{"id":"https://openalex.org/W2139249750","doi":"https://doi.org/10.18632/oncotarget.3245","title":"Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma","display_name":"Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma","publication_year":2014,"publication_date":"2014-12-31","ids":{"openalex":"https://openalex.org/W2139249750","doi":"https://doi.org/10.18632/oncotarget.3245","mag":"2139249750","pmid":"https://pubmed.ncbi.nlm.nih.gov/25739120","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413659"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.3245","doi":"https://doi.org/10.18632/oncotarget.3245","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3245","pdf_url":"https://www.oncotarget.com/article/3245/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/3245/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008966396","display_name":"Roberto Jose Diaz","orcid":"https://orcid.org/0000-0003-0804-9952","observed_orcids":["https://orcid.org/0000-0003-0804-9952"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Roberto Jose Diaz","raw_affiliation_strings":["Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017136932","display_name":"Brian J. Golbourn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Brian Golbourn","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101926244","display_name":"Cl\u00e1udia C. Faria","orcid":"https://orcid.org/0000-0003-1259-9922","observed_orcids":["https://orcid.org/0000-0003-1259-9922"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Claudia Faria","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083880051","display_name":"Daniel J. Picard","orcid":"https://orcid.org/0000-0003-3375-6202","observed_orcids":["https://orcid.org/0000-0003-3375-6202"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniel Picard","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008096194","display_name":"David J. H. Shih","orcid":"https://orcid.org/0000-0002-9802-4937","observed_orcids":["https://orcid.org/0000-0002-9802-4937"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Shih","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Denis Raynaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Denis Raynaud","raw_affiliation_strings":["Analytical Facility for Bioactive Molecules, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Facility for Bioactive Molecules, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028089040","display_name":"Michael Leadly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Leadly","raw_affiliation_strings":["Analytical Facility for Bioactive Molecules, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Facility for Bioactive Molecules, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037852813","display_name":"Danielle Mackenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle MacKenzie","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082795916","display_name":"Melissa Bryant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Melissa Bryant","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057776642","display_name":"Matthew Bebenek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Bebenek","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029519500","display_name":"Christian A. Smith","orcid":"https://orcid.org/0000-0001-9002-7861","observed_orcids":["https://orcid.org/0000-0001-9002-7861"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christian A. Smith","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644772","display_name":"Michael D. Taylor","orcid":"https://orcid.org/0000-0001-7009-3466","observed_orcids":["https://orcid.org/0000-0001-7009-3466","https://orcid.org/0009-0001-7181-1906"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael D. Taylor","raw_affiliation_strings":["Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053563254","display_name":"Annie Huang","orcid":"https://orcid.org/0000-0002-1987-6980","observed_orcids":["https://orcid.org/0000-0002-1987-6980"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Annie Huang","raw_affiliation_strings":["The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067215084","display_name":"James T. Rutka","orcid":"https://orcid.org/0000-0003-0851-7330","observed_orcids":["https://orcid.org/0000-0003-0851-7330"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James T. Rutka","raw_affiliation_strings":["Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Hospital for Sick Children. Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008966396","https://openalex.org/A5017136932"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":null,"apc_paid":null,"fwci":0.6151,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.6561469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"5","first_page":"3359","last_page":"3374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/myc-overexpression","display_name":"MYC overexpression","score":0.9879999756813049},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.800000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/endoreplication","display_name":"endoreplication","score":0.777999997138977},{"id":"https://openalex.org/keywords/group-3-medulloblastoma","display_name":"Group 3 medulloblastoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intracranial-tumor-growth","display_name":"intracranial tumor growth","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-distribution-in-brain","display_name":"brain drug distribution","score":0.7350000143051147},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4950000047683716},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9368795156478882},{"id":"https://openalex.org/C141937037","wikidata":"https://www.wikidata.org/wiki/Q14911664","display_name":"Aurora B kinase","level":5,"score":0.7168113589286804},{"id":"https://openalex.org/C145226528","wikidata":"https://www.wikidata.org/wiki/Q1340781","display_name":"Endoreduplication","level":4,"score":0.7043545842170715},{"id":"https://openalex.org/C2780808130","wikidata":"https://www.wikidata.org/wiki/Q24745285","display_name":"Aurora kinase","level":4,"score":0.6406663656234741},{"id":"https://openalex.org/C20552341","wikidata":"https://www.wikidata.org/wiki/Q4822632","display_name":"Aurora inhibitor","level":4,"score":0.5651935338973999},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5257188677787781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5248408913612366},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4727543294429779},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44905853271484375},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43595850467681885},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4307704567909241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.340317964553833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2869926691055298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2709791958332062},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2513243854045868},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.19788414239883423},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.1380479633808136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10863056778907776}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064107","descriptor_name":"Aurora Kinase B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064107","descriptor_name":"Aurora Kinase B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064107","descriptor_name":"Aurora Kinase B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.3245","doi":"https://doi.org/10.18632/oncotarget.3245","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3245","pdf_url":"https://www.oncotarget.com/article/3245/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3391315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4413659","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413659","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:25739120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25739120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.3245","doi":"https://doi.org/10.18632/oncotarget.3245","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.3245","pdf_url":"https://www.oncotarget.com/article/3245/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000105062","display_name":null,"funder_award_id":"MOP 74610","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139249750.pdf","grobid_xml":"https://content.openalex.org/works/W2139249750.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1517044333","https://openalex.org/W1947312736","https://openalex.org/W1967580058","https://openalex.org/W1972215727","https://openalex.org/W1974952191","https://openalex.org/W1980924853","https://openalex.org/W1983973807","https://openalex.org/W1992446787","https://openalex.org/W1994488152","https://openalex.org/W1996409634","https://openalex.org/W2006303534","https://openalex.org/W2021780761","https://openalex.org/W2026315306","https://openalex.org/W2027315326","https://openalex.org/W2027516869","https://openalex.org/W2029714022","https://openalex.org/W2036473725","https://openalex.org/W2039379153","https://openalex.org/W2043179978","https://openalex.org/W2052870347","https://openalex.org/W2060387110","https://openalex.org/W2062831570","https://openalex.org/W2063794672","https://openalex.org/W2071156666","https://openalex.org/W2072015866","https://openalex.org/W2082080058","https://openalex.org/W2094252236","https://openalex.org/W2099696802","https://openalex.org/W2104323199","https://openalex.org/W2112064734","https://openalex.org/W2113159346","https://openalex.org/W2