{"id":"https://openalex.org/W2139234952","doi":"https://doi.org/10.1152/ajplung.00303.2009","title":"Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema","display_name":"Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema","publication_year":2010,"publication_date":"2010-05-15","ids":{"openalex":"https://openalex.org/W2139234952","doi":"https://doi.org/10.1152/ajplung.00303.2009","mag":"2139234952","pmid":"https://pubmed.ncbi.nlm.nih.gov/20472710"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00303.2009","doi":"https://doi.org/10.1152/ajplung.00303.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00303.2009","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074311299","display_name":"Gu Seob Roh","orcid":"https://orcid.org/0000-0003-4010-9628","observed_orcids":["https://orcid.org/0000-0003-4010-9628"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gu Seob Roh","raw_affiliation_strings":["Departments of 1Anatomy,","Departments of Anatomy, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy,","institution_ids":[]},{"raw_affiliation_string":"Departments of Anatomy, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, South Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112034070","display_name":"Chin\u2010ok Yi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chin-ok Yi","raw_affiliation_strings":["Departments of 1Anatomy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016837023","display_name":"Yu Ji Cho","orcid":"https://orcid.org/0000-0002-0247-802X","observed_orcids":["https://orcid.org/0000-0002-0247-802X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu Ji Cho","raw_affiliation_strings":["Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028356700","display_name":"Byeong Tak Jeon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byeong Tak Jeon","raw_affiliation_strings":["Departments of 1Anatomy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Anatomy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014697755","display_name":"Irina Tsoy Nizamudtinova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Tsoy Nizamudtinova","raw_affiliation_strings":["Pharmacology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101531645","display_name":"Hye Jung Kim","orcid":"https://orcid.org/0000-0002-7067-6810","observed_orcids":["https://orcid.org/0000-0002-7067-6810","https://orcid.org/0000-0002-7181-3696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hye Jung Kim","raw_affiliation_strings":["Pharmacology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775963","display_name":"Jinhyun Kim","orcid":"https://orcid.org/0000-0001-5235-2612","observed_orcids":["https://orcid.org/0000-0001-5235-2612"]},"institutions":[{"id":"https://openalex.org/I4210091148","display_name":"Gyeongsang National University Hospital","ror":"https://ror.org/00gbcc509","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I189442560","https://openalex.org/I4210091148"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hyun Kim","raw_affiliation_strings":["Clinical Research Institute, Gyeongsang National University Hospital, Jinju;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute, Gyeongsang National University Hospital, Jinju;","institution_ids":["https://openalex.org/I4210091148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024663629","display_name":"Yeon\u2010Mok Oh","orcid":"https://orcid.org/0000-0003-0116-4683","observed_orcids":["https://orcid.org/0000-0003-0116-4683"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon-Mok Oh","raw_affiliation_strings":["Department of Internal Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul;","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047175737","display_name":"Jin Won Huh","orcid":"https://orcid.org/0000-0002-3449-0461","observed_orcids":["https://orcid.org/0000-0002-3449-0461"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210108408","display_name":"Inje University Ilsan Paik Hospital","ror":"https://ror.org/01zx5ww52","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210108408","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Won Huh","raw_affiliation_strings":["Department of Internal Medicine, Ilsan Paik Hospital, Inje University, Goyang; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ilsan Paik Hospital, Inje University, Goyang; and","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210108408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413498","display_name":"Ji\u2010Hyun Lee","orcid":"https://orcid.org/0000-0002-0645-675X","observed_orcids":["https://orcid.org/0000-0002-0645-675X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]},{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hyun Lee","raw_affiliation_strings":["Department of Internal Medicine, Bundang CHA Hospital, University of Pocheon Jungmoon College of Medicine, Seongnam, South Korea","Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bundang CHA Hospital, University of Pocheon Jungmoon College of Medicine, Seongnam, South Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110364036","display_name":"Young Sil Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Sil Hwang","raw_affiliation_strings":["Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103081980","display_name":"Sang\u2010Do Lee","orcid":"https://orcid.org/0000-0001-8189-4509","observed_orcids":["https://orcid.org/0000-0001-8189-4509"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Do Lee","raw_affiliation_strings":["Department of Internal Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul;","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045510114","display_name":"Jong Deog Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]},{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Deog Lee","raw_affiliation_strings":["Department of Internal Medicine, Bundang CHA Hospital, University of Pocheon Jungmoon College of Medicine, Seongnam, South Korea","Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bundang CHA Hospital, University of Pocheon Jungmoon College of