{"id":"https://openalex.org/W2139232211","doi":"https://doi.org/10.1093/ntr/ntq179","title":"Behavioral Effects of Nicotine Withdrawal Differ by Genetic Strain in Male and Female Adolescent Rats","display_name":"Behavioral Effects of Nicotine Withdrawal Differ by Genetic Strain in Male and Female Adolescent Rats","publication_year":2010,"publication_date":"2010-11-11","ids":{"openalex":"https://openalex.org/W2139232211","doi":"https://doi.org/10.1093/ntr/ntq179","mag":"2139232211","pmid":"https://pubmed.ncbi.nlm.nih.gov/21071625"},"language":"en","primary_location":{"id":"doi:10.1093/ntr/ntq179","doi":"https://doi.org/10.1093/ntr/ntq179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ntr/ntq179","pdf_url":null,"source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine &amp; Tobacco Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055191678","display_name":"Kristen R. Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. R. Hamilton","raw_affiliation_strings":["Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland 20814, USA. KristenH.818@gmail.com","Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland 20814, USA. KristenH.818@gmail.com","institution_ids":["https://openalex.org/I148314036"]},{"raw_affiliation_string":"Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland 20814, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081280179","display_name":"Michael E. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. E. Perry","raw_affiliation_strings":["Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. S. Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Berger","raw_affiliation_strings":["Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090134782","display_name":"Neil E. Grunberg","orcid":"https://orcid.org/0000-0002-2334-600X","observed_orcids":["https://orcid.org/0000-0002-2334-600X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. E. Grunberg","raw_affiliation_strings":["Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniformed Services University, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":5392,"currency":"USD","value_usd":5392},"apc_paid":null,"fwci":1.2983,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.80032131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"12","first_page":"1236","last_page":"1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine-withdrawal","display_name":"nicotine withdrawal","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adolescent-rats","display_name":"adolescent rats","score":0.6919999718666077},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9580000042915344},{"id":"https://openalex.org/keywords/genetic-strain-differences","display_name":"genetic strain differences","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.9440000057220459},{"id":"https://openalex.org/keywords/long-evans-rats","display_name":"Long-Evans rats","score":1.0},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.4099999964237213},{"id":"https://openalex.org/keywords/withdrawal-behavior","display_name":"withdrawal behavior","score":0.6759999990463257},{"id":"https://openalex.org/keywords/smoking-initiation","display_name":"smoking initiation","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.9184948801994324},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.761053204536438},{"id":"https://openalex.org/C2779177420","wikidata":"https://www.wikidata.org/wiki/Q3961638","display_name":"Nicotine withdrawal","level":3,"score":0.724969744682312},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.5634504556655884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5567159056663513},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4490250051021576},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.44793379306793213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44682469964027405},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4195578396320343},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38009583950042725},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3602107763290405},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000294","descriptor_name":"Adolescent Behavior","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/ntr/ntq179","doi":"https://doi.org/10.1093/ntr/ntq179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ntr/ntq179","pdf_url":null,"source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine &amp; Tobacco Research","raw_type":"journal-article"},{"id":"pmid:21071625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21071625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco","raw_type":"Comparative