{"id":"https://openalex.org/W2139237341","doi":"https://doi.org/10.1073/pnas.0708474105","title":"Activation of the hypoxia-inducible factor-1\u03b1 pathway accelerates bone regeneration","display_name":"Activation of the hypoxia-inducible factor-1\u03b1 pathway accelerates bone regeneration","publication_year":2008,"publication_date":"2008-01-09","ids":{"openalex":"https://openalex.org/W2139237341","doi":"https://doi.org/10.1073/pnas.0708474105","mag":"2139237341","pmid":"https://pubmed.ncbi.nlm.nih.gov/18184809"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0708474105","doi":"https://doi.org/10.1073/pnas.0708474105","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0708474105","pdf_url":"https://www.pnas.org/content/pnas/105/2/686.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/105/2/686.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106482730","display_name":"Chao Wan","orcid":"https://orcid.org/0000-0001-6780-2006","observed_orcids":["https://orcid.org/0000-0001-6780-2006"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Wan","raw_affiliation_strings":["Departments of *Pathology,","Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078490495","display_name":"Shawn R. Gilbert","orcid":"https://orcid.org/0000-0002-0683-3172","observed_orcids":["https://orcid.org/0000-0002-0683-3172"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn R. Gilbert","raw_affiliation_strings":["Surgery, and","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, and","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347261","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0003-4524-1812","observed_orcids":["https://orcid.org/0000-0003-4524-1812"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Departments of *Pathology,","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044176332","display_name":"Xuemei Cao","orcid":"https://orcid.org/0000-0001-5504-5554","observed_orcids":["https://orcid.org/0000-0001-5504-5554","https://orcid.org/0000-0002-8877-5518"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Cao","raw_affiliation_strings":["Departments of *Pathology,","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079944579","display_name":"Xing Shen","orcid":"https://orcid.org/0000-0003-3041-301X","observed_orcids":["https://orcid.org/0000-0003-3041-301X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Shen","raw_affiliation_strings":["Departments of *Pathology,","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015760289","display_name":"Girish Ramaswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girish Ramaswamy","raw_affiliation_strings":["Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003931300","display_name":"Kimberly A. Jacobsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly A. Jacobsen","raw_affiliation_strings":["Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063302945","display_name":"Zainab S Al-Aql","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zainab S. Alaql","raw_affiliation_strings":["Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025629716","display_name":"Alan W. Eberhardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan W. Eberhardt","raw_affiliation_strings":["Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844477","display_name":"Louis C. Gerstenfeld","orcid":"https://orcid.org/0000-0002-0477-1211","observed_orcids":["https://orcid.org/0000-0002-0477-1211"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis C. Gerstenfeld","raw_affiliation_strings":["Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081041296","display_name":"Thomas A. Einhorn","orcid":"https://orcid.org/0000-0002-5075-4885","observed_orcids":["https://orcid.org/0000-0002-5075-4885"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Einhorn","raw_affiliation_strings":["Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103366638","display_name":"Lianfu Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lianfu Deng","raw_affiliation_strings":["Departments of *Pathology,","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108588602","display_name":"Thomas L. Clemens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Clemens","raw_affiliation_strings":["Departments of *Pathology,","Veterans Administration Medical Center, Birmingham, AL 35294","Department of Veterans Affairs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Pathology,","institution_ids":[]},{"raw_affiliation_string":"Veterans Administration Medical Center, Birmingham, AL 35294","institution_ids":["https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Department of Veterans Affairs","institution_ids":["https://openalex.org/I1322918889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.1738,"has_fulltext":true,"cited_by_count":517,"citation_normalized_percentile":{"value":0.99000086,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"105","issue":"2","first_page":"686","last_page":"691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.3215000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.3215000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.26269999146461487,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.1054999977350235,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/distraction-osteogenesis","display_name":"distraction osteogenesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8360000252723694},{"id":"https://openalex.org/keywords/von-hippel-lindau-protein","display_name":"von Hippel-Lindau protein","score":0.7329999804496765},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.7229999899864197},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.4970000088214874},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7706141471862793},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6136725544929504},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5743399858474731},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.537018358707428},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.5271931290626526},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.4804753363132477},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4750880300998688},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.41366660594940186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4022185206413269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3662109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35567110776901245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3320273756980896},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3309723436832428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1837683916091919},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1422378122806549},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11886107921600342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10801589488983154},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.10055384039878845},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0708474105","doi":"https://doi.org/10.1073/pnas.0708474105","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0708474105","pdf_url":"https://www.pnas.org/content/pnas/105/2/686.