{"id":"https://openalex.org/W2139232274","doi":"https://doi.org/10.2174/156800909789271512","title":"Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?","display_name":"Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2139232274","doi":"https://doi.org/10.2174/156800909789271512","mag":"2139232274","pmid":"https://pubmed.ncbi.nlm.nih.gov/19754356"},"language":"en","primary_location":{"id":"doi:10.2174/156800909789271512","doi":"https://doi.org/10.2174/156800909789271512","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156800909789271512","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087273398","display_name":"Constantina Constantinou","orcid":"https://orcid.org/0000-0001-6167-4023","observed_orcids":["https://orcid.org/0000-0001-6167-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Constantinou","raw_affiliation_strings":["Yasoo Health Ltd, Nicosia, Cyprus. constantina@yasoo.com","Yasoo Health Ltd, Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yasoo Health Ltd, Nicosia, Cyprus. constantina@yasoo.com","institution_ids":[]},{"raw_affiliation_string":"Yasoo Health Ltd, Nicosia, Cyprus","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Papas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Papas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017936206","display_name":"Andreas Ioannou Constantinou","orcid":"https://orcid.org/0000-0003-0365-1821","observed_orcids":["https://orcid.org/0000-0003-0365-1821"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Constantinou","raw_affiliation_strings":["Yasoo Health Ltd, P.O. Box 25193, 1307 Nicosia, Cyprus.,Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yasoo Health Ltd, P.O. Box 25193, 1307 Nicosia, Cyprus.,Cyprus","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017936206"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.486,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.93595798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"717","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cathepsins","display_name":"cathepsins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aif","display_name":"AIF","score":0.7789999842643738},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6624124646186829},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5832219123840332},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.5801422595977783},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5663935542106628},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5545853972434998},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4701920747756958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39020031690597534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2799726724624634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08079087734222412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07226777076721191}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/156800909789271512","doi":"https://doi.org/10.2174/156800909789271512","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156800909789271512","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},{"id":"pmid:19754356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19754356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current cancer drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000083423","https://openalex.org/W4390085934","https://openalex.org/W2138509357","https://openalex.org/W2039191003","https://openalex.org/W1995684250","https://openalex.org/W4297474458","https://openalex.org/W1598164462","https://openalex.org/W1724254908","https://openalex.org/W1993331127","https://openalex.org/W2360384271"],"abstract_inverted_index":{"In":[0,71,119],"the":[1,8,11,40,52,55,59,67,73,94,98,100,115,140,152,164,197],"past":[2],"few":[3],"years,":[4],"accumulating":[5],"evidence":[6,130],"in":[7,83,114,139,145,163],"literature":[9],"supports":[10],"existence":[12],"of":[13,15,36,61,69,117,154,167,171,178,193,199,202],"pathways":[14,22,186],"caspase-independent":[16],"programmed":[17,48],"cell":[18,49],"death":[19,50],"(CI-PCD).":[20],"These":[21],"are":[23,64,79],"likely":[24],"to":[25,43,87],"be":[26],"acting":[27],"as":[28],"'death":[29],"backup":[30],"systems'":[31],"that":[32],"ensure":[33],"effective":[34,173],"removal":[35],"defective":[37],"cells":[38,195],"from":[39],"organism.":[41],"Similar":[42],"classical":[44],"apoptosis":[45],"i.e.":[46],"caspase-dependent":[47],"(CD-PCD),":[51],"mitochondrion":[53],"is":[54],"main":[56],"organelle":[57],"orchestrating":[58],"series":[60],"events":[62],"which":[63,96],"required":[65],"for":[66,131],"induction":[68,116],"CI-PCD.":[70,84,118],"addition,":[72],"pro-apoptotic":[74],"proteins":[75],"Bax":[76],"and":[77,102,128,142,156,184,196],"Bid":[78],"also":[80,109],"key":[81],"participants":[82],"However,":[85],"contrary":[86],"CD-PCD,":[88],"CI-PCD":[89,127,160,185],"involves":[90],"executioners":[91],"other":[92],"than":[93],"caspases":[95],"include":[97],"cathepsins,":[99],"calpains":[101],"serine":[103],"proteases.":[104],"The":[105,176],"protein":[106],"AIF":[107],"may":[108,161],"play":[110],"an":[111],"important":[112],"role":[113],"this":[120],"review":[121],"we":[122,149],"report":[123],"current":[124],"knowledge":[125],"on":[126],"provide":[129],"its":[132],"regulation":[133],"by":[134],"chemotherapeutic":[135,174],"agents":[136,158],"currently":[137],"used":[138],"clinic":[141],"under":[143],"investigation":[144],"clinical":[146],"trials.":[147],"Lastly,":[148],"discuss":[150],"how":[151],"study":[153],"natural":[155],"synthetic":[157],"triggering":[159],"help":[162],"pharmacological":[165],"design":[166],"a":[168,189],"new":[169],"generation":[170],"more":[172,190],"drugs.":[175],"use":[177],"such":[179],"drugs":[180],"activating":[181],"both":[182],"CD-PCD":[183],"should":[187],"achieve":[188],"successful":[191],"eradication":[192],"carcinogenic":[194],"attainment":[198],"lower":[200],"levels":[201],"tumor":[203],"resistance.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}