{"id":"https://openalex.org/W2139229692","doi":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","title":"Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt","display_name":"Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2139229692","doi":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","mag":"2139229692","pmid":"https://pubmed.ncbi.nlm.nih.gov/10899066"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.2000.279.1.h269","doi":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046557083","display_name":"Timothy Robert Nurkiewicz","orcid":"https://orcid.org/0000-0001-9105-970X","observed_orcids":["https://orcid.org/0000-0001-9105-970X"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R. Nurkiewicz","raw_affiliation_strings":["Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26505-9229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26505-9229","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070683975","display_name":"Matthew A. Boegehold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Boegehold","raw_affiliation_strings":["Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26505-9229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26505-9229","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":null,"apc_paid":null,"fwci":1.234,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.82494023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"279","issue":"1","first_page":"H269","last_page":"H278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8619999885559082},{"id":"https://openalex.org/keywords/myogenic-response","display_name":"myogenic response","score":0.6800000071525574},{"id":"https://openalex.org/keywords/arteriolar-vasoconstriction","display_name":"arteriolar constriction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dietary-salt","display_name":"dietary salt","score":0.8920000195503235},{"id":"https://openalex.org/keywords/striated-muscle","display_name":"striated muscle","score":0.6370000243186951},{"id":"https://openalex.org/keywords/spinotrapezius-muscle","display_name":"spinotrapezius muscle","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bradykinin-receptors","display_name":"bradykinin receptors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/saralasin","display_name":"saralasin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.996999979019165},{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":0.9660000205039978},{"id":"https://openalex.org/keywords/microvascular-pressure","display_name":"microvascular pressure","score":0.5},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.5370000004768372},{"id":"https://openalex.org/keywords/kinins","display_name":"kinins","score":0.375}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7752461433410645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7484049201011658},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.6857081651687622},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6364702582359314},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.5788788199424744},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5674759745597839},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5608911514282227},{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.5492536425590515},{"id":"https://openalex.org/C58336856","wikidata":"https://www.wikidata.org/wiki/Q6947924","display_name":"Myogenic contraction","level":3,"score":0.5237510204315186},{"id":"https://openalex.org/C2776823063","wikidata":"https://www.wikidata.org/wiki/Q410298","display_name":"Saralasin","level":4,"score":0.4957810342311859},{"id":"https://openalex.org/C2779482390","wikidata":"https://www.wikidata.org/wiki/Q501908","display_name":"Arteriole","level":3,"score":0.43946942687034607},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34573209285736084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21834483742713928},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.1896284520626068},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17671918869018555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1481194794178009},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.08910664916038513}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004039","descriptor_name":"Diet, Sodium-Restricted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012504","descriptor_name":"Saralasin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012982","descriptor_name":"Sodium, Dietary","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.2000.279.1.h269","doi":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2000.279.1.h269","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:10899066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10899066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2227409452","display_name":null,"funder_award_id":"HL 