{"id":"https://openalex.org/W2139240734","doi":null,"title":"Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.","display_name":"Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2139240734","mag":"2139240734","pmid":"https://pubmed.ncbi.nlm.nih.gov/10676648"},"language":"en","primary_location":{"id":"pmid:10676648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10676648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059195101","display_name":"Ingolf Cascorbi","orcid":"https://orcid.org/0000-0002-2182-9534","observed_orcids":["https://orcid.org/0000-0002-2182-9534"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I Cascorbi","raw_affiliation_strings":["Institute of Clinical Pharmacology, University Medical Center Charit\u00e9, Humboldt University of Berlin, Germany. ingolf.cascorbi@charite.de","Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pharmacology, University Medical Center Charit\u00e9, Humboldt University of Berlin, Germany. ingolf.cascorbi@charite.de","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071690638","display_name":"Stefan W. Henning","orcid":"https://orcid.org/0000-0003-3125-4073","observed_orcids":["https://orcid.org/0000-0003-3125-4073"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Henning","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064971840","display_name":"J\u00fcrgen Brockm\u00f6ller","orcid":"https://orcid.org/0000-0002-8854-1340","observed_orcids":["https://orcid.org/0000-0002-8854-1340"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Brockm\u00f6ller","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085609731","display_name":"J\u00fcrgen Gephart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Gephart","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Meisel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Meisel","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107446273","display_name":"Joachim Michael M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J M M\u00fcller","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004238053","display_name":"Robert Loddenkemper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Loddenkemper","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001414279","display_name":"Ivar Roots","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I Roots","raw_affiliation_strings":["Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.1782,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.99222546,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"60","issue":"3","first_page":"644","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharyngeal-cancer","display_name":"pharyngeal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aerodigestive-tract-cancer","display_name":"aerodigestive tract cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5509999990463257},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5270000100135803},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.5120000243186951},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.753000020980835},{"id":"https://openalex.org/keywords/aromatic-amines","display_name":"aromatic amines","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7384318709373474},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7376483082771301},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7251474857330322},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.684241533279419},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6271297931671143},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6033428907394409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5862959623336792},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5781328082084656},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5404245853424072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2441825568675995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17013603448867798},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14300352334976196},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010610","descriptor_name":"Pharyngeal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010610","descriptor_name":"Pharyngeal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10676648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10676648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2139240734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10676648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W174630865","https://openalex.org/W1521885247","https://openalex.org/W1552162400","https://openalex.org/W1558170944","https://openalex.org/W1559870962","https://openalex.org/W1600