113933978","https://openalex.org/W2118124054","https://openalex.org/W2118528246","https://openalex.org/W2123035617","https://openalex.org/W2125624250","https://openalex.org/W2127621535","https://openalex.org/W2127643721","https://openalex.org/W2128016549","https://openalex.org/W2128784982","https://openalex.org/W2130296076","https://openalex.org/W2134816104","https://openalex.org/W2150122219","https://openalex.org/W2153384414","https://openalex.org/W2153398041","https://openalex.org/W2153850465","https://openalex.org/W2156903057","https://openalex.org/W2158094911","https://openalex.org/W2167297605","https://openalex.org/W2167869412","https://openalex.org/W2171975491"],"related_works":["https://openalex.org/W2167297605","https://openalex.org/W2128680604","https://openalex.org/W2332497092","https://openalex.org/W4404129746","https://openalex.org/W4381951356","https://openalex.org/W2322524813","https://openalex.org/W2008170212","https://openalex.org/W2063844597","https://openalex.org/W2767368317","https://openalex.org/W2325142196"],"abstract_inverted_index":{"//":[0,130],"Roberto":[1],"Jose":[2],"Diaz":[3],"1,2,3,*":[4],",":[5,9,13,17,21,25,29,33,37,41,46,51],"Brian":[6],"Golbourn":[7],"1,*":[8],"Claudia":[10],"Faria":[11],"1":[12,16,20,32,36,40,45,54,60],"Daniel":[14],"Picard":[15],"David":[18],"Shih":[19],"Denis":[22],"Raynaud":[23],"4":[24,28,103],"Michael":[26,47],"Leadly":[27],"Danielle":[30],"MacKenzie":[31],"Melissa":[34],"Bryant":[35],"Matthew":[38],"Bebenek":[39],"Christian":[42],"A.":[43],"Smith":[44],"D.":[48],"Taylor":[49],"1,2,3":[50,59],"Annie":[52],"Huang":[53],"and":[55,67,170,266,289,303,311],"James":[56,126],"T.":[57,127],"Rutka":[58],"The":[61,109,226],"Hospital":[62,110],"for":[63,106,111,328],"Sick":[64,112],"Children.":[65],"Arthur":[66],"Sonia":[68],"Labatt":[69],"Brain":[70],"Tumour":[71],"Research":[72],"Centre,":[73],"Toronto,":[74,86,87,99,100,114],"Ontario,":[75,88,101,115],"Canada":[76,89,102,116],"2":[77],"Department":[78,94],"of":[79,85,92,95,98,160,178,188,191,200,222,229,261,297,331,339],"Laboratory":[80],"Medicine":[81],"&":[82],"Pathobiology,":[83],"University":[84,97],"3":[90,163,341],"Division":[91],"Neurosurgery,":[93],"Surgery,":[96],"Analytical":[104],"Facility":[105],"Bioactive":[107],"Molecules,":[108],"Children,":[113],"*":[117],"These":[118],"authors":[119],"contributed":[120],"equally":[121],"to":[122,182,218,247,258,282,306],"this":[123],"work":[124],"Correspondence:":[125],"Rutka,":[128],"email:":[129],"Keywords:":[131],"Aurora":[132,203,223,230,251,283,332],"kinase,":[133],"medulloblastoma,":[134],"tumor":[135,309],"biology,":[136],"molecular":[137,158],"therapy,cell-cycle":[138],"Received":[139],":":[140,145,150],"June":[141],"29,":[142],"2014":[143,148,153],"Accepted":[144],"December":[146,151],"24,":[147],"Published":[149],"31,":[152],"Abstract":[154],"Medulloblastoma":[155],"comprises":[156],"four":[157],"subgroups":[159],"which":[161],"Group":[162,340],"medulloblastoma":[164,209,238,245,277,321],"is":[165,202],"characterized":[166],"by":[167],"MYC":[168,171,179,213,242],"amplification":[169],"overexpression.":[172],"Lymphoma":[173],"cells":[174,210,239,246,278],"expressing":[175],"high":[176],"levels":[177],"are":[180],"susceptible":[181],"apoptosis":[183,290],"following":[184],"treatment":[185,338],"with":[186,240],"inhibitors":[187,335],"mitosis.":[189],"One":[190],"the":[192,219,295,300,304,326,337],"key":[193],"regulatory":[194],"kinases":[195],"involved":[196],"in":[197,235,314,336],"multiple":[198],"stages":[199],"mitosis":[201],"kinase":[204,231,333],"B.":[205],"We":[206],"hypothesized":[207],"that":[208,211,272],"overexpress":[212],"would":[214],"be":[215,259],"uniquely":[216],"sensitized":[217,244],"apoptotic":[220],"effects":[221],"B":[224,232,252,284,334],"inhibition.":[225,253],"specific":[227],"inhibition":[228,285],"was":[233,256],"achieved":[234],"MYC-":[236],"overexpressing":[237],"AZD1152-HQPA.":[241],"overexpression":[243],"cell":[248],"death":[249],"upon":[250],"This":[254],"process":[255],"found":[257],"independent":[260],"endoreplication.":[262],"Using":[263],"both":[264],"flank":[265],"intracranial":[267,308],"cerebellar":[268],"xenografts":[269],"we":[270,293],"demonstrate":[271],"tumors":[273,317],"formed":[274,318],"from":[275,319],"MYC-overexpressing":[276,320],"show":[279,294],"a":[280],"response":[281],"including":[286],"growth":[287,310],"impairment":[288],"induction.":[291],"Lastly,":[292],"distribution":[296],"AZD1152-HQPA":[298],"within":[299],"mouse":[301],"brain":[302],"ability":[305],"inhibit":[307],"prolong":[312],"survival":[313],"mice":[315],"bearing":[316],"cells.":[322],"Our":[323],"results":[324],"suggest":[325],"potential":[327],"therapeutic":[329],"application":[330],"medulloblastoma.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}