{"id":"https://openalex.org/W2139238152","doi":"https://doi.org/10.1155/2015/417586","title":"Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib","display_name":"Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2139238152","doi":"https://doi.org/10.1155/2015/417586","mag":"2139238152","pmid":"https://pubmed.ncbi.nlm.nih.gov/26539491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4619821"},"language":"en","primary_location":{"id":"doi:10.1155/2015/417586","doi":"https://doi.org/10.1155/2015/417586","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/417586","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/417586.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2015/417586.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033610151","display_name":"Barbara Muz","orcid":"https://orcid.org/0000-0003-4125-4624","observed_orcids":["https://orcid.org/0000-0003-4125-4624"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Muz","raw_affiliation_strings":["Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055205128","display_name":"Feda Azab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feda Azab","raw_affiliation_strings":["Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016763648","display_name":"Pilar de la Puente","orcid":"https://orcid.org/0000-0001-5953-1197","observed_orcids":["https://orcid.org/0000-0001-5953-1197"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pilar de la Puente","raw_affiliation_strings":["Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015226531","display_name":"Scott A. Rollins","orcid":"https://orcid.org/0009-0003-2658-0082","observed_orcids":["https://orcid.org/0009-0003-2658-0082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Rollins","raw_affiliation_strings":["Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111159066","display_name":"Richard Alvarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Alvarez","raw_affiliation_strings":["Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068812618","display_name":"Ziad S. Kawar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziad Kawar","raw_affiliation_strings":["Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selexys Pharmaceuticals, 840 Research Parkway, Suite 510, Oklahoma City, OK 73104, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061338314","display_name":"Abdel Kareem Azab","orcid":"https://orcid.org/0000-0002-6371-2780","observed_orcids":["https://orcid.org/0000-0002-6371-2780"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abdel Kareem Azab","raw_affiliation_strings":["Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Division, Department of Radiation Oncology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061338314"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":1.5448,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82913018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2015","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/psgl-1","display_name":"PSGL-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tumor-cell-homing","display_name":"tumor cell homing","score":0.6470000147819519},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.652999997138977},{"id":"https://openalex.org/keywords/tumor-cell-dissemination","display_name":"tumor cell dissemination","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5699999928474426},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5690000057220459},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7380358576774597},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.7032832503318787},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6797772645950317},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6606863141059875},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6066479682922363},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6044164896011353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5249873399734497},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4638047218322754},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.42950907349586487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42219078540802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40671125054359436},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38743385672569275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29770320653915405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2445923388004303},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1155/2015/417586","doi":"https://doi.org/10.1155/2015/417586","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/417586","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/417586.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3607707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4619821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26539491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26539491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4619821","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4619821/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.7658","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.7658","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f0/07/BMRI2015-417586.PMC4619821.pdf","raw_type":"text"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5427","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-7373","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/6366","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1155/2015/417586","doi":"https://doi.org/10.1155/2015/417586","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/417586","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/417586.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139238152.pdf","grobid_xml":"https://content.openalex.org/works/W2139238152.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W38241211","https://openalex.org/W293207910","https://openalex.org/W1528751727","https://openalex.org/W1964036701","https://openalex.org/W1969000446","https://openalex.org/W2001174679","https://openalex.org/W2011849469","https://openalex.org/W2021680023","https://openalex.org/W2022817530","https://openalex.org/W2023693583","https://openalex.org/W2031348406","https://openalex.org/W2041546745","https://openalex.org/W2048720119","https://openalex.org/W2048916873","https://openalex.org/W2051517030","https://openalex.org/W2065815553","https://openalex.org/W2074209546","https://openalex.org/W2079863468","https://openalex.org/W2093622106","https://openalex.org/W2112998064","https://openalex.org/W2114915026","https://openalex.org/W2122028809","https://openalex.org/W2150091398","https://openalex.org/W2157453847","https://openalex.org/W2158736158","https://openalex.org/W2169864898","https://openalex.org/W2994044151","https://openalex.org/W4246991801"],"related_works":["https://openalex.org/W7098251379","https://openalex.org/W1170561581","https://openalex.org/W2074209546","https://openalex.org/W2560858090","https://openalex.org/W2558371886","https://openalex.org/W7061572800","https://openalex.org/W2150091398","https://openalex.org/W2969795870","https://openalex.org/W1581454711","https://openalex.org/W2920418016"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1],"(MM)":[2],"is":[3],"a":[4,38,165],"plasma":[5],"cell":[6],"malignancy":[7],"localized":[8],"in":[9,41,81,106,110,129,136,178],"the":[10,14,94,115,123,137,143,169],"bone":[11,144],"marrow.":[12],"Despite":[13],"introduction":[15],"of":[16,20,30,43,49,73,168,171,182],"novel":[17],"therapies":[18],"majority":[19],"MM":[21,44,52,85,97,107,133,148,183],"patients":[22],"relapse.":[23],"We":[24,89],"have":[25,90],"previously":[26],"shown":[27],"that":[28,92],"inhibition":[29],"P-selectin":[31,33,64,74,172],"and":[32,45,65,75,99,101,109,139,158,173,175,180],"glycoprotein":[34],"ligand-1":[35],"(PSGL-1)":[36],"play":[37],"key":[39],"role":[40],"proliferation":[42,105],"using":[46,77],"small-molecule":[47,58],"inhibitors":[48,59],"P-selectin/PSGL-1":[50],"sensitized":[51],"cells":[53,86,98,103,108,134,149],"to":[54,63,83,87,114,119,132,142,150,154,184],"therapy.":[55,88],"However,":[56],"these":[57],"had":[60],"low":[61],"specificity":[62],"showed":[66],"poor":[67],"pharmacokinetics.":[68],"Therefore,":[69],"we":[70],"tested":[71],"blocking":[72,126],"PSGL-1":[76,174],"functional":[78],"monoclonal":[79],"antibodies":[80],"order":[82],"sensitize":[84],"demonstrated":[91],"inhibiting":[93],"interaction":[95,128],"between":[96],"endothelial":[100],"stromal":[102],"decreased":[104],"parallel":[111],"induced":[112],"loose-adhesion":[113],"primary":[116],"tumor":[117,156],"site":[118],"facilitate":[120],"egress.":[121],"At":[122],"same":[124],"time,":[125],"this":[127],"vivo":[130],"led":[131],"retention":[135],"circulation":[138],"delayed":[140],"homing":[141],"marrow,":[145],"thus":[146],"exposing":[147],"bortezomib":[151],"which":[152],"contributed":[153],"reduced":[155],"growth":[157],"better":[159,166],"mice":[160],"survival.":[161],"This":[162],"study":[163],"provides":[164],"understanding":[167],"biology":[170],"their":[176],"roles":[177],"dissemination":[179],"resensitization":[181],"treatment.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}