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:18184809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18184809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1457894","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC2206597","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2206597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2206597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.0708474105","doi":"https://doi.org/10.1073/pnas.0708474105","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0708474105","pdf_url":"https://www.pnas.org/content/pnas/105/2/686.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2005671287","display_name":null,"funder_award_id":"P01 AR049920","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2261988208","display_name":"UAB Core Center for Basic Skeletal Research (CCBSR)","funder_award_id":"5p30ar046031-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2599434185","display_name":null,"funder_award_id":"R01 AR049410","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G33895227","display_name":null,"funder_award_id":"P30-AR046031","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5004010814","display_name":null,"funder_award_id":"R21 AR054771","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6977728123","display_name":null,"funder_award_id":"AR49410","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G923313191","display_name":null,"funder_award_id":"AR054771","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320312852","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139237341.pdf","grobid_xml":"https://content.openalex.org/works/W2139237341.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1490068297","https://openalex.org/W1749022239","https://openalex.org/W1783580437","https://openalex.org/W1975643300","https://openalex.org/W1982861439","https://openalex.org/W1983620316","https://openalex.org/W1987155597","https://openalex.org/W1988363595","https://openalex.org/W1989796644","https://openalex.org/W1991742354","https://openalex.org/W1992955128","https://openalex.org/W1993066851","https://openalex.org/W1996356693","https://openalex.org/W2003818582","https://openalex.org/W2006174806","https://openalex.org/W2006771354","https://openalex.org/W2017309637","https://openalex.org/W2025283556","https://openalex.org/W2025974453","https://openalex.org/W2026185771","https://openalex.org/W2036222893","https://openalex.org/W2038607522","https://openalex.org/W2040031153","https://openalex.org/W2052620919","https://openalex.org/W2057551034","https://openalex.org/W2061968656","https://openalex.org/W2065704432","https://openalex.org/W2067673651","https://openalex.org/W2068654254","https://openalex.org/W2075054245","https://openalex.org/W2082566600","https://openalex.org/W2083957739","https://openalex.org/W2088887175","https://openalex.org/W2098921416","https://openalex.org/W2099281806","https://openalex.org/W2099397203","https://openalex.org/W2103158810","https://openalex.org/W2109293470","https://openalex.org/W2124287509","https://openalex.org/W2137305295","https://openalex.org/W2138305712","https://openalex.org/W2143035259","https://openalex.org/W2144625075","https://openalex.org/W2146749461","https://openalex.org/W2149472502","https://openalex.org/W2151615254","https://openalex.org/W2155907836","https://openalex.org/W2158351424","https://openalex.org/W2161336519","https://openalex.org/W2168789685","https://openalex.org/W2322126443","https://openalex.org/W2472167186","https://openalex.org/W6610412359"],"related_works":["https://openalex.org/W1953262712","https://openalex.org/W2405357586","https://openalex.org/W4237337617","https://openalex.org/W2147372674","https://openalex.org/W2381595950","https://openalex.org/W3031917702","https://openalex.org/W3029904244","https://openalex.org/W2160758535","https://openalex.org/W2099215275","https://openalex.org/W3030464759"],"abstract_inverted_index":{"The":[0,82],"hypoxia-inducible":[1],"factor-1alpha":[2],"(HIF-1alpha)":[3],"pathway":[4,29,142],"is":[5,17,30],"the":[6,27,89,127,140,155],"central":[7],"regulator":[8],"of":[9,100,106,119,147,157],"adaptive":[10],"responses":[11],"to":[12,42,67,162],"low":[13],"oxygen":[14],"availability":[15],"and":[16,35,40,61,79,85,95,113,132,153],"required":[18,149],"for":[19,150],"normal":[20],"skeletal":[21,44,151],"development.":[22],"Here,":[23],"we":[24],"demonstrate":[25],"that":[26],"HIF-1alpha":[28,53,73,141],"activated":[31],"during":[32],"bone":[33,64,80,86,135,164],"repair":[34],"can":[36],"be":[37],"manipulated":[38],"genetically":[39],"pharmacologically":[41],"improve":[43,163],"healing.":[45,81,165],"Mice":[46],"lacking":[47,72],"pVHL":[48,90],"in":[49,55,65,74,88,116,124],"osteoblasts":[50,56,75],"with":[51],"constitutive":[52],"activation":[54],"had":[57,76],"markedly":[58,133],"increased":[59,83,114,130],"vascularity":[60,84],"produced":[62],"more":[63],"response":[66],"distraction":[68,128],"osteogenesis,":[69],"whereas":[70],"mice":[71],"impaired":[77],"angiogenesis":[78,115,131],"regeneration":[87,152],"mutants":[91],"were":[92],"VEGF":[93,101],"dependent":[94],"eliminated":[96],"by":[97],"concomitant":[98],"administration":[99],"receptor":[102],"antibodies.":[103],"Small-molecule":[104],"inhibitors":[105],"HIF":[107,158],"prolyl":[108],"hydroxylation":[109],"stabilized":[110],"HIF/VEGF":[111],"production":[112],"vitro.":[117],"One":[118],"these":[120],"molecules":[121],"(DFO)":[122],"administered":[123],"vivo":[125],"into":[126],"gap":[129],"improved":[134],"regeneration.":[136],"These":[137],"results":[138],"identify":[139],"as":[143,160],"a":[144],"critical":[145],"mediator":[146],"neoangiogenesis":[148],"suggest":[154],"application":[156],"activators":[159],"therapies":[161]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":28}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