Study"},{"id":"pmh:oai:open-archive.highwire.org:nictob:ntq179v1","doi":null,"is_oa":false,"landing_page_url":"http://ntr.oxfordjournals.org/cgi/content/short/ntq179v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W2040695","https://openalex.org/W29281053","https://openalex.org/W157212322","https://openalex.org/W1516172865","https://openalex.org/W1534681831","https://openalex.org/W1933095040","https://openalex.org/W1936476494","https://openalex.org/W1970290009","https://openalex.org/W1981667704","https://openalex.org/W1982978113","https://openalex.org/W1983036753","https://openalex.org/W1984130100","https://openalex.org/W1985645068","https://openalex.org/W1985797498","https://openalex.org/W1986183173","https://openalex.org/W1987318732","https://openalex.org/W2002531463","https://openalex.org/W2003174307","https://openalex.org/W2004239987","https://openalex.org/W2004309460","https://openalex.org/W2006294684","https://openalex.org/W2007753563","https://openalex.org/W2020582575","https://openalex.org/W2021089766","https://openalex.org/W2025491101","https://openalex.org/W2029680130","https://openalex.org/W2036345851","https://openalex.org/W2042886270","https://openalex.org/W2045197882","https://openalex.org/W2048956896","https://openalex.org/W2049979645","https://openalex.org/W2050526587","https://openalex.org/W2054388960","https://openalex.org/W2059022383","https://openalex.org/W2064466803","https://openalex.org/W2064861243","https://openalex.org/W2083993994","https://openalex.org/W2085299802","https://openalex.org/W2086962429","https://openalex.org/W2092894525","https://openalex.org/W2093867596","https://openalex.org/W2098436801","https://openalex.org/W2102510891","https://openalex.org/W2119968344","https://openalex.org/W2120481990","https://openalex.org/W2126347413","https://openalex.org/W2130528787","https://openalex.org/W2141547840","https://openalex.org/W2158219670","https://openalex.org/W2159869092","https://openalex.org/W2161008067","https://openalex.org/W2165810630","https://openalex.org/W2168015246","https://openalex.org/W2168426190","https://openalex.org/W2304131176","https://openalex.org/W4200592891","https://openalex.org/W4244098017"],"related_works":["https://openalex.org/W2625408141","https://openalex.org/W293104324","https://openalex.org/W2036345851","https://openalex.org/W2156627321","https://openalex.org/W2019674734","https://openalex.org/W2141547840","https://openalex.org/W2981813191","https://openalex.org/W2023272465","https://openalex.org/W2028068179","https://openalex.org/W2006805783"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Gender":[1],"and":[2,9,36,55,60,88,113,118,130,197],"ethnicity":[3],"are":[4],"powerful":[5],"predictors":[6],"of":[7,11,72,95,135,164,182],"initiation":[8],"maintenance":[10],"cigarette":[12],"smoking":[13,24],"in":[14,23,25,39,51,191],"adults":[15],"but":[16,158],"less":[17],"is":[18],"known":[19],"about":[20],"their":[21],"role":[22],"adolescents.":[26],"Consistent":[27],"with":[28,139,168],"human":[29],"studies,":[30],"rat":[31],"models":[32],"also":[33],"reveal":[34],"sex":[35,196],"strain":[37],"differences":[38],"response":[40],"to":[41],"nicotine":[42,48,77,92,123,136,150,165,183,189],"administration.":[43,93,184],"METHODS:":[44],"This":[45],"research":[46],"examined":[47],"withdrawal":[49,127,154,178,190],"behaviors":[50,98,128,155,179],"96":[52],"adolescent,":[53],"male":[54,117,146],"female,":[56],"Sprague":[57],"Dawley":[58],"(SD)":[59],"Long":[61],"Evans":[62],"(LE)":[63],"rats.":[64],"Rats":[65],"received":[66,122,143,149,171],"seven":[67],"days":[68,132,161],"continuous":[69],"subcutaneous":[70],"infusion":[71],"saline":[73,90],"or":[74,91,103],"3.16":[75],"mg/kg":[76],"via":[78],"Alzet":[79],"osmotic":[80],"minipumps.":[81],"Behavioral":[82],"observations":[83],"were":[84,99],"made":[85],"before,":[86],"during,":[87],"after":[89,133,162,180],"Occurrences":[94],"six":[96],"specific":[97],"quantified:":[100],"abnormal":[101,105],"posture":[102],"movement,":[104],"grooming,":[106],"whole-body":[107],"shakes,":[108],"ptosis,":[109],"empty-mouth":[110],"chewing/teeth":[111],"chattering,":[112],"diarrhea.":[114],"RESULTS:":[115],"SD":[116],"female":[119],"rats":[120,140,147,193],"that":[121,141,148,170,188],"displayed":[124,151],"significantly":[125,152],"more":[126,153],"1":[129,156],"2":[131,160],"cessation":[134,163,181],"administration":[137,166],"compared":[138,167],"had":[142],"saline.":[144,172],"LE":[145,173],"day":[157],"not":[159],"males":[169],"females":[174],"showed":[175],"no":[176],"significant":[177],"CONCLUSION:":[185],"Results":[186],"indicate":[187],"adolescent":[192],"depends":[194],"on":[195],"strain.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