44012","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3845251669","display_name":"HEMODYNAMIC SHEAR AND THE MICROVASCULAR ENDOTHELIUM","funder_award_id":"5r01hl052019-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6882003103","display_name":null,"funder_award_id":"HL-52019","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W56278486","https://openalex.org/W164612407","https://openalex.org/W1577710131","https://openalex.org/W1764686129","https://openalex.org/W1846153624","https://openalex.org/W1901307347","https://openalex.org/W1917603878","https://openalex.org/W1972441590","https://openalex.org/W1974146850","https://openalex.org/W2003011648","https://openalex.org/W2012505976","https://openalex.org/W2022480747","https://openalex.org/W2031789966","https://openalex.org/W2035821934","https://openalex.org/W2043563682","https://openalex.org/W2058138585","https://openalex.org/W2060186899","https://openalex.org/W2063517016","https://openalex.org/W2063580331","https://openalex.org/W2072282898","https://openalex.org/W2084279444","https://openalex.org/W2085376059","https://openalex.org/W2086603908","https://openalex.org/W2089561471","https://openalex.org/W2089904626","https://openalex.org/W2091413897","https://openalex.org/W2096682768","https://openalex.org/W2101722224","https://openalex.org/W2107290312","https://openalex.org/W2114078844","https://openalex.org/W2118463160","https://openalex.org/W2121688425","https://openalex.org/W2122228543","https://openalex.org/W2123777106","https://openalex.org/W2125659917","https://openalex.org/W2151120287","https://openalex.org/W2152100167","https://openalex.org/W2185525505","https://openalex.org/W2227892608","https://openalex.org/W2252818142","https://openalex.org/W2268368775","https://openalex.org/W2297595497","https://openalex.org/W2308395310","https://openalex.org/W2336886330","https://openalex.org/W2341636139","https://openalex.org/W2397712656","https://openalex.org/W2397912504","https://openalex.org/W2412412126","https://openalex.org/W2414629428","https://openalex.org/W2416186957","https://openalex.org/W2417903773","https://openalex.org/W2418579540","https://openalex.org/W2419595658","https://openalex.org/W2420788226","https://openalex.org/W2420838040","https://openalex.org/W2466489690"],"related_works":["https://openalex.org/W7172334776","https://openalex.org/W2184804607","https://openalex.org/W2089561471","https://openalex.org/W2297595497","https://openalex.org/W2167927265","https://openalex.org/W2341636139","https://openalex.org/W2107290312","https://openalex.org/W2296122219","https://openalex.org/W2099216792","https://openalex.org/W2252318615"],"abstract_inverted_index":{"The":[0,103,120],"purpose":[1],"of":[2,39],"this":[3],"study":[4],"was":[5],"to":[6,92,100,150,187],"determine":[7],"whether":[8,32],"endogenous":[9,164],"ANG":[10,21,40,104,165,190],"II":[11,22,41,166,191],"augments":[12],"arteriolar":[13,76,86,169],"myogenic":[14,43,111,128,135,148,170,178],"behavior":[15,171,179],"in":[16,58,88,96,113,130,137,154,158,172],"striated":[17,173],"muscle.":[18],"Because":[19],"circulating":[20,189],"is":[23,185],"decreased":[24,188],"during":[25],"high":[26,182],"salt":[27,34,71,183],"intake,":[28],"we":[29],"also":[30],"investigated":[31],"dietary":[33],"could":[35],"alter":[36],"any":[37],"influence":[38],"on":[42,127],"behavior.":[44],"Normotensive":[45],"rats":[46,90,98,115,132,156],"fed":[47],"low-salt":[48],"(0.45%,":[49],"LS)":[50],"or":[51],"high-salt":[52],"(7%,":[53],"HS)":[54],"diets":[55],"were":[56],"enclosed":[57],"a":[59,151],"ventilated":[60],"box":[61,82],"with":[62,141,181],"the":[63,142],"spinotrapezius":[64],"muscle":[65,174],"exteriorized":[66],"for":[67],"intravital":[68],"microscopy.":[69],"Dietary":[70],"did":[72],"not":[73,117],"affect":[74],"resting":[75],"diameters.":[77],"Microvascular":[78],"pressure":[79],"elevation":[80],"by":[81],"pressurization":[83],"caused":[84],"greater":[85,152],"constriction":[87],"LS":[89,114,131,155],"(up":[91,99],"12":[93],"microm)":[94],"than":[95,157],"HS":[97,118,138,159],"4":[101],"microm).":[102],"II-receptor":[105],"antagonists":[106],"saralasin":[107],"and":[108,175,192],"losartan":[109],"attenuated":[110,147,177],"responsiveness":[112,129,136,149],"but":[116,133],"rats.":[119,139,160],"bradykinin-receptor":[121],"antagonist":[122],"HOE-140":[123,140],"had":[124],"no":[125],"effect":[126],"augmented":[134],"angiotensin-converting":[143],"enzyme":[144],"inhibitor":[145],"captopril":[146],"extent":[153],"We":[161],"conclude":[162],"that":[163,176],"normally":[167],"reinforces":[168],"associated":[180],"intake":[184],"due":[186],"increased":[193],"local":[194],"kinin":[195],"levels.":[196]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}