Medicine, Seongnam, South Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and","institution_ids":["https://openalex.org/I189442560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5103081980"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"],"apc_list":null,"apc_paid":null,"fwci":2.1263,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.87979293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"299","issue":"2","first_page":"L184","last_page":"L191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.921999990940094},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8379999995231628},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.9913404583930969},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7443013191223145},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6577357053756714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6306045055389404},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5879756808280945},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.5597819685935974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5232961773872375},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.37003105878829956},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33182454109191895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3292137384414673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27666744589805603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26932501792907715},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13555222749710083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08666321635246277}],"mesh":[{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097382","descriptor_name":"CD68 Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00303.2009","doi":"https://doi.org/10.1152/ajplung.00303.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00303.2009","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:20472710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20472710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W36475533","https://openalex.org/W1913041723","https://openalex.org/W1926689118","https://openalex.org/W1929009802","https://openalex.org/W1969798546","https://openalex.org/W1971059986","https://openalex.org/W1973741488","https://openalex.org/W1976326847","https://openalex.org/W1979558674","https://openalex.org/W1984154319","https://openalex.org/W1985002063","https://openalex.org/W1987544132","https://openalex.org/W1991453413","https://openalex.org/W1994512268","https://openalex.org/W1997364548","https://openalex.org/W1999223067","https://openalex.org/W2012323932","https://openalex.org/W2012810767","https://openalex.org/W2017487826","https://openalex.org/W2023662838","https://openalex.org/W2038410983","https://openalex.org/W2040999273","https://openalex.org/W2048545157","https://openalex.org/W2049780604","https://openalex.org/W2064273864","https://openalex.org/W2073810634","https://openalex.org/W2079003073","https://openalex.org/W2100631748","https://openalex.org/W2101182707","https://openalex.org/W2102962902","https://openalex.org/W2104447131","https://openalex.org/W2104573070","https://openalex.org/W2114521101","https://openalex.org/W2115014494","https://openalex.org/W2125690417","https://openalex.org/W2127089922","https://openalex.org/W2147243248","https://openalex.org/W2154213275","https://openalex.org/W2160669858","https://openalex.org/W2161669060","https://openalex.org/W2237014276","https://openalex.org/W2331176038"],"related_works":["https://openalex.org/W2034972265","https://openalex.org/W4408643950","https://openalex.org/W2114521101","https://openalex.org/W2357989828","https://openalex.org/W2104573070","https://openalex.org/W2052351422","https://openalex.org/W2123108235","https://openalex.org/W2411143729","https://openalex.org/W7211179653","https://openalex.org/W1983093148"],"abstract_inverted_index":{"Chronic":[0],"airway":[1],"inflammation":[2,55,84],"is":[3,25],"a":[4,20],"characteristic":[5],"feature":[6],"of":[7,88,125,140,173,189],"destructive":[8],"cigarette":[9],"smoking":[10],"(CS)-induced":[11],"lung":[12,104],"disease,":[13],"particularly":[14],"in":[15,45,56,85,102,129,149,159],"patients":[16],"with":[17],"emphysema.":[18,47,192],"Celecoxib,":[19],"specific":[21],"cyclooxygenase-2":[22],"(COX-2)":[23],"inhibitor,":[24],"widely":[26],"used":[27],"to":[28,62],"treat":[29],"inflammation.":[30],"However,":[31],"the":[32,86,123,143,170,187],"exact":[33],"mechanisms":[34],"underlying":[35],"this":[36],"drug's":[37],"anti-inflammatory":[38,171],"effects":[39,172,179],"have":[40],"not":[41],"yet":[42],"been":[43],"determined":[44],"pulmonary":[46,83,191],"Here,":[48],"we":[49],"explore":[50],"whether":[51],"celecoxib":[52,66,77,121,141,174],"attenuates":[53],"CS-induced":[54,111,190],"rat":[57,131],"lungs.":[58],"Rats":[59],"were":[60,116],"exposed":[61],"smoke":[63],"and":[64,82,99,113,127,146],"received":[65],"via":[67],"intragastric":[68],"feeding":[69],"daily":[70],"for":[71],"20":[72],"wk.":[73],"We":[74],"found":[75],"that":[76,110,169],"inhibited":[78,92,117],"interalveolar":[79],"wall":[80],"distance":[81],"lungs":[87],"CS-treated":[89,103,130],"rats.":[90],"Celecoxib":[91,154],"serum":[93],"NO":[94],"production,":[95],"iNOS,":[96],"COX-2":[97,114,144,160],"expression,":[98,183],"PGE(2)":[100],"production":[101],"tissues.":[105],"Our":[106],"immunohistochemical":[107],"data":[108],"showed":[109],"CD68":[112],"expression":[115,145],"by":[118,177],"celecoxib.":[119],"Furthermore,":[120],"attenuated":[122,156],"activation":[124,148,158],"phospho-IkappaBalpha":[126],"NF-kappaB":[128,147,157],"lung.":[132],"In":[133],"addition,":[134],"there":[135],"was":[136],"an":[137],"inhibitory":[138],"effect":[139],"on":[142,180],"LPS-stimulated":[150],"RAW":[151,162],"264.7":[152,163],"macrophages.":[153,164],"also":[155],"siRNA-transfected":[161],"Thus,":[165],"our":[166],"findings":[167],"suggest":[168],"are":[175],"mediated":[176],"its":[178],"NF-kappaB-regulated":[181],"gene":[182],"which":[184],"ultimately":[185],"reduces":[186],"progression":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