783018","https://openalex.org/W1637003823","https://openalex.org/W1725300350","https://openalex.org/W1886998470","https://openalex.org/W1966335631","https://openalex.org/W1967978735","https://openalex.org/W1968212813","https://openalex.org/W1976178228","https://openalex.org/W1985394365","https://openalex.org/W1993067220","https://openalex.org/W2015252699","https://openalex.org/W2020858574","https://openalex.org/W2029945308","https://openalex.org/W2031967567","https://openalex.org/W2032522259","https://openalex.org/W2045541899","https://openalex.org/W2047932752","https://openalex.org/W2052991105","https://openalex.org/W2080734374","https://openalex.org/W2083141752","https://openalex.org/W2083841608","https://openalex.org/W2089055247","https://openalex.org/W2090003851","https://openalex.org/W2090347206","https://openalex.org/W2152850394","https://openalex.org/W2276234297","https://openalex.org/W2409681254","https://openalex.org/W2410861909","https://openalex.org/W2418325212","https://openalex.org/W4360893946"],"related_works":["https://openalex.org/W1914775755","https://openalex.org/W2069820921","https://openalex.org/W2257064529","https://openalex.org/W2027434740","https://openalex.org/W2184696255","https://openalex.org/W2079295255","https://openalex.org/W2370465739","https://openalex.org/W1990401036","https://openalex.org/W2166816681","https://openalex.org/W1995013605"],"abstract_inverted_index":{"Myeloperoxidase":[0],"(MPO),":[1],"an":[2],"enzyme":[3],"that":[4,280],"is":[5,285],"highly":[6,20],"expressed":[7],"in":[8,33,122,289],"neutrophil":[9],"leukocytes,":[10],"transforms":[11],"precarcinogens":[12],"such":[13],"as":[14],"benzo(a)pyrene":[15],"and":[16,53,79,107,116,172,191,211,222,256,267,294],"aromatic":[17],"amines":[18],"to":[19,81,144],"reactive":[21],"intermediates.":[22],"A":[23,141],"G/A":[24,262],"polymorphism":[25,69],"located":[26],"463":[27],"bp":[28],"upstream":[29],"of":[30,66,95,102,109,137,193,231,235,292,300],"exon":[31],"1":[32],"the":[34,59,67,236,281,290],"promoter":[35],"region":[36],"strongly":[37],"reduces":[38],"MPO":[39,98,282],"mRNA":[40],"expression.":[41],"In":[42,114],"a":[43,271,286],"matched":[44,76],"case-control":[45],"study,":[46],"196":[47],"lung":[48,115,158,237,254,293],"cancer,":[49,52,224,250,255,296],"245":[50],"laryngeal":[51,117,169],"255":[54],"pharyngeal":[55,123,181,223,301],"cancer":[56,118,124,159,170,182],"patients":[57,83],"from":[58],"Berlin":[60],"area":[61],"were":[62,75,91,128,147,196],"investigated":[63],"for":[64,135,157,168,180,188,219,229],"frequency":[65],"G-463A":[68],"by":[70,77],"PCR/RFLP,":[71],"using":[72],"AciI.":[73],"They":[74],"age":[78],"gender":[80],"hospital":[82],"without":[84],"known":[85],"malignancies.":[86],"Moreover,":[87],"270":[88],"healthy":[89],"volunteers":[90],"genotyped,":[92],"obtaining":[93],"61.1%":[94],"individuals":[96,103,110],"with":[97,104,111,248,253],"genotype":[99,105,112],"-463G/G,":[100],"34.8%":[101],"G/A,":[106],"4.1%":[108],"A/A.":[113],"patients,":[119,125,160,171],"but":[120,297],"not":[121,299],"mutant":[126],"genotypes":[127],"significantly":[129],"less":[130],"frequent.":[131],"Crude":[132],"odds":[133],"ratios":[134],"carriers":[136,230],"one":[138,251,257],"or":[139],"two":[140],"alleles,":[142],"compared":[143],"wild-type":[145],"G/G,":[146],"0.58":[148],"[95%":[149],"confidence":[150],"interval":[151],"(CI),":[152],"0.38-0.88;":[153],"P":[154,165,177,201,208,216,243],"=":[155,166,178,202,209,217,244],"0.011]":[156],"0.63":[161],"(95%":[162,174,198,205,213,240],"CI,":[163,175,199,206,214,241],"0.43-0.92;":[164],"0.017)":[167],"0.82":[173],"0.57-1.17;":[176],"0.27)":[179],"patients.":[183],"The":[184],"relative":[185,227],"risks,":[186],"adjusted":[187],"age,":[189],"gender,":[190],"extent":[192],"cigarette":[194],"smoking":[195],"0.47":[197],"0.28-0.79;":[200],"0.004),":[203],"0.66":[204],"0.44-1.01;":[207],"0.054),":[210],"0.75":[212],"0.51-1.12;":[215],"0.16)":[218],"lung,":[220],"larynx,":[221],"respectively.":[225],"Strikingly,":[226],"risk":[228],"-463A":[232,283],"among":[233],"adenocarcinoma":[234],"was":[238],"0.24":[239],"0.10-0.58;":[242],"0.002).":[245],"Two":[246],"cases":[247],"larynx":[249,295],"case":[252],"reference":[258],"subject":[259],"displayed":[260],"novel":[261],"mutations":[263],"at":[264],"-297":[265],"nucleotide":[266],"-296":[268],"nucleotide,":[269],"destroying":[270],"constitutive":[272],"AciI":[273],"cleavage":[274],"site.":[275],"Our":[276],"data":[277],"finally":[278],"suggest":[279],"variant":[284],"protective":[287],"factor":[288],"etiology":[291],"possibly":[298],"cancer.":[302]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
