);":[133],"however,":[134],"no":[135],"associations":[137],"for":[140],"tHcy.":[143],"Differences":[144],"mean":[146,215],"biomarker":[147],"levels":[148],"between":[149,158,189],"controls":[152],"widened":[153,225],"an":[155,206,236],"increasing":[156,168],"delivery":[159,193],"maternal":[161,199],"blood":[162,195,200],"collection.":[163,196],"Decreased":[164],"quartiles":[169],"PF,":[171,219],"EF,":[172,220],"decreasing":[176],"tHcy":[177,223],"more":[179],"apparent":[180],"mothers":[182],"longer":[185],"shorter":[187],"index":[191],"child":[192],"CONCLUSION:":[197],"Low":[198],"concentration":[202],"increased":[207],"clefts,":[210],"differences":[213],"case":[216],"control":[218],"PLP,":[221],"over":[226],"time.":[227],"Additional":[228],"mechanistic":[229],"studies":[230],"are":[231],"warranted":[232],"to":[233],"elucidate":[234],"whether":[235],"acquired":[237],"inherited":[239],"disorder":[240],"metabolism":[243],"plays":[244],"role":[246],"etiology":[249]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}