{"id":"https://openalex.org/W2139235684","doi":"https://doi.org/10.4049/jimmunol.104.3.648","title":"The Dissociation of Human Serum 7S and Bovine Colostrum Immune Globulins into Subunits by Reduction-Alkylation-Succinylation","display_name":"The Dissociation of Human Serum 7S and Bovine Colostrum Immune Globulins into Subunits by Reduction-Alkylation-Succinylation","publication_year":1970,"publication_date":"1970-03-01","ids":{"openalex":"https://openalex.org/W2139235684","doi":"https://doi.org/10.4049/jimmunol.104.3.648","mag":"2139235684","pmid":"https://pubmed.ncbi.nlm.nih.gov/4985172"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.104.3.648","doi":"https://doi.org/10.4049/jimmunol.104.3.648","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.104.3.648","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049252721","display_name":"Anatoly Bezkorovainy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoly Bezkorovainy","raw_affiliation_strings":["Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029611565","display_name":"Rainer H. Zschocke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rainer Zschocke","raw_affiliation_strings":["Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066519401","display_name":"Dietmar Grohlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dietmar Grohlich","raw_affiliation_strings":["Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Presbyterian-St. Luke's Hospital and the Department of Biological Chemistry, University of Illinois, College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, College of Medicine and the , Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.287,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80257791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"3","first_page":"648","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7s-immunoglobulin","display_name":"7S immunoglobulin","score":0.859000027179718},{"id":"https://openalex.org/keywords/colostrum-immunoglobulins","display_name":"colostrum immunoglobulins","score":0.8650000095367432},{"id":"https://openalex.org/keywords/heavy-chain","display_name":"heavy chain","score":0.6159999966621399},{"id":"https://openalex.org/keywords/light-chain","display_name":"light chain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/succinylation","display_name":"succinylation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/molecular-weight-determination","display_name":"molecular weight determination","score":0.8389999866485596},{"id":"https://openalex.org/keywords/precipitin-lines","display_name":"precipitin lines","score":0.5830000042915344},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.5419999957084656},{"id":"https://openalex.org/keywords/bovine-colostrum","display_name":"bovine colostrum","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C12290205","wikidata":"https://www.wikidata.org/wiki/Q22284030","display_name":"Succinylation","level":4,"score":0.8592272996902466},{"id":"https://openalex.org/C2779073587","wikidata":"https://www.wikidata.org/wiki/Q192746","display_name":"Colostrum","level":3,"score":0.8169604539871216},{"id":"https://openalex.org/C133229898","wikidata":"https://www.wikidata.org/wiki/Q7239484","display_name":"Precipitin","level":3,"score":0.7633675336837769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7167534828186035},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.7030541300773621},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.6838468313217163},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6537428498268127},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.6292739510536194},{"id":"https://openalex.org/C2781054842","wikidata":"https://www.wikidata.org/wiki/Q6725283","display_name":"Macroglobulin","level":2,"score":0.5914559364318848},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.5024333000183105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4661152958869934},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.4299781322479248},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4234505891799927},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3762879967689514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18001839518547058},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10041090846061707},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.08704406023025513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07859086990356445},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000812","descriptor_name":"Anhydrides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003126","descriptor_name":"Colostrum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007120","descriptor_name":"Immunochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008623","descriptor_name":"Mercaptoethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012712","descriptor_name":"Serum Globulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.104.3.648","doi":"https://doi.org/10.4049/jimmunol.104.3.648","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.104.3.648","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:4985172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4985172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963840770","https://openalex.org/W2099195270","https://openalex.org/W2071016554","https://openalex.org/W1984004823","https://openalex.org/W2077988117","https://openalex.org/W1990690036","https://openalex.org/W4233189173","https://openalex.org/W2398453874","https://openalex.org/W3006764596","https://openalex.org/W2018853257"],"abstract_inverted_index":{"Abstract":[0],"Human":[1,22],"7S":[2,23],"and":[3,9,11,34,48,56,76,107],"bovine":[4,106],"colostral":[5,44,65,90],"immunoglobulins":[6,45],"were":[7,14],"succinylated":[8,93],"reduced-alkylated,":[10],"their":[12,96],"subunits":[13],"separated":[15],"by":[16,73],"chromatography":[17],"on":[18],"Sephadex":[19],"G-200":[20],"columns.":[21],"immunoglobulin":[24,66],"yielded":[25],"heavy":[26,47,75],"chains":[27,36,50],"with":[28,37,51,102,120],"a":[29,38],"molecular":[30,39,52,61],"weight":[31,40,62],"of":[32,41,54,63,67],"55,700":[33],"light":[35,49,78],"22,300.":[42],"Bovine":[43],"gave":[46],"weights":[53],"49,500":[55],"25,200,":[57],"respectively.":[58],"Since":[59],"the":[60,64,80,116,124],"166,000":[68],"is":[69,82],"not":[70],"accounted":[71],"for":[72],"two":[74,77],"chains,":[79],"possibility":[81],"raised":[83],"that":[84],"another":[85],"subunit":[86],"possibly":[87],"exists":[88],"in":[89,115],"immunoglobulin.":[91],"The":[92],"proteins":[94],"lost":[95],"ability":[97],"to":[98,104,123],"form":[99],"precipitin":[100,113],"lines":[101,114],"antisera":[103],"native":[105],"human":[108],"immunoglobulins,":[109],"but":[110],"they":[111],"formed":[112],"double":[117],"diffusion":[118],"system":[119],"an":[121],"antiserum":[122],"succinyl":[125],"hapten":[126],"residues.":[127